3une

Mouse constitutive 20S proteasome

Method: X-RAY DIFFRACTION

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1. Protein Identity and Related Structures Protein Identity & Related Structures

Proteasome subunit alpha type-2

OrganismNot specified

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type-4 × 2 （Q9R1P0） Proteasome subunit alpha type-7 × 2 （Q9Z2U0） Proteasome subunit alpha type-5 × 2 （Q9Z2U1） Proteasome subunit alpha type-1 × 2 （Q9R1P4） Proteasome subunit alpha type-3 × 2 （O70435） Proteasome subunit alpha type-6 × 2 （Q9QUM9） Proteasome subunit beta type-7 × 2 （P70195） Proteasome subunit beta type-3 × 2 （Q9R1P1） Proteasome subunit beta type-2 × 2 （Q9R1P3） Proteasome subunit beta type-5 × 2 （O55234） Proteasome subunit beta type-1 × 2 （O09061） Proteasome subunit beta type-4 × 2 （P99026） Proteasome subunit beta type-6 × 2 （Q60692） water × 28	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type-4 × 2 （Q9R1P0） Proteasome subunit alpha type-7 × 2 （Q9Z2U0） Proteasome subunit alpha type-5 × 2 （Q9Z2U1） Proteasome subunit alpha type-1 × 2 （Q9R1P4） Proteasome subunit alpha type-3 × 2 （O70435） Proteasome subunit alpha type-6 × 2 （Q9QUM9） Proteasome subunit beta type-7 × 2 （P70195） Proteasome subunit beta type-3 × 2 （Q9R1P1） Proteasome subunit beta type-2 × 2 （Q9R1P3） Proteasome subunit beta type-5 × 2 （O55234） Proteasome subunit beta type-1 × 2 （O09061） Proteasome subunit beta type-4 × 2 （P99026） Proteasome subunit beta type-6 × 2 （Q60692） water × 28	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSA2_MOUSE
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 1–234； UniProt 1–234 Author chain O； PDBConstruct 1–234； UniProt 1–234 Author chain c； PDBConstruct 1–234； UniProt 1–234 Author chain q； PDBConstruct 1–234； UniProt 1–234

Proteasome subunit alpha type-4

OrganismNot specified

UniProt Q9R1P0

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type-2 × 2 （P49722） Proteasome subunit alpha type-7 × 2 （Q9Z2U0） Proteasome subunit alpha type-5 × 2 （Q9Z2U1） Proteasome subunit alpha type-1 × 2 （Q9R1P4） Proteasome subunit alpha type-3 × 2 （O70435） Proteasome subunit alpha type-6 × 2 （Q9QUM9） Proteasome subunit beta type-7 × 2 （P70195） Proteasome subunit beta type-3 × 2 （Q9R1P1） Proteasome subunit beta type-2 × 2 （Q9R1P3） Proteasome subunit beta type-5 × 2 （O55234） Proteasome subunit beta type-1 × 2 （O09061） Proteasome subunit beta type-4 × 2 （P99026） Proteasome subunit beta type-6 × 2 （Q60692） water × 28	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type-2 × 2 （P49722） Proteasome subunit alpha type-7 × 2 （Q9Z2U0） Proteasome subunit alpha type-5 × 2 （Q9Z2U1） Proteasome subunit alpha type-1 × 2 （Q9R1P4） Proteasome subunit alpha type-3 × 2 （O70435） Proteasome subunit alpha type-6 × 2 （Q9QUM9） Proteasome subunit beta type-7 × 2 （P70195） Proteasome subunit beta type-3 × 2 （Q9R1P1） Proteasome subunit beta type-2 × 2 （Q9R1P3） Proteasome subunit beta type-5 × 2 （O55234） Proteasome subunit beta type-1 × 2 （O09061） Proteasome subunit beta type-4 × 2 （P99026） Proteasome subunit beta type-6 × 2 （Q60692） water × 28	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSA4_MOUSE
Isoform	—
PDB entities	2
Chains and sequence ranges	Author chain B； PDBConstruct 1–261； UniProt 1–261 Author chain P； PDBConstruct 1–261； UniProt 1–261 Author chain d； PDBConstruct 1–261； UniProt 1–261 Author chain r； PDBConstruct 1–261； UniProt 1–261

Proteasome subunit alpha type-7

OrganismNot specified

UniProt Q9Z2U0

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type-2 × 2 （P49722） Proteasome subunit alpha type-4 × 2 （Q9R1P0） Proteasome subunit alpha type-5 × 2 （Q9Z2U1） Proteasome subunit alpha type-1 × 2 （Q9R1P4） Proteasome subunit alpha type-3 × 2 （O70435） Proteasome subunit alpha type-6 × 2 （Q9QUM9） Proteasome subunit beta type-7 × 2 （P70195） Proteasome subunit beta type-3 × 2 （Q9R1P1） Proteasome subunit beta type-2 × 2 （Q9R1P3） Proteasome subunit beta type-5 × 2 （O55234） Proteasome subunit beta type-1 × 2 （O09061） Proteasome subunit beta type-4 × 2 （P99026） Proteasome subunit beta type-6 × 2 （Q60692） water × 28	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type-2 × 2 （P49722） Proteasome subunit alpha type-4 × 2 （Q9R1P0） Proteasome subunit alpha type-5 × 2 （Q9Z2U1） Proteasome subunit alpha type-1 × 2 （Q9R1P4） Proteasome subunit alpha type-3 × 2 （O70435） Proteasome subunit alpha type-6 × 2 （Q9QUM9） Proteasome subunit beta type-7 × 2 （P70195） Proteasome subunit beta type-3 × 2 （Q9R1P1） Proteasome subunit beta type-2 × 2 （Q9R1P3） Proteasome subunit beta type-5 × 2 （O55234） Proteasome subunit beta type-1 × 2 （O09061） Proteasome subunit beta type-4 × 2 （P99026） Proteasome subunit beta type-6 × 2 （Q60692） water × 28	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSA7_MOUSE
Isoform	—
PDB entities	3
Chains and sequence ranges	Author chain C； PDBConstruct 1–248； UniProt 1–248 Author chain Q； PDBConstruct 1–248； UniProt 1–248 Author chain e； PDBConstruct 1–248； UniProt 1–248 Author chain s； PDBConstruct 1–248； UniProt 1–248

Proteasome subunit alpha type-5

OrganismNot specified

UniProt Q9Z2U1

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type-2 × 2 （P49722） Proteasome subunit alpha type-4 × 2 （Q9R1P0） Proteasome subunit alpha type-7 × 2 （Q9Z2U0） Proteasome subunit alpha type-1 × 2 （Q9R1P4） Proteasome subunit alpha type-3 × 2 （O70435） Proteasome subunit alpha type-6 × 2 （Q9QUM9） Proteasome subunit beta type-7 × 2 （P70195） Proteasome subunit beta type-3 × 2 （Q9R1P1） Proteasome subunit beta type-2 × 2 （Q9R1P3） Proteasome subunit beta type-5 × 2 （O55234） Proteasome subunit beta type-1 × 2 （O09061） Proteasome subunit beta type-4 × 2 （P99026） Proteasome subunit beta type-6 × 2 （Q60692） water × 28	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type-2 × 2 （P49722） Proteasome subunit alpha type-4 × 2 （Q9R1P0） Proteasome subunit alpha type-7 × 2 （Q9Z2U0） Proteasome subunit alpha type-1 × 2 （Q9R1P4） Proteasome subunit alpha type-3 × 2 （O70435） Proteasome subunit alpha type-6 × 2 （Q9QUM9） Proteasome subunit beta type-7 × 2 （P70195） Proteasome subunit beta type-3 × 2 （Q9R1P1） Proteasome subunit beta type-2 × 2 （Q9R1P3） Proteasome subunit beta type-5 × 2 （O55234） Proteasome subunit beta type-1 × 2 （O09061） Proteasome subunit beta type-4 × 2 （P99026） Proteasome subunit beta type-6 × 2 （Q60692） water × 28	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSA5_MOUSE
Isoform	—
PDB entities	4
Chains and sequence ranges	Author chain D； PDBConstruct 1–241； UniProt 1–241 Author chain R； PDBConstruct 1–241； UniProt 1–241 Author chain f； PDBConstruct 1–241； UniProt 1–241 Author chain t； PDBConstruct 1–241； UniProt 1–241

Proteasome subunit alpha type-1

OrganismNot specified

UniProt Q9R1P4

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type-2 × 2 （P49722） Proteasome subunit alpha type-4 × 2 （Q9R1P0） Proteasome subunit alpha type-7 × 2 （Q9Z2U0） Proteasome subunit alpha type-5 × 2 （Q9Z2U1） Proteasome subunit alpha type-3 × 2 （O70435） Proteasome subunit alpha type-6 × 2 （Q9QUM9） Proteasome subunit beta type-7 × 2 （P70195） Proteasome subunit beta type-3 × 2 （Q9R1P1） Proteasome subunit beta type-2 × 2 （Q9R1P3） Proteasome subunit beta type-5 × 2 （O55234） Proteasome subunit beta type-1 × 2 （O09061） Proteasome subunit beta type-4 × 2 （P99026） Proteasome subunit beta type-6 × 2 （Q60692） water × 28	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type-2 × 2 （P49722） Proteasome subunit alpha type-4 × 2 （Q9R1P0） Proteasome subunit alpha type-7 × 2 （Q9Z2U0） Proteasome subunit alpha type-5 × 2 （Q9Z2U1） Proteasome subunit alpha type-3 × 2 （O70435） Proteasome subunit alpha type-6 × 2 （Q9QUM9） Proteasome subunit beta type-7 × 2 （P70195） Proteasome subunit beta type-3 × 2 （Q9R1P1） Proteasome subunit beta type-2 × 2 （Q9R1P3） Proteasome subunit beta type-5 × 2 （O55234） Proteasome subunit beta type-1 × 2 （O09061） Proteasome subunit beta type-4 × 2 （P99026） Proteasome subunit beta type-6 × 2 （Q60692） water × 28	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSA1_MOUSE
Isoform	—
PDB entities	5
Chains and sequence ranges	Author chain E； PDBConstruct 1–263； UniProt 1–263 Author chain S； PDBConstruct 1–263； UniProt 1–263 Author chain g； PDBConstruct 1–263； UniProt 1–263 Author chain u； PDBConstruct 1–263； UniProt 1–263

Proteasome subunit alpha type-3

OrganismNot specified

UniProt O70435

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type-2 × 2 （P49722） Proteasome subunit alpha type-4 × 2 （Q9R1P0） Proteasome subunit alpha type-7 × 2 （Q9Z2U0） Proteasome subunit alpha type-5 × 2 （Q9Z2U1） Proteasome subunit alpha type-1 × 2 （Q9R1P4） Proteasome subunit alpha type-6 × 2 （Q9QUM9） Proteasome subunit beta type-7 × 2 （P70195） Proteasome subunit beta type-3 × 2 （Q9R1P1） Proteasome subunit beta type-2 × 2 （Q9R1P3） Proteasome subunit beta type-5 × 2 （O55234） Proteasome subunit beta type-1 × 2 （O09061） Proteasome subunit beta type-4 × 2 （P99026） Proteasome subunit beta type-6 × 2 （Q60692） water × 28	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type-2 × 2 （P49722） Proteasome subunit alpha type-4 × 2 （Q9R1P0） Proteasome subunit alpha type-7 × 2 （Q9Z2U0） Proteasome subunit alpha type-5 × 2 （Q9Z2U1） Proteasome subunit alpha type-1 × 2 （Q9R1P4） Proteasome subunit alpha type-6 × 2 （Q9QUM9） Proteasome subunit beta type-7 × 2 （P70195） Proteasome subunit beta type-3 × 2 （Q9R1P1） Proteasome subunit beta type-2 × 2 （Q9R1P3） Proteasome subunit beta type-5 × 2 （O55234） Proteasome subunit beta type-1 × 2 （O09061） Proteasome subunit beta type-4 × 2 （P99026） Proteasome subunit beta type-6 × 2 （Q60692） water × 28	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSA3_MOUSE
Isoform	—
PDB entities	6
Chains and sequence ranges	Author chain F； PDBConstruct 1–255； UniProt 1–255 Author chain T； PDBConstruct 1–255； UniProt 1–255 Author chain h； PDBConstruct 1–255； UniProt 1–255 Author chain v； PDBConstruct 1–255； UniProt 1–255

Proteasome subunit alpha type-6

OrganismNot specified

UniProt Q9QUM9

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type-2 × 2 （P49722） Proteasome subunit alpha type-4 × 2 （Q9R1P0） Proteasome subunit alpha type-7 × 2 （Q9Z2U0） Proteasome subunit alpha type-5 × 2 （Q9Z2U1） Proteasome subunit alpha type-1 × 2 （Q9R1P4） Proteasome subunit alpha type-3 × 2 （O70435） Proteasome subunit beta type-7 × 2 （P70195） Proteasome subunit beta type-3 × 2 （Q9R1P1） Proteasome subunit beta type-2 × 2 （Q9R1P3） Proteasome subunit beta type-5 × 2 （O55234） Proteasome subunit beta type-1 × 2 （O09061） Proteasome subunit beta type-4 × 2 （P99026） Proteasome subunit beta type-6 × 2 （Q60692） water × 28	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type-2 × 2 （P49722） Proteasome subunit alpha type-4 × 2 （Q9R1P0） Proteasome subunit alpha type-7 × 2 （Q9Z2U0） Proteasome subunit alpha type-5 × 2 （Q9Z2U1） Proteasome subunit alpha type-1 × 2 （Q9R1P4） Proteasome subunit alpha type-3 × 2 （O70435） Proteasome subunit beta type-7 × 2 （P70195） Proteasome subunit beta type-3 × 2 （Q9R1P1） Proteasome subunit beta type-2 × 2 （Q9R1P3） Proteasome subunit beta type-5 × 2 （O55234） Proteasome subunit beta type-1 × 2 （O09061） Proteasome subunit beta type-4 × 2 （P99026） Proteasome subunit beta type-6 × 2 （Q60692） water × 28	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSA6_MOUSE
Isoform	—
PDB entities	7
Chains and sequence ranges	Author chain G； PDBConstruct 1–246； UniProt 1–246 Author chain U； PDBConstruct 1–246； UniProt 1–246 Author chain i； PDBConstruct 1–246； UniProt 1–246 Author chain w； PDBConstruct 1–246； UniProt 1–246

Proteasome subunit beta type-7

OrganismNot specified

UniProt P70195

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type-2 × 2 （P49722） Proteasome subunit alpha type-4 × 2 （Q9R1P0） Proteasome subunit alpha type-7 × 2 （Q9Z2U0） Proteasome subunit alpha type-5 × 2 （Q9Z2U1） Proteasome subunit alpha type-1 × 2 （Q9R1P4） Proteasome subunit alpha type-3 × 2 （O70435） Proteasome subunit alpha type-6 × 2 （Q9QUM9） Proteasome subunit beta type-3 × 2 （Q9R1P1） Proteasome subunit beta type-2 × 2 （Q9R1P3） Proteasome subunit beta type-5 × 2 （O55234） Proteasome subunit beta type-1 × 2 （O09061） Proteasome subunit beta type-4 × 2 （P99026） Proteasome subunit beta type-6 × 2 （Q60692） water × 28	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type-2 × 2 （P49722） Proteasome subunit alpha type-4 × 2 （Q9R1P0） Proteasome subunit alpha type-7 × 2 （Q9Z2U0） Proteasome subunit alpha type-5 × 2 （Q9Z2U1） Proteasome subunit alpha type-1 × 2 （Q9R1P4） Proteasome subunit alpha type-3 × 2 （O70435） Proteasome subunit alpha type-6 × 2 （Q9QUM9） Proteasome subunit beta type-3 × 2 （Q9R1P1） Proteasome subunit beta type-2 × 2 （Q9R1P3） Proteasome subunit beta type-5 × 2 （O55234） Proteasome subunit beta type-1 × 2 （O09061） Proteasome subunit beta type-4 × 2 （P99026） Proteasome subunit beta type-6 × 2 （Q60692） water × 28	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSB7_MOUSE
Isoform	—
PDB entities	8
Chains and sequence ranges	Author chain H； PDBConstruct 1–234； UniProt 44–277 Author chain V； PDBConstruct 1–234； UniProt 44–277 Author chain j； PDBConstruct 1–234； UniProt 44–277 Author chain x； PDBConstruct 1–234； UniProt 44–277

Proteasome subunit beta type-3

OrganismNot specified

UniProt Q9R1P1

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type-2 × 2 （P49722） Proteasome subunit alpha type-4 × 2 （Q9R1P0） Proteasome subunit alpha type-7 × 2 （Q9Z2U0） Proteasome subunit alpha type-5 × 2 （Q9Z2U1） Proteasome subunit alpha type-1 × 2 （Q9R1P4） Proteasome subunit alpha type-3 × 2 （O70435） Proteasome subunit alpha type-6 × 2 （Q9QUM9） Proteasome subunit beta type-7 × 2 （P70195） Proteasome subunit beta type-2 × 2 （Q9R1P3） Proteasome subunit beta type-5 × 2 （O55234） Proteasome subunit beta type-1 × 2 （O09061） Proteasome subunit beta type-4 × 2 （P99026） Proteasome subunit beta type-6 × 2 （Q60692） water × 28	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type-2 × 2 （P49722） Proteasome subunit alpha type-4 × 2 （Q9R1P0） Proteasome subunit alpha type-7 × 2 （Q9Z2U0） Proteasome subunit alpha type-5 × 2 （Q9Z2U1） Proteasome subunit alpha type-1 × 2 （Q9R1P4） Proteasome subunit alpha type-3 × 2 （O70435） Proteasome subunit alpha type-6 × 2 （Q9QUM9） Proteasome subunit beta type-7 × 2 （P70195） Proteasome subunit beta type-2 × 2 （Q9R1P3） Proteasome subunit beta type-5 × 2 （O55234） Proteasome subunit beta type-1 × 2 （O09061） Proteasome subunit beta type-4 × 2 （P99026） Proteasome subunit beta type-6 × 2 （Q60692） water × 28	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSB3_MOUSE
Isoform	—
PDB entities	9
Chains and sequence ranges	Author chain I； PDBConstruct 1–205； UniProt 1–205 Author chain W； PDBConstruct 1–205； UniProt 1–205 Author chain k； PDBConstruct 1–205； UniProt 1–205 Author chain y； PDBConstruct 1–205； UniProt 1–205

Proteasome subunit beta type-2

OrganismNot specified

UniProt Q9R1P3

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type-2 × 2 （P49722） Proteasome subunit alpha type-4 × 2 （Q9R1P0） Proteasome subunit alpha type-7 × 2 （Q9Z2U0） Proteasome subunit alpha type-5 × 2 （Q9Z2U1） Proteasome subunit alpha type-1 × 2 （Q9R1P4） Proteasome subunit alpha type-3 × 2 （O70435） Proteasome subunit alpha type-6 × 2 （Q9QUM9） Proteasome subunit beta type-7 × 2 （P70195） Proteasome subunit beta type-3 × 2 （Q9R1P1） Proteasome subunit beta type-5 × 2 （O55234） Proteasome subunit beta type-1 × 2 （O09061） Proteasome subunit beta type-4 × 2 （P99026） Proteasome subunit beta type-6 × 2 （Q60692） water × 28	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type-2 × 2 （P49722） Proteasome subunit alpha type-4 × 2 （Q9R1P0） Proteasome subunit alpha type-7 × 2 （Q9Z2U0） Proteasome subunit alpha type-5 × 2 （Q9Z2U1） Proteasome subunit alpha type-1 × 2 （Q9R1P4） Proteasome subunit alpha type-3 × 2 （O70435） Proteasome subunit alpha type-6 × 2 （Q9QUM9） Proteasome subunit beta type-7 × 2 （P70195） Proteasome subunit beta type-3 × 2 （Q9R1P1） Proteasome subunit beta type-5 × 2 （O55234） Proteasome subunit beta type-1 × 2 （O09061） Proteasome subunit beta type-4 × 2 （P99026） Proteasome subunit beta type-6 × 2 （Q60692） water × 28	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSB2_MOUSE
Isoform	—
PDB entities	10
Chains and sequence ranges	Author chain J； PDBConstruct 1–201； UniProt 1–201 Author chain X； PDBConstruct 1–201； UniProt 1–201 Author chain l； PDBConstruct 1–201； UniProt 1–201 Author chain z； PDBConstruct 1–201； UniProt 1–201

Proteasome subunit beta type-5

OrganismNot specified

UniProt O55234

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type-2 × 2 （P49722） Proteasome subunit alpha type-4 × 2 （Q9R1P0） Proteasome subunit alpha type-7 × 2 （Q9Z2U0） Proteasome subunit alpha type-5 × 2 （Q9Z2U1） Proteasome subunit alpha type-1 × 2 （Q9R1P4） Proteasome subunit alpha type-3 × 2 （O70435） Proteasome subunit alpha type-6 × 2 （Q9QUM9） Proteasome subunit beta type-7 × 2 （P70195） Proteasome subunit beta type-3 × 2 （Q9R1P1） Proteasome subunit beta type-2 × 2 （Q9R1P3） Proteasome subunit beta type-1 × 2 （O09061） Proteasome subunit beta type-4 × 2 （P99026） Proteasome subunit beta type-6 × 2 （Q60692） water × 28	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type-2 × 2 （P49722） Proteasome subunit alpha type-4 × 2 （Q9R1P0） Proteasome subunit alpha type-7 × 2 （Q9Z2U0） Proteasome subunit alpha type-5 × 2 （Q9Z2U1） Proteasome subunit alpha type-1 × 2 （Q9R1P4） Proteasome subunit alpha type-3 × 2 （O70435） Proteasome subunit alpha type-6 × 2 （Q9QUM9） Proteasome subunit beta type-7 × 2 （P70195） Proteasome subunit beta type-3 × 2 （Q9R1P1） Proteasome subunit beta type-2 × 2 （Q9R1P3） Proteasome subunit beta type-1 × 2 （O09061） Proteasome subunit beta type-4 × 2 （P99026） Proteasome subunit beta type-6 × 2 （Q60692） water × 28	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSB5_MOUSE
Isoform	—
PDB entities	11
Chains and sequence ranges	Author chain 1； PDBConstruct 1–205； UniProt 60–264 Author chain K； PDBConstruct 1–205； UniProt 60–264 Author chain Y； PDBConstruct 1–205； UniProt 60–264 Author chain m； PDBConstruct 1–205； UniProt 60–264

Proteasome subunit beta type-1

OrganismNot specified

UniProt O09061

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type-2 × 2 （P49722） Proteasome subunit alpha type-4 × 2 （Q9R1P0） Proteasome subunit alpha type-7 × 2 （Q9Z2U0） Proteasome subunit alpha type-5 × 2 （Q9Z2U1） Proteasome subunit alpha type-1 × 2 （Q9R1P4） Proteasome subunit alpha type-3 × 2 （O70435） Proteasome subunit alpha type-6 × 2 （Q9QUM9） Proteasome subunit beta type-7 × 2 （P70195） Proteasome subunit beta type-3 × 2 （Q9R1P1） Proteasome subunit beta type-2 × 2 （Q9R1P3） Proteasome subunit beta type-5 × 2 （O55234） Proteasome subunit beta type-4 × 2 （P99026） Proteasome subunit beta type-6 × 2 （Q60692） water × 28	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type-2 × 2 （P49722） Proteasome subunit alpha type-4 × 2 （Q9R1P0） Proteasome subunit alpha type-7 × 2 （Q9Z2U0） Proteasome subunit alpha type-5 × 2 （Q9Z2U1） Proteasome subunit alpha type-1 × 2 （Q9R1P4） Proteasome subunit alpha type-3 × 2 （O70435） Proteasome subunit alpha type-6 × 2 （Q9QUM9） Proteasome subunit beta type-7 × 2 （P70195） Proteasome subunit beta type-3 × 2 （Q9R1P1） Proteasome subunit beta type-2 × 2 （Q9R1P3） Proteasome subunit beta type-5 × 2 （O55234） Proteasome subunit beta type-4 × 2 （P99026） Proteasome subunit beta type-6 × 2 （Q60692） water × 28	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSB1_MOUSE
Isoform	—
PDB entities	12
Chains and sequence ranges	Author chain 2； PDBConstruct 1–213； UniProt 28–240 Author chain L； PDBConstruct 1–213； UniProt 28–240 Author chain Z； PDBConstruct 1–213； UniProt 28–240 Author chain n； PDBConstruct 1–213； UniProt 28–240

Proteasome subunit beta type-4

OrganismNot specified

UniProt P99026

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type-2 × 2 （P49722） Proteasome subunit alpha type-4 × 2 （Q9R1P0） Proteasome subunit alpha type-7 × 2 （Q9Z2U0） Proteasome subunit alpha type-5 × 2 （Q9Z2U1） Proteasome subunit alpha type-1 × 2 （Q9R1P4） Proteasome subunit alpha type-3 × 2 （O70435） Proteasome subunit alpha type-6 × 2 （Q9QUM9） Proteasome subunit beta type-7 × 2 （P70195） Proteasome subunit beta type-3 × 2 （Q9R1P1） Proteasome subunit beta type-2 × 2 （Q9R1P3） Proteasome subunit beta type-5 × 2 （O55234） Proteasome subunit beta type-1 × 2 （O09061） Proteasome subunit beta type-6 × 2 （Q60692） water × 28	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type-2 × 2 （P49722） Proteasome subunit alpha type-4 × 2 （Q9R1P0） Proteasome subunit alpha type-7 × 2 （Q9Z2U0） Proteasome subunit alpha type-5 × 2 （Q9Z2U1） Proteasome subunit alpha type-1 × 2 （Q9R1P4） Proteasome subunit alpha type-3 × 2 （O70435） Proteasome subunit alpha type-6 × 2 （Q9QUM9） Proteasome subunit beta type-7 × 2 （P70195） Proteasome subunit beta type-3 × 2 （Q9R1P1） Proteasome subunit beta type-2 × 2 （Q9R1P3） Proteasome subunit beta type-5 × 2 （O55234） Proteasome subunit beta type-1 × 2 （O09061） Proteasome subunit beta type-6 × 2 （Q60692） water × 28	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSB4_MOUSE
Isoform	—
PDB entities	13
Chains and sequence ranges	Author chain 3； PDBConstruct 1–219； UniProt 46–264 Author chain M； PDBConstruct 1–219； UniProt 46–264 Author chain a； PDBConstruct 1–219； UniProt 46–264 Author chain o； PDBConstruct 1–219； UniProt 46–264

Proteasome subunit beta type-6

OrganismNot specified

UniProt Q60692

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type-2 × 2 （P49722） Proteasome subunit alpha type-4 × 2 （Q9R1P0） Proteasome subunit alpha type-7 × 2 （Q9Z2U0） Proteasome subunit alpha type-5 × 2 （Q9Z2U1） Proteasome subunit alpha type-1 × 2 （Q9R1P4） Proteasome subunit alpha type-3 × 2 （O70435） Proteasome subunit alpha type-6 × 2 （Q9QUM9） Proteasome subunit beta type-7 × 2 （P70195） Proteasome subunit beta type-3 × 2 （Q9R1P1） Proteasome subunit beta type-2 × 2 （Q9R1P3） Proteasome subunit beta type-5 × 2 （O55234） Proteasome subunit beta type-1 × 2 （O09061） Proteasome subunit beta type-4 × 2 （P99026） water × 28	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 28	Proteasome subunit alpha type-2 × 2 （P49722） Proteasome subunit alpha type-4 × 2 （Q9R1P0） Proteasome subunit alpha type-7 × 2 （Q9Z2U0） Proteasome subunit alpha type-5 × 2 （Q9Z2U1） Proteasome subunit alpha type-1 × 2 （Q9R1P4） Proteasome subunit alpha type-3 × 2 （O70435） Proteasome subunit alpha type-6 × 2 （Q9QUM9） Proteasome subunit beta type-7 × 2 （P70195） Proteasome subunit beta type-3 × 2 （Q9R1P1） Proteasome subunit beta type-2 × 2 （Q9R1P3） Proteasome subunit beta type-5 × 2 （O55234） Proteasome subunit beta type-1 × 2 （O09061） Proteasome subunit beta type-4 × 2 （P99026） water × 28	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSB6_MOUSE
Isoform	—
PDB entities	14
Chains and sequence ranges	Author chain 4； PDBConstruct 1–205； UniProt 34–238 Author chain N； PDBConstruct 1–205； UniProt 34–238 Author chain b； PDBConstruct 1–205； UniProt 34–238 Author chain p； PDBConstruct 1–205； UniProt 34–238

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	3une
Deposition date deposition_date	2011-11-15
Structure title title	Mouse constitutive 20S proteasome
Keywords keywords	20S proteasome comprises 28 subunits, Protease, Cytosol, HYDROLASE; HYDROLASE
Experimental Method method	X-RAY DIFFRACTION

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

3une__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

3une__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

3une__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	60.69 Å
Rg (electron density)	60.30 Å
Total Rg	60.48 Å
Atom count	48658
Residues	6262
Excluded volume	867970 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`3une__assembly_1__model_1`	28-meric （28）	Success	4.1.3-1-20251215 (887e7ef)	View Download
2	1	`3une__assembly_2__model_1`	28-meric （28）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

▶

5. Entities and Polymers Entities & Polymers (15)

Entity 1 Entity 1 polymer

Description description	Proteasome subunit alpha type-2
Molecular weight formula_weight	25955.6 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	4

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	A,O,c,q
Atom count atom_count	97956

MAKRGYSFSLTTFSPSGKLVQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILYDERSVHKVEPITKHIGLVYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQEYTQSGGVRPFGVSLLICGWNEGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNEDLELEDAIHTAILTLKESFEGQMTEDNIEVGICNEAGFRRLTPTEVRDYLAAIA

Entity 2 Entity 2 polymer

Description description	Proteasome subunit alpha type-4
Molecular weight formula_weight	29512.8 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	4

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	B,P,d,r

MSRRYDSRTTIFSPEGRLYQVEYAMEAIGHAGTCLGILANDGVLLAAERRNIHKLLDEVFFSEKIYKLNEDMACSVAGITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTALCDIKQAYTQFGGKRPFGVSLLYIGWDKHYGFQLYQSDPSGNYGGWKATCIGNNSAAAVSMLKQDYKEGEMTLKSALALAVKVLNKTMDVSKLSAEKVEIATLTRESGKTVIRVLKQKEVEQLIKKHEEEEAKAEREKKEKEQREKDK

Entity 3 Entity 3 polymer

Description description	Proteasome subunit alpha type-7
Molecular weight formula_weight	27897.9 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	4

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	C,Q,e,s

MSYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGVRGKDIVVLGVEKKSVAKLQDERTVRKICALDDNVCMAFAGLTADARIVINRARVECQSHRLTVEDPVTVEYITRYIASLKQRYTQSNGRRPFGISALIVGFDFDGTPRLYQTDPSGTYHAWKANAIGRGAKSVREFLEKNYTDDAIETDDLTIKLVIKALLEVVQSGGKNIELAVMRRDQPLKILNPEEIEKYVAEIEKEKEENEKKKQKKAS

Entity 4 Entity 4 polymer

Description description	Proteasome subunit alpha type-5
Molecular weight formula_weight	26436.0 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	4

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	D,R,f,t

MFLTRSEYDRGVNTFSPEGRLFQVEYAIEAIKLGSTAIGIQTSEGVCLAVEKRITSPLMEPSSIEKIVEIDAHIGCAMSGLIADAKTLIDKARVETQNHWFTYNETMTVESVTQAVSNLALQFGEEDADPGAMSRPFGVALLFGGVDEKGPQLFHMDPSGTFVQCDARAIGSASEGAQSSLQEVYHKSMTLKEAIKSSLIILKQVMEEKLNATNIELATVQPGQNFHMFTKEELEEVIKDI

Entity 5 Entity 5 polymer

Description description	Proteasome subunit alpha type-1
Molecular weight formula_weight	29586.6 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	4

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	E,S,g,u

MFRNQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHQKKILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPTQRYGRRPYGVGLLIAGYDDMGPHIFQTCPSANYFDCRAMSIGARSQSARTYLERHMSEFMECNLDELVKHGLRALRETLPAEQDLTTKNVSIGIVGKDLEFTIYDDDDVSPFLDGLEERPQRKAQPSQAAEEPAEKADEPMEH

Entity 6 Entity 6 polymer

Description description	Proteasome subunit alpha type-3
Molecular weight formula_weight	28442.2 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	4

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	F,T,h,v

MSSIGTGYDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYEEGSNKRLFNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYVHAYTLYSAVRPFGCSFMLGSYSANDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKLQMKEMTCRDVVKEVAKIIYIVHDEVKDKAFELELSWVGELTKGRHEIVPKDIREEAEKYAKESLKEEDESDDDNM

Entity 7 Entity 7 polymer

Description description	Proteasome subunit alpha type-6
Molecular weight formula_weight	27405.4 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	4

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	G,U,i,w

MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKLLDSSTVTHLFKITESIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHLVALAERD

Entity 8 Entity 8 polymer

Description description	Proteasome subunit beta type-7
Molecular weight formula_weight	25280.0 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	4

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	H,V,j,x

TTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLTTGRLPRVVTANRMLKQMLFRYQGYIGAALVLGGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAVFEDKFRPDMEEEEAKKLVSEAIAAGIFNDLGSGSNIDLCVISKSKLDFLRPFSVPNKKGTRLGRYRCEKGTTAVLTEKVTPLEIEVLEETVQTMDTS

Entity 9 Entity 9 polymer

Description description	Proteasome subunit beta type-3
Molecular weight formula_weight	22988.9 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	4

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	I,W,k,y

MSIMSYNGGAVMAMKGKNCVAIAADRRFGIQAQMVTTDFQKIFPMGDRLYIGLAGLATDVQTVAQRLKFRLNLYELKEGRQIKPYTLMSMVANLLYEKRFGPYYTEPVIAGLDPKTFKPFICSLDLIGCPMVTDDFVVSGTCSEQMYGMCESLWEPNMDPEHLFETISQAMLNAVDRDAVSGMGVIVHVIEKDKITTRTLKARMD

Entity 10 Entity 10 polymer

Description description	Proteasome subunit beta type-2
Molecular weight formula_weight	22935.4 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	4

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	J,X,l,z

MEYLIGIQGPDYVLVASDRVAASNIVQMKDDHDKMFKMSEKILLLCVGEAGDTVQFAEYIQKNVQLYKMRNGYELSPTAAANFTRRNLADCLRSRTPYHVNLLLAGYDEHEGPALYYMDYLAALAKAPFAAHGYGAFLTLSILDRYYTPTISRERAVELLRKCLEELQKRFILNLPTFSVRVIDKDGIHNLENIAFPKRDS

Entity 11 Entity 11 polymer

Description description	Proteasome subunit beta type-5
Molecular weight formula_weight	22554.5 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	4

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	K,Y,m,1

TTTLAFKFLHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGTAFSVGSGSVYAYGVMDRGYSYDLKVEEAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHDKYSSVSVP

Entity 12 Entity 12 polymer

Description description	Proteasome subunit beta type-1
Molecular weight formula_weight	23577.0 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	4

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	L,Z,n,2

RFSPYAFNGGTVLAIAGEDFSIVASDTRLSEGFSIHTRDSPKCYKLTDKTVIGCSGFHGDCLTLTKIIEARLKMYKHSNNKAMTTGAIAAMLSTILYSRRFFPYYVYNIIGGLDEEGKGAVYSFDPVGSYQRDSFKAGGSASAMLQPLLDNQVGFKNMQNVEHVPLTLDRAMRLVKDVFISAAERDVYTGDALRICIVTKEGIREETVPLRKD

Entity 13 Entity 13 polymer

Description description	Proteasome subunit beta type-4
Molecular weight formula_weight	24384.7 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	4

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	M,a,o,3

TQNPMVTGTSVLGVKFDGGVVIAADMLGSYGSLARFRNISRIMRVNDSTMLGASGDYADFQYLKQVLGQMVIDEELLGDGHSYSPRAIHSWLTRAMYSRRSKMNPLWNTMVIGGYADGESFLGYVDMLGVAYEAPSLATGYGAYLAQPLLREVLEKQPVLSQTEARELVERCMRVLYYRDARSYNRFQIATVTEKGVEIEGPLSAQTNWDIAHMISGFE

Entity 14 Entity 14 polymer

Description description	Proteasome subunit beta type-6
Molecular weight formula_weight	22014.9 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	4

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	N,b,p,4

TTIMAVQFNGGVVLGADSRTTTGSYIANRVTDKLTPIHDHIFCCRSGSAADTQAVADAVTYQLGFHSIELNEPPLVHTAASLFKEMCYRYREDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAIGGSGSSYIYGYVDATYREGMTKDECLQFTANALALAMERDGSSGGVIRLAAIQESGVERQVLLGDQIPKFTIATLPPP

Entity 15 Entity 15 water

Description description	water
Molecular weight formula_weight	18.0 kDa
Source method src_method	nat
Copy count entity_count	640

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6. Fold Classification (SCOP + CATH) 56 domains

CATH v4.4 (56 domains)

Domain ID domain_id	3une100
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3une200
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3une300
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3une400
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3uneA00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3uneB00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3uneC00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3uneD00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3uneE00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3uneF00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3uneG00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3uneH00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3uneI00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3uneJ00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3uneK00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3uneL00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3uneM00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3uneN00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3uneO00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3uneP00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3uneQ00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3uneR00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3uneS00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3uneT00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3uneU00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3uneV00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3uneW00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3uneX00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3uneY00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3uneZ00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3unea00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3uneb00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3unec00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3uned00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3unee00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3unef00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3uneg00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3uneh00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3unei00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3unej00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3unek00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3unel00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3unem00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3unen00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3uneo00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3unep00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3uneq00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3uner00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3unes00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3unet00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3uneu00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3unev00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3unew00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3unex00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3uney00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	3unez00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

▶

Unit-cell length a length_a	170.970 Å
Unit-cell length b length_b	201.300 Å
Unit-cell length c length_c	226.010 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	108.07 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	8

Space group space_group	P 1 21 1
Space-group number int_tables_number	4
Crystal system crystal_system	—

Resolution resolution	3.200 Å
Low-resolution limit resolution_low	15.000 Å
R factor r_factor	0.2217
R_work r_work	0.2204
R_free r_free	0.2464

Mouse constitutive 20S proteasome

1. Protein Identity and Related Structures Protein Identity & Related Structures

Proteasome subunit alpha type-2

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Proteasome subunit alpha type-4

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Proteasome subunit alpha type-7

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Proteasome subunit alpha type-5

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Proteasome subunit alpha type-1

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Proteasome subunit alpha type-3

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Proteasome subunit alpha type-6

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Proteasome subunit beta type-7

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Proteasome subunit beta type-3

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Proteasome subunit beta type-2

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer