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3tw6

Structure of Rhizobium etli pyruvate carboxylase T882A with the allosteric activator, acetyl coenzyme-A

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Pyruvate carboxylase protein

Rhizobium etli

UniProt Q2K340

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 4 CHLORIDE ION × 8 ADENOSINE-5'-DIPHOSPHATE × 4 ZINC ION × 4 MAGNESIUM ION × 8 COENZYME A × 2 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL × 2 water × 4 Consistent with protein count
2 Protein homooligomer Homooligomer Protein 4 CHLORIDE ION × 8 ADENOSINE-5'-DIPHOSPHATE × 4 ZINC ION × 4 MAGNESIUM ION × 6 COENZYME A × 2 PHOSPHONOACETIC ACID × 2 water × 4 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer
4jx4 4jx4 4jx5 4jx5 4jx6 4jx6

6 assemblies

Homotetramer
2qf7 3tw6 3tw6 3tw7 4jx4 4jx5 4jx6 4loc 4m6v 4mfd 4mfe 4mim

12 assemblies

Other homooligomers

None

Heteromeric or nucleic-acid complex

None

View Construct and Data Evidence
UniProt name Q2K340_RHIEC
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 13–1165； UniProt 2–1154 Author chain B； PDBConstruct 13–1165； UniProt 2–1154 Author chain C； PDBConstruct 13–1165； UniProt 2–1154 Author chain D； PDBConstruct 13–1165； UniProt 2–1154

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id3tw6
Deposition date deposition_date2011-09-21
Structure title titleStructure of Rhizobium etli pyruvate carboxylase T882A with the allosteric activator, acetyl coenzyme-A
Keywords keywordsBIOTIN CARBOXYLASE, LIGASE-ACTIVATOR complex; LIGASE/ACTIVATOR
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

3tw6__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

3tw6__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

3tw6__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）56.73 Å
Rg (electron density)56.23 Å
Total Rg56.40 Å
Atom count31662
Residues4268
Excluded volume559050 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 3tw6__assembly_1__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 3tw6__assembly_2__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (9)

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6. Fold Classification (SCOP + CATH) 19 domains

CATH v4.4 (19 domains)

Domain ID domain_id3tw6A01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily20 —
Domain ID domain_id3tw6A02
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology470 — D-amino Acid Aminotransferase; Chain A, domain 1
Homologous superfamily homologous superfamily20 — ATP-grasp fold, B domain
Domain ID domain_id3tw6A03
Class class3 — Alpha Beta
Architecture architecture10 — Roll
Topology topology600 — pyruvate carboxylase f1077a mutant fold
Homologous superfamily homologous superfamily10 — pyruvate carboxylase f1077a mutant domain
Domain ID domain_id3tw6A04
Class class3 — Alpha Beta
Architecture architecture20 — Alpha-Beta Barrel
Topology topology20 — TIM Barrel
Homologous superfamily homologous superfamily70 — Aldolase class I
Domain ID domain_id3tw6A05
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology472 — Cyclin A; domain 1
Homologous superfamily homologous superfamily90 — Conserved carboxylase domain
Domain ID domain_id3tw6A06
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology10 — Arc Repressor Mutant, subunit A
Homologous superfamily homologous superfamily60 — Homeodomain-like
Domain ID domain_id3tw6B01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology470 — D-amino Acid Aminotransferase; Chain A, domain 1
Homologous superfamily homologous superfamily20 — ATP-grasp fold, B domain
Domain ID domain_id3tw6B02
Class class3 — Alpha Beta
Architecture architecture10 — Roll
Topology topology600 — pyruvate carboxylase f1077a mutant fold
Homologous superfamily homologous superfamily10 — pyruvate carboxylase f1077a mutant domain
Domain ID domain_id3tw6B03
Class class3 — Alpha Beta
Architecture architecture20 — Alpha-Beta Barrel
Topology topology20 — TIM Barrel
Homologous superfamily homologous superfamily70 — Aldolase class I
Domain ID domain_id3tw6B04
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homologous superfamily homologous superfamily100 — RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain
Domain ID domain_id3tw6C01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology470 — D-amino Acid Aminotransferase; Chain A, domain 1
Homologous superfamily homologous superfamily20 — ATP-grasp fold, B domain
Domain ID domain_id3tw6C02
Class class3 — Alpha Beta
Architecture architecture10 — Roll
Topology topology600 — pyruvate carboxylase f1077a mutant fold
Homologous superfamily homologous superfamily10 — pyruvate carboxylase f1077a mutant domain
Domain ID domain_id3tw6C03
Class class3 — Alpha Beta
Architecture architecture20 — Alpha-Beta Barrel
Topology topology20 — TIM Barrel
Homologous superfamily homologous superfamily70 — Aldolase class I
Domain ID domain_id3tw6C04
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology472 — Cyclin A; domain 1
Homologous superfamily homologous superfamily90 — Conserved carboxylase domain
Domain ID domain_id3tw6C05
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology10 — Arc Repressor Mutant, subunit A
Homologous superfamily homologous superfamily60 — Homeodomain-like
Domain ID domain_id3tw6D01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology470 — D-amino Acid Aminotransferase; Chain A, domain 1
Homologous superfamily homologous superfamily20 — ATP-grasp fold, B domain
Domain ID domain_id3tw6D02
Class class3 — Alpha Beta
Architecture architecture10 — Roll
Topology topology600 — pyruvate carboxylase f1077a mutant fold
Homologous superfamily homologous superfamily10 — pyruvate carboxylase f1077a mutant domain
Domain ID domain_id3tw6D03
Class class3 — Alpha Beta
Architecture architecture20 — Alpha-Beta Barrel
Topology topology20 — TIM Barrel
Homologous superfamily homologous superfamily70 — Aldolase class I
Domain ID domain_id3tw6D04
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homologous superfamily homologous superfamily100 — RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain
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7. Citations (1)