4v7q

Atomic model of an infectious rotavirus particle

Method: ELECTRON MICROSCOPY

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1. Protein Identity and Related Structures Protein Identity & Related Structures

Core scaffold protein

Simian rotavirus A

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Other combination	Heteromer	Protein 1860 其他Polymer 420	Intermediate capsid protein VP6 × 780 （B2BN53） Outer layer protein VP7 × 780 （C3RX25） Outer capsid protein VP4 × 180 （C3RX20） 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 420 ZINC ION × 300 2-acetamido-2-deoxy-beta-D-glucopyranose × 60	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	B3F2X3_9REOV
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain AA； PDBConstruct 1–800； UniProt 88–887 Author chain AB； PDBConstruct 1–800； UniProt 88–887

Intermediate capsid protein VP6

Rhesus rotavirus

UniProt B2BN53

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Other combination	Heteromer	Protein 1860 其他Polymer 420	Core scaffold protein × 120 （B3F2X3） Outer layer protein VP7 × 780 （C3RX25） Outer capsid protein VP4 × 180 （C3RX20） 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 420 ZINC ION × 300 2-acetamido-2-deoxy-beta-D-glucopyranose × 60	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	VP6_ROTRH
Isoform	—
PDB entities	2
Chains and sequence ranges	Author chain AC； PDBConstruct 1–397； UniProt 1–397 Author chain AD； PDBConstruct 1–397； UniProt 1–397 Author chain AE； PDBConstruct 1–397； UniProt 1–397 Author chain AF； PDBConstruct 1–397； UniProt 1–397 Author chain AG； PDBConstruct 1–397； UniProt 1–397 Author chain AH； PDBConstruct 1–397； UniProt 1–397 Author chain AI； PDBConstruct 1–397； UniProt 1–397 Author chain AJ； PDBConstruct 1–397； UniProt 1–397 Author chain AK； PDBConstruct 1–397； UniProt 1–397 Author chain AL； PDBConstruct 1–397； UniProt 1–397 Author chain AM； PDBConstruct 1–397； UniProt 1–397 Author chain AN； PDBConstruct 1–397； UniProt 1–397 Author chain AO； PDBConstruct 1–397； UniProt 1–397

Outer layer protein VP7

Simian rotavirus A

UniProt C3RX25

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Other combination	Heteromer	Protein 1860 其他Polymer 420	Core scaffold protein × 120 （B3F2X3） Intermediate capsid protein VP6 × 780 （B2BN53） Outer capsid protein VP4 × 180 （C3RX20） 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 420 ZINC ION × 300 2-acetamido-2-deoxy-beta-D-glucopyranose × 60	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	C3RX25_9REOV
Isoform	—
PDB entities	3
Chains and sequence ranges	Author chain BA； PDBConstruct 1–276； UniProt 51–326 Author chain BF； PDBConstruct 1–276； UniProt 51–326 Author chain BG； PDBConstruct 1–276； UniProt 51–326 Author chain BH； PDBConstruct 1–276； UniProt 51–326 Author chain BI； PDBConstruct 1–276； UniProt 51–326 Author chain BJ； PDBConstruct 1–276； UniProt 51–326 Author chain BK； PDBConstruct 1–276； UniProt 51–326 Author chain BL； PDBConstruct 1–276； UniProt 51–326 Author chain BM； PDBConstruct 1–276； UniProt 51–326 Author chain BN； PDBConstruct 1–276； UniProt 51–326 Author chain BO； PDBConstruct 1–276； UniProt 51–326 Author chain BP； PDBConstruct 1–276； UniProt 51–326 Author chain BQ； PDBConstruct 1–276； UniProt 51–326

Outer capsid protein VP4

Simian rotavirus A

UniProt C3RX20

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Other combination	Heteromer	Protein 1860 其他Polymer 420	Core scaffold protein × 120 （B3F2X3） Intermediate capsid protein VP6 × 780 （B2BN53） Outer layer protein VP7 × 780 （C3RX25） 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 420 ZINC ION × 300 2-acetamido-2-deoxy-beta-D-glucopyranose × 60	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	C3RX20_9REOV
Isoform	—
PDB entities	4
Chains and sequence ranges	Author chain BX； PDBConstruct 1–776； UniProt 1–776 Author chain BY； PDBConstruct 1–776； UniProt 1–776 Author chain BZ； PDBConstruct 1–776； UniProt 1–776

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	4v7q
Deposition date deposition_date	2010-05-13
Structure title title	Atomic model of an infectious rotavirus particle
Keywords keywords	;Rotavirus, Triple Layered Particle, Near Atomic Resolution, VP2, VP6, VP4, VP7, Double layered particle, de novo, Infectious, Virus, DLP, ICOSAHEDRAL VIRUS ;; VIRUS
Experimental Method method	ELECTRON MICROSCOPY

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

4v7q__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

4v7q__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

4v7q__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	0.00 Å
Rg (electron density)	331.50 Å
Total Rg	331.30 Å
Atom count	5837220
Residues	731880
Excluded volume	103820000 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`4v7q__assembly_1__model_1`	1860-meric （1860）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (7)

Entity 1 Entity 1 polymer

Description description	Core scaffold protein
Molecular weight formula_weight	93190.6 kDa
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	AA,AB
Atom count atom_count	97287

EHQKEVQYEILQKTIPTFEPKESILKKLEDIKPEQVKKQTKLFRIFEPRQLPVYRANGEKELRNRWYWKLKRDTLPDGDYDVREYFLNLYDQVLTEMPDYLLLKDMAVENKNSRDAGKVVDSETAAICDAIFQDEETEGVVRRFIAEMRQRVQADRNVVNYPSILHPIDHAFNEYFLQHQLVEPLNNDIIFNYIPERIRNDVNYILNMDRNLPSTARYIRPNLLQDRLNLHDNFESLWDTITTSNYILARSVVPDLKELVSTEAQIQKMSQDLQLEALTIQSETQFLTGINSQAANDCFKTLIAAMLSQRTMSLDFVTTNYMSLISGMWLLTVVPNDMFIRESLVACQLAIINTIIYPAFGMQRMHYRNGDPQTPFQIAEQQIQNFQVANWLHFVNNNQFRQVVIDGVLNQVLNDNIRNGHVVNQLMEALMQLSRQQFPTMPVDYKRSIQRGILLLSNRLGQLVDLTRLLAYNYETLMACITMNMQHVQTLTTEKLQLTSVTSLCMLIGNATVIPSPQTLFHYYNVNVNFHSNYNERINDAVAIITAANRLNLYQKKMKSIVEDFLKRLQIFDISRVPDDQMYRLRDRLRLLPVEIRRLDIFNLILMNMEQIERASDKIAQGVIIAYRDMQLERDEMYGYVNIARNLDGFQQINLEELMRTGDYAQITNMLLNNQPVALVGALPFITDSSVISLVAKLDATVFAQIVKLRKVDTLKPILYKINSDSNDFYLVANYDWVPTSTTKVYKQIPQQFDFRASMHMLTSNLTFTVYSDLLAFVSADTVEPINAVAFDNMRIMNEL

Source Source

Source organism organism	Simian rotavirus A
NCBI taxonomy ID ncbi_taxonomy_id	444185
Host organism host_organism	Chlorocebus sabaeus

Entity 2 Entity 2 polymer

Description description	Intermediate capsid protein VP6
Molecular weight formula_weight	44934.8 kDa
Source method src_method	man
Copy count entity_count	13

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	AC,AD,AE,AF,AG,AH,AI,AJ,AK,AL,AM,AN,AO

MDVLYSLSKTLKDARDKIVEGTLYSNVSDLIQQFNQMIITMNGNEFQTGGIGNLPIRNWNFDFGLLGTTLLNLDANYVETARNTIDYFVDFVDNVCMDEMVRESQRNGIAPQSDSLRKLSGIKFKRINFDNSSEYIENWNLQNRRQRTGFTFHKPNIFPYSASFTLNRSQPAHDNLMGTMWLNAGSEIQVAGFDYSCAINAPANIQQFEHIVQLRRVLTTATITLLPDAERFSFPRVINSADGATTWYFNPVILRPNNVEVEFLLNGQIINTYQARFGTIIARNFDTIRLSFQLMRPPNMTPAVAALFPNAQPFEHHATVGLTLRIESAVCESVLADASKTMLANVTSVRQEYAIPVGPVFPPGMNWTDLITNYSPSREDNLQRVFTVASIRSMLVK

Source Source

Source organism organism	Rhesus rotavirus
Common name common_name	RV-A
NCBI taxonomy ID ncbi_taxonomy_id	10969
Host organism host_organism	Chlorocebus sabaeus

Entity 3 Entity 3 polymer

Description description	Outer layer protein VP7
Molecular weight formula_weight	31232.2 kDa
Source method src_method	man
Copy count entity_count	13

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	BA,BF,BG,BH,BI,BJ,BK,BL,BM,BN,BO,BP,BQ

QNYGINLPITGSMDTAYANSTQEETFLTSTLCLYYPTEAATEINDNSWKDTLSQLFLTKGWPTGSVYFKEYTDIASFSVDPQLYCDYNVVLMKYDATLQLDMSELADLILNEWLCNPMDITLYYYQQTDEANKWISMGSSCTIKVCPLNTQTLGIGCLTTDTATFEEVATAEKLVITDVVDGVNHKLDVTTATCTIRNCKKLGPRENVAVIQVGGSDVLDITADPTTAPQTERMMRINWKKWWQVFYTVVDYVNQIIQAMSKRSRSLNSAAFYYRI

Source Source

Source organism organism	Simian rotavirus A
NCBI taxonomy ID ncbi_taxonomy_id	444185
Host organism host_organism	Chlorocebus sabaeus

Entity 4 Entity 4 polymer

Description description	Outer capsid protein VP4
Molecular weight formula_weight	86655.6 kDa
Source method src_method	man
Copy count entity_count	3

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	BX,BY,BZ

MASLIYRQLLTNSYTVDLSDEIQEIGSTKTQNVTINLGPFAQTGYAPVNWGPGETNDSTTVEPVLDGPYQPTTFNPPVDYWMLLAPTAAGVVVEGTNNTDRWLATILVEPNVTSETRSYTLFGTQEQITIANASQTQWKFIDVVKTTQNGSYSQYGPLQSTPKLYAVMKHNGKIYTYNGETPNVTTKYYSTTNYDSVNMTAFCDFYIIPREEESTCTEYINNGLPPIQNTRNIVPLALSARNIISHRAQANEDIVVSKTSLWKEMQYNRDITIRFKFASSIVKSGGLGYKWSEISFKPANYQYTYTRDGEEVTAHTTCSVNGMNDFNFNGGSLPTDFVISRYEVIKENSYVYVDYWDDSQAFRNMVYVRSLAANLNSVICTGGDYSFALPVGQWPVMTGGAVSLHSAGVTLSTQFTDFVSLNSLRFRFRLTVEEPSFSITRTRVSRLYGLPAANPNNGKEYYEVAGRFSLISLVPSNDDYQTPITNSVTVRQDLERQLGELREEFNALSQEIAMSQLIDLALLPLDMFSMFSGIKSTIDAAKSMATSVMKKFKKSGLANSVSTLTDSLSDAASSISRGASIRSVGSSASAWTDVSTQITDVSSSVSSISTQTSTISRRLRLKEMATQTEGMNFDDISAAVLKTKIDRSTQISPNTLPDIVTEASEKFIPNRAYRVINNDEVFEAGTDGRFFAYRVETFDEIPFDVQKFADLVTDSPVISAIIDFKTLKNLNDNYGISRQQAFNLLRSDPRVLREFINQDNPIIRNRIEQLIMQCRL

Source Source

Source organism organism	Simian rotavirus A
NCBI taxonomy ID ncbi_taxonomy_id	444185
Host organism host_organism	Chlorocebus sabaeus

Entity 5 Entity 5 branched

Description description	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Molecular weight formula_weight	424.4 kDa
Source method src_method	syn
Copy count entity_count	7

Entity 6 Entity 6 non-polymer

Description description	ZINC ION
Molecular weight formula_weight	65.4 kDa
Source method src_method	syn
Copy count entity_count	5

Entity 7 Entity 7 non-polymer

Description description	2-acetamido-2-deoxy-beta-D-glucopyranose
Molecular weight formula_weight	221.2 kDa
Source method src_method	syn
Copy count entity_count	1

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Resolution resolution	3.80 Å
Resolution测定Method resolution_method	projection matching
颗粒数 num_particles	4187

Atomic model of an infectious rotavirus particle

1. Protein Identity and Related Structures Protein Identity & Related Structures

Core scaffold protein

State in the Current Structure

Other States of the Same Protein in the Database

Intermediate capsid protein VP6

State in the Current Structure

Other States of the Same Protein in the Database

Outer layer protein VP7

State in the Current Structure

Other States of the Same Protein in the Database

Outer capsid protein VP4

State in the Current Structure

Other States of the Same Protein in the Database

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

4v7q__assembly_1__model_1

4v7q__assembly_1__model_1 | I(q)

4v7q__assembly_1__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

冷冻电镜 EM 3D

5. Entities and Polymers Entities & Polymers (7)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

Entity 2 Entity 2 polymer

Polymer Polymer

Source Source

Entity 3 Entity 3 polymer

Polymer Polymer

Source Source

Entity 4 Entity 4 polymer

Polymer Polymer

Source Source

Entity 5 Entity 5 branched

Entity 6 Entity 6 non-polymer

Entity 7 Entity 7 non-polymer

7. Citations (1)

Atomic model of an infectious rotavirus particle

1. Protein Identity and Related Structures Protein Identity & Related Structures

Core scaffold protein

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Intermediate capsid protein VP6

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Outer layer protein VP7

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Outer capsid protein VP4

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

4v7q__assembly_1__model_1

4v7q__assembly_1__model_1 | I(q)

4v7q__assembly_1__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

冷冻电镜 EM 3D

5. Entities and Polymers Entities & Polymers (7)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

Entity 2 Entity 2 polymer

Polymer Polymer

Source Source

Entity 3 Entity 3 polymer

Polymer Polymer

Source Source

Entity 4 Entity 4 polymer

Polymer Polymer

Source Source

Entity 5 Entity 5 branched

Entity 6 Entity 6 non-polymer

Entity 7 Entity 7 non-polymer

7. Citations (1)