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3tw2

High resolution structure of human histidine triad nucleotide-binding protein 1 (hHINT1)/AMP complex in a monoclinic space group

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Histidine triad nucleotide-binding protein 1

Homo sapiens

UniProt P49773

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 2 ADENOSINE MONOPHOSPHATE × 1 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer
1av5 1kpa 1kpb 1kpc 1kpc 1kpe 1kpf 3tw2 4eqe 4eqg 4eqh 4zkl

68 assemblies; showing the first 12

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex

None

View Construct and Data Evidence
UniProt name HINT1_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–126； UniProt 1–126 Author chain B； PDBConstruct 1–126； UniProt 1–126

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id3tw2
Deposition date deposition_date2011-09-21
Structure title titleHigh resolution structure of human histidine triad nucleotide-binding protein 1 (hHINT1)/AMP complex in a monoclinic space group
Keywords keywordsHYDROLASE; HYDROLASE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

3tw2__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

3tw2__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

3tw2__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）17.72 Å
Rg (electron density)16.70 Å
Total Rg17.68 Å
Atom count1790
Residues228
Excluded volume31769 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 3tw2__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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6. Fold Classification (SCOP + CATH) 4 domains

SCOP 2.08 (2 domains)

Domain ID domain_idd3tw2a_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.13 — HIT-like
Superfamily Superfamily superfamilyd.13.1 — HIT-like
Family Family familyd.13.1.1 — HIT (HINT, histidine triad) family of protein kinase-interacting proteins
Domain ID domain_idd3tw2b_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.13 — HIT-like
Superfamily Superfamily superfamilyd.13.1 — HIT-like
Family Family familyd.13.1.1 — HIT (HINT, histidine triad) family of protein kinase-interacting proteins

CATH v4.4 (2 domains)

Domain ID domain_id3tw2A00
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology428 — HIT family, subunit A
Homologous superfamily homologous superfamily10 — HIT-like
Domain ID domain_id3tw2B00
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology428 — HIT family, subunit A
Homologous superfamily homologous superfamily10 — HIT-like
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7. Citations (1)