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4g5o

Structure of LGN GL4/Galphai3(Q147L) complex

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Guanine nucleotide-binding protein G(k) subunit alpha

Homo sapiens

UniProt P08754

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 G-protein-signaling modulator 2 × 1 （Q8VDU0） GUANOSINE-5'-DIPHOSPHATE × 1 CITRIC ACID × 2 SULFATE ION × 4 water × 1 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 G-protein-signaling modulator 2 × 1 （Q8VDU0） GUANOSINE-5'-DIPHOSPHATE × 1 SULFATE ION × 4 water × 2 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 2 G-protein-signaling modulator 2 × 1 （Q8VDU0） GUANOSINE-5'-DIPHOSPHATE × 1 CITRIC ACID × 1 SULFATE ION × 4 water × 2 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 2 G-protein-signaling modulator 2 × 1 （Q8VDU0） GUANOSINE-5'-DIPHOSPHATE × 1 CITRIC ACID × 1 SULFATE ION × 5 water × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
8oy1

1 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2ihb 2ode 2ode 2v4z 4g5o 4g5o 4g5o 4g5o 4g5r 4g5r 4g5r 4g5r

34 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name GNAI3_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–330； UniProt 25–354 Author chain B； PDBConstruct 1–330； UniProt 25–354 Author chain C； PDBConstruct 1–330； UniProt 25–354 Author chain D； PDBConstruct 1–330； UniProt 25–354

G-protein-signaling modulator 2

OrganismNot specified

UniProt Q8VDU0

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 Guanine nucleotide-binding protein G(k) subunit alpha × 1 （P08754） GUANOSINE-5'-DIPHOSPHATE × 1 CITRIC ACID × 2 SULFATE ION × 4 water × 1 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 Guanine nucleotide-binding protein G(k) subunit alpha × 1 （P08754） GUANOSINE-5'-DIPHOSPHATE × 1 SULFATE ION × 4 water × 2 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 2 Guanine nucleotide-binding protein G(k) subunit alpha × 1 （P08754） GUANOSINE-5'-DIPHOSPHATE × 1 CITRIC ACID × 1 SULFATE ION × 4 water × 2 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 2 Guanine nucleotide-binding protein G(k) subunit alpha × 1 （P08754） GUANOSINE-5'-DIPHOSPHATE × 1 CITRIC ACID × 1 SULFATE ION × 5 water × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer
4jhr

1 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
3ro2 3ro3 4g2v 4g5o 4g5o 4g5o 4g5o 4g5q 4g5q 4g5q 4g5q 4g5r

20 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name GPSM2_MOUSE
Isoform —
PDB entities 2
Chains and sequence ranges Author chain E； PDBConstruct 1–26； UniProt 628–653 Author chain F； PDBConstruct 1–26； UniProt 628–653 Author chain G； PDBConstruct 1–26； UniProt 628–653 Author chain H； PDBConstruct 1–26； UniProt 628–653

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id4g5o
Deposition date deposition_date2012-07-18
Structure title titleStructure of LGN GL4/Galphai3(Q147L) complex
Keywords keywordsGalphai, GoLoco, Galpha signaling, asymmetric cell division, CELL CYCLE-SIGNALING PROTEIN complex; CELL CYCLE/SIGNALING PROTEIN
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

4g5o__assembly_2__model_1

Assembly 2 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

4g5o__assembly_2__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

4g5o__assembly_2__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）21.72 Å
Rg (electron density)20.77 Å
Total Rg21.60 Å
Atom count2751
Residues337
Excluded volume48791 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 4g5o__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 4g5o__assembly_2__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 4g5o__assembly_3__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
4 1 4g5o__assembly_4__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (6)

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6. Fold Classification (SCOP + CATH) 8 domains

CATH v4.4 (8 domains)

Domain ID domain_id4g5oA01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
Domain ID domain_id4g5oA02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology400 — GI Alpha 1, domain 2-like
Homologous superfamily homologous superfamily10 — GI Alpha 1, domain 2-like
Domain ID domain_id4g5oB01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
Domain ID domain_id4g5oB02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology400 — GI Alpha 1, domain 2-like
Homologous superfamily homologous superfamily10 — GI Alpha 1, domain 2-like
Domain ID domain_id4g5oC01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
Domain ID domain_id4g5oC02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology400 — GI Alpha 1, domain 2-like
Homologous superfamily homologous superfamily10 — GI Alpha 1, domain 2-like
Domain ID domain_id4g5oD01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
Domain ID domain_id4g5oD02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology400 — GI Alpha 1, domain 2-like
Homologous superfamily homologous superfamily10 — GI Alpha 1, domain 2-like
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7. Citations (1)