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3qs8

Anthranilate phosphoribosyltransferase (trpD) from Mycobacterium tuberculosis (complex with inhibitor ACS174)

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Anthranilate phosphoribosyltransferase

Mycobacterium tuberculosis

UniProt P66992

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 2 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose × 2 MAGNESIUM ION × 4 2-benzylbenzoic acid × 3 water × 2 Consistent with protein count
2 Protein homooligomer Homooligomer Protein 2 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose × 2 MAGNESIUM ION × 4 2-benzylbenzoic acid × 3 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1zvw 1zvw 3r6c 3r6c 3uu1 3uu1 3uu1 3uu1

8 assemblies

Homodimer
2bpq 3qqs 3qqs 3qr9 3qs8 3qs8 3qsa 3r88 3twp 3twp 4giu 4gkm

24 assemblies; showing the first 12

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex

None

View Construct and Data Evidence
UniProt name TRPD_MYCTU
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–369； UniProt 2–370 Author chain B； PDBConstruct 1–369； UniProt 2–370 Author chain C； PDBConstruct 1–369； UniProt 2–370 Author chain D； PDBConstruct 1–369； UniProt 2–370

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id3qs8
Deposition date deposition_date2011-02-20
Structure title titleAnthranilate phosphoribosyltransferase (trpD) from Mycobacterium tuberculosis (complex with inhibitor ACS174)
Keywords keywords;Anthranilate Phosphoribosyltransferase, Anthranilic Acids, Magnesium, Tryptophan, Magnesium binding Phosphoribosyl pyrophosphate, Transferase-Transferase Inhibitor complex, Structural Genomics, TB Structural Genomics Consortium, TBSGC ;; Transferase/Transferase Inhibitor
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

3qs8__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

3qs8__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

3qs8__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）32.00 Å
Rg (electron density)31.86 Å
Total Rg32.19 Å
Atom count5106
Residues692
Excluded volume90144 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 3qs8__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 3qs8__assembly_2__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (5)

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6. Fold Classification (SCOP + CATH) 8 domains

CATH v4.4 (8 domains)

Domain ID domain_id3qs8A01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology970 — Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3
Homologous superfamily homologous superfamily10 — Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C
Domain ID domain_id3qs8A02
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology1030 — Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2
Homologous superfamily homologous superfamily10 — Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain
Domain ID domain_id3qs8B01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology970 — Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3
Homologous superfamily homologous superfamily10 — Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C
Domain ID domain_id3qs8B02
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology1030 — Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2
Homologous superfamily homologous superfamily10 — Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain
Domain ID domain_id3qs8C01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology970 — Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3
Homologous superfamily homologous superfamily10 — Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C
Domain ID domain_id3qs8C02
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology1030 — Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2
Homologous superfamily homologous superfamily10 — Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain
Domain ID domain_id3qs8D01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology970 — Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3
Homologous superfamily homologous superfamily10 — Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C
Domain ID domain_id3qs8D02
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology1030 — Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2
Homologous superfamily homologous superfamily10 — Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain
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7. Citations (1)