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4ovn

Voltage-gated Sodium Channel 1.5 (Nav1.5) C-terminal domain in complex with Calmodulin poised for activation

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Calmodulin

Homo sapiens

UniProt P62158

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 Sodium channel protein type 5 subunit alpha × 1 （Q14524） MAGNESIUM ION × 4 SULFATE ION × 2 water × 2 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 Sodium channel protein type 5 subunit alpha × 1 （Q14524） MAGNESIUM ION × 3 SULFATE ION × 1 PHOSPHATE ION × 1 water × 2 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 2 Sodium channel protein type 5 subunit alpha × 1 （Q14524） MAGNESIUM ION × 5 SULFATE ION × 1 PHOSPHATE ION × 1 water × 2 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 2 Sodium channel protein type 5 subunit alpha × 1 （Q14524） MAGNESIUM ION × 4 water × 2 Consistent with protein count
5 Protein heterocomplex Heteromer Protein 2 Sodium channel protein type 5 subunit alpha × 1 （Q14524） MAGNESIUM ION × 2 SULFATE ION × 1 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1cll 1ctr 1j7o 1j7p 1sw8 1y6w 2hf5 2k0e 2k0j 2k61 2kuh 2lqp

22 assemblies; showing the first 12

Homodimer
3uct 3uct 3ucw 3ucw 3ucy 4bw7

6 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1cdl 1cdl 1cdl 1cdl 1iwq 1iwq 1l7z 1pk0 1pk0 1pk0 1pk0 1s26

149 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name CALM_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–149； UniProt 1–149 Author chain B； PDBConstruct 1–149； UniProt 1–149 Author chain C； PDBConstruct 1–149； UniProt 1–149 Author chain D； PDBConstruct 1–149； UniProt 1–149 Author chain E； PDBConstruct 1–149； UniProt 1–149

Sodium channel protein type 5 subunit alpha

Homo sapiens

UniProt Q14524

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 Calmodulin × 1 （P62158） MAGNESIUM ION × 4 SULFATE ION × 2 water × 2 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 Calmodulin × 1 （P62158） MAGNESIUM ION × 3 SULFATE ION × 1 PHOSPHATE ION × 1 water × 2 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 2 Calmodulin × 1 （P62158） MAGNESIUM ION × 5 SULFATE ION × 1 PHOSPHATE ION × 1 water × 2 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 2 Calmodulin × 1 （P62158） MAGNESIUM ION × 4 water × 2 Consistent with protein count
5 Protein heterocomplex Heteromer Protein 2 Calmodulin × 1 （P62158） MAGNESIUM ION × 2 SULFATE ION × 1 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
2kbi 6lqa 7dtc 7l83 9ith 9p24 9v3s

7 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
4dck 4dck 4djc 4jq0 4ovn 4ovn 4ovn 4ovn 4ovn 5dbr 6mud 8vyj

13 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name SCN5A_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain F； PDBConstruct 1–157； UniProt 1773–1929 Author chain G； PDBConstruct 1–157； UniProt 1773–1929 Author chain H； PDBConstruct 1–157； UniProt 1773–1929 Author chain I； PDBConstruct 1–157； UniProt 1773–1929 Author chain J； PDBConstruct 1–157； UniProt 1773–1929

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id4ovn
Deposition date deposition_date2013-12-10
Structure title titleVoltage-gated Sodium Channel 1.5 (Nav1.5) C-terminal domain in complex with Calmodulin poised for activation
Keywords keywordsSCN5A, Voltage Gated Sodium Channel, Calmodulin, METAL BINDING PROTEIN; METAL BINDING PROTEIN
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

4ovn__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

4ovn__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

4ovn__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）23.01 Å
Rg (electron density)22.19 Å
Total Rg22.78 Å
Atom count4588
Residues274
Excluded volume41631 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 4ovn__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 4ovn__assembly_2__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 4ovn__assembly_3__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
4 1 4ovn__assembly_4__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
5 1 4ovn__assembly_5__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (6)

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6. Fold Classification (SCOP + CATH) 15 domains

SCOP 2.08 (5 domains)

Domain ID domain_idd4ovna_
Class classa — All alpha proteins
Fold Fold folda.39 — EF Hand-like
Superfamily Superfamily superfamilya.39.1 — EF-hand
Family Family familya.39.1.5 — Calmodulin-like
Domain ID domain_idd4ovnb_
Class classa — All alpha proteins
Fold Fold folda.39 — EF Hand-like
Superfamily Superfamily superfamilya.39.1 — EF-hand
Family Family familya.39.1.5 — Calmodulin-like
Domain ID domain_idd4ovnc_
Class classa — All alpha proteins
Fold Fold folda.39 — EF Hand-like
Superfamily Superfamily superfamilya.39.1 — EF-hand
Family Family familya.39.1.5 — Calmodulin-like
Domain ID domain_idd4ovnd_
Class classa — All alpha proteins
Fold Fold folda.39 — EF Hand-like
Superfamily Superfamily superfamilya.39.1 — EF-hand
Family Family familya.39.1.5 — Calmodulin-like
Domain ID domain_idd4ovne_
Class classa — All alpha proteins
Fold Fold folda.39 — EF Hand-like
Superfamily Superfamily superfamilya.39.1 — EF-hand
Family Family familya.39.1.5 — Calmodulin-like

CATH v4.4 (10 domains)

Domain ID domain_id4ovnF01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology238 — Recoverin; domain 1
Homologous superfamily homologous superfamily10 — EF-hand
Domain ID domain_id4ovnF02
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homologous superfamily homologous superfamily1190 — iswi atpase
Domain ID domain_id4ovnG01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology238 — Recoverin; domain 1
Homologous superfamily homologous superfamily10 — EF-hand
Domain ID domain_id4ovnG02
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homologous superfamily homologous superfamily1190 — iswi atpase
Domain ID domain_id4ovnH01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology238 — Recoverin; domain 1
Homologous superfamily homologous superfamily10 — EF-hand
Domain ID domain_id4ovnH02
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homologous superfamily homologous superfamily1190 — iswi atpase
Domain ID domain_id4ovnI01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology238 — Recoverin; domain 1
Homologous superfamily homologous superfamily10 — EF-hand
Domain ID domain_id4ovnI02
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homologous superfamily homologous superfamily1190 — iswi atpase
Domain ID domain_id4ovnJ01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology238 — Recoverin; domain 1
Homologous superfamily homologous superfamily10 — EF-hand
Domain ID domain_id4ovnJ02
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homologous superfamily homologous superfamily1190 — iswi atpase
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7. Citations (1)