4wjg

Structure of T. brucei haptoglobin-hemoglobin receptor binding to human haptoglobin-hemoglobin

Method: X-RAY DIFFRACTION

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1. Protein Identity and Related Structures Protein Identity & Related Structures

Hemoglobin subunit alpha

OrganismNot specified

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Other combination	Heteromer	Protein 10 其他Polymer 3	Hemoglobin subunit beta × 2 （P68871） Haptoglobin × 2 （P00738） Iron-regulated surface determinant protein H × 2 （Q99TD3） Haptoglobin-hemoglobin receptor × 2 （I7BA80） 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 3 PROTOPORPHYRIN IX CONTAINING FE × 4 OXYGEN MOLECULE × 4 2-acetamido-2-deoxy-beta-D-glucopyranose × 8	Consistent with protein count
2	Other combination	Heteromer	Protein 10 其他Polymer 4	Hemoglobin subunit beta × 2 （P68871） Haptoglobin × 2 （P00738） Iron-regulated surface determinant protein H × 2 （Q99TD3） Haptoglobin-hemoglobin receptor × 2 （I7BA80） 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 4 PROTOPORPHYRIN IX CONTAINING FE × 4 OXYGEN MOLECULE × 4 2-acetamido-2-deoxy-beta-D-glucopyranose × 8	Consistent with protein count
3	Other combination	Heteromer	Protein 10 其他Polymer 3	Hemoglobin subunit beta × 2 （P68871） Haptoglobin × 2 （P00738） Iron-regulated surface determinant protein H × 2 （Q99TD3） Haptoglobin-hemoglobin receptor × 2 （I7BA80） 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 3 PROTOPORPHYRIN IX CONTAINING FE × 4 OXYGEN MOLECULE × 4 2-acetamido-2-deoxy-beta-D-glucopyranose × 7	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	HBA_HUMAN
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 1–141； UniProt 2–142 Author chain F； PDBConstruct 1–141； UniProt 2–142 Author chain K； PDBConstruct 1–141； UniProt 2–142 Author chain P； PDBConstruct 1–141； UniProt 2–142 Author chain U； PDBConstruct 1–141； UniProt 2–142 Author chain Z； PDBConstruct 1–141； UniProt 2–142

Hemoglobin subunit beta

OrganismNot specified

UniProt P68871

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Other combination	Heteromer	Protein 10 其他Polymer 3	Hemoglobin subunit alpha × 2 （P69905） Haptoglobin × 2 （P00738） Iron-regulated surface determinant protein H × 2 （Q99TD3） Haptoglobin-hemoglobin receptor × 2 （I7BA80） 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 3 PROTOPORPHYRIN IX CONTAINING FE × 4 OXYGEN MOLECULE × 4 2-acetamido-2-deoxy-beta-D-glucopyranose × 8	Consistent with protein count
2	Other combination	Heteromer	Protein 10 其他Polymer 4	Hemoglobin subunit alpha × 2 （P69905） Haptoglobin × 2 （P00738） Iron-regulated surface determinant protein H × 2 （Q99TD3） Haptoglobin-hemoglobin receptor × 2 （I7BA80） 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 4 PROTOPORPHYRIN IX CONTAINING FE × 4 OXYGEN MOLECULE × 4 2-acetamido-2-deoxy-beta-D-glucopyranose × 8	Consistent with protein count
3	Other combination	Heteromer	Protein 10 其他Polymer 3	Hemoglobin subunit alpha × 2 （P69905） Haptoglobin × 2 （P00738） Iron-regulated surface determinant protein H × 2 （Q99TD3） Haptoglobin-hemoglobin receptor × 2 （I7BA80） 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 3 PROTOPORPHYRIN IX CONTAINING FE × 4 OXYGEN MOLECULE × 4 2-acetamido-2-deoxy-beta-D-glucopyranose × 7	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	HBB_HUMAN
Isoform	—
PDB entities	2
Chains and sequence ranges	Author chain 1； PDBConstruct 1–146； UniProt 2–147 Author chain B； PDBConstruct 1–146； UniProt 2–147 Author chain G； PDBConstruct 1–146； UniProt 2–147 Author chain L； PDBConstruct 1–146； UniProt 2–147 Author chain Q； PDBConstruct 1–146； UniProt 2–147 Author chain V； PDBConstruct 1–146； UniProt 2–147

Haptoglobin

OrganismNot specified

UniProt P00738

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Other combination	Heteromer	Protein 10 其他Polymer 3	Hemoglobin subunit alpha × 2 （P69905） Hemoglobin subunit beta × 2 （P68871） Iron-regulated surface determinant protein H × 2 （Q99TD3） Haptoglobin-hemoglobin receptor × 2 （I7BA80） 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 3 PROTOPORPHYRIN IX CONTAINING FE × 4 OXYGEN MOLECULE × 4 2-acetamido-2-deoxy-beta-D-glucopyranose × 8	Consistent with protein count
2	Other combination	Heteromer	Protein 10 其他Polymer 4	Hemoglobin subunit alpha × 2 （P69905） Hemoglobin subunit beta × 2 （P68871） Iron-regulated surface determinant protein H × 2 （Q99TD3） Haptoglobin-hemoglobin receptor × 2 （I7BA80） 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 4 PROTOPORPHYRIN IX CONTAINING FE × 4 OXYGEN MOLECULE × 4 2-acetamido-2-deoxy-beta-D-glucopyranose × 8	Consistent with protein count
3	Other combination	Heteromer	Protein 10 其他Polymer 3	Hemoglobin subunit alpha × 2 （P69905） Hemoglobin subunit beta × 2 （P68871） Iron-regulated surface determinant protein H × 2 （Q99TD3） Haptoglobin-hemoglobin receptor × 2 （I7BA80） 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 3 PROTOPORPHYRIN IX CONTAINING FE × 4 OXYGEN MOLECULE × 4 2-acetamido-2-deoxy-beta-D-glucopyranose × 7	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	HPT_HUMAN
Isoform	—
PDB entities	3
Chains and sequence ranges	Author chain 2； PDBConstruct 1–315； UniProt 92–406 Author chain C； PDBConstruct 1–315； UniProt 92–406 Author chain H； PDBConstruct 1–315； UniProt 92–406 Author chain M； PDBConstruct 1–315； UniProt 92–406 Author chain R； PDBConstruct 1–315； UniProt 92–406 Author chain W； PDBConstruct 1–315； UniProt 92–406

Iron-regulated surface determinant protein H

Staphylococcus aureus subsp. aureus N315

UniProt Q99TD3

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Other combination	Heteromer	Protein 10 其他Polymer 3	Hemoglobin subunit alpha × 2 （P69905） Hemoglobin subunit beta × 2 （P68871） Haptoglobin × 2 （P00738） Haptoglobin-hemoglobin receptor × 2 （I7BA80） 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 3 PROTOPORPHYRIN IX CONTAINING FE × 4 OXYGEN MOLECULE × 4 2-acetamido-2-deoxy-beta-D-glucopyranose × 8	Consistent with protein count
2	Other combination	Heteromer	Protein 10 其他Polymer 4	Hemoglobin subunit alpha × 2 （P69905） Hemoglobin subunit beta × 2 （P68871） Haptoglobin × 2 （P00738） Haptoglobin-hemoglobin receptor × 2 （I7BA80） 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 4 PROTOPORPHYRIN IX CONTAINING FE × 4 OXYGEN MOLECULE × 4 2-acetamido-2-deoxy-beta-D-glucopyranose × 8	Consistent with protein count
3	Other combination	Heteromer	Protein 10 其他Polymer 3	Hemoglobin subunit alpha × 2 （P69905） Hemoglobin subunit beta × 2 （P68871） Haptoglobin × 2 （P00738） Haptoglobin-hemoglobin receptor × 2 （I7BA80） 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 3 PROTOPORPHYRIN IX CONTAINING FE × 4 OXYGEN MOLECULE × 4 2-acetamido-2-deoxy-beta-D-glucopyranose × 7	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	ISDH_STAAN
Isoform	—
PDB entities	4
Chains and sequence ranges	Author chain 3； PDBConstruct 3–146； UniProt 86–229 Author chain D； PDBConstruct 3–146； UniProt 86–229 Author chain I； PDBConstruct 3–146； UniProt 86–229 Author chain N； PDBConstruct 3–146； UniProt 86–229 Author chain S； PDBConstruct 3–146； UniProt 86–229 Author chain X； PDBConstruct 3–146； UniProt 86–229

Haptoglobin-hemoglobin receptor

Trypanosoma brucei brucei

UniProt I7BA80

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Other combination	Heteromer	Protein 10 其他Polymer 3	Hemoglobin subunit alpha × 2 （P69905） Hemoglobin subunit beta × 2 （P68871） Haptoglobin × 2 （P00738） Iron-regulated surface determinant protein H × 2 （Q99TD3） 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 3 PROTOPORPHYRIN IX CONTAINING FE × 4 OXYGEN MOLECULE × 4 2-acetamido-2-deoxy-beta-D-glucopyranose × 8	Consistent with protein count
2	Other combination	Heteromer	Protein 10 其他Polymer 4	Hemoglobin subunit alpha × 2 （P69905） Hemoglobin subunit beta × 2 （P68871） Haptoglobin × 2 （P00738） Iron-regulated surface determinant protein H × 2 （Q99TD3） 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 4 PROTOPORPHYRIN IX CONTAINING FE × 4 OXYGEN MOLECULE × 4 2-acetamido-2-deoxy-beta-D-glucopyranose × 8	Consistent with protein count
3	Other combination	Heteromer	Protein 10 其他Polymer 3	Hemoglobin subunit alpha × 2 （P69905） Hemoglobin subunit beta × 2 （P68871） Haptoglobin × 2 （P00738） Iron-regulated surface determinant protein H × 2 （Q99TD3） 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 3 PROTOPORPHYRIN IX CONTAINING FE × 4 OXYGEN MOLECULE × 4 2-acetamido-2-deoxy-beta-D-glucopyranose × 7	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	I7BA80_TRYBB
Isoform	—
PDB entities	5
Chains and sequence ranges	Author chain 4； PDBConstruct 1–343； UniProt 36–378 Author chain E； PDBConstruct 1–343； UniProt 36–378 Author chain J； PDBConstruct 1–343； UniProt 36–378 Author chain O； PDBConstruct 1–343； UniProt 36–378 Author chain T； PDBConstruct 1–343； UniProt 36–378 Author chain Y； PDBConstruct 1–343； UniProt 36–378

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	4wjg
Deposition date deposition_date	2014-09-30
Structure title title	Structure of T. brucei haptoglobin-hemoglobin receptor binding to human haptoglobin-hemoglobin
Keywords keywords	Endocytosis, Trypanosome, Receptor; ENDOCYTOSIS
Experimental Method method	X-RAY DIFFRACTION

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

4wjg__assembly_3__model_1

Assembly 3 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

4wjg__assembly_3__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

4wjg__assembly_3__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	63.89 Å
Rg (electron density)	65.01 Å
Total Rg	64.78 Å
Atom count	15912
Residues	2004
Excluded volume	282650 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`4wjg__assembly_1__model_1`	Decameric （10）	Success	4.1.3-1-20251215 (887e7ef)	View Download
2	1	`4wjg__assembly_2__model_1`	Decameric （10）	Success	4.1.3-1-20251215 (887e7ef)	View Download
3	1	`4wjg__assembly_3__model_1`	Decameric （10）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (9)

Entity 1 Entity 1 polymer

Description description	Hemoglobin subunit alpha
Molecular weight formula_weight	15150.4 kDa
Source method src_method	nat
Copy count entity_count	6

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	A,F,K,P,U,Z
Atom count atom_count	47792

VLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHGKKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTPAVHASLDKFLASVSTVLTSKYR

Entity 2 Entity 2 polymer

Description description	Hemoglobin subunit beta
Molecular weight formula_weight	15890.2 kDa
Source method src_method	nat
Copy count entity_count	6

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	B,G,L,Q,V,1

VHLTPEEKSAVTALWGKVNVDEVGGEALGRLLVVYPWTQRFFESFGDLSTPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLKGTFATLSELHCDKLHVDPENFRLLGNVLVCVLAHHFGKEFTPPVQAAYQKVVAGVANALAHKYH

Entity 3 Entity 3 polymer

Description description	Haptoglobin
Molecular weight formula_weight	35267.1 kDa
Source method src_method	nat
Copy count entity_count	6

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	C,H,M,R,W,2

CPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDKSCAVAEYGVYVKVTSIQDWVQKTIAEN

Entity 4 Entity 4 polymer

Description description	Iron-regulated surface determinant protein H
Molecular weight formula_weight	16877.6 kDa
Source method src_method	man
Copy count entity_count	6

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	D,I,N,S,X,3

GSADESLKDAIKDPALENKEHDIGPREQVNFQLLDKNNETQYYHFFSIKDPADVYYTKKKAEVELDINTASTWKKFEVYENNQKLPVRLVSYSPVPEDHAYIRFPVSDGTQELKIVSSTQIDDGEETNYDYTKLVFAKPIYNDPSL

Source Source

Source organism organism	Staphylococcus aureus subsp. aureus N315
NCBI taxonomy ID ncbi_taxonomy_id	158879
Host organism host_organism	Escherichia coli BL21(DE3)

Entity 5 Entity 5 polymer

Description description	Haptoglobin-hemoglobin receptor
Molecular weight formula_weight	36848.6 kDa
Source method src_method	man
Copy count entity_count	6

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	E,J,O,T,Y,4

AEGLKTKDEVEKACHLAQQLKEVSITLGVIYRTTERHSVQVEAHKTAIDKHADAVSRAVEALTRVDVALQRLKELGKANDTKAVKIIENITSARENLALFNNETQAVLTARDHVHKHRAAALQGWSDAKEKGDAAAEDVWVLLNAAKKGNGSADVKAAAEKCSRYSSSSTSETELQKAIDAAANVGGLSAHKSKYGDVLNKFKLSNASVGAVRDTSGRGGKHMEKVNNVAKLLKDAEVSLAAAAAEIEEVKNAHETKAQEEMKRNGNPIENESETNSGGNAESQGNGDREDKNDEQQQVDEEETKVENGSSEEGSCCGNESNGPHVMKKRHGVEGPRPVDVVS

Source Source

Source organism organism	Trypanosoma brucei brucei
NCBI taxonomy ID ncbi_taxonomy_id	5702
Host organism host_organism	Komagataella pastoris

Entity 6 Entity 6 branched

Description description	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Molecular weight formula_weight	424.4 kDa
Source method src_method	man
Copy count entity_count	10

Source Source

Source organism organism	Trypanosoma brucei brucei
NCBI taxonomy ID ncbi_taxonomy_id	5702
Host organism host_organism	Komagataella pastoris

Entity 7 Entity 7 non-polymer

Description description	PROTOPORPHYRIN IX CONTAINING FE
Molecular weight formula_weight	616.5 kDa
Source method src_method	syn
Copy count entity_count	12

Entity 8 Entity 8 non-polymer

Description description	OXYGEN MOLECULE
Molecular weight formula_weight	32.0 kDa
Source method src_method	syn
Copy count entity_count	12

Entity 9 Entity 9 non-polymer

Description description	2-acetamido-2-deoxy-beta-D-glucopyranose
Molecular weight formula_weight	221.2 kDa
Source method src_method	man
Copy count entity_count	23

Source Source

Source organism organism	Trypanosoma brucei brucei
NCBI taxonomy ID ncbi_taxonomy_id	5702
Host organism host_organism	Komagataella pastoris

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6. Fold Classification (SCOP + CATH) 60 domains

SCOP 2.08 (18 domains)

Domain ID domain_id	d4wjg1_
Class class	a — All alpha proteins
Fold Fold fold	a.1 — Globin-like
Superfamily Superfamily superfamily	a.1.1 — Globin-like
Family Family family	a.1.1.2 — Globins

Domain ID domain_id	d4wjg3_
Class class	b — All beta proteins
Fold Fold fold	b.1 — Immunoglobulin-like beta-sandwich
Superfamily Superfamily superfamily	b.1.28 — NEAT domain-like
Family Family family	b.1.28.1 — NEAT domain

Domain ID domain_id	d4wjga_
Class class	a — All alpha proteins
Fold Fold fold	a.1 — Globin-like
Superfamily Superfamily superfamily	a.1.1 — Globin-like
Family Family family	a.1.1.2 — Globins

Domain ID domain_id	d4wjgb_
Class class	a — All alpha proteins
Fold Fold fold	a.1 — Globin-like
Superfamily Superfamily superfamily	a.1.1 — Globin-like
Family Family family	a.1.1.2 — Globins

Domain ID domain_id	d4wjgd_
Class class	b — All beta proteins
Fold Fold fold	b.1 — Immunoglobulin-like beta-sandwich
Superfamily Superfamily superfamily	b.1.28 — NEAT domain-like
Family Family family	b.1.28.1 — NEAT domain

Domain ID domain_id	d4wjgf_
Class class	a — All alpha proteins
Fold Fold fold	a.1 — Globin-like
Superfamily Superfamily superfamily	a.1.1 — Globin-like
Family Family family	a.1.1.2 — Globins

Domain ID domain_id	d4wjgg_
Class class	a — All alpha proteins
Fold Fold fold	a.1 — Globin-like
Superfamily Superfamily superfamily	a.1.1 — Globin-like
Family Family family	a.1.1.2 — Globins

Domain ID domain_id	d4wjgi_
Class class	b — All beta proteins
Fold Fold fold	b.1 — Immunoglobulin-like beta-sandwich
Superfamily Superfamily superfamily	b.1.28 — NEAT domain-like
Family Family family	b.1.28.1 — NEAT domain

Domain ID domain_id	d4wjgk_
Class class	a — All alpha proteins
Fold Fold fold	a.1 — Globin-like
Superfamily Superfamily superfamily	a.1.1 — Globin-like
Family Family family	a.1.1.2 — Globins

Domain ID domain_id	d4wjgl_
Class class	a — All alpha proteins
Fold Fold fold	a.1 — Globin-like
Superfamily Superfamily superfamily	a.1.1 — Globin-like
Family Family family	a.1.1.2 — Globins

Domain ID domain_id	d4wjgn_
Class class	b — All beta proteins
Fold Fold fold	b.1 — Immunoglobulin-like beta-sandwich
Superfamily Superfamily superfamily	b.1.28 — NEAT domain-like
Family Family family	b.1.28.1 — NEAT domain

Domain ID domain_id	d4wjgp_
Class class	a — All alpha proteins
Fold Fold fold	a.1 — Globin-like
Superfamily Superfamily superfamily	a.1.1 — Globin-like
Family Family family	a.1.1.2 — Globins

Domain ID domain_id	d4wjgq_
Class class	a — All alpha proteins
Fold Fold fold	a.1 — Globin-like
Superfamily Superfamily superfamily	a.1.1 — Globin-like
Family Family family	a.1.1.2 — Globins

Domain ID domain_id	d4wjgs_
Class class	b — All beta proteins
Fold Fold fold	b.1 — Immunoglobulin-like beta-sandwich
Superfamily Superfamily superfamily	b.1.28 — NEAT domain-like
Family Family family	b.1.28.1 — NEAT domain

Domain ID domain_id	d4wjgu_
Class class	a — All alpha proteins
Fold Fold fold	a.1 — Globin-like
Superfamily Superfamily superfamily	a.1.1 — Globin-like
Family Family family	a.1.1.2 — Globins

Domain ID domain_id	d4wjgv_
Class class	a — All alpha proteins
Fold Fold fold	a.1 — Globin-like
Superfamily Superfamily superfamily	a.1.1 — Globin-like
Family Family family	a.1.1.2 — Globins

Domain ID domain_id	d4wjgx_
Class class	b — All beta proteins
Fold Fold fold	b.1 — Immunoglobulin-like beta-sandwich
Superfamily Superfamily superfamily	b.1.28 — NEAT domain-like
Family Family family	b.1.28.1 — NEAT domain

Domain ID domain_id	d4wjgz_
Class class	a — All alpha proteins
Fold Fold fold	a.1 — Globin-like
Superfamily Superfamily superfamily	a.1.1 — Globin-like
Family Family family	a.1.1.2 — Globins

CATH v4.4 (42 domains)

Domain ID domain_id	4wjg100
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	490 — Globin-like
Homologous superfamily homologous superfamily	10 — Globins

Domain ID domain_id	4wjg201
Class class	2 — Mainly Beta
Architecture architecture	10 — Ribbon
Topology topology	70 — Complement Module; domain 1
Homologous superfamily homologous superfamily	10 — Complement Module, domain 1

Domain ID domain_id	4wjg202
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	10 — Thrombin, subunit H
Homologous superfamily homologous superfamily	10 — Trypsin-like serine proteases

Domain ID domain_id	4wjg203
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	10 — Thrombin, subunit H
Homologous superfamily homologous superfamily	10 — Trypsin-like serine proteases

Domain ID domain_id	4wjg300
Class class	2 — Mainly Beta
Architecture architecture	60 — Sandwich
Topology topology	40 — Immunoglobulin-like
Homologous superfamily homologous superfamily	1850 —

Domain ID domain_id	4wjg400
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	1260 — Ferritin
Homologous superfamily homologous superfamily	80 —

Domain ID domain_id	4wjgA00
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	490 — Globin-like
Homologous superfamily homologous superfamily	10 — Globins

Domain ID domain_id	4wjgB00
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	490 — Globin-like
Homologous superfamily homologous superfamily	10 — Globins

Domain ID domain_id	4wjgC01
Class class	2 — Mainly Beta
Architecture architecture	10 — Ribbon
Topology topology	70 — Complement Module; domain 1
Homologous superfamily homologous superfamily	10 — Complement Module, domain 1

Domain ID domain_id	4wjgC02
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	10 — Thrombin, subunit H
Homologous superfamily homologous superfamily	10 — Trypsin-like serine proteases

Domain ID domain_id	4wjgC03
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	10 — Thrombin, subunit H
Homologous superfamily homologous superfamily	10 — Trypsin-like serine proteases

Domain ID domain_id	4wjgD00
Class class	2 — Mainly Beta
Architecture architecture	60 — Sandwich
Topology topology	40 — Immunoglobulin-like
Homologous superfamily homologous superfamily	1850 —

Domain ID domain_id	4wjgE00
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	1260 — Ferritin
Homologous superfamily homologous superfamily	80 —

Domain ID domain_id	4wjgF00
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	490 — Globin-like
Homologous superfamily homologous superfamily	10 — Globins

Domain ID domain_id	4wjgG00
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	490 — Globin-like
Homologous superfamily homologous superfamily	10 — Globins

Domain ID domain_id	4wjgH01
Class class	2 — Mainly Beta
Architecture architecture	10 — Ribbon
Topology topology	70 — Complement Module; domain 1
Homologous superfamily homologous superfamily	10 — Complement Module, domain 1

Domain ID domain_id	4wjgH02
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	10 — Thrombin, subunit H
Homologous superfamily homologous superfamily	10 — Trypsin-like serine proteases

Domain ID domain_id	4wjgH03
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	10 — Thrombin, subunit H
Homologous superfamily homologous superfamily	10 — Trypsin-like serine proteases

Domain ID domain_id	4wjgI00
Class class	2 — Mainly Beta
Architecture architecture	60 — Sandwich
Topology topology	40 — Immunoglobulin-like
Homologous superfamily homologous superfamily	1850 —

Domain ID domain_id	4wjgJ00
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	1260 — Ferritin
Homologous superfamily homologous superfamily	80 —

Domain ID domain_id	4wjgK00
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	490 — Globin-like
Homologous superfamily homologous superfamily	10 — Globins

Domain ID domain_id	4wjgL00
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	490 — Globin-like
Homologous superfamily homologous superfamily	10 — Globins

Domain ID domain_id	4wjgM01
Class class	2 — Mainly Beta
Architecture architecture	10 — Ribbon
Topology topology	70 — Complement Module; domain 1
Homologous superfamily homologous superfamily	10 — Complement Module, domain 1

Domain ID domain_id	4wjgM02
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	10 — Thrombin, subunit H
Homologous superfamily homologous superfamily	10 — Trypsin-like serine proteases

Domain ID domain_id	4wjgM03
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	10 — Thrombin, subunit H
Homologous superfamily homologous superfamily	10 — Trypsin-like serine proteases

Domain ID domain_id	4wjgN00
Class class	2 — Mainly Beta
Architecture architecture	60 — Sandwich
Topology topology	40 — Immunoglobulin-like
Homologous superfamily homologous superfamily	1850 —

Domain ID domain_id	4wjgO00
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	1260 — Ferritin
Homologous superfamily homologous superfamily	80 —

Domain ID domain_id	4wjgP00
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	490 — Globin-like
Homologous superfamily homologous superfamily	10 — Globins

Domain ID domain_id	4wjgQ00
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	490 — Globin-like
Homologous superfamily homologous superfamily	10 — Globins

Domain ID domain_id	4wjgR01
Class class	2 — Mainly Beta
Architecture architecture	10 — Ribbon
Topology topology	70 — Complement Module; domain 1
Homologous superfamily homologous superfamily	10 — Complement Module, domain 1

Domain ID domain_id	4wjgR02
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	10 — Thrombin, subunit H
Homologous superfamily homologous superfamily	10 — Trypsin-like serine proteases

Domain ID domain_id	4wjgR03
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	10 — Thrombin, subunit H
Homologous superfamily homologous superfamily	10 — Trypsin-like serine proteases

Domain ID domain_id	4wjgS00
Class class	2 — Mainly Beta
Architecture architecture	60 — Sandwich
Topology topology	40 — Immunoglobulin-like
Homologous superfamily homologous superfamily	1850 —

Domain ID domain_id	4wjgT00
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	1260 — Ferritin
Homologous superfamily homologous superfamily	80 —

Domain ID domain_id	4wjgU00
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	490 — Globin-like
Homologous superfamily homologous superfamily	10 — Globins

Domain ID domain_id	4wjgV00
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	490 — Globin-like
Homologous superfamily homologous superfamily	10 — Globins

Domain ID domain_id	4wjgW01
Class class	2 — Mainly Beta
Architecture architecture	10 — Ribbon
Topology topology	70 — Complement Module; domain 1
Homologous superfamily homologous superfamily	10 — Complement Module, domain 1

Domain ID domain_id	4wjgW02
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	10 — Thrombin, subunit H
Homologous superfamily homologous superfamily	10 — Trypsin-like serine proteases

Domain ID domain_id	4wjgW03
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	10 — Thrombin, subunit H
Homologous superfamily homologous superfamily	10 — Trypsin-like serine proteases

Domain ID domain_id	4wjgX00
Class class	2 — Mainly Beta
Architecture architecture	60 — Sandwich
Topology topology	40 — Immunoglobulin-like
Homologous superfamily homologous superfamily	1850 —

Domain ID domain_id	4wjgY00
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	1260 — Ferritin
Homologous superfamily homologous superfamily	80 —

Domain ID domain_id	4wjgZ00
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	490 — Globin-like
Homologous superfamily homologous superfamily	10 — Globins

▶

Unit-cell length a length_a	143.230 Å
Unit-cell length b length_b	140.950 Å
Unit-cell length c length_c	267.180 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	98.54 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	12

Space group space_group	P 1 21 1
Space-group number int_tables_number	4
Crystal system crystal_system	—

Resolution resolution	3.100 Å
Low-resolution limit resolution_low	29.000 Å
R factor r_factor	0.2553
R_work r_work	0.2551
R_free r_free	0.2709

Structure of T. brucei haptoglobin-hemoglobin receptor binding to human haptoglobin-hemoglobin

1. Protein Identity and Related Structures Protein Identity & Related Structures

Hemoglobin subunit alpha

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Hemoglobin subunit beta

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Haptoglobin

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Iron-regulated surface determinant protein H

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Haptoglobin-hemoglobin receptor

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

4wjg__assembly_3__model_1

4wjg__assembly_3__model_1 | I(q)

4wjg__assembly_3__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

Refinement Refinement

Diffraction experiment Diffraction

5. Entities and Polymers Entities & Polymers (9)

Entity 1 Entity 1 polymer

Polymer Polymer

Entity 2 Entity 2 polymer

Polymer Polymer

Entity 3 Entity 3 polymer

Polymer Polymer

Entity 4 Entity 4 polymer

Polymer Polymer

Source Source

Entity 5 Entity 5 polymer

Polymer Polymer

Source Source

Entity 6 Entity 6 branched

Source Source

Entity 7 Entity 7 non-polymer

Entity 8 Entity 8 non-polymer

Entity 9 Entity 9 non-polymer

Source Source

6. Fold Classification (SCOP + CATH) 60 domains

SCOP 2.08 (18 domains)

CATH v4.4 (42 domains)

7. Citations (1)