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4z07

Co-crystal structure of the tandem CNB (CNB-A/B) domains of human PKG I beta with cGMP

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

cGMP-dependent protein kinase 1

Homo sapiens

UniProt Q13976

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 2 CYCLIC GUANOSINE MONOPHOSPHATE × 4 SULFATE ION × 1 ISOPROPYL ALCOHOL × 2 water × 2 Consistent with protein count
2 Protein monomer Monomer Protein 1 CYCLIC GUANOSINE MONOPHOSPHATE × 1 water × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
4ku7 4ku8 4ku8 4ku8 4qx5 4qxk 4z07 5j48 5j48 5jax 5jd7 5l0n

30 assemblies; showing the first 12

Homodimer
1zxa 4r4l 4r4l 4r4m 4r4m 4z07 7lv3

7 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex

None

View Construct and Data Evidence
UniProt name KGP1_HUMAN
Isoform Q13976-2
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 3–262； UniProt 92–351 Author chain C； PDBConstruct 3–262； UniProt 92–351 Author chain E； PDBConstruct 3–262； UniProt 92–351

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id4z07
Deposition date deposition_date2015-03-25
Structure title titleCo-crystal structure of the tandem CNB (CNB-A/B) domains of human PKG I beta with cGMP
Keywords keywordscGMP-binding domains, cGMP mediated dimeric interface, allosteric regulatory domain, serine-threonine kinase, TRANSFERASE; TRANSFERASE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

4z07__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

4z07__assembly_1__model_1 | I(q)

10-2 10-1 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

4z07__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）31.84 Å
Rg (electron density)31.50 Å
Total Rg31.49 Å
Atom count4130
Residues518
Excluded volume73778 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 4z07__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 4z07__assembly_2__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (5)

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6. Fold Classification (SCOP + CATH) 10 domains

SCOP 2.08 (5 domains)

Domain ID domain_idd4z07a1
Class classb — All beta proteins
Fold Fold foldb.82 — Double-stranded beta-helix
Superfamily Superfamily superfamilyb.82.3 — cAMP-binding domain-like
Family Family familyb.82.3.0 — automated matches
Domain ID domain_idd4z07a2
Class classb — All beta proteins
Fold Fold foldb.82 — Double-stranded beta-helix
Superfamily Superfamily superfamilyb.82.3 — cAMP-binding domain-like
Family Family familyb.82.3.0 — automated matches
Domain ID domain_idd4z07c1
Class classb — All beta proteins
Fold Fold foldb.82 — Double-stranded beta-helix
Superfamily Superfamily superfamilyb.82.3 — cAMP-binding domain-like
Family Family familyb.82.3.0 — automated matches
Domain ID domain_idd4z07c2
Class classb — All beta proteins
Fold Fold foldb.82 — Double-stranded beta-helix
Superfamily Superfamily superfamilyb.82.3 — cAMP-binding domain-like
Family Family familyb.82.3.0 — automated matches
Domain ID domain_idd4z07e_
Class classb — All beta proteins
Fold Fold foldb.82 — Double-stranded beta-helix
Superfamily Superfamily superfamilyb.82.3 — cAMP-binding domain-like
Family Family familyb.82.3.0 — automated matches

CATH v4.4 (5 domains)

Domain ID domain_id4z07A01
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology120 — Jelly Rolls
Homologous superfamily homologous superfamily10 — Jelly Rolls
Domain ID domain_id4z07A02
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology120 — Jelly Rolls
Homologous superfamily homologous superfamily10 — Jelly Rolls
Domain ID domain_id4z07C01
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology120 — Jelly Rolls
Homologous superfamily homologous superfamily10 — Jelly Rolls
Domain ID domain_id4z07C02
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology120 — Jelly Rolls
Homologous superfamily homologous superfamily10 — Jelly Rolls
Domain ID domain_id4z07E00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology120 — Jelly Rolls
Homologous superfamily homologous superfamily10 — Jelly Rolls
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7. Citations (1)