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3r84

Structure of the Mediator head subcomplex Med11/22

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Mediator of RNA polymerase II transcription subunit 11

Saccharomyces cerevisiae

UniProt Q99278

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 Mediator of RNA polymerase II transcription subunit 22 × 1 （P32570） water × 2 Consistent with protein count
10 Protein heterocomplex Heteromer Protein 2 Mediator of RNA polymerase II transcription subunit 22 × 1 （P32570） water × 2 Consistent with protein count
11 Protein heterocomplex Heteromer Protein 2 Mediator of RNA polymerase II transcription subunit 22 × 1 （P32570） water × 2 Consistent with protein count
12 Protein heterocomplex Heteromer Protein 2 Mediator of RNA polymerase II transcription subunit 22 × 1 （P32570） water × 2 Consistent with protein count
13 Protein heterocomplex Heteromer Protein 4 Mediator of RNA polymerase II transcription subunit 22 × 2 （P32570） water × 4 Consistent with protein count
14 Protein heterocomplex Heteromer Protein 4 Mediator of RNA polymerase II transcription subunit 22 × 2 （P32570） water × 4 Consistent with protein count
15 Protein heterocomplex Heteromer Protein 4 Mediator of RNA polymerase II transcription subunit 22 × 2 （P32570） water × 4 Consistent with protein count
16 Protein heterocomplex Heteromer Protein 4 Mediator of RNA polymerase II transcription subunit 22 × 2 （P32570） water × 4 Consistent with protein count
17 Protein heterocomplex Heteromer Protein 4 Mediator of RNA polymerase II transcription subunit 22 × 2 （P32570） water × 4 Consistent with protein count
18 Protein heterocomplex Heteromer Protein 4 Mediator of RNA polymerase II transcription subunit 22 × 2 （P32570） water × 4 Consistent with protein count
19 Protein heterocomplex Heteromer Protein 24 Mediator of RNA polymerase II transcription subunit 22 × 12 （P32570） water × 24 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 Mediator of RNA polymerase II transcription subunit 22 × 1 （P32570） water × 2 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 2 Mediator of RNA polymerase II transcription subunit 22 × 1 （P32570） water × 2 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 2 Mediator of RNA polymerase II transcription subunit 22 × 1 （P32570） water × 2 Consistent with protein count
5 Protein heterocomplex Heteromer Protein 2 Mediator of RNA polymerase II transcription subunit 22 × 1 （P32570） water × 2 Consistent with protein count
6 Protein heterocomplex Heteromer Protein 2 Mediator of RNA polymerase II transcription subunit 22 × 1 （P32570） water × 2 Consistent with protein count
7 Protein heterocomplex Heteromer Protein 2 Mediator of RNA polymerase II transcription subunit 22 × 1 （P32570） water × 2 Consistent with protein count
8 Protein heterocomplex Heteromer Protein 2 Mediator of RNA polymerase II transcription subunit 22 × 1 （P32570） water × 2 Consistent with protein count
9 Protein heterocomplex Heteromer Protein 2 Mediator of RNA polymerase II transcription subunit 22 × 1 （P32570） water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
3r84 3r84 3r84 3r84 3r84 3r84 3r84 3r84 3r84 3r84 3r84 3r84

32 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name MED11_YEAST
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 2–86； UniProt 21–105 Author chain C； PDBConstruct 2–86； UniProt 21–105 Author chain E； PDBConstruct 2–86； UniProt 21–105 Author chain G； PDBConstruct 2–86； UniProt 21–105 Author chain I； PDBConstruct 2–86； UniProt 21–105 Author chain K； PDBConstruct 2–86； UniProt 21–105 Author chain M； PDBConstruct 2–86； UniProt 21–105 Author chain O； PDBConstruct 2–86； UniProt 21–105 Author chain Q； PDBConstruct 2–86； UniProt 21–105 Author chain S； PDBConstruct 2–86； UniProt 21–105 Author chain U； PDBConstruct 2–86； UniProt 21–105 Author chain W； PDBConstruct 2–86； UniProt 21–105

Mediator of RNA polymerase II transcription subunit 22

Saccharomyces cerevisiae

UniProt P32570

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 Mediator of RNA polymerase II transcription subunit 11 × 1 （Q99278） water × 2 Consistent with protein count
10 Protein heterocomplex Heteromer Protein 2 Mediator of RNA polymerase II transcription subunit 11 × 1 （Q99278） water × 2 Consistent with protein count
11 Protein heterocomplex Heteromer Protein 2 Mediator of RNA polymerase II transcription subunit 11 × 1 （Q99278） water × 2 Consistent with protein count
12 Protein heterocomplex Heteromer Protein 2 Mediator of RNA polymerase II transcription subunit 11 × 1 （Q99278） water × 2 Consistent with protein count
13 Protein heterocomplex Heteromer Protein 4 Mediator of RNA polymerase II transcription subunit 11 × 2 （Q99278） water × 4 Consistent with protein count
14 Protein heterocomplex Heteromer Protein 4 Mediator of RNA polymerase II transcription subunit 11 × 2 （Q99278） water × 4 Consistent with protein count
15 Protein heterocomplex Heteromer Protein 4 Mediator of RNA polymerase II transcription subunit 11 × 2 （Q99278） water × 4 Consistent with protein count
16 Protein heterocomplex Heteromer Protein 4 Mediator of RNA polymerase II transcription subunit 11 × 2 （Q99278） water × 4 Consistent with protein count
17 Protein heterocomplex Heteromer Protein 4 Mediator of RNA polymerase II transcription subunit 11 × 2 （Q99278） water × 4 Consistent with protein count
18 Protein heterocomplex Heteromer Protein 4 Mediator of RNA polymerase II transcription subunit 11 × 2 （Q99278） water × 4 Consistent with protein count
19 Protein heterocomplex Heteromer Protein 24 Mediator of RNA polymerase II transcription subunit 11 × 12 （Q99278） water × 24 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 Mediator of RNA polymerase II transcription subunit 11 × 1 （Q99278） water × 2 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 2 Mediator of RNA polymerase II transcription subunit 11 × 1 （Q99278） water × 2 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 2 Mediator of RNA polymerase II transcription subunit 11 × 1 （Q99278） water × 2 Consistent with protein count
5 Protein heterocomplex Heteromer Protein 2 Mediator of RNA polymerase II transcription subunit 11 × 1 （Q99278） water × 2 Consistent with protein count
6 Protein heterocomplex Heteromer Protein 2 Mediator of RNA polymerase II transcription subunit 11 × 1 （Q99278） water × 2 Consistent with protein count
7 Protein heterocomplex Heteromer Protein 2 Mediator of RNA polymerase II transcription subunit 11 × 1 （Q99278） water × 2 Consistent with protein count
8 Protein heterocomplex Heteromer Protein 2 Mediator of RNA polymerase II transcription subunit 11 × 1 （Q99278） water × 2 Consistent with protein count
9 Protein heterocomplex Heteromer Protein 2 Mediator of RNA polymerase II transcription subunit 11 × 1 （Q99278） water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
3j1o 3r84 3r84 3r84 3r84 3r84 3r84 3r84 3r84 3r84 3r84 3r84

34 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name MED22_YEAST
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 5–92； UniProt 2–89 Author chain D； PDBConstruct 5–92； UniProt 2–89 Author chain F； PDBConstruct 5–92； UniProt 2–89 Author chain H； PDBConstruct 5–92； UniProt 2–89 Author chain J； PDBConstruct 5–92； UniProt 2–89 Author chain L； PDBConstruct 5–92； UniProt 2–89 Author chain N； PDBConstruct 5–92； UniProt 2–89 Author chain P； PDBConstruct 5–92； UniProt 2–89 Author chain R； PDBConstruct 5–92； UniProt 2–89 Author chain T； PDBConstruct 5–92； UniProt 2–89 Author chain V； PDBConstruct 5–92； UniProt 2–89 Author chain X； PDBConstruct 5–92； UniProt 2–89

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id3r84
Deposition date deposition_date2011-03-23
Structure title titleStructure of the Mediator head subcomplex Med11/22
Keywords keywordsfour-helix bundle, transcription, nucleus; TRANSCRIPTION
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

3r84__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

3r84__assembly_1__model_1 | I(q)

10-2 10-1 105 106 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

3r84__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）20.30 Å
Rg (electron density)20.04 Å
Total Rg20.52 Å
Atom count1301
Residues157
Excluded volume23474 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 3r84__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 3r84__assembly_2__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 3r84__assembly_3__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
4 1 3r84__assembly_4__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
5 1 3r84__assembly_5__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
6 1 3r84__assembly_6__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
7 1 3r84__assembly_7__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
8 1 3r84__assembly_8__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
9 1 3r84__assembly_9__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
10 1 3r84__assembly_10__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
11 1 3r84__assembly_11__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
12 1 3r84__assembly_12__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
13 1 3r84__assembly_13__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
14 1 3r84__assembly_14__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
15 1 3r84__assembly_15__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
16 1 3r84__assembly_16__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
17 1 3r84__assembly_17__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
18 1 3r84__assembly_18__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
19 1 3r84__assembly_19__model_1 24-meric （24） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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6. Fold Classification (SCOP + CATH) 24 domains

CATH v4.4 (24 domains)

Domain ID domain_id3r84A00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology287 — Helix Hairpins
Homologous superfamily homologous superfamily3490 —
Domain ID domain_id3r84B00
Class class6 — Special
Architecture architecture10 — Helix non-globular
Topology topology280 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily160 — Mediator of RNA polymerase II transcription subunit 22
Domain ID domain_id3r84C00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology287 — Helix Hairpins
Homologous superfamily homologous superfamily3490 —
Domain ID domain_id3r84D00
Class class6 — Special
Architecture architecture10 — Helix non-globular
Topology topology280 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily160 — Mediator of RNA polymerase II transcription subunit 22
Domain ID domain_id3r84E00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology287 — Helix Hairpins
Homologous superfamily homologous superfamily3490 —
Domain ID domain_id3r84F00
Class class6 — Special
Architecture architecture10 — Helix non-globular
Topology topology280 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily160 — Mediator of RNA polymerase II transcription subunit 22
Domain ID domain_id3r84G00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology287 — Helix Hairpins
Homologous superfamily homologous superfamily3490 —
Domain ID domain_id3r84H00
Class class6 — Special
Architecture architecture10 — Helix non-globular
Topology topology280 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily160 — Mediator of RNA polymerase II transcription subunit 22
Domain ID domain_id3r84I00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology287 — Helix Hairpins
Homologous superfamily homologous superfamily3490 —
Domain ID domain_id3r84J00
Class class6 — Special
Architecture architecture10 — Helix non-globular
Topology topology280 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily160 — Mediator of RNA polymerase II transcription subunit 22
Domain ID domain_id3r84K00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology287 — Helix Hairpins
Homologous superfamily homologous superfamily3490 —
Domain ID domain_id3r84L00
Class class6 — Special
Architecture architecture10 — Helix non-globular
Topology topology280 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily160 — Mediator of RNA polymerase II transcription subunit 22
Domain ID domain_id3r84M00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology287 — Helix Hairpins
Homologous superfamily homologous superfamily3490 —
Domain ID domain_id3r84N00
Class class6 — Special
Architecture architecture10 — Helix non-globular
Topology topology280 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily160 — Mediator of RNA polymerase II transcription subunit 22
Domain ID domain_id3r84O00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology287 — Helix Hairpins
Homologous superfamily homologous superfamily3490 —
Domain ID domain_id3r84P00
Class class6 — Special
Architecture architecture10 — Helix non-globular
Topology topology280 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily160 — Mediator of RNA polymerase II transcription subunit 22
Domain ID domain_id3r84Q00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology287 — Helix Hairpins
Homologous superfamily homologous superfamily3490 —
Domain ID domain_id3r84R00
Class class6 — Special
Architecture architecture10 — Helix non-globular
Topology topology280 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily160 — Mediator of RNA polymerase II transcription subunit 22
Domain ID domain_id3r84S00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology287 — Helix Hairpins
Homologous superfamily homologous superfamily3490 —
Domain ID domain_id3r84T00
Class class6 — Special
Architecture architecture10 — Helix non-globular
Topology topology280 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily160 — Mediator of RNA polymerase II transcription subunit 22
Domain ID domain_id3r84U00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology287 — Helix Hairpins
Homologous superfamily homologous superfamily3490 —
Domain ID domain_id3r84V00
Class class6 — Special
Architecture architecture10 — Helix non-globular
Topology topology280 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily160 — Mediator of RNA polymerase II transcription subunit 22
Domain ID domain_id3r84W00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology287 — Helix Hairpins
Homologous superfamily homologous superfamily3490 —
Domain ID domain_id3r84X00
Class class6 — Special
Architecture architecture10 — Helix non-globular
Topology topology280 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily160 — Mediator of RNA polymerase II transcription subunit 22
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7. Citations (1)