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3mhk

Human tankyrase 2 - catalytic PARP domain in complex with 2-(2-pyridyl)-7,8-dihydro-5h-thiino[4,3-d]pyrimidin-4-ol

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Tankyrase-2

Homo sapiens

UniProt Q9H2K2

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein monomer Monomer Protein 1 ZINC ION × 1 2-pyridin-2-yl-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol × 1 GLYCEROL × 3 water × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
3kr7 3kr8 3kr8 3mhj 3mhj 3mhk 3p0n 3p0n 3p0p 3p0p 3p0q 3p0q

221 assemblies; showing the first 12

Homodimer
3twq 4hki 4hki 4hkk 4hkk 4hkn 4hl5 4hlf 4hlf 4hlg 4hlg 4hlh

138 assemblies; showing the first 12

Homotetramer

None

Other homooligomers
8aly 8w2u

2 assemblies

Heteromeric or nucleic-acid complex
2y0i 3twr 3twr 3twr 3twr 3tws 3tws 3tws 3tws 3twt 3twt 3twt

30 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name TNKS2_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 2–216； UniProt 952–1166

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id3mhk
Deposition date deposition_date2010-04-08
Structure title titleHuman tankyrase 2 - catalytic PARP domain in complex with 2-(2-pyridyl)-7,8-dihydro-5h-thiino[4,3-d]pyrimidin-4-ol
Keywords keywords;CATALYTIC FRAGMENT, PARP, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, ADP-RIBOSYLATION, ANK REPEAT, CHROMOSOMAL PROTEIN, GLYCOSYLTRANSFERASE, GOLGI APPARATUS, MEMBRANE, MRNA TRANSPORT, NAD, NUCLEUS, PHOSPHORYLATION, PROTEIN TRANSPORT, TELOMERE, TRANSFERASE, TRANSLOCATION, TRANSPORT, WNT-SIGNALLING ;; TRANSFERASE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

3mhk__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

3mhk__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

3mhk__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）18.10 Å
Rg (electron density)16.91 Å
Total Rg18.00 Å
Atom count1722
Residues210
Excluded volume30295 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 3mhk__assembly_1__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (5)

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6. Fold Classification (SCOP + CATH) 1 domains

CATH v4.4 (1 domains)

Domain ID domain_id3mhkA00
Class class3 — Alpha Beta
Architecture architecture90 — Alpha-Beta Complex
Topology topology228 — Phosphoenolpyruvate Carboxykinase; domain 3
Homologous superfamily homologous superfamily10 —
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7. Citations (1)