3u7u

Crystal structure of extracellular region of human epidermal growth factor receptor 4 in complex with neuregulin-1 beta

Method: X-RAY DIFFRACTION

1. 蛋白身份与相关结构 Protein Identity & Related Structures

Receptor tyrosine-protein kinase erbB-4

Homo sapiens

UniProt Q15303

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 2 Neuregulin 1 × 1 (Q96IB3) 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 water × 2 与蛋白数一致
2 蛋白异源复合物 异源复合物 蛋白 2 Neuregulin 1 × 1 (Q96IB3) 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 water × 2 与蛋白数一致
3 蛋白异源复合物 异源复合物 蛋白 2 Neuregulin 1 × 1 (Q96IB3) 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 water × 2 与蛋白数一致
4 蛋白异源复合物 异源复合物 蛋白 2 Neuregulin 1 × 1 (Q96IB3) 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 water × 2 与蛋白数一致
5 蛋白异源复合物 异源复合物 蛋白 2 Neuregulin 1 × 1 (Q96IB3) 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 water × 2 与蛋白数一致
6 蛋白异源复合物 异源复合物 蛋白 2 Neuregulin 1 × 1 (Q96IB3) 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 water × 2 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 ERBB4_HUMAN
Isoform
PDB实体 1
链与序列区间 作者链 A; PDB构建体 1–615; UniProt 26–640 作者链 B; PDB构建体 1–615; UniProt 26–640 作者链 C; PDB构建体 1–615; UniProt 26–640 作者链 D; PDB构建体 1–615; UniProt 26–640 作者链 E; PDB构建体 1–615; UniProt 26–640 作者链 F; PDB构建体 1–615; UniProt 26–640

Neuregulin 1

Homo sapiens

UniProt Q96IB3

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 2 Receptor tyrosine-protein kinase erbB-4 × 1 (Q15303) 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 water × 2 与蛋白数一致
2 蛋白异源复合物 异源复合物 蛋白 2 Receptor tyrosine-protein kinase erbB-4 × 1 (Q15303) 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 water × 2 与蛋白数一致
3 蛋白异源复合物 异源复合物 蛋白 2 Receptor tyrosine-protein kinase erbB-4 × 1 (Q15303) 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 water × 2 与蛋白数一致
4 蛋白异源复合物 异源复合物 蛋白 2 Receptor tyrosine-protein kinase erbB-4 × 1 (Q15303) 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 water × 2 与蛋白数一致
5 蛋白异源复合物 异源复合物 蛋白 2 Receptor tyrosine-protein kinase erbB-4 × 1 (Q15303) 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 water × 2 与蛋白数一致
6 蛋白异源复合物 异源复合物 蛋白 2 Receptor tyrosine-protein kinase erbB-4 × 1 (Q15303) 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 water × 2 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 Q96IB3_HUMAN
Isoform
PDB实体 2
链与序列区间 作者链 G; PDB构建体 1–55; UniProt 230–284 作者链 H; PDB构建体 1–55; UniProt 230–284 作者链 I; PDB构建体 1–55; UniProt 230–284 作者链 J; PDB构建体 1–55; UniProt 230–284 作者链 K; PDB构建体 1–55; UniProt 230–284 作者链 L; PDB构建体 1–55; UniProt 230–284

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中;数据库内部编号、导入时间和 assembly 操作表达式仅用于维护,因此不在读者页面展示。

2. 结构基本信息 2. Structure Basics

条目编号 entry_id3u7u
沉积日期 deposition_date2011-10-14
结构标题 titleCrystal structure of extracellular region of human epidermal growth factor receptor 4 in complex with neuregulin-1 beta
关键词 keywordssignaling protein, TRANSFERASE-TRANSFERASE REGULATOR COMPLEX, Glycosylation; TRANSFERASE/TRANSFERASE REGULATOR
实验方法 methodX-RAY DIFFRACTION

3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

3u7u__assembly_3__model_1

Assembly 3 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

3u7u__assembly_3__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 个绘图点;横轴和纵轴均采用对数尺度。

3u7u__assembly_3__model_1 | P(r) · Pending

新版 assembly/model P(r) 尚未计算 此处仅保留位置,不展示旧数据 r (Angstrom) P(r)
P(r) 将按相同 assembly/model 分别计算和展示。
Rg(Guinier)34.44 Å
Rg(电子密度)33.94 Å
总 Rg34.22 Å
原子数5068
残基数648
排除体积89197 ų
最大 q0.500 Å⁻¹
Assembly Model 结构单元 聚集说明 状态 CRYSOL 操作
1 1 3u7u__assembly_1__model_1 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
2 1 3u7u__assembly_2__model_1 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
3 1 3u7u__assembly_3__model_1 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
4 1 3u7u__assembly_4__model_1 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
5 1 3u7u__assembly_5__model_1 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
6 1 3u7u__assembly_6__model_1 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载

4. 晶体学与实验 4. Crystallography & Experiment

5. 实体与聚合物信息 Entities & Polymers (4)

6. 折叠分类 (SCOP + CATH) 33 domains

SCOP 2.08 (3 domains)

结构域编号 domain_idd3u7ua1
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.10 — Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)
超家族 Superfamily superfamilyc.10.2 — L domain-like
家族 Family familyc.10.2.0 — automated matches
结构域编号 domain_idd3u7ua2
类 Class classg — Small proteins
折叠类型 Fold foldg.3 — Knottins (small inhibitors, toxins, lectins)
超家族 Superfamily superfamilyg.3.9 — Growth factor receptor domain
家族 Family familyg.3.9.0 — automated matches
结构域编号 domain_idd3u7ua3
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.10 — Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)
超家族 Superfamily superfamilyc.10.2 — L domain-like
家族 Family familyc.10.2.0 — automated matches

CATH v4.4 (30 domains)

结构域编号 domain_id3u7uA01
类 Class class3 — Alpha Beta
架构 Architecture architecture80 — Alpha-Beta Horseshoe
拓扑 Topology topology20 — 24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a'; Chain A
同源超家族 H-superfamily homologous superfamily20 — Receptor L-domain
结构域编号 domain_id3u7uA02
类 Class class2 — Mainly Beta
架构 Architecture architecture10 — Ribbon
拓扑 Topology topology220 — Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A domain 2
同源超家族 H-superfamily homologous superfamily10 — Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2
结构域编号 domain_id3u7uA03
类 Class class3 — Alpha Beta
架构 Architecture architecture80 — Alpha-Beta Horseshoe
拓扑 Topology topology20 — 24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a'; Chain A
同源超家族 H-superfamily homologous superfamily20 — Receptor L-domain
结构域编号 domain_id3u7uA04
类 Class class2 — Mainly Beta
架构 Architecture architecture10 — Ribbon
拓扑 Topology topology220 — Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A domain 2
同源超家族 H-superfamily homologous superfamily10 — Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2
结构域编号 domain_id3u7uB01
类 Class class3 — Alpha Beta
架构 Architecture architecture80 — Alpha-Beta Horseshoe
拓扑 Topology topology20 — 24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a'; Chain A
同源超家族 H-superfamily homologous superfamily20 — Receptor L-domain
结构域编号 domain_id3u7uB02
类 Class class2 — Mainly Beta
架构 Architecture architecture10 — Ribbon
拓扑 Topology topology220 — Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A domain 2
同源超家族 H-superfamily homologous superfamily10 — Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2
结构域编号 domain_id3u7uB03
类 Class class3 — Alpha Beta
架构 Architecture architecture80 — Alpha-Beta Horseshoe
拓扑 Topology topology20 — 24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a'; Chain A
同源超家族 H-superfamily homologous superfamily20 — Receptor L-domain
结构域编号 domain_id3u7uB04
类 Class class2 — Mainly Beta
架构 Architecture architecture10 — Ribbon
拓扑 Topology topology220 — Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A domain 2
同源超家族 H-superfamily homologous superfamily10 — Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2
结构域编号 domain_id3u7uC01
类 Class class3 — Alpha Beta
架构 Architecture architecture80 — Alpha-Beta Horseshoe
拓扑 Topology topology20 — 24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a'; Chain A
同源超家族 H-superfamily homologous superfamily20 — Receptor L-domain
结构域编号 domain_id3u7uC02
类 Class class2 — Mainly Beta
架构 Architecture architecture10 — Ribbon
拓扑 Topology topology220 — Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A domain 2
同源超家族 H-superfamily homologous superfamily10 — Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2
结构域编号 domain_id3u7uC03
类 Class class3 — Alpha Beta
架构 Architecture architecture80 — Alpha-Beta Horseshoe
拓扑 Topology topology20 — 24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a'; Chain A
同源超家族 H-superfamily homologous superfamily20 — Receptor L-domain
结构域编号 domain_id3u7uC04
类 Class class2 — Mainly Beta
架构 Architecture architecture10 — Ribbon
拓扑 Topology topology220 — Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A domain 2
同源超家族 H-superfamily homologous superfamily10 — Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2
结构域编号 domain_id3u7uD01
类 Class class3 — Alpha Beta
架构 Architecture architecture80 — Alpha-Beta Horseshoe
拓扑 Topology topology20 — 24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a'; Chain A
同源超家族 H-superfamily homologous superfamily20 — Receptor L-domain
结构域编号 domain_id3u7uD02
类 Class class2 — Mainly Beta
架构 Architecture architecture10 — Ribbon
拓扑 Topology topology220 — Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A domain 2
同源超家族 H-superfamily homologous superfamily10 — Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2
结构域编号 domain_id3u7uD03
类 Class class3 — Alpha Beta
架构 Architecture architecture80 — Alpha-Beta Horseshoe
拓扑 Topology topology20 — 24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a'; Chain A
同源超家族 H-superfamily homologous superfamily20 — Receptor L-domain
结构域编号 domain_id3u7uD04
类 Class class2 — Mainly Beta
架构 Architecture architecture10 — Ribbon
拓扑 Topology topology220 — Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A domain 2
同源超家族 H-superfamily homologous superfamily10 — Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2
结构域编号 domain_id3u7uE01
类 Class class3 — Alpha Beta
架构 Architecture architecture80 — Alpha-Beta Horseshoe
拓扑 Topology topology20 — 24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a'; Chain A
同源超家族 H-superfamily homologous superfamily20 — Receptor L-domain
结构域编号 domain_id3u7uE02
类 Class class2 — Mainly Beta
架构 Architecture architecture10 — Ribbon
拓扑 Topology topology220 — Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A domain 2
同源超家族 H-superfamily homologous superfamily10 — Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2
结构域编号 domain_id3u7uE03
类 Class class3 — Alpha Beta
架构 Architecture architecture80 — Alpha-Beta Horseshoe
拓扑 Topology topology20 — 24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a'; Chain A
同源超家族 H-superfamily homologous superfamily20 — Receptor L-domain
结构域编号 domain_id3u7uE04
类 Class class2 — Mainly Beta
架构 Architecture architecture10 — Ribbon
拓扑 Topology topology220 — Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A domain 2
同源超家族 H-superfamily homologous superfamily10 — Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2
结构域编号 domain_id3u7uF01
类 Class class3 — Alpha Beta
架构 Architecture architecture80 — Alpha-Beta Horseshoe
拓扑 Topology topology20 — 24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a'; Chain A
同源超家族 H-superfamily homologous superfamily20 — Receptor L-domain
结构域编号 domain_id3u7uF02
类 Class class2 — Mainly Beta
架构 Architecture architecture10 — Ribbon
拓扑 Topology topology220 — Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A domain 2
同源超家族 H-superfamily homologous superfamily10 — Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2
结构域编号 domain_id3u7uF03
类 Class class3 — Alpha Beta
架构 Architecture architecture80 — Alpha-Beta Horseshoe
拓扑 Topology topology20 — 24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a'; Chain A
同源超家族 H-superfamily homologous superfamily20 — Receptor L-domain
结构域编号 domain_id3u7uF04
类 Class class2 — Mainly Beta
架构 Architecture architecture10 — Ribbon
拓扑 Topology topology220 — Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A domain 2
同源超家族 H-superfamily homologous superfamily10 — Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2
结构域编号 domain_id3u7uG00
类 Class class2 — Mainly Beta
架构 Architecture architecture10 — Ribbon
拓扑 Topology topology25 — Laminin
同源超家族 H-superfamily homologous superfamily10 — Laminin
结构域编号 domain_id3u7uH00
类 Class class2 — Mainly Beta
架构 Architecture architecture10 — Ribbon
拓扑 Topology topology25 — Laminin
同源超家族 H-superfamily homologous superfamily10 — Laminin
结构域编号 domain_id3u7uI00
类 Class class2 — Mainly Beta
架构 Architecture architecture10 — Ribbon
拓扑 Topology topology25 — Laminin
同源超家族 H-superfamily homologous superfamily10 — Laminin
结构域编号 domain_id3u7uJ00
类 Class class2 — Mainly Beta
架构 Architecture architecture10 — Ribbon
拓扑 Topology topology25 — Laminin
同源超家族 H-superfamily homologous superfamily10 — Laminin
结构域编号 domain_id3u7uK00
类 Class class2 — Mainly Beta
架构 Architecture architecture10 — Ribbon
拓扑 Topology topology25 — Laminin
同源超家族 H-superfamily homologous superfamily10 — Laminin
结构域编号 domain_id3u7uL00
类 Class class2 — Mainly Beta
架构 Architecture architecture10 — Ribbon
拓扑 Topology topology25 — Laminin
同源超家族 H-superfamily homologous superfamily10 — Laminin

7. 引用文献 (1)