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3o8r

Visualizing ATP-dependent RNA Translocation by the NS3 Helicase from HCV

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

HCV NS3 protease/helicase

Hepatitis C virus subtype 1b

UniProt Q99AU2

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Homooligomer Protein 2 RNA 1 ;RNA (5'-R(P*UP*(5BU)P*UP*UP*UP*U)-3') ; × 1 ZINC ION × 2 MAGNESIUM ION × 1 ADENOSINE-5'-DIPHOSPHATE × 1 BERYLLIUM TRIFLUORIDE ION × 1 SULFATE ION × 2 water × 3 Consistent with all polymers

Other States of the Same Protein in the Database

Monomer
2d3u 2d3u 2d3z 2d3z 2d41 2d41 2gc8 2gc8 2ijn 2ijn 2qe2 2qe2

34 assemblies; showing the first 12

Homodimer
3o8d

1 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
3o8c 3o8r

2 assemblies

View Construct and Data Evidence
UniProt name Q99AU2_9HEPC
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 38–666； UniProt 1029–1657 Author chain B； PDBConstruct 38–666； UniProt 1029–1657

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id3o8r
Deposition date deposition_date2010-08-03
Structure title titleVisualizing ATP-dependent RNA Translocation by the NS3 Helicase from HCV
Keywords keywordshelicase, NTPase, HCV, RNA, translocation, ADP, beryllium trifluoride, protease/NTPase/helicase, HYDROLASE-RNA complex; HYDROLASE/RNA
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

3o8r__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

3o8r__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

3o8r__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）34.22 Å
Rg (electron density)33.48 Å
Total Rg33.97 Å
Atom count9780
Residues1295
Excluded volume173450 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 3o8r__assembly_1__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (8)

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6. Fold Classification (SCOP + CATH) 10 domains

CATH v4.4 (10 domains)

Domain ID domain_id3o8rA01
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology10 — Thrombin, subunit H
Homologous superfamily homologous superfamily120 —
Domain ID domain_id3o8rA02
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology10 — Thrombin, subunit H
Homologous superfamily homologous superfamily10 — Trypsin-like serine proteases
Domain ID domain_id3o8rA03
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
Domain ID domain_id3o8rA04
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
Domain ID domain_id3o8rA05
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology820 — RNA Helicase; Chain A, domain 3
Homologous superfamily homologous superfamily10 — RNA Helicase Chain A , domain 3
Domain ID domain_id3o8rB01
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology10 — Thrombin, subunit H
Homologous superfamily homologous superfamily120 —
Domain ID domain_id3o8rB02
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology10 — Thrombin, subunit H
Homologous superfamily homologous superfamily10 — Trypsin-like serine proteases
Domain ID domain_id3o8rB03
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
Domain ID domain_id3o8rB04
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
Domain ID domain_id3o8rB05
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology820 — RNA Helicase; Chain A, domain 3
Homologous superfamily homologous superfamily10 — RNA Helicase Chain A , domain 3
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7. Citations (1)