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3tnp

Structure and Allostery of the PKA RIIb Tetrameric Holoenzyme

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

cAMP-dependent protein kinase catalytic subunit alpha

Mus musculus

UniProt P05132

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 cAMP-dependent protein kinase type II-beta regulatory subunit × 2 （P31324） water × 4 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 cAMP-dependent protein kinase type II-beta regulatory subunit × 1 （P31324） water × 2 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 2 cAMP-dependent protein kinase type II-beta regulatory subunit × 1 （P31324） water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1bkx 1bx6 1j3h 1j3h 1re8 1rej 1rek 1syk 1syk 4dfy 4dfy 4nts

23 assemblies; showing the first 12

Homodimer
4dfy

1 assemblies

Homotetramer
4dfy

1 assemblies

Other homooligomers

None

Heteromeric or nucleic-acid complex
1apm 1atp 1fmo 1jbp 1jlu 1l3r 1rdq 2cpk 2erz 2qcs 2qur 2qvs

75 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name KAPCA_MOUSE
Isoform —
PDB entities 1
Chains and sequence ranges Author chain C； PDBConstruct 1–350； UniProt 2–351 Author chain F； PDBConstruct 1–350； UniProt 2–351

cAMP-dependent protein kinase type II-beta regulatory subunit

Mus musculus

UniProt P31324

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 cAMP-dependent protein kinase catalytic subunit alpha × 2 （P05132） water × 4 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 cAMP-dependent protein kinase catalytic subunit alpha × 1 （P05132） water × 2 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 2 cAMP-dependent protein kinase catalytic subunit alpha × 1 （P05132） water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
3tnp 3tnp 3tnp 3tnq 4wbb 4x6q

6 assemblies

View Construct and Data Evidence
UniProt name KAP3_MOUSE
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 1–416； UniProt 1–416 Author chain E； PDBConstruct 1–416； UniProt 1–416

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id3tnp
Deposition date deposition_date2011-09-01
Structure title titleStructure and Allostery of the PKA RIIb Tetrameric Holoenzyme
Keywords keywordsPKA RIIb tetrameric holoenzyme, TRANSFERASE; TRANSFERASE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

3tnp__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

3tnp__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

3tnp__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）38.75 Å
Rg (electron density)38.23 Å
Total Rg38.72 Å
Atom count9836
Residues1206
Excluded volume176230 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 3tnp__assembly_1__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 3tnp__assembly_2__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 3tnp__assembly_3__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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6. Fold Classification (SCOP + CATH) 10 domains

SCOP 2.08 (2 domains)

Domain ID domain_idd3tnpc_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.144 — Protein kinase-like (PK-like)
Superfamily Superfamily superfamilyd.144.1 — Protein kinase-like (PK-like)
Family Family familyd.144.1.7 — Protein kinases, catalytic subunit
Domain ID domain_idd3tnpf_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.144 — Protein kinase-like (PK-like)
Superfamily Superfamily superfamilyd.144.1 — Protein kinase-like (PK-like)
Family Family familyd.144.1.7 — Protein kinases, catalytic subunit

CATH v4.4 (8 domains)

Domain ID domain_id3tnpB01
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology120 — Jelly Rolls
Homologous superfamily homologous superfamily10 — Jelly Rolls
Domain ID domain_id3tnpB02
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology120 — Jelly Rolls
Homologous superfamily homologous superfamily10 — Jelly Rolls
Domain ID domain_id3tnpC01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology510 — Transferase(Phosphotransferase); domain 1
Homologous superfamily homologous superfamily10 — Transferase(Phosphotransferase) domain 1
Domain ID domain_id3tnpC02
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology200 — Phosphorylase Kinase; domain 1
Homologous superfamily homologous superfamily20 — Phosphorylase Kinase; domain 1
Domain ID domain_id3tnpE01
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology120 — Jelly Rolls
Homologous superfamily homologous superfamily10 — Jelly Rolls
Domain ID domain_id3tnpE02
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology120 — Jelly Rolls
Homologous superfamily homologous superfamily10 — Jelly Rolls
Domain ID domain_id3tnpF01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology510 — Transferase(Phosphotransferase); domain 1
Homologous superfamily homologous superfamily10 — Transferase(Phosphotransferase) domain 1
Domain ID domain_id3tnpF02
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology200 — Phosphorylase Kinase; domain 1
Homologous superfamily homologous superfamily20 — Phosphorylase Kinase; domain 1
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7. Citations (1)