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4fnc

Human TDG in a post-reactive complex with 5-hydroxymethyluracil (5hmU)

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

G/T mismatch-specific thymine DNA glycosylase

Homo sapiens

UniProt Q13569

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–DNA Monomer Protein 1 DNA 2 DNA (28-MER) × 1 DNA (29-MER) × 1 5-HYDROXYMETHYL URACIL × 1 water × 3 Consistent with all polymers

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1wyw 2d07 2rba 3ufj 3ufj 3uo7 3uob 4fnc 4jgc 4xeg 4z3a 4z47

22 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name TDG_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 7–204； UniProt 111–308

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id4fnc
Deposition date deposition_date2012-06-19
Structure title titleHuman TDG in a post-reactive complex with 5-hydroxymethyluracil (5hmU)
Keywords keywordsbase excision repair, HYDROLASE-DNA complex; HYDROLASE/DNA
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

4fnc__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

4fnc__assembly_1__model_1 | I(q)

10-2 10-1 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

4fnc__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）26.71 Å
Rg (electron density)25.38 Å
Total Rg26.00 Å
Atom count2674
Residues252
Excluded volume43991 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 4fnc__assembly_1__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (5)

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6. Fold Classification (SCOP + CATH) 1 domains

CATH v4.4 (1 domains)

Domain ID domain_id4fncA00
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology470 — Uracil-DNA Glycosylase, subunit E
Homologous superfamily homologous superfamily10 — Uracil-DNA glycosylase-like domain
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7. Citations (1)