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The crystal structure of the large ribosomal subunit of Staphylococcus aureus in complex with BC-3205

Method: X-RAY DIFFRACTION

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1. Protein Identity and Related Structures Protein Identity & Related Structures

50S ribosomal protein L2

OrganismNot specified

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 26 RNA 2	23S rRNA × 1 5S rRNA × 1 50S ribosomal protein L3 × 1 （Q2FW06） 50S ribosomal protein L4 × 1 （Q2FW07） 50S ribosomal protein L5 × 1 （Q2FW18） 50S ribosomal protein L6 × 1 （Q2FW21） 50S ribosomal protein L13 × 1 （Q2FW38） 50S ribosomal protein L14 × 1 （Q2FW16） 50S ribosomal protein L15 × 1 （P0A0F8） 50S ribosomal protein L16 × 1 （Q2FW13） 50S ribosomal protein L17 × 1 （Q2FW33） 50S ribosomal protein L18 × 1 （Q2FW22） 50S ribosomal protein L19 × 1 （Q2FZ42） 50S ribosomal protein L20 × 1 （Q2FXQ1） 50S ribosomal protein L21 × 1 （Q2FXS8） 50S ribosomal protein L22 × 1 （Q2FW11） 50S ribosomal protein L23 × 1 （Q2FW08） 50S ribosomal protein L24 × 1 （Q2FW17） 50S ribosomal protein L25 × 1 （Q2FJE0） 50S ribosomal protein L27 × 1 （Q2FXT0） 50S ribosomal protein L28 × 1 （Q2FZ60） 50S ribosomal protein L29 × 1 （Q2FW14） 50S ribosomal protein L30 × 1 （P0A0G2） 50S ribosomal protein L32 × 1 （Q2FZF1） 50S ribosomal protein L34 × 1 （Q2FUQ0） 50S ribosomal protein L35 × 1 （Q2FXQ0） 50S ribosomal protein L36 × 1 （Q2FW29） BC-3205 × 1 (4S)-2-METHYL-2,4-PENTANEDIOL × 15 MAGNESIUM ION × 111 MANGANESE (II) ION × 311 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 4 SPERMIDINE × 11 ETHANOL × 13	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RL2_STAA8
Isoform	—
PDB entities	3
Chains and sequence ranges	Author chain A； PDBConstruct 1–277； UniProt 1–277

50S ribosomal protein L3

OrganismNot specified

UniProt Q2FW06

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 26 RNA 2	23S rRNA × 1 5S rRNA × 1 50S ribosomal protein L2 × 1 （P60430） 50S ribosomal protein L4 × 1 （Q2FW07） 50S ribosomal protein L5 × 1 （Q2FW18） 50S ribosomal protein L6 × 1 （Q2FW21） 50S ribosomal protein L13 × 1 （Q2FW38） 50S ribosomal protein L14 × 1 （Q2FW16） 50S ribosomal protein L15 × 1 （P0A0F8） 50S ribosomal protein L16 × 1 （Q2FW13） 50S ribosomal protein L17 × 1 （Q2FW33） 50S ribosomal protein L18 × 1 （Q2FW22） 50S ribosomal protein L19 × 1 （Q2FZ42） 50S ribosomal protein L20 × 1 （Q2FXQ1） 50S ribosomal protein L21 × 1 （Q2FXS8） 50S ribosomal protein L22 × 1 （Q2FW11） 50S ribosomal protein L23 × 1 （Q2FW08） 50S ribosomal protein L24 × 1 （Q2FW17） 50S ribosomal protein L25 × 1 （Q2FJE0） 50S ribosomal protein L27 × 1 （Q2FXT0） 50S ribosomal protein L28 × 1 （Q2FZ60） 50S ribosomal protein L29 × 1 （Q2FW14） 50S ribosomal protein L30 × 1 （P0A0G2） 50S ribosomal protein L32 × 1 （Q2FZF1） 50S ribosomal protein L34 × 1 （Q2FUQ0） 50S ribosomal protein L35 × 1 （Q2FXQ0） 50S ribosomal protein L36 × 1 （Q2FW29） BC-3205 × 1 (4S)-2-METHYL-2,4-PENTANEDIOL × 15 MAGNESIUM ION × 111 MANGANESE (II) ION × 311 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 4 SPERMIDINE × 11 ETHANOL × 13	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RL3_STAA8
Isoform	—
PDB entities	4
Chains and sequence ranges	Author chain B； PDBConstruct 1–220； UniProt 1–220

50S ribosomal protein L4

OrganismNot specified

UniProt Q2FW07

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 26 RNA 2	23S rRNA × 1 5S rRNA × 1 50S ribosomal protein L2 × 1 （P60430） 50S ribosomal protein L3 × 1 （Q2FW06） 50S ribosomal protein L5 × 1 （Q2FW18） 50S ribosomal protein L6 × 1 （Q2FW21） 50S ribosomal protein L13 × 1 （Q2FW38） 50S ribosomal protein L14 × 1 （Q2FW16） 50S ribosomal protein L15 × 1 （P0A0F8） 50S ribosomal protein L16 × 1 （Q2FW13） 50S ribosomal protein L17 × 1 （Q2FW33） 50S ribosomal protein L18 × 1 （Q2FW22） 50S ribosomal protein L19 × 1 （Q2FZ42） 50S ribosomal protein L20 × 1 （Q2FXQ1） 50S ribosomal protein L21 × 1 （Q2FXS8） 50S ribosomal protein L22 × 1 （Q2FW11） 50S ribosomal protein L23 × 1 （Q2FW08） 50S ribosomal protein L24 × 1 （Q2FW17） 50S ribosomal protein L25 × 1 （Q2FJE0） 50S ribosomal protein L27 × 1 （Q2FXT0） 50S ribosomal protein L28 × 1 （Q2FZ60） 50S ribosomal protein L29 × 1 （Q2FW14） 50S ribosomal protein L30 × 1 （P0A0G2） 50S ribosomal protein L32 × 1 （Q2FZF1） 50S ribosomal protein L34 × 1 （Q2FUQ0） 50S ribosomal protein L35 × 1 （Q2FXQ0） 50S ribosomal protein L36 × 1 （Q2FW29） BC-3205 × 1 (4S)-2-METHYL-2,4-PENTANEDIOL × 15 MAGNESIUM ION × 111 MANGANESE (II) ION × 311 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 4 SPERMIDINE × 11 ETHANOL × 13	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RL4_STAA8
Isoform	—
PDB entities	5
Chains and sequence ranges	Author chain C； PDBConstruct 1–207； UniProt 1–207

50S ribosomal protein L5

OrganismNot specified

UniProt Q2FW18

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 26 RNA 2	23S rRNA × 1 5S rRNA × 1 50S ribosomal protein L2 × 1 （P60430） 50S ribosomal protein L3 × 1 （Q2FW06） 50S ribosomal protein L4 × 1 （Q2FW07） 50S ribosomal protein L6 × 1 （Q2FW21） 50S ribosomal protein L13 × 1 （Q2FW38） 50S ribosomal protein L14 × 1 （Q2FW16） 50S ribosomal protein L15 × 1 （P0A0F8） 50S ribosomal protein L16 × 1 （Q2FW13） 50S ribosomal protein L17 × 1 （Q2FW33） 50S ribosomal protein L18 × 1 （Q2FW22） 50S ribosomal protein L19 × 1 （Q2FZ42） 50S ribosomal protein L20 × 1 （Q2FXQ1） 50S ribosomal protein L21 × 1 （Q2FXS8） 50S ribosomal protein L22 × 1 （Q2FW11） 50S ribosomal protein L23 × 1 （Q2FW08） 50S ribosomal protein L24 × 1 （Q2FW17） 50S ribosomal protein L25 × 1 （Q2FJE0） 50S ribosomal protein L27 × 1 （Q2FXT0） 50S ribosomal protein L28 × 1 （Q2FZ60） 50S ribosomal protein L29 × 1 （Q2FW14） 50S ribosomal protein L30 × 1 （P0A0G2） 50S ribosomal protein L32 × 1 （Q2FZF1） 50S ribosomal protein L34 × 1 （Q2FUQ0） 50S ribosomal protein L35 × 1 （Q2FXQ0） 50S ribosomal protein L36 × 1 （Q2FW29） BC-3205 × 1 (4S)-2-METHYL-2,4-PENTANEDIOL × 15 MAGNESIUM ION × 111 MANGANESE (II) ION × 311 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 4 SPERMIDINE × 11 ETHANOL × 13	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RL5_STAA8
Isoform	—
PDB entities	6
Chains and sequence ranges	Author chain D； PDBConstruct 1–179； UniProt 1–179

50S ribosomal protein L6

OrganismNot specified

UniProt Q2FW21

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 26 RNA 2	23S rRNA × 1 5S rRNA × 1 50S ribosomal protein L2 × 1 （P60430） 50S ribosomal protein L3 × 1 （Q2FW06） 50S ribosomal protein L4 × 1 （Q2FW07） 50S ribosomal protein L5 × 1 （Q2FW18） 50S ribosomal protein L13 × 1 （Q2FW38） 50S ribosomal protein L14 × 1 （Q2FW16） 50S ribosomal protein L15 × 1 （P0A0F8） 50S ribosomal protein L16 × 1 （Q2FW13） 50S ribosomal protein L17 × 1 （Q2FW33） 50S ribosomal protein L18 × 1 （Q2FW22） 50S ribosomal protein L19 × 1 （Q2FZ42） 50S ribosomal protein L20 × 1 （Q2FXQ1） 50S ribosomal protein L21 × 1 （Q2FXS8） 50S ribosomal protein L22 × 1 （Q2FW11） 50S ribosomal protein L23 × 1 （Q2FW08） 50S ribosomal protein L24 × 1 （Q2FW17） 50S ribosomal protein L25 × 1 （Q2FJE0） 50S ribosomal protein L27 × 1 （Q2FXT0） 50S ribosomal protein L28 × 1 （Q2FZ60） 50S ribosomal protein L29 × 1 （Q2FW14） 50S ribosomal protein L30 × 1 （P0A0G2） 50S ribosomal protein L32 × 1 （Q2FZF1） 50S ribosomal protein L34 × 1 （Q2FUQ0） 50S ribosomal protein L35 × 1 （Q2FXQ0） 50S ribosomal protein L36 × 1 （Q2FW29） BC-3205 × 1 (4S)-2-METHYL-2,4-PENTANEDIOL × 15 MAGNESIUM ION × 111 MANGANESE (II) ION × 311 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 4 SPERMIDINE × 11 ETHANOL × 13	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RL6_STAA8
Isoform	—
PDB entities	7
Chains and sequence ranges	Author chain E； PDBConstruct 1–178； UniProt 1–178

50S ribosomal protein L13

OrganismNot specified

UniProt Q2FW38

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 26 RNA 2	23S rRNA × 1 5S rRNA × 1 50S ribosomal protein L2 × 1 （P60430） 50S ribosomal protein L3 × 1 （Q2FW06） 50S ribosomal protein L4 × 1 （Q2FW07） 50S ribosomal protein L5 × 1 （Q2FW18） 50S ribosomal protein L6 × 1 （Q2FW21） 50S ribosomal protein L14 × 1 （Q2FW16） 50S ribosomal protein L15 × 1 （P0A0F8） 50S ribosomal protein L16 × 1 （Q2FW13） 50S ribosomal protein L17 × 1 （Q2FW33） 50S ribosomal protein L18 × 1 （Q2FW22） 50S ribosomal protein L19 × 1 （Q2FZ42） 50S ribosomal protein L20 × 1 （Q2FXQ1） 50S ribosomal protein L21 × 1 （Q2FXS8） 50S ribosomal protein L22 × 1 （Q2FW11） 50S ribosomal protein L23 × 1 （Q2FW08） 50S ribosomal protein L24 × 1 （Q2FW17） 50S ribosomal protein L25 × 1 （Q2FJE0） 50S ribosomal protein L27 × 1 （Q2FXT0） 50S ribosomal protein L28 × 1 （Q2FZ60） 50S ribosomal protein L29 × 1 （Q2FW14） 50S ribosomal protein L30 × 1 （P0A0G2） 50S ribosomal protein L32 × 1 （Q2FZF1） 50S ribosomal protein L34 × 1 （Q2FUQ0） 50S ribosomal protein L35 × 1 （Q2FXQ0） 50S ribosomal protein L36 × 1 （Q2FW29） BC-3205 × 1 (4S)-2-METHYL-2,4-PENTANEDIOL × 15 MAGNESIUM ION × 111 MANGANESE (II) ION × 311 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 4 SPERMIDINE × 11 ETHANOL × 13	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RL13_STAA8
Isoform	—
PDB entities	8
Chains and sequence ranges	Author chain G； PDBConstruct 1–145； UniProt 1–145

50S ribosomal protein L14

OrganismNot specified

UniProt Q2FW16

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 26 RNA 2	23S rRNA × 1 5S rRNA × 1 50S ribosomal protein L2 × 1 （P60430） 50S ribosomal protein L3 × 1 （Q2FW06） 50S ribosomal protein L4 × 1 （Q2FW07） 50S ribosomal protein L5 × 1 （Q2FW18） 50S ribosomal protein L6 × 1 （Q2FW21） 50S ribosomal protein L13 × 1 （Q2FW38） 50S ribosomal protein L15 × 1 （P0A0F8） 50S ribosomal protein L16 × 1 （Q2FW13） 50S ribosomal protein L17 × 1 （Q2FW33） 50S ribosomal protein L18 × 1 （Q2FW22） 50S ribosomal protein L19 × 1 （Q2FZ42） 50S ribosomal protein L20 × 1 （Q2FXQ1） 50S ribosomal protein L21 × 1 （Q2FXS8） 50S ribosomal protein L22 × 1 （Q2FW11） 50S ribosomal protein L23 × 1 （Q2FW08） 50S ribosomal protein L24 × 1 （Q2FW17） 50S ribosomal protein L25 × 1 （Q2FJE0） 50S ribosomal protein L27 × 1 （Q2FXT0） 50S ribosomal protein L28 × 1 （Q2FZ60） 50S ribosomal protein L29 × 1 （Q2FW14） 50S ribosomal protein L30 × 1 （P0A0G2） 50S ribosomal protein L32 × 1 （Q2FZF1） 50S ribosomal protein L34 × 1 （Q2FUQ0） 50S ribosomal protein L35 × 1 （Q2FXQ0） 50S ribosomal protein L36 × 1 （Q2FW29） BC-3205 × 1 (4S)-2-METHYL-2,4-PENTANEDIOL × 15 MAGNESIUM ION × 111 MANGANESE (II) ION × 311 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 4 SPERMIDINE × 11 ETHANOL × 13	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RL14_STAA8
Isoform	—
PDB entities	9
Chains and sequence ranges	Author chain H； PDBConstruct 1–122； UniProt 1–122

50S ribosomal protein L15

OrganismNot specified

UniProt P0A0F8

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 26 RNA 2	23S rRNA × 1 5S rRNA × 1 50S ribosomal protein L2 × 1 （P60430） 50S ribosomal protein L3 × 1 （Q2FW06） 50S ribosomal protein L4 × 1 （Q2FW07） 50S ribosomal protein L5 × 1 （Q2FW18） 50S ribosomal protein L6 × 1 （Q2FW21） 50S ribosomal protein L13 × 1 （Q2FW38） 50S ribosomal protein L14 × 1 （Q2FW16） 50S ribosomal protein L16 × 1 （Q2FW13） 50S ribosomal protein L17 × 1 （Q2FW33） 50S ribosomal protein L18 × 1 （Q2FW22） 50S ribosomal protein L19 × 1 （Q2FZ42） 50S ribosomal protein L20 × 1 （Q2FXQ1） 50S ribosomal protein L21 × 1 （Q2FXS8） 50S ribosomal protein L22 × 1 （Q2FW11） 50S ribosomal protein L23 × 1 （Q2FW08） 50S ribosomal protein L24 × 1 （Q2FW17） 50S ribosomal protein L25 × 1 （Q2FJE0） 50S ribosomal protein L27 × 1 （Q2FXT0） 50S ribosomal protein L28 × 1 （Q2FZ60） 50S ribosomal protein L29 × 1 （Q2FW14） 50S ribosomal protein L30 × 1 （P0A0G2） 50S ribosomal protein L32 × 1 （Q2FZF1） 50S ribosomal protein L34 × 1 （Q2FUQ0） 50S ribosomal protein L35 × 1 （Q2FXQ0） 50S ribosomal protein L36 × 1 （Q2FW29） BC-3205 × 1 (4S)-2-METHYL-2,4-PENTANEDIOL × 15 MAGNESIUM ION × 111 MANGANESE (II) ION × 311 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 4 SPERMIDINE × 11 ETHANOL × 13	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RL15_STAA8
Isoform	—
PDB entities	10
Chains and sequence ranges	Author chain I； PDBConstruct 1–146； UniProt 1–146

50S ribosomal protein L16

OrganismNot specified

UniProt Q2FW13

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 26 RNA 2	23S rRNA × 1 5S rRNA × 1 50S ribosomal protein L2 × 1 （P60430） 50S ribosomal protein L3 × 1 （Q2FW06） 50S ribosomal protein L4 × 1 （Q2FW07） 50S ribosomal protein L5 × 1 （Q2FW18） 50S ribosomal protein L6 × 1 （Q2FW21） 50S ribosomal protein L13 × 1 （Q2FW38） 50S ribosomal protein L14 × 1 （Q2FW16） 50S ribosomal protein L15 × 1 （P0A0F8） 50S ribosomal protein L17 × 1 （Q2FW33） 50S ribosomal protein L18 × 1 （Q2FW22） 50S ribosomal protein L19 × 1 （Q2FZ42） 50S ribosomal protein L20 × 1 （Q2FXQ1） 50S ribosomal protein L21 × 1 （Q2FXS8） 50S ribosomal protein L22 × 1 （Q2FW11） 50S ribosomal protein L23 × 1 （Q2FW08） 50S ribosomal protein L24 × 1 （Q2FW17） 50S ribosomal protein L25 × 1 （Q2FJE0） 50S ribosomal protein L27 × 1 （Q2FXT0） 50S ribosomal protein L28 × 1 （Q2FZ60） 50S ribosomal protein L29 × 1 （Q2FW14） 50S ribosomal protein L30 × 1 （P0A0G2） 50S ribosomal protein L32 × 1 （Q2FZF1） 50S ribosomal protein L34 × 1 （Q2FUQ0） 50S ribosomal protein L35 × 1 （Q2FXQ0） 50S ribosomal protein L36 × 1 （Q2FW29） BC-3205 × 1 (4S)-2-METHYL-2,4-PENTANEDIOL × 15 MAGNESIUM ION × 111 MANGANESE (II) ION × 311 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 4 SPERMIDINE × 11 ETHANOL × 13	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RL16_STAA8
Isoform	—
PDB entities	11
Chains and sequence ranges	Author chain J； PDBConstruct 1–144； UniProt 1–144

50S ribosomal protein L17

OrganismNot specified

UniProt Q2FW33

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 26 RNA 2	23S rRNA × 1 5S rRNA × 1 50S ribosomal protein L2 × 1 （P60430） 50S ribosomal protein L3 × 1 （Q2FW06） 50S ribosomal protein L4 × 1 （Q2FW07） 50S ribosomal protein L5 × 1 （Q2FW18） 50S ribosomal protein L6 × 1 （Q2FW21） 50S ribosomal protein L13 × 1 （Q2FW38） 50S ribosomal protein L14 × 1 （Q2FW16） 50S ribosomal protein L15 × 1 （P0A0F8） 50S ribosomal protein L16 × 1 （Q2FW13） 50S ribosomal protein L18 × 1 （Q2FW22） 50S ribosomal protein L19 × 1 （Q2FZ42） 50S ribosomal protein L20 × 1 （Q2FXQ1） 50S ribosomal protein L21 × 1 （Q2FXS8） 50S ribosomal protein L22 × 1 （Q2FW11） 50S ribosomal protein L23 × 1 （Q2FW08） 50S ribosomal protein L24 × 1 （Q2FW17） 50S ribosomal protein L25 × 1 （Q2FJE0） 50S ribosomal protein L27 × 1 （Q2FXT0） 50S ribosomal protein L28 × 1 （Q2FZ60） 50S ribosomal protein L29 × 1 （Q2FW14） 50S ribosomal protein L30 × 1 （P0A0G2） 50S ribosomal protein L32 × 1 （Q2FZF1） 50S ribosomal protein L34 × 1 （Q2FUQ0） 50S ribosomal protein L35 × 1 （Q2FXQ0） 50S ribosomal protein L36 × 1 （Q2FW29） BC-3205 × 1 (4S)-2-METHYL-2,4-PENTANEDIOL × 15 MAGNESIUM ION × 111 MANGANESE (II) ION × 311 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 4 SPERMIDINE × 11 ETHANOL × 13	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RL17_STAA8
Isoform	—
PDB entities	12
Chains and sequence ranges	Author chain K； PDBConstruct 1–122； UniProt 1–122

50S ribosomal protein L18

OrganismNot specified

UniProt Q2FW22

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 26 RNA 2	23S rRNA × 1 5S rRNA × 1 50S ribosomal protein L2 × 1 （P60430） 50S ribosomal protein L3 × 1 （Q2FW06） 50S ribosomal protein L4 × 1 （Q2FW07） 50S ribosomal protein L5 × 1 （Q2FW18） 50S ribosomal protein L6 × 1 （Q2FW21） 50S ribosomal protein L13 × 1 （Q2FW38） 50S ribosomal protein L14 × 1 （Q2FW16） 50S ribosomal protein L15 × 1 （P0A0F8） 50S ribosomal protein L16 × 1 （Q2FW13） 50S ribosomal protein L17 × 1 （Q2FW33） 50S ribosomal protein L19 × 1 （Q2FZ42） 50S ribosomal protein L20 × 1 （Q2FXQ1） 50S ribosomal protein L21 × 1 （Q2FXS8） 50S ribosomal protein L22 × 1 （Q2FW11） 50S ribosomal protein L23 × 1 （Q2FW08） 50S ribosomal protein L24 × 1 （Q2FW17） 50S ribosomal protein L25 × 1 （Q2FJE0） 50S ribosomal protein L27 × 1 （Q2FXT0） 50S ribosomal protein L28 × 1 （Q2FZ60） 50S ribosomal protein L29 × 1 （Q2FW14） 50S ribosomal protein L30 × 1 （P0A0G2） 50S ribosomal protein L32 × 1 （Q2FZF1） 50S ribosomal protein L34 × 1 （Q2FUQ0） 50S ribosomal protein L35 × 1 （Q2FXQ0） 50S ribosomal protein L36 × 1 （Q2FW29） BC-3205 × 1 (4S)-2-METHYL-2,4-PENTANEDIOL × 15 MAGNESIUM ION × 111 MANGANESE (II) ION × 311 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 4 SPERMIDINE × 11 ETHANOL × 13	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RL18_STAA8
Isoform	—
PDB entities	13
Chains and sequence ranges	Author chain L； PDBConstruct 1–119； UniProt 1–119

50S ribosomal protein L19

OrganismNot specified

UniProt Q2FZ42

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 26 RNA 2	23S rRNA × 1 5S rRNA × 1 50S ribosomal protein L2 × 1 （P60430） 50S ribosomal protein L3 × 1 （Q2FW06） 50S ribosomal protein L4 × 1 （Q2FW07） 50S ribosomal protein L5 × 1 （Q2FW18） 50S ribosomal protein L6 × 1 （Q2FW21） 50S ribosomal protein L13 × 1 （Q2FW38） 50S ribosomal protein L14 × 1 （Q2FW16） 50S ribosomal protein L15 × 1 （P0A0F8） 50S ribosomal protein L16 × 1 （Q2FW13） 50S ribosomal protein L17 × 1 （Q2FW33） 50S ribosomal protein L18 × 1 （Q2FW22） 50S ribosomal protein L20 × 1 （Q2FXQ1） 50S ribosomal protein L21 × 1 （Q2FXS8） 50S ribosomal protein L22 × 1 （Q2FW11） 50S ribosomal protein L23 × 1 （Q2FW08） 50S ribosomal protein L24 × 1 （Q2FW17） 50S ribosomal protein L25 × 1 （Q2FJE0） 50S ribosomal protein L27 × 1 （Q2FXT0） 50S ribosomal protein L28 × 1 （Q2FZ60） 50S ribosomal protein L29 × 1 （Q2FW14） 50S ribosomal protein L30 × 1 （P0A0G2） 50S ribosomal protein L32 × 1 （Q2FZF1） 50S ribosomal protein L34 × 1 （Q2FUQ0） 50S ribosomal protein L35 × 1 （Q2FXQ0） 50S ribosomal protein L36 × 1 （Q2FW29） BC-3205 × 1 (4S)-2-METHYL-2,4-PENTANEDIOL × 15 MAGNESIUM ION × 111 MANGANESE (II) ION × 311 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 4 SPERMIDINE × 11 ETHANOL × 13	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RL19_STAA8
Isoform	—
PDB entities	14
Chains and sequence ranges	Author chain M； PDBConstruct 1–116； UniProt 1–116

50S ribosomal protein L20

OrganismNot specified

UniProt Q2FXQ1

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 26 RNA 2	23S rRNA × 1 5S rRNA × 1 50S ribosomal protein L2 × 1 （P60430） 50S ribosomal protein L3 × 1 （Q2FW06） 50S ribosomal protein L4 × 1 （Q2FW07） 50S ribosomal protein L5 × 1 （Q2FW18） 50S ribosomal protein L6 × 1 （Q2FW21） 50S ribosomal protein L13 × 1 （Q2FW38） 50S ribosomal protein L14 × 1 （Q2FW16） 50S ribosomal protein L15 × 1 （P0A0F8） 50S ribosomal protein L16 × 1 （Q2FW13） 50S ribosomal protein L17 × 1 （Q2FW33） 50S ribosomal protein L18 × 1 （Q2FW22） 50S ribosomal protein L19 × 1 （Q2FZ42） 50S ribosomal protein L21 × 1 （Q2FXS8） 50S ribosomal protein L22 × 1 （Q2FW11） 50S ribosomal protein L23 × 1 （Q2FW08） 50S ribosomal protein L24 × 1 （Q2FW17） 50S ribosomal protein L25 × 1 （Q2FJE0） 50S ribosomal protein L27 × 1 （Q2FXT0） 50S ribosomal protein L28 × 1 （Q2FZ60） 50S ribosomal protein L29 × 1 （Q2FW14） 50S ribosomal protein L30 × 1 （P0A0G2） 50S ribosomal protein L32 × 1 （Q2FZF1） 50S ribosomal protein L34 × 1 （Q2FUQ0） 50S ribosomal protein L35 × 1 （Q2FXQ0） 50S ribosomal protein L36 × 1 （Q2FW29） BC-3205 × 1 (4S)-2-METHYL-2,4-PENTANEDIOL × 15 MAGNESIUM ION × 111 MANGANESE (II) ION × 311 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 4 SPERMIDINE × 11 ETHANOL × 13	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RL20_STAA8
Isoform	—
PDB entities	15
Chains and sequence ranges	Author chain N； PDBConstruct 1–118； UniProt 1–118

50S ribosomal protein L21

OrganismNot specified

UniProt Q2FXS8

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 26 RNA 2	23S rRNA × 1 5S rRNA × 1 50S ribosomal protein L2 × 1 （P60430） 50S ribosomal protein L3 × 1 （Q2FW06） 50S ribosomal protein L4 × 1 （Q2FW07） 50S ribosomal protein L5 × 1 （Q2FW18） 50S ribosomal protein L6 × 1 （Q2FW21） 50S ribosomal protein L13 × 1 （Q2FW38） 50S ribosomal protein L14 × 1 （Q2FW16） 50S ribosomal protein L15 × 1 （P0A0F8） 50S ribosomal protein L16 × 1 （Q2FW13） 50S ribosomal protein L17 × 1 （Q2FW33） 50S ribosomal protein L18 × 1 （Q2FW22） 50S ribosomal protein L19 × 1 （Q2FZ42） 50S ribosomal protein L20 × 1 （Q2FXQ1） 50S ribosomal protein L22 × 1 （Q2FW11） 50S ribosomal protein L23 × 1 （Q2FW08） 50S ribosomal protein L24 × 1 （Q2FW17） 50S ribosomal protein L25 × 1 （Q2FJE0） 50S ribosomal protein L27 × 1 （Q2FXT0） 50S ribosomal protein L28 × 1 （Q2FZ60） 50S ribosomal protein L29 × 1 （Q2FW14） 50S ribosomal protein L30 × 1 （P0A0G2） 50S ribosomal protein L32 × 1 （Q2FZF1） 50S ribosomal protein L34 × 1 （Q2FUQ0） 50S ribosomal protein L35 × 1 （Q2FXQ0） 50S ribosomal protein L36 × 1 （Q2FW29） BC-3205 × 1 (4S)-2-METHYL-2,4-PENTANEDIOL × 15 MAGNESIUM ION × 111 MANGANESE (II) ION × 311 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 4 SPERMIDINE × 11 ETHANOL × 13	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RL21_STAA8
Isoform	—
PDB entities	16
Chains and sequence ranges	Author chain O； PDBConstruct 1–102； UniProt 1–102

50S ribosomal protein L22

OrganismNot specified

UniProt Q2FW11

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 26 RNA 2	23S rRNA × 1 5S rRNA × 1 50S ribosomal protein L2 × 1 （P60430） 50S ribosomal protein L3 × 1 （Q2FW06） 50S ribosomal protein L4 × 1 （Q2FW07） 50S ribosomal protein L5 × 1 （Q2FW18） 50S ribosomal protein L6 × 1 （Q2FW21） 50S ribosomal protein L13 × 1 （Q2FW38） 50S ribosomal protein L14 × 1 （Q2FW16） 50S ribosomal protein L15 × 1 （P0A0F8） 50S ribosomal protein L16 × 1 （Q2FW13） 50S ribosomal protein L17 × 1 （Q2FW33） 50S ribosomal protein L18 × 1 （Q2FW22） 50S ribosomal protein L19 × 1 （Q2FZ42） 50S ribosomal protein L20 × 1 （Q2FXQ1） 50S ribosomal protein L21 × 1 （Q2FXS8） 50S ribosomal protein L23 × 1 （Q2FW08） 50S ribosomal protein L24 × 1 （Q2FW17） 50S ribosomal protein L25 × 1 （Q2FJE0） 50S ribosomal protein L27 × 1 （Q2FXT0） 50S ribosomal protein L28 × 1 （Q2FZ60） 50S ribosomal protein L29 × 1 （Q2FW14） 50S ribosomal protein L30 × 1 （P0A0G2） 50S ribosomal protein L32 × 1 （Q2FZF1） 50S ribosomal protein L34 × 1 （Q2FUQ0） 50S ribosomal protein L35 × 1 （Q2FXQ0） 50S ribosomal protein L36 × 1 （Q2FW29） BC-3205 × 1 (4S)-2-METHYL-2,4-PENTANEDIOL × 15 MAGNESIUM ION × 111 MANGANESE (II) ION × 311 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 4 SPERMIDINE × 11 ETHANOL × 13	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RL22_STAA8
Isoform	—
PDB entities	17
Chains and sequence ranges	Author chain P； PDBConstruct 1–117； UniProt 1–117

50S ribosomal protein L23

OrganismNot specified

UniProt Q2FW08

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 26 RNA 2	23S rRNA × 1 5S rRNA × 1 50S ribosomal protein L2 × 1 （P60430） 50S ribosomal protein L3 × 1 （Q2FW06） 50S ribosomal protein L4 × 1 （Q2FW07） 50S ribosomal protein L5 × 1 （Q2FW18） 50S ribosomal protein L6 × 1 （Q2FW21） 50S ribosomal protein L13 × 1 （Q2FW38） 50S ribosomal protein L14 × 1 （Q2FW16） 50S ribosomal protein L15 × 1 （P0A0F8） 50S ribosomal protein L16 × 1 （Q2FW13） 50S ribosomal protein L17 × 1 （Q2FW33） 50S ribosomal protein L18 × 1 （Q2FW22） 50S ribosomal protein L19 × 1 （Q2FZ42） 50S ribosomal protein L20 × 1 （Q2FXQ1） 50S ribosomal protein L21 × 1 （Q2FXS8） 50S ribosomal protein L22 × 1 （Q2FW11） 50S ribosomal protein L24 × 1 （Q2FW17） 50S ribosomal protein L25 × 1 （Q2FJE0） 50S ribosomal protein L27 × 1 （Q2FXT0） 50S ribosomal protein L28 × 1 （Q2FZ60） 50S ribosomal protein L29 × 1 （Q2FW14） 50S ribosomal protein L30 × 1 （P0A0G2） 50S ribosomal protein L32 × 1 （Q2FZF1） 50S ribosomal protein L34 × 1 （Q2FUQ0） 50S ribosomal protein L35 × 1 （Q2FXQ0） 50S ribosomal protein L36 × 1 （Q2FW29） BC-3205 × 1 (4S)-2-METHYL-2,4-PENTANEDIOL × 15 MAGNESIUM ION × 111 MANGANESE (II) ION × 311 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 4 SPERMIDINE × 11 ETHANOL × 13	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RL23_STAA8
Isoform	—
PDB entities	18
Chains and sequence ranges	Author chain Q； PDBConstruct 1–91； UniProt 1–91

50S ribosomal protein L24

OrganismNot specified

UniProt Q2FW17

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 26 RNA 2	23S rRNA × 1 5S rRNA × 1 50S ribosomal protein L2 × 1 （P60430） 50S ribosomal protein L3 × 1 （Q2FW06） 50S ribosomal protein L4 × 1 （Q2FW07） 50S ribosomal protein L5 × 1 （Q2FW18） 50S ribosomal protein L6 × 1 （Q2FW21） 50S ribosomal protein L13 × 1 （Q2FW38） 50S ribosomal protein L14 × 1 （Q2FW16） 50S ribosomal protein L15 × 1 （P0A0F8） 50S ribosomal protein L16 × 1 （Q2FW13） 50S ribosomal protein L17 × 1 （Q2FW33） 50S ribosomal protein L18 × 1 （Q2FW22） 50S ribosomal protein L19 × 1 （Q2FZ42） 50S ribosomal protein L20 × 1 （Q2FXQ1） 50S ribosomal protein L21 × 1 （Q2FXS8） 50S ribosomal protein L22 × 1 （Q2FW11） 50S ribosomal protein L23 × 1 （Q2FW08） 50S ribosomal protein L25 × 1 （Q2FJE0） 50S ribosomal protein L27 × 1 （Q2FXT0） 50S ribosomal protein L28 × 1 （Q2FZ60） 50S ribosomal protein L29 × 1 （Q2FW14） 50S ribosomal protein L30 × 1 （P0A0G2） 50S ribosomal protein L32 × 1 （Q2FZF1） 50S ribosomal protein L34 × 1 （Q2FUQ0） 50S ribosomal protein L35 × 1 （Q2FXQ0） 50S ribosomal protein L36 × 1 （Q2FW29） BC-3205 × 1 (4S)-2-METHYL-2,4-PENTANEDIOL × 15 MAGNESIUM ION × 111 MANGANESE (II) ION × 311 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 4 SPERMIDINE × 11 ETHANOL × 13	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RL24_STAA8
Isoform	—
PDB entities	19
Chains and sequence ranges	Author chain R； PDBConstruct 1–105； UniProt 1–105

50S ribosomal protein L25

OrganismNot specified

UniProt Q2FJE0

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 26 RNA 2	23S rRNA × 1 5S rRNA × 1 50S ribosomal protein L2 × 1 （P60430） 50S ribosomal protein L3 × 1 （Q2FW06） 50S ribosomal protein L4 × 1 （Q2FW07） 50S ribosomal protein L5 × 1 （Q2FW18） 50S ribosomal protein L6 × 1 （Q2FW21） 50S ribosomal protein L13 × 1 （Q2FW38） 50S ribosomal protein L14 × 1 （Q2FW16） 50S ribosomal protein L15 × 1 （P0A0F8） 50S ribosomal protein L16 × 1 （Q2FW13） 50S ribosomal protein L17 × 1 （Q2FW33） 50S ribosomal protein L18 × 1 （Q2FW22） 50S ribosomal protein L19 × 1 （Q2FZ42） 50S ribosomal protein L20 × 1 （Q2FXQ1） 50S ribosomal protein L21 × 1 （Q2FXS8） 50S ribosomal protein L22 × 1 （Q2FW11） 50S ribosomal protein L23 × 1 （Q2FW08） 50S ribosomal protein L24 × 1 （Q2FW17） 50S ribosomal protein L27 × 1 （Q2FXT0） 50S ribosomal protein L28 × 1 （Q2FZ60） 50S ribosomal protein L29 × 1 （Q2FW14） 50S ribosomal protein L30 × 1 （P0A0G2） 50S ribosomal protein L32 × 1 （Q2FZF1） 50S ribosomal protein L34 × 1 （Q2FUQ0） 50S ribosomal protein L35 × 1 （Q2FXQ0） 50S ribosomal protein L36 × 1 （Q2FW29） BC-3205 × 1 (4S)-2-METHYL-2,4-PENTANEDIOL × 15 MAGNESIUM ION × 111 MANGANESE (II) ION × 311 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 4 SPERMIDINE × 11 ETHANOL × 13	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RL25_STAA3
Isoform	—
PDB entities	20
Chains and sequence ranges	Author chain S； PDBConstruct 1–217； UniProt 1–217

50S ribosomal protein L27

OrganismNot specified

UniProt Q2FXT0

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 26 RNA 2	23S rRNA × 1 5S rRNA × 1 50S ribosomal protein L2 × 1 （P60430） 50S ribosomal protein L3 × 1 （Q2FW06） 50S ribosomal protein L4 × 1 （Q2FW07） 50S ribosomal protein L5 × 1 （Q2FW18） 50S ribosomal protein L6 × 1 （Q2FW21） 50S ribosomal protein L13 × 1 （Q2FW38） 50S ribosomal protein L14 × 1 （Q2FW16） 50S ribosomal protein L15 × 1 （P0A0F8） 50S ribosomal protein L16 × 1 （Q2FW13） 50S ribosomal protein L17 × 1 （Q2FW33） 50S ribosomal protein L18 × 1 （Q2FW22） 50S ribosomal protein L19 × 1 （Q2FZ42） 50S ribosomal protein L20 × 1 （Q2FXQ1） 50S ribosomal protein L21 × 1 （Q2FXS8） 50S ribosomal protein L22 × 1 （Q2FW11） 50S ribosomal protein L23 × 1 （Q2FW08） 50S ribosomal protein L24 × 1 （Q2FW17） 50S ribosomal protein L25 × 1 （Q2FJE0） 50S ribosomal protein L28 × 1 （Q2FZ60） 50S ribosomal protein L29 × 1 （Q2FW14） 50S ribosomal protein L30 × 1 （P0A0G2） 50S ribosomal protein L32 × 1 （Q2FZF1） 50S ribosomal protein L34 × 1 （Q2FUQ0） 50S ribosomal protein L35 × 1 （Q2FXQ0） 50S ribosomal protein L36 × 1 （Q2FW29） BC-3205 × 1 (4S)-2-METHYL-2,4-PENTANEDIOL × 15 MAGNESIUM ION × 111 MANGANESE (II) ION × 311 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 4 SPERMIDINE × 11 ETHANOL × 13	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RL27_STAA8
Isoform	—
PDB entities	21
Chains and sequence ranges	Author chain T； PDBConstruct 1–94； UniProt 1–94

50S ribosomal protein L28

OrganismNot specified

UniProt Q2FZ60

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 26 RNA 2	23S rRNA × 1 5S rRNA × 1 50S ribosomal protein L2 × 1 （P60430） 50S ribosomal protein L3 × 1 （Q2FW06） 50S ribosomal protein L4 × 1 （Q2FW07） 50S ribosomal protein L5 × 1 （Q2FW18） 50S ribosomal protein L6 × 1 （Q2FW21） 50S ribosomal protein L13 × 1 （Q2FW38） 50S ribosomal protein L14 × 1 （Q2FW16） 50S ribosomal protein L15 × 1 （P0A0F8） 50S ribosomal protein L16 × 1 （Q2FW13） 50S ribosomal protein L17 × 1 （Q2FW33） 50S ribosomal protein L18 × 1 （Q2FW22） 50S ribosomal protein L19 × 1 （Q2FZ42） 50S ribosomal protein L20 × 1 （Q2FXQ1） 50S ribosomal protein L21 × 1 （Q2FXS8） 50S ribosomal protein L22 × 1 （Q2FW11） 50S ribosomal protein L23 × 1 （Q2FW08） 50S ribosomal protein L24 × 1 （Q2FW17） 50S ribosomal protein L25 × 1 （Q2FJE0） 50S ribosomal protein L27 × 1 （Q2FXT0） 50S ribosomal protein L29 × 1 （Q2FW14） 50S ribosomal protein L30 × 1 （P0A0G2） 50S ribosomal protein L32 × 1 （Q2FZF1） 50S ribosomal protein L34 × 1 （Q2FUQ0） 50S ribosomal protein L35 × 1 （Q2FXQ0） 50S ribosomal protein L36 × 1 （Q2FW29） BC-3205 × 1 (4S)-2-METHYL-2,4-PENTANEDIOL × 15 MAGNESIUM ION × 111 MANGANESE (II) ION × 311 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 4 SPERMIDINE × 11 ETHANOL × 13	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RL28_STAA8
Isoform	—
PDB entities	22
Chains and sequence ranges	Author chain U； PDBConstruct 1–62； UniProt 1–62

50S ribosomal protein L29

OrganismNot specified

UniProt Q2FW14

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 26 RNA 2	23S rRNA × 1 5S rRNA × 1 50S ribosomal protein L2 × 1 （P60430） 50S ribosomal protein L3 × 1 （Q2FW06） 50S ribosomal protein L4 × 1 （Q2FW07） 50S ribosomal protein L5 × 1 （Q2FW18） 50S ribosomal protein L6 × 1 （Q2FW21） 50S ribosomal protein L13 × 1 （Q2FW38） 50S ribosomal protein L14 × 1 （Q2FW16） 50S ribosomal protein L15 × 1 （P0A0F8） 50S ribosomal protein L16 × 1 （Q2FW13） 50S ribosomal protein L17 × 1 （Q2FW33） 50S ribosomal protein L18 × 1 （Q2FW22） 50S ribosomal protein L19 × 1 （Q2FZ42） 50S ribosomal protein L20 × 1 （Q2FXQ1） 50S ribosomal protein L21 × 1 （Q2FXS8） 50S ribosomal protein L22 × 1 （Q2FW11） 50S ribosomal protein L23 × 1 （Q2FW08） 50S ribosomal protein L24 × 1 （Q2FW17） 50S ribosomal protein L25 × 1 （Q2FJE0） 50S ribosomal protein L27 × 1 （Q2FXT0） 50S ribosomal protein L28 × 1 （Q2FZ60） 50S ribosomal protein L30 × 1 （P0A0G2） 50S ribosomal protein L32 × 1 （Q2FZF1） 50S ribosomal protein L34 × 1 （Q2FUQ0） 50S ribosomal protein L35 × 1 （Q2FXQ0） 50S ribosomal protein L36 × 1 （Q2FW29） BC-3205 × 1 (4S)-2-METHYL-2,4-PENTANEDIOL × 15 MAGNESIUM ION × 111 MANGANESE (II) ION × 311 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 4 SPERMIDINE × 11 ETHANOL × 13	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RL29_STAA8
Isoform	—
PDB entities	23
Chains and sequence ranges	Author chain V； PDBConstruct 1–69； UniProt 1–69

50S ribosomal protein L30

OrganismNot specified

UniProt P0A0G2

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 26 RNA 2	23S rRNA × 1 5S rRNA × 1 50S ribosomal protein L2 × 1 （P60430） 50S ribosomal protein L3 × 1 （Q2FW06） 50S ribosomal protein L4 × 1 （Q2FW07） 50S ribosomal protein L5 × 1 （Q2FW18） 50S ribosomal protein L6 × 1 （Q2FW21） 50S ribosomal protein L13 × 1 （Q2FW38） 50S ribosomal protein L14 × 1 （Q2FW16） 50S ribosomal protein L15 × 1 （P0A0F8） 50S ribosomal protein L16 × 1 （Q2FW13） 50S ribosomal protein L17 × 1 （Q2FW33） 50S ribosomal protein L18 × 1 （Q2FW22） 50S ribosomal protein L19 × 1 （Q2FZ42） 50S ribosomal protein L20 × 1 （Q2FXQ1） 50S ribosomal protein L21 × 1 （Q2FXS8） 50S ribosomal protein L22 × 1 （Q2FW11） 50S ribosomal protein L23 × 1 （Q2FW08） 50S ribosomal protein L24 × 1 （Q2FW17） 50S ribosomal protein L25 × 1 （Q2FJE0） 50S ribosomal protein L27 × 1 （Q2FXT0） 50S ribosomal protein L28 × 1 （Q2FZ60） 50S ribosomal protein L29 × 1 （Q2FW14） 50S ribosomal protein L32 × 1 （Q2FZF1） 50S ribosomal protein L34 × 1 （Q2FUQ0） 50S ribosomal protein L35 × 1 （Q2FXQ0） 50S ribosomal protein L36 × 1 （Q2FW29） BC-3205 × 1 (4S)-2-METHYL-2,4-PENTANEDIOL × 15 MAGNESIUM ION × 111 MANGANESE (II) ION × 311 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 4 SPERMIDINE × 11 ETHANOL × 13	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RL30_STAA8
Isoform	—
PDB entities	24
Chains and sequence ranges	Author chain W； PDBConstruct 1–59； UniProt 1–59

50S ribosomal protein L32

OrganismNot specified

UniProt Q2FZF1

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 26 RNA 2	23S rRNA × 1 5S rRNA × 1 50S ribosomal protein L2 × 1 （P60430） 50S ribosomal protein L3 × 1 （Q2FW06） 50S ribosomal protein L4 × 1 （Q2FW07） 50S ribosomal protein L5 × 1 （Q2FW18） 50S ribosomal protein L6 × 1 （Q2FW21） 50S ribosomal protein L13 × 1 （Q2FW38） 50S ribosomal protein L14 × 1 （Q2FW16） 50S ribosomal protein L15 × 1 （P0A0F8） 50S ribosomal protein L16 × 1 （Q2FW13） 50S ribosomal protein L17 × 1 （Q2FW33） 50S ribosomal protein L18 × 1 （Q2FW22） 50S ribosomal protein L19 × 1 （Q2FZ42） 50S ribosomal protein L20 × 1 （Q2FXQ1） 50S ribosomal protein L21 × 1 （Q2FXS8） 50S ribosomal protein L22 × 1 （Q2FW11） 50S ribosomal protein L23 × 1 （Q2FW08） 50S ribosomal protein L24 × 1 （Q2FW17） 50S ribosomal protein L25 × 1 （Q2FJE0） 50S ribosomal protein L27 × 1 （Q2FXT0） 50S ribosomal protein L28 × 1 （Q2FZ60） 50S ribosomal protein L29 × 1 （Q2FW14） 50S ribosomal protein L30 × 1 （P0A0G2） 50S ribosomal protein L34 × 1 （Q2FUQ0） 50S ribosomal protein L35 × 1 （Q2FXQ0） 50S ribosomal protein L36 × 1 （Q2FW29） BC-3205 × 1 (4S)-2-METHYL-2,4-PENTANEDIOL × 15 MAGNESIUM ION × 111 MANGANESE (II) ION × 311 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 4 SPERMIDINE × 11 ETHANOL × 13	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RL32_STAA8
Isoform	—
PDB entities	25
Chains and sequence ranges	Author chain Z； PDBConstruct 1–58； UniProt 1–58

50S ribosomal protein L34

OrganismNot specified

UniProt Q2FUQ0

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 26 RNA 2	23S rRNA × 1 5S rRNA × 1 50S ribosomal protein L2 × 1 （P60430） 50S ribosomal protein L3 × 1 （Q2FW06） 50S ribosomal protein L4 × 1 （Q2FW07） 50S ribosomal protein L5 × 1 （Q2FW18） 50S ribosomal protein L6 × 1 （Q2FW21） 50S ribosomal protein L13 × 1 （Q2FW38） 50S ribosomal protein L14 × 1 （Q2FW16） 50S ribosomal protein L15 × 1 （P0A0F8） 50S ribosomal protein L16 × 1 （Q2FW13） 50S ribosomal protein L17 × 1 （Q2FW33） 50S ribosomal protein L18 × 1 （Q2FW22） 50S ribosomal protein L19 × 1 （Q2FZ42） 50S ribosomal protein L20 × 1 （Q2FXQ1） 50S ribosomal protein L21 × 1 （Q2FXS8） 50S ribosomal protein L22 × 1 （Q2FW11） 50S ribosomal protein L23 × 1 （Q2FW08） 50S ribosomal protein L24 × 1 （Q2FW17） 50S ribosomal protein L25 × 1 （Q2FJE0） 50S ribosomal protein L27 × 1 （Q2FXT0） 50S ribosomal protein L28 × 1 （Q2FZ60） 50S ribosomal protein L29 × 1 （Q2FW14） 50S ribosomal protein L30 × 1 （P0A0G2） 50S ribosomal protein L32 × 1 （Q2FZF1） 50S ribosomal protein L35 × 1 （Q2FXQ0） 50S ribosomal protein L36 × 1 （Q2FW29） BC-3205 × 1 (4S)-2-METHYL-2,4-PENTANEDIOL × 15 MAGNESIUM ION × 111 MANGANESE (II) ION × 311 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 4 SPERMIDINE × 11 ETHANOL × 13	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RL34_STAA8
Isoform	—
PDB entities	26
Chains and sequence ranges	Author chain 2； PDBConstruct 1–45； UniProt 1–45

50S ribosomal protein L35

OrganismNot specified

UniProt Q2FXQ0

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 26 RNA 2	23S rRNA × 1 5S rRNA × 1 50S ribosomal protein L2 × 1 （P60430） 50S ribosomal protein L3 × 1 （Q2FW06） 50S ribosomal protein L4 × 1 （Q2FW07） 50S ribosomal protein L5 × 1 （Q2FW18） 50S ribosomal protein L6 × 1 （Q2FW21） 50S ribosomal protein L13 × 1 （Q2FW38） 50S ribosomal protein L14 × 1 （Q2FW16） 50S ribosomal protein L15 × 1 （P0A0F8） 50S ribosomal protein L16 × 1 （Q2FW13） 50S ribosomal protein L17 × 1 （Q2FW33） 50S ribosomal protein L18 × 1 （Q2FW22） 50S ribosomal protein L19 × 1 （Q2FZ42） 50S ribosomal protein L20 × 1 （Q2FXQ1） 50S ribosomal protein L21 × 1 （Q2FXS8） 50S ribosomal protein L22 × 1 （Q2FW11） 50S ribosomal protein L23 × 1 （Q2FW08） 50S ribosomal protein L24 × 1 （Q2FW17） 50S ribosomal protein L25 × 1 （Q2FJE0） 50S ribosomal protein L27 × 1 （Q2FXT0） 50S ribosomal protein L28 × 1 （Q2FZ60） 50S ribosomal protein L29 × 1 （Q2FW14） 50S ribosomal protein L30 × 1 （P0A0G2） 50S ribosomal protein L32 × 1 （Q2FZF1） 50S ribosomal protein L34 × 1 （Q2FUQ0） 50S ribosomal protein L36 × 1 （Q2FW29） BC-3205 × 1 (4S)-2-METHYL-2,4-PENTANEDIOL × 15 MAGNESIUM ION × 111 MANGANESE (II) ION × 311 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 4 SPERMIDINE × 11 ETHANOL × 13	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RL35_STAA8
Isoform	—
PDB entities	27
Chains and sequence ranges	Author chain 3； PDBConstruct 1–66； UniProt 1–66

50S ribosomal protein L36

OrganismNot specified

UniProt Q2FW29

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 26 RNA 2	23S rRNA × 1 5S rRNA × 1 50S ribosomal protein L2 × 1 （P60430） 50S ribosomal protein L3 × 1 （Q2FW06） 50S ribosomal protein L4 × 1 （Q2FW07） 50S ribosomal protein L5 × 1 （Q2FW18） 50S ribosomal protein L6 × 1 （Q2FW21） 50S ribosomal protein L13 × 1 （Q2FW38） 50S ribosomal protein L14 × 1 （Q2FW16） 50S ribosomal protein L15 × 1 （P0A0F8） 50S ribosomal protein L16 × 1 （Q2FW13） 50S ribosomal protein L17 × 1 （Q2FW33） 50S ribosomal protein L18 × 1 （Q2FW22） 50S ribosomal protein L19 × 1 （Q2FZ42） 50S ribosomal protein L20 × 1 （Q2FXQ1） 50S ribosomal protein L21 × 1 （Q2FXS8） 50S ribosomal protein L22 × 1 （Q2FW11） 50S ribosomal protein L23 × 1 （Q2FW08） 50S ribosomal protein L24 × 1 （Q2FW17） 50S ribosomal protein L25 × 1 （Q2FJE0） 50S ribosomal protein L27 × 1 （Q2FXT0） 50S ribosomal protein L28 × 1 （Q2FZ60） 50S ribosomal protein L29 × 1 （Q2FW14） 50S ribosomal protein L30 × 1 （P0A0G2） 50S ribosomal protein L32 × 1 （Q2FZF1） 50S ribosomal protein L34 × 1 （Q2FUQ0） 50S ribosomal protein L35 × 1 （Q2FXQ0） BC-3205 × 1 (4S)-2-METHYL-2,4-PENTANEDIOL × 15 MAGNESIUM ION × 111 MANGANESE (II) ION × 311 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 4 SPERMIDINE × 11 ETHANOL × 13	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RL36_STAA8
Isoform	—
PDB entities	28
Chains and sequence ranges	Author chain 4； PDBConstruct 1–37； UniProt 1–37

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	4wfb
Deposition date deposition_date	2014-09-14
Structure title title	The crystal structure of the large ribosomal subunit of Staphylococcus aureus in complex with BC-3205
Keywords keywords	Ribosome, RNA, bacteria; RIBOSOME
Experimental Method method	X-RAY DIFFRACTION

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

4wfb__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

4wfb__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

4wfb__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	67.14 Å
Rg (electron density)	67.56 Å
Total Rg	67.36 Å
Atom count	81184
Residues	5771
Excluded volume	1222200 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`4wfb__assembly_1__model_1`	28-mer （28）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (35)

Entity 1 Entity 1 polymer

Description description	23S rRNA
Molecular weight formula_weight	946687.7 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polyribonucleotide
Chain IDs strand_id	X
Atom count atom_count	81184

GAUUAAGUUAUUAAGGGCGCACGGUGGAUGCCUUGGCACUAGAAGCCAAUGAAGGACGUUACUAACGACGAUAUGCUUUGGGGAGCUGUAAGUAAGCUUUGAUCCAGAGAUUUCCGAAUGGGGAAACCCAGCAUGAGUUAUGUCAUGUUAUCGAUAUGUGAAUACAUAGCAUAUCAGAAGGCACACCCGGAGAACUGAAACAUCUUAGUACCCGGAGGAAGAGAAAGAAAAUUCGAUUCCCUUAGUAGCGGCGAGCGAAACGGGAAGAGCCCAAACCAACAAGCUUGCUUGUUGGGGUUGUAGGACACUCUAUACGGAGUUACAAAGGACGACAUUAGACGAAUCAUCUGGAAAGAUGAAUCAAAGAAGGUAAUAAUCCUGUAGUCGAAAAUGUUGUCUCUCUUGAGUGGAUCCUGAGUACGACGGAGCACGUGAAAUUCCGUCGGAAUCUGGGAGGACCAUCUCCUAAGGCUAAAUACUCUCUAGUGACCGAUAGUGAACCAGUACCGUGAGGGAAAGGUGAAAAGCACCCCGGAAGGGGAGUGAAAUAGAACCUGAAACCGUGUGCUUACAAGUAGUCAGAGCCCGUUAAUGGGUGAUGGCGUGCCUUUUGUAGAAUGAACCGGCGAGUUACGAUUUGAUGCAAGGUUAAGCAGUAAAUGUGGAGCCGUAGCGAAAGCGAGUCUGAAUAGGGCGUUUAGUAUUUGGUCGUAGACCCGAAACCAGGUGAUCUACCCUUGGUCAGGUUGAAGUUCAGGUAACACUGAAUGGAGGACCGAACCGACUUACGUUGAAAAGUGAGCGGAUGAACUGAGGGUAGCGGAGAAAUUCCAAUCGAACCUGGAGAUAGCUGGUUCUCUCCGAAAUAGCUUUAGGGCUAGCCUCAAGUGAUGAUUAUUGGAGGUAGAGCACUGUUUGGACGAGGGGCCCCUCUCGGGUUACCGAAUUCAGACAAACUCCGAAUGCCAAUUAAUUUAACUUGGGAGUCAGAACAUGGGUGAUAAGGUCCGUGUUCGAAAGGGAAACAGCCCAGACCACCAGCUAAGGUCCCAAAAUAUAUGUUAAGUGGAAAAGGAUGUGGCGUUGCCCAGACAACUAGGAUGUUGGCUUAGAAGCAGCCAUCAUUUAAAGAGUGCGUAAUAGCUCACUAGUCGAGUGACACUGCGCCGAAAAUGUACCGGGGCUAAACAUAUUACCGAAGCUGUGGAUUGUCCUUUGGACAAUGGUAGGAGAGCGUUCUAAGGGCGUUGAAGCAUGAUCGUAAGGACAUGUGGAGCGCUUAGAAGUGAGAAUGCCGGUGUGAGUAGCGAAAGACGGGUGAGAAUCCCGUCCACCGAUUGACUAAGGUUUCCAGAGGAAGGCUCGUCCGCUCUGGGUUAGUCGGGUCCUAAGCUGAGGCCGACAGGCGUAGGCGAUGGAUAACAGGUUGAUAUUCCUGUACCACCUAUAAUCGUUUUAAUCGAUGGGGGGACGCAGUAGGAUAGGCGAAGCGUGCGAUUGGAUUGCACGUCUAAGCAGUAAGGCUGAGUAUUAGGCAAAUCCGGUACUCGUUAAGGCUGAGCUGUGAUGGGGAGAAGACAUUGAGUCUUCGAGUCGUUGAUUUCACACUGCCGAGAAAAGCCUCUAGAUAGAAAAUAGGUGCCCGUACCGCAAACCGACACAGGUAGUCAAGAUGAGAAUUCUAAGGUGAGCGAGCGAACUCUCGUUAAGGAACUCGGCAAAAUGACCCCGUAACUUCGGGAGAAGGGGUGCUCUUUAGGGUUAACGCCCAGAAGAGCCGCAGUGAAUAGGCCCAAGCGACUGUUUAUCAAAAACACAGGUCUCUGCUAAACCGUAAGGUGAUGUAUAGGGGCUGACGCCUGCCCGGUGCUGGAAGGUUAAGAGGAGUGGUUAGCUUCUGCGAAGCUACGAAUCGAAGCCCCAGUAAACGGCGGCCGUAACUAUAACGGUCCUAAGGUAGCGAAAUUCCUUGUCGGGUAAGUUCCGACCCGCACGAAAGGCGUAACGAUUUGGGCACUGUCUCAACGAGAGACUCGGUGAAAUCAUAGUACCUGUGAAGAUGCAGGUUACCCGCGACAGGACGGAAAGACCCCGUGGAGCUUUACUGUAGCCUGAUAUUGAAAUUCGGCACAGCUUGUACAGGAUAGGUAGGAGCCUUUGAAACGUGAGCGCUAGCUUACGUGGAGGCGCUGGUGGGAUACUACCCUAGCUGUGUUGGCUUUCUAACCCGCACCACUUAUCGUGGUGGGAGACAGUGUCAAGCGGGCAGUUUGACUGGGGCGGUCGCCUCCUAAAAGGUAACGGAGGCGCUCAAAGGUUCCCUCAGAAUGGUUGGAAAUCAUUCAUAGAGUGUAAAGGCAUAAGGGAGCUUGACUGCGAGACCUACAAGUCGAGCAGGGUCGAAAGACGGACUUAGUGAUCCGGUGGUUCCGCAUGGAAGGGCCAUCGCUCAACGGAUAAAAGCUACCCCGGGGAUAACAGGCUUAUCUCCCCCAAGAGUUCACAUCGACGGGGAGGUUUGGCACCUCGAUGUCGGCUCAUCGCAUCCUGGGGCUGUAGUCGGUCCCAAGGGUUGGGCUGUUCGCCCAUUAAAGCGGUACGCGAGCUGGGUUCAGAACGUCGUGAGACAGUUCGGUCCCUAUCCGUCGUGGGCGUAGGAAAUUUGAGAGGAGCUGUCCUUAGUACGAGAGGACCGGGAUGGACAUACCUCUGGUGUACCAGUUGUCGUGCCAACGGCAUAGCUGGGUAGCUAUGUGUGGACGGGAUAAGUGCUGAAAGCAUCUAAGCAUGAAGCCCCCCUCAAGAUGAGAUUUCCCAACUUCGGUUAUAAGAUCCCUCAAAGAUGAUGAGGUUAAUAGGUUCGAGGUGGAAGCAUGGUGACAUGUGGAGCUGACGAAUACUAAUCGAUCGAAGACUUAAUCAA

Entity 2 Entity 2 polymer

Description description	5S rRNA
Molecular weight formula_weight	36692.8 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polyribonucleotide
Chain IDs strand_id	Y

UCUGGUGACUAUAGCAAGGAGGUCACACCUGUUCCCAUGCCGAACACAGAAGUUAAGGUCUUUAGCGACGAUGGUAGCCAACUUACGUUCCGCUAGAGUAGAACGUUGCCAGGC

Entity 3 Entity 3 polymer

Description description	50S ribosomal protein L2
Molecular weight formula_weight	30217.2 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	A

MAIKKYKPITNGRRNMTSLDFAEITKTTPEKSLLKPLPKKAGRNNQGKLTVRHHGGGHKRQYRVIDFKRNKDGINAKVDSIQYDPNRSANIALVVYADGEKRYIIAPKGLEVGQIVESGAEADIKVGNALPLQNIPVGTVVHNIELKPGKGGQIARSAGASAQVLGKEGKYVLIRLRSGEVRMILSTCRATIGQVGNLQHELVNVGKAGRSRWKGIRPTVRGSVMNPNDHPHGGGEGRAPIGRPSPMSPWGKPTLGKKTRRGKKSSDKLIVRGRKKK

Entity 4 Entity 4 polymer

Description description	50S ribosomal protein L3
Molecular weight formula_weight	23760.3 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	B

MTKGILGRKIGMTQVFGENGELIPVTVVEAKENVVLQKKTVEVDGYNAIQVGFEDKKAYKKDAKSNKYANKPAEGHAKKADAAPKRFIREFRNVDVDAYEVGQEVSVDTFVAGDVIDVTGVSKGKGFQGAIKRHGQSRGPMSHGSHFHRAPGSVGMASDASRVFKGQKMPGRMGGNTVTVQNLEVVQVDTENKVILVKGNVPGPKKGLVEIRTSIKKGNK

Entity 5 Entity 5 polymer

Description description	50S ribosomal protein L4
Molecular weight formula_weight	22495.7 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	C

MANYDVLKLDGTKSGSIELSDAVFGIEPNNSVLFEAINLQRASLRQGTHAVKNRSAVSGGGRKPWKQKGTGRARQGTIRAPQWRGGGIVFGPTPRSYAYKMPKKMRRLALRSALSFKAQENGLTVVDAFNFEAPKTKEFKNVLSTLEQPKKVLVVTENEDVNVELSARNIPGVQVTTAQGLNVLDITNADSLVITEAAAKKVEEVLG

Entity 6 Entity 6 polymer

Description description	50S ribosomal protein L5
Molecular weight formula_weight	20296.6 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	D

MNRLKEKFNTEVTENLMKKFNYSSVMEVPKIDKIVVNMGVGDAVQNSKVLDNAVEELELITGQKPLVTKAKKSIATFRLREGMPIGAKVTLRGERMYEFLDKLISVSLPRVRDFQGVSKKAFDGRGNYTLGVKEQLIFPEIDYDKVSKVRGMDIVIVTTANTDEEARELLANFGMPFRK

Entity 7 Entity 7 polymer

Description description	50S ribosomal protein L6
Molecular weight formula_weight	19818.6 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	E

MSRVGKKIIDIPSDVTVTFDGNHVTVKGPKGELSRTLNERMTFKQEENTIEVVRPSDSKEDRTNHGTTRALLNNMVQGVSQGYVKVLELVGVGYRAQMQGKDLILNVGYSHPVEIKAEENITFSVEKNTVVKVEGISKEQVGALASNIRSVRPPEPYKGKGIRYQGEYVRRKEGKTGK

Entity 8 Entity 8 polymer

Description description	50S ribosomal protein L13
Molecular weight formula_weight	16359.4 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	G

MRQTFMANESNIERKWYVIDAEGQTLGRLSSEVASILRGKNKVTYTPHVDTGDYVIVINASKIEFTGNKETDKVYYRHSNHPGGIKSITAGELRRTNPERLIENSIKGMLPSTRLGEKQGKKLFVYGGAEHPHAAQQPENYELRG

Entity 9 Entity 9 polymer

Description description	50S ribosomal protein L14
Molecular weight formula_weight	13157.3 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	H

MIQQETRLKVADNSGAREVLTIKVLGGSGRKTANIGDVIVCTVKNATPGGVVKKGDVVKAVIVRTKSGVRRNDGSYIKFDENACVIIRDDKGPRGTRIFGPVARELREGNFMKIVSLAPEVL

Entity 10 Entity 10 polymer

Description description	50S ribosomal protein L15
Molecular weight formula_weight	15628.9 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	I

MKLHELKPAEGSRKERNRVGRGVATGNGKTSGRGHKGQKARSGGGVRPGFEGGQLPLFRRLPKRGFTNINRKEYAIVNLDQLNKFEDGTEVTPALLVESGVVKNEKSGIKILGNGSLDKKLTVKAHKFSASAAEAIDAKGGAHEVI

Entity 11 Entity 11 polymer

Description description	50S ribosomal protein L16
Molecular weight formula_weight	16274.0 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	J

MLLPKRVKYRRQHRPKTTGRSKGGNYVTFGEFGLQATTTSWITSRQIESARIAMTRYMKRGGKVWIKIFPHTPYTKKPLEVRMGAGKGAVEGWIAVVKPGRILFEVAGVSEEVAREALRLASHKLPVKTKFVKREELGGETNES

Entity 12 Entity 12 polymer

Description description	50S ribosomal protein L17
Molecular weight formula_weight	13771.8 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	K

MGYRKLGRTSDQRKAMLRDLATSLIISERIETTEARAKEVRSVVEKLITLGKKGDLASRRNAAKTLRNVEILNEDETTQTALQKLFGEIAERYTERQGGYTRILKQGPRRGDGAESVIIELV

Entity 13 Entity 13 polymer

Description description	50S ribosomal protein L18
Molecular weight formula_weight	13124.1 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	L

MISKIDKNKVRLKRHARVRTNLSGTAEKPRLNVYRSNKHIYAQIIDDNKGVTLAQASSKDSDIATTATKVELATKVGEAIAKKAADKGIKEIVFDRGGYLYHGRVKALAEAARESGLEF

Entity 14 Entity 14 polymer

Description description	50S ribosomal protein L19
Molecular weight formula_weight	13392.8 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	M

MTNHKLIEAVTKSQLRTDLPSFRPGDTLRVHVRIIEGTRERIQVFEGVVIKRRGGGVSETFTVRKISSGVGVERTFPLHTPKIEKIEVKRRGKVRRAKLYYLRSLRGKAARIQEIR

Entity 15 Entity 15 polymer

Description description	50S ribosomal protein L20
Molecular weight formula_weight	13720.3 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	N

MPRVKGGTVTRARRKKTIKLAKGYFGSKHTLYKVAKQQVMKSGQYAFRDRRQRKRDFRKLWITRINAAARQHEMSYSRLMNGLKKAGIDINRKMLSEIAISDEKAFAQLVTKAKDALK

Entity 16 Entity 16 polymer

Description description	50S ribosomal protein L21
Molecular weight formula_weight	11354.1 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	O

MFAIIETGGKQIKVEEGQEIFVEKLDVNEGDTFTFDKVLFVGGDSVKVGAPTVEGATVTATVNKQGRGKKITVFTYKRRKNSKRKKGHRQPYTKLTIDKINA

Entity 17 Entity 17 polymer

Description description	50S ribosomal protein L22
Molecular weight formula_weight	12857.9 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	P

MEAKAVARTIRIAPRKVRLVLDLIRGKNAAEAIAILKLTNKASSPVIEKVLMSALANAEHNYDMNTDELVVKEAYANEGPTLKRFRPRAQGRASAINKRTSHITIVVSDGKEEAKEA

Entity 18 Entity 18 polymer

Description description	50S ribosomal protein L23
Molecular weight formula_weight	10625.4 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	Q

MEARDILKRPVITEKSSEAMAEDKYTFDVDTRVNKTQVKMAVEEIFNVKVASVNIMNYKPKKKRMGRYQGYTNKRRKAIVTLKEGSIDLFN

Entity 19 Entity 19 polymer

Description description	50S ribosomal protein L24
Molecular weight formula_weight	11561.5 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	R

MHIKKGDNVKVIAGKDKGKEGKVIATLPKKDRVVVEGVNIMKKHQKPTQLNPEGGILETEAAIHVSNVQLLDPKTNEPTRVGYKFVDGKKVRIAKKSGEEIKSNN

Entity 20 Entity 20 polymer

Description description	50S ribosomal protein L25
Molecular weight formula_weight	23810.6 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	S

MASLKSIIRQGKQTRSDLKQLRKSGKVPAVVYGYGTKNVSVKVDEVEFIKVIREVGRNGVIELGVGSKTIKVMVADYQFDPLKNQITHIDFLAINMSEERTVEVPVQLVGEAVGAKEGGVVEQPLFNLEVTATPDNIPEAIEVDITELNINDSLTVADVKVTGDFKIENDSAESVVTVVAPTEEPTEEEIEAMEGEQQTEEPEVVGESKEDEEKTEE

Entity 21 Entity 21 polymer

Description description	50S ribosomal protein L27
Molecular weight formula_weight	10334.8 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	T

MLKLNLQFFASKKGVSSTKNGRDSESKRLGAKRADGQFVTGGSILYRQRGTKIYPGENVGRGGDDTLFAKIDGVVKFERKGRDKKQVSVYAVAE

Entity 22 Entity 22 polymer

Description description	50S ribosomal protein L28
Molecular weight formula_weight	6995.3 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	U

MGKQCFVTGRKASTGNRRSHALNSTKRRWNANLQKVRILVDGKPKKVWVSARALKSGKVTRV

Entity 23 Entity 23 polymer

Description description	50S ribosomal protein L29
Molecular weight formula_weight	8105.3 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	V

MKAKEIRDLTTSEIEEQIKSSKEELFNLRFQLATGQLEETARIRTVRKTIARLKTVAREREIEQSKANQ

Entity 24 Entity 24 polymer

Description description	50S ribosomal protein L30
Molecular weight formula_weight	6565.7 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	W

MAKLQITLTRSVIGRPETQRKTVEALGLKKTNSSVVVEDNPAIRGQINKVKHLVTVEEK

Entity 25 Entity 25 polymer

Description description	50S ribosomal protein L32
Molecular weight formula_weight	6657.8 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	Z

MAVPKRRTSKTRKNKRRTHFKISVPGMTECPNCGREYKLSHRVCKNCGSYNGEEVAAK

Entity 26 Entity 26 polymer

Description description	50S ribosomal protein L34
Molecular weight formula_weight	5454.6 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	2

MVKRTYQPNKRKHSKVHGFRKRMSTKNGRKVLARRRRKGRKVLSA

Entity 27 Entity 27 polymer

Description description	50S ribosomal protein L35
Molecular weight formula_weight	7722.4 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	3

MPKMKTHRGAAKRVKRTASGQLKRSRAFTSHLFANKSTKQKRQLRKARLVSKSDMKRVKQLLAYKK

Entity 28 Entity 28 polymer

Description description	50S ribosomal protein L36
Molecular weight formula_weight	4318.4 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	4

MKVRPSVKPICEKCKVIKRKGKVMVICENPKHKQRQG

Entity 29 Entity 29 non-polymer

Description description	BC-3205
Molecular weight formula_weight	578.8 kDa
Source method src_method	syn
Copy count entity_count	1

Entity 30 Entity 30 non-polymer

Description description	(4S)-2-METHYL-2,4-PENTANEDIOL
Molecular weight formula_weight	118.2 kDa
Source method src_method	syn
Copy count entity_count	15

Entity 31 Entity 31 non-polymer

Description description	MAGNESIUM ION
Molecular weight formula_weight	24.3 kDa
Source method src_method	syn
Copy count entity_count	111

Entity 32 Entity 32 non-polymer

Description description	MANGANESE (II) ION
Molecular weight formula_weight	54.9 kDa
Source method src_method	syn
Copy count entity_count	311

Entity 33 Entity 33 non-polymer

Description description	4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Molecular weight formula_weight	238.3 kDa
Source method src_method	syn
Copy count entity_count	4

Entity 34 Entity 34 non-polymer

Description description	SPERMIDINE
Molecular weight formula_weight	145.2 kDa
Source method src_method	syn
Copy count entity_count	11

Entity 35 Entity 35 non-polymer

Description description	ETHANOL
Molecular weight formula_weight	46.1 kDa
Source method src_method	syn
Copy count entity_count	13

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6. Fold Classification (SCOP + CATH) 16 domains

CATH v4.4 (16 domains)

Domain ID domain_id	4wfb200
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	287 — Helix Hairpins
Homologous superfamily homologous superfamily	3980 —

Domain ID domain_id	4wfbA01
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homologous superfamily homologous superfamily	140 — Nucleic acid-binding proteins

Domain ID domain_id	4wfbA03
Class class	4 — Few Secondary Structures
Architecture architecture	10 — Irregular
Topology topology	950 — Ribosomal protein L2; domain 3
Homologous superfamily homologous superfamily	10 — Ribosomal protein L2, domain 3

Domain ID domain_id	4wfbD00
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	1440 — 50s Ribosomal Protein L5; Chain: A,
Homologous superfamily homologous superfamily	10 — Ribosomal protein L5

Domain ID domain_id	4wfbE01
Class class	3 — Alpha Beta
Architecture architecture	90 — Alpha-Beta Complex
Topology topology	930 — Outer Surface Protein A; domain 3
Homologous superfamily homologous superfamily	12 — Ribosomal protein L6

Domain ID domain_id	4wfbE02
Class class	3 — Alpha Beta
Architecture architecture	90 — Alpha-Beta Complex
Topology topology	930 — Outer Surface Protein A; domain 3
Homologous superfamily homologous superfamily	12 — Ribosomal protein L6

Domain ID domain_id	4wfbH00
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	150 — Ribosomal Protein L14
Homologous superfamily homologous superfamily	20 — Ribosomal protein L14/L23

Domain ID domain_id	4wfbJ01
Class class	3 — Alpha Beta
Architecture architecture	90 — Alpha-Beta Complex
Topology topology	1170 — Aldehyde Oxidoreductase; domain 3
Homologous superfamily homologous superfamily	10 — Ribosomal protein L16/L10

Domain ID domain_id	4wfbK00
Class class	3 — Alpha Beta
Architecture architecture	90 — Alpha-Beta Complex
Topology topology	1030 — 50s Ribosomal Protein L17; Chain: A,
Homologous superfamily homologous superfamily	10 — Ribosomal protein L17

Domain ID domain_id	4wfbL01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	420 — Nucleotidyltransferase; domain 5
Homologous superfamily homologous superfamily	100 —

Domain ID domain_id	4wfbP00
Class class	3 — Alpha Beta
Architecture architecture	90 — Alpha-Beta Complex
Topology topology	470 — Ribosomal Protein L22; Chain A
Homologous superfamily homologous superfamily	10 — Ribosomal protein L22/L17

Domain ID domain_id	4wfbQ00
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	70 — Alpha-Beta Plaits
Homologous superfamily homologous superfamily	330 — RRM (RNA recognition motif) domain

Domain ID domain_id	4wfbS01
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	240 — Ribosomal Protein L25; Chain P
Homologous superfamily homologous superfamily	10 — Ribosomal Protein L25; Chain P

Domain ID domain_id	4wfbS02
Class class	2 — Mainly Beta
Architecture architecture	170 — Beta Complex
Topology topology	120 — RNA Polymerase Alpha Subunit; Chain A, domain 2
Homologous superfamily homologous superfamily	20 — Ribosomal protein L25, C-terminal domain

Domain ID domain_id	4wfbV00
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	287 — Helix Hairpins
Homologous superfamily homologous superfamily	310 —

Domain ID domain_id	4wfbW00
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	1390 — Ribosomal Protein L30; Chain: A,
Homologous superfamily homologous superfamily	20 — Ribosomal protein L30/L7

▶

Unit-cell length a length_a	280.918 Å
Unit-cell length b length_b	280.918 Å
Unit-cell length c length_c	875.585 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	90.00 °
Unit-cell angle γ angle_gamma	120.00 °
Molecules per unit cell Z z_pdb	12

Space group space_group	P 65 2 2
Space-group number int_tables_number	179
Crystal system crystal_system	—

Resolution resolution	3.430 Å
Low-resolution limit resolution_low	49.539 Å
R factor r_factor	0.2061
R_work r_work	0.2042
R_free r_free	0.2420

The crystal structure of the large ribosomal subunit of Staphylococcus aureus in complex with BC-3205

1. Protein Identity and Related Structures Protein Identity & Related Structures

50S ribosomal protein L2

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

50S ribosomal protein L3

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

50S ribosomal protein L4

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

50S ribosomal protein L5

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

50S ribosomal protein L6

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

50S ribosomal protein L13

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

50S ribosomal protein L14

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

50S ribosomal protein L15

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

50S ribosomal protein L16

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

50S ribosomal protein L17

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer