4cbo

Crystal structure of Complement Factor D mutant R202A after ensemble refinement

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

COMPLEMENT FACTOR D

HOMO SAPIENS

UniProt P00746

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein monomer Monomer Protein 1 GLYCEROL × 1 water × 1 Consistent with protein count
2 Protein monomer Monomer Protein 1 GLYCEROL × 1 water × 1 Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name CFAD_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A; PDBConstruct 1–228; UniProt 26–253 Author chain B; PDBConstruct 1–228; UniProt 26–253

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id4cbo
Deposition date deposition_date2013-10-15
Structure title titleCrystal structure of Complement Factor D mutant R202A after ensemble refinement
Keywords keywordsHYDROLASE, FACTOR D, ENSEMBLE REFINEMENT; HYDROLASE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

4cbo__assembly_2__model_33

Assembly 2 · Model 33 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

4cbo__assembly_2__model_33 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

4cbo__assembly_2__model_33 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg(Guinier)17.61 Å
Rg (electron density)16.43 Å
Total Rg17.42 Å
Atom count3420
Residues228
Excluded volume30142 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 4cbo__assembly_1__model_1 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 2 4cbo__assembly_1__model_2 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 3 4cbo__assembly_1__model_3 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 4 4cbo__assembly_1__model_4 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 5 4cbo__assembly_1__model_5 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 6 4cbo__assembly_1__model_6 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 7 4cbo__assembly_1__model_7 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 8 4cbo__assembly_1__model_8 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 9 4cbo__assembly_1__model_9 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 10 4cbo__assembly_1__model_10 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 11 4cbo__assembly_1__model_11 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 12 4cbo__assembly_1__model_12 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 13 4cbo__assembly_1__model_13 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 14 4cbo__assembly_1__model_14 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 15 4cbo__assembly_1__model_15 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 16 4cbo__assembly_1__model_16 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 17 4cbo__assembly_1__model_17 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 18 4cbo__assembly_1__model_18 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 19 4cbo__assembly_1__model_19 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 20 4cbo__assembly_1__model_20 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 21 4cbo__assembly_1__model_21 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 22 4cbo__assembly_1__model_22 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 23 4cbo__assembly_1__model_23 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 24 4cbo__assembly_1__model_24 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 25 4cbo__assembly_1__model_25 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 26 4cbo__assembly_1__model_26 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 27 4cbo__assembly_1__model_27 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 28 4cbo__assembly_1__model_28 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 29 4cbo__assembly_1__model_29 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 30 4cbo__assembly_1__model_30 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 31 4cbo__assembly_1__model_31 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 32 4cbo__assembly_1__model_32 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 33 4cbo__assembly_1__model_33 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 34 4cbo__assembly_1__model_34 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 35 4cbo__assembly_1__model_35 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 36 4cbo__assembly_1__model_36 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 37 4cbo__assembly_1__model_37 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 38 4cbo__assembly_1__model_38 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 39 4cbo__assembly_1__model_39 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 40 4cbo__assembly_1__model_40 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 41 4cbo__assembly_1__model_41 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 42 4cbo__assembly_1__model_42 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 43 4cbo__assembly_1__model_43 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 44 4cbo__assembly_1__model_44 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 45 4cbo__assembly_1__model_45 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 46 4cbo__assembly_1__model_46 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 47 4cbo__assembly_1__model_47 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 48 4cbo__assembly_1__model_48 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 49 4cbo__assembly_1__model_49 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 50 4cbo__assembly_1__model_50 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 51 4cbo__assembly_1__model_51 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 52 4cbo__assembly_1__model_52 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 53 4cbo__assembly_1__model_53 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 54 4cbo__assembly_1__model_54 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 55 4cbo__assembly_1__model_55 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 56 4cbo__assembly_1__model_56 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 57 4cbo__assembly_1__model_57 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 58 4cbo__assembly_1__model_58 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 59 4cbo__assembly_1__model_59 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 60 4cbo__assembly_1__model_60 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 61 4cbo__assembly_1__model_61 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 62 4cbo__assembly_1__model_62 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 63 4cbo__assembly_1__model_63 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 64 4cbo__assembly_1__model_64 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 65 4cbo__assembly_1__model_65 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 66 4cbo__assembly_1__model_66 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 67 4cbo__assembly_1__model_67 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 68 4cbo__assembly_1__model_68 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 69 4cbo__assembly_1__model_69 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 70 4cbo__assembly_1__model_70 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 71 4cbo__assembly_1__model_71 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 72 4cbo__assembly_1__model_72 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 73 4cbo__assembly_1__model_73 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 74 4cbo__assembly_1__model_74 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 75 4cbo__assembly_1__model_75 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 76 4cbo__assembly_1__model_76 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
1 77 4cbo__assembly_1__model_77 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 4cbo__assembly_2__model_1 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 2 4cbo__assembly_2__model_2 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 3 4cbo__assembly_2__model_3 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 4 4cbo__assembly_2__model_4 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 5 4cbo__assembly_2__model_5 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 6 4cbo__assembly_2__model_6 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 7 4cbo__assembly_2__model_7 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 8 4cbo__assembly_2__model_8 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 9 4cbo__assembly_2__model_9 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 10 4cbo__assembly_2__model_10 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 11 4cbo__assembly_2__model_11 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 12 4cbo__assembly_2__model_12 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 13 4cbo__assembly_2__model_13 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 14 4cbo__assembly_2__model_14 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 15 4cbo__assembly_2__model_15 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 16 4cbo__assembly_2__model_16 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 17 4cbo__assembly_2__model_17 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 18 4cbo__assembly_2__model_18 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 19 4cbo__assembly_2__model_19 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 20 4cbo__assembly_2__model_20 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 21 4cbo__assembly_2__model_21 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 22 4cbo__assembly_2__model_22 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 23 4cbo__assembly_2__model_23 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 24 4cbo__assembly_2__model_24 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 25 4cbo__assembly_2__model_25 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 26 4cbo__assembly_2__model_26 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 27 4cbo__assembly_2__model_27 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 28 4cbo__assembly_2__model_28 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 29 4cbo__assembly_2__model_29 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 30 4cbo__assembly_2__model_30 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 31 4cbo__assembly_2__model_31 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 32 4cbo__assembly_2__model_32 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 33 4cbo__assembly_2__model_33 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 34 4cbo__assembly_2__model_34 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 35 4cbo__assembly_2__model_35 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 36 4cbo__assembly_2__model_36 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 37 4cbo__assembly_2__model_37 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 38 4cbo__assembly_2__model_38 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 39 4cbo__assembly_2__model_39 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 40 4cbo__assembly_2__model_40 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 41 4cbo__assembly_2__model_41 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 42 4cbo__assembly_2__model_42 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 43 4cbo__assembly_2__model_43 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 44 4cbo__assembly_2__model_44 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 45 4cbo__assembly_2__model_45 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 46 4cbo__assembly_2__model_46 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 47 4cbo__assembly_2__model_47 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 48 4cbo__assembly_2__model_48 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 49 4cbo__assembly_2__model_49 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 50 4cbo__assembly_2__model_50 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 51 4cbo__assembly_2__model_51 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 52 4cbo__assembly_2__model_52 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 53 4cbo__assembly_2__model_53 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 54 4cbo__assembly_2__model_54 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 55 4cbo__assembly_2__model_55 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 56 4cbo__assembly_2__model_56 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 57 4cbo__assembly_2__model_57 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 58 4cbo__assembly_2__model_58 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 59 4cbo__assembly_2__model_59 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 60 4cbo__assembly_2__model_60 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 61 4cbo__assembly_2__model_61 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 62 4cbo__assembly_2__model_62 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 63 4cbo__assembly_2__model_63 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 64 4cbo__assembly_2__model_64 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 65 4cbo__assembly_2__model_65 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 66 4cbo__assembly_2__model_66 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 67 4cbo__assembly_2__model_67 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 68 4cbo__assembly_2__model_68 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 69 4cbo__assembly_2__model_69 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 70 4cbo__assembly_2__model_70 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 71 4cbo__assembly_2__model_71 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 72 4cbo__assembly_2__model_72 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 73 4cbo__assembly_2__model_73 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 74 4cbo__assembly_2__model_74 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 75 4cbo__assembly_2__model_75 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 76 4cbo__assembly_2__model_76 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
2 77 4cbo__assembly_2__model_77 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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6. Fold Classification (SCOP + CATH) 6 domains

SCOP 2.08 (2 domains)

Domain ID domain_idd4cboa_
Class classb — All beta proteins
Fold Fold foldb.47 — Trypsin-like serine proteases
Superfamily Superfamily superfamilyb.47.1 — Trypsin-like serine proteases
Family Family familyb.47.1.2 — Eukaryotic proteases
Domain ID domain_idd4cbob_
Class classb — All beta proteins
Fold Fold foldb.47 — Trypsin-like serine proteases
Superfamily Superfamily superfamilyb.47.1 — Trypsin-like serine proteases
Family Family familyb.47.1.2 — Eukaryotic proteases

CATH v4.4 (4 domains)

Domain ID domain_id4cboA01
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology10 — Thrombin, subunit H
Homologous superfamily homologous superfamily10 — Trypsin-like serine proteases
Domain ID domain_id4cboA02
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology10 — Thrombin, subunit H
Homologous superfamily homologous superfamily10 — Trypsin-like serine proteases
Domain ID domain_id4cboB01
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology10 — Thrombin, subunit H
Homologous superfamily homologous superfamily10 — Trypsin-like serine proteases
Domain ID domain_id4cboB02
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology10 — Thrombin, subunit H
Homologous superfamily homologous superfamily10 — Trypsin-like serine proteases
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7. Citations (1)