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4c7o

The structural basis of FtsY recruitment and GTPase activation by SRP RNA

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

SIGNAL RECOGNITION PARTICLE PROTEIN

ESCHERICHIA COLI

UniProt P0AGD7

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 2 RNA 1 SIGNAL RECOGNITION PARTICLE RECEPTOR FTSY × 1 （P10121） SRP RNA × 1 TETRAFLUOROALUMINATE ION × 2 MAGNESIUM ION × 2 GUANOSINE-5'-DIPHOSPHATE × 2 water × 3 Consistent with all polymers
2 Protein heterocomplex Heteromer Protein 2 SIGNAL RECOGNITION PARTICLE RECEPTOR FTSY × 1 （P10121） TETRAFLUOROALUMINATE ION × 2 MAGNESIUM ION × 2 GUANOSINE-5'-DIPHOSPHATE × 3 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
7o9i

1 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1dul 2pxb 2pxd 2pxe 2pxf 2pxk 2pxl 2pxp 2pxq 2pxt 2pxu 2pxv

20 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name SRP54_ECOLI
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–298； UniProt 1–298 Author chain C； PDBConstruct 1–298； UniProt 1–298

SIGNAL RECOGNITION PARTICLE RECEPTOR FTSY

OrganismNot specified

UniProt P10121

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 2 RNA 1 SIGNAL RECOGNITION PARTICLE PROTEIN × 1 （P0AGD7） SRP RNA × 1 TETRAFLUOROALUMINATE ION × 2 MAGNESIUM ION × 2 GUANOSINE-5'-DIPHOSPHATE × 2 water × 3 Consistent with all polymers
2 Protein heterocomplex Heteromer Protein 2 SIGNAL RECOGNITION PARTICLE PROTEIN × 1 （P0AGD7） TETRAFLUOROALUMINATE ION × 2 MAGNESIUM ION × 2 GUANOSINE-5'-DIPHOSPHATE × 3 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1fts 2qy9 2yhs 6fpk 6fpr 6fpr 6fqd 6fqd 6n5i 6n5i 6n5j 6n5j

20 assemblies; showing the first 12

Homodimer
6cqp 6cs8 6cvd

3 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2xxa 2xxa 3zn8 4c7o 4c7o 5gad 5nco

7 assemblies

View Construct and Data Evidence
UniProt name FTSY_ECOLI
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 5–278； UniProt 224–497 Author chain D； PDBConstruct 5–278； UniProt 224–497

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id4c7o
Deposition date deposition_date2013-09-23
Structure title titleThe structural basis of FtsY recruitment and GTPase activation by SRP RNA
Keywords keywords;NUCLEAR PROTEIN-RNA COMPLEX, NUCLEAR PROTEIN, PROTEIN TRANSLOCATION, SIGNAL RECOGNITION PARTICLE, SIGNAL RECOGNITION PARTICLE RECEPTOR, GDP ALF3/4 ;; NUCLEAR PROTEIN/RNA
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

4c7o__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

4c7o__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

4c7o__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）28.65 Å
Rg (electron density)27.45 Å
Total Rg28.13 Å
Atom count5396
Residues612
Excluded volume92626 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 4c7o__assembly_1__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 4c7o__assembly_2__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (7)

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6. Fold Classification (SCOP + CATH) 13 domains

SCOP 2.08 (5 domains)

Domain ID domain_idd4c7ob1
Class classa — All alpha proteins
Fold Fold folda.24 — Four-helical up-and-down bundle
Superfamily Superfamily superfamilya.24.13 — Domain of the SRP/SRP receptor G-proteins
Family Family familya.24.13.0 — automated matches
Domain ID domain_idd4c7ob2
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.37 — P-loop containing nucleoside triphosphate hydrolases
Superfamily Superfamily superfamilyc.37.1 — P-loop containing nucleoside triphosphate hydrolases
Family Family familyc.37.1.10 — Nitrogenase iron protein-like
Domain ID domain_idd4c7od1
Class classa — All alpha proteins
Fold Fold folda.24 — Four-helical up-and-down bundle
Superfamily Superfamily superfamilya.24.13 — Domain of the SRP/SRP receptor G-proteins
Family Family familya.24.13.0 — automated matches
Domain ID domain_idd4c7od2
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.37 — P-loop containing nucleoside triphosphate hydrolases
Superfamily Superfamily superfamilyc.37.1 — P-loop containing nucleoside triphosphate hydrolases
Family Family familyc.37.1.10 — Nitrogenase iron protein-like
Domain ID domain_idd4c7od3
Class classl — Artifacts
Fold Fold foldl.1 — Tags
Superfamily Superfamily superfamilyl.1.1 — Tags
Family Family familyl.1.1.1 — Tags

CATH v4.4 (8 domains)

Domain ID domain_id4c7oA01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily140 — SRP54, nucleotide-binding domain
Domain ID domain_id4c7oA02
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
Domain ID domain_id4c7oB01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily140 — SRP54, nucleotide-binding domain
Domain ID domain_id4c7oB02
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
Domain ID domain_id4c7oC01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily140 — SRP54, nucleotide-binding domain
Domain ID domain_id4c7oC02
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
Domain ID domain_id4c7oD01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily140 — SRP54, nucleotide-binding domain
Domain ID domain_id4c7oD02
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
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7. Citations (1)