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4ezs

Crystal structure of the substrate binding domain of E.coli DnaK in complex with metchnikowin (residues 20 to 26)

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Chaperone protein DnaK

Escherichia coli

UniProt P0A6Y8

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 8 Metchnikowin × 4 （Q24395） SULFATE ION × 4 water × 8 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 4 Metchnikowin × 2 （Q24395） SULFATE ION × 2 water × 4 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 4 Metchnikowin × 2 （Q24395） SULFATE ION × 2 water × 4 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 4 Metchnikowin × 2 （Q24395） SULFATE ION × 2 water × 4 Consistent with protein count
5 Protein heterocomplex Heteromer Protein 2 Metchnikowin × 1 （Q24395） SULFATE ION × 1 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1bpr 1dg4 2bpr 2kho 4b9q 4b9q 4b9q 4b9q 4f01 4f01 4jnf 5oow

13 assemblies; showing the first 12

Homodimer
4f01 4jn4 4jne 4r5g 4r5g 4r5j 4r5j 4r5k 4r5l 4r5l

10 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1dkx 1dkx 1dky 1dky 1dky 1dkz 1dkz 1q5l 3dpo 3dpo 3dpo 3dpp

103 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name DNAK_ECOLI
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–219； UniProt 389–607

Metchnikowin

OrganismNot specified

UniProt Q24395

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 8 Chaperone protein DnaK × 4 （P0A6Y8） SULFATE ION × 4 water × 8 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 4 Chaperone protein DnaK × 2 （P0A6Y8） SULFATE ION × 2 water × 4 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 4 Chaperone protein DnaK × 2 （P0A6Y8） SULFATE ION × 2 water × 4 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 4 Chaperone protein DnaK × 2 （P0A6Y8） SULFATE ION × 2 water × 4 Consistent with protein count
5 Protein heterocomplex Heteromer Protein 2 Chaperone protein DnaK × 1 （P0A6Y8） SULFATE ION × 1 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
4ezs 4ezs 4ezs 4ezs 4ezs

5 assemblies

View Construct and Data Evidence
UniProt name MTK_DROME
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 1–7； UniProt 46–52

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id4ezs
Deposition date deposition_date2012-05-03
Structure title titleCrystal structure of the substrate binding domain of E.coli DnaK in complex with metchnikowin (residues 20 to 26)
Keywords keywordschaperone, peptide binding, CHAPERONE-PEPTIDE BINDING PROTEIN complex; CHAPERONE/PEPTIDE BINDING PROTEIN
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

4ezs__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

4ezs__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

4ezs__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）34.96 Å
Rg (electron density)34.86 Å
Total Rg35.08 Å
Atom count6888
Residues904
Excluded volume121740 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 4ezs__assembly_1__model_1 octameric （8） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 4ezs__assembly_2__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 4ezs__assembly_3__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
4 1 4ezs__assembly_4__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
5 1 4ezs__assembly_5__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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6. Fold Classification (SCOP + CATH) 2 domains

CATH v4.4 (2 domains)

Domain ID domain_id4ezsA01
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology34 — Substrate Binding Domain Of DNAk; Chain A, domain 1
Homologous superfamily homologous superfamily10 — Substrate Binding Domain Of DNAk; Chain A, domain 1
Domain ID domain_id4ezsA02
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1270 — Substrate Binding Domain Of Dnak; Chain:A; Domain 2
Homologous superfamily homologous superfamily10 —
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7. Citations (1)