Mycobacterium tuberculosis
| Assembly | 物理组成 | 蛋白状态 | 分子拷贝数 | 共同组分 | 数据核对 |
|---|---|---|---|---|---|
| 1 | 蛋白同源多聚体 | 同源多聚体 | 蛋白 2 | ETHANOL × 5 GLYCEROL × 5 5-methoxy-N-(methylsulfonyl)-1H-indole-2-carboxamide × 2 SULFATE ION × 1 water × 2 | 与蛋白数一致 |
| UniProt名称 | PANC_MYCTU |
| Isoform | — |
| PDB实体 | 1 |
| 链与序列区间 | 作者链 A； PDB构建体 2–289； UniProt 2–289 作者链 B； PDB构建体 2–289； UniProt 2–289 |
页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中；数据库内部编号、导入时间和 assembly 操作表达式仅用于维护，因此不在读者页面展示。
| 条目编号 entry_id | 3isj |
| 沉积日期 deposition_date | 2009-08-26 |
| 结构标题 title | Crystal structure of pantothenate synthetase from Mycobacterium tuberculosis in complex with 5-methoxy-N-(methylsulfonyl)-1H-indole-2-carboxamide |
| 关键词 keywords | ;Mycobacterium tuberculosis, pantothenate synthetase, fragment-based drug design, ATP-binding, Ligase, Magnesium, Metal-binding, Nucleotide-binding, Pantothenate biosynthesis ;; LIGASE |
| 实验方法 method | X-RAY DIFFRACTION |
页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。
Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)
| Rg（Guinier） | 31.62 Å |
| Rg（电子密度） | 31.54 Å |
| 总 Rg | 32.02 Å |
| 原子数 | 4255 |
| 残基数 | 566 |
| 排除体积 | 76178 ų |
| 最大 q | 0.500 Å⁻¹ |
| 结构域编号 domain_id | d3isja_ |
| 类 Class class | c — Alpha and beta proteins (a/b) |
| 折叠类型 Fold fold | c.26 — Adenine nucleotide alpha hydrolase-like |
| 超家族 Superfamily superfamily | c.26.1 — Nucleotidylyl transferase |
| 家族 Family family | c.26.1.4 — Pantothenate synthetase (Pantoate-beta-alanine ligase, PanC) |
| 结构域编号 domain_id | d3isjb_ |
| 类 Class class | c — Alpha and beta proteins (a/b) |
| 折叠类型 Fold fold | c.26 — Adenine nucleotide alpha hydrolase-like |
| 超家族 Superfamily superfamily | c.26.1 — Nucleotidylyl transferase |
| 家族 Family family | c.26.1.4 — Pantothenate synthetase (Pantoate-beta-alanine ligase, PanC) |
| 结构域编号 domain_id | 3isjA01 |
| 类 Class class | 3 — Alpha Beta |
| 架构 Architecture architecture | 40 — 3-Layer(aba) Sandwich |
| 拓扑 Topology topology | 50 — Rossmann fold |
| 同源超家族 H-superfamily homologous superfamily | 620 — HUPs |
| 结构域编号 domain_id | 3isjA02 |
| 类 Class class | 3 — Alpha Beta |
| 架构 Architecture architecture | 30 — 2-Layer Sandwich |
| 拓扑 Topology topology | 1300 — Pantoate--beta-alanine Ligase; Chain: A,domain 2 |
| 同源超家族 H-superfamily homologous superfamily | 10 — Pantoate-beta-alanine ligase, C-terminal domain |
| 结构域编号 domain_id | 3isjB01 |
| 类 Class class | 3 — Alpha Beta |
| 架构 Architecture architecture | 40 — 3-Layer(aba) Sandwich |
| 拓扑 Topology topology | 50 — Rossmann fold |
| 同源超家族 H-superfamily homologous superfamily | 620 — HUPs |
| 结构域编号 domain_id | 3isjB02 |
| 类 Class class | 3 — Alpha Beta |
| 架构 Architecture architecture | 30 — 2-Layer Sandwich |
| 拓扑 Topology topology | 1300 — Pantoate--beta-alanine Ligase; Chain: A,domain 2 |
| 同源超家族 H-superfamily homologous superfamily | 10 — Pantoate-beta-alanine ligase, C-terminal domain |