SAXSdb — 5bpv

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1. Protein Identity and Related Structures Protein Identity & Related Structures

Polymerase cofactor VP35

Zaire ebolavirus

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein monomer	Monomer	Protein 1	water × 1	Consistent with protein count
2	Protein monomer	Monomer	Protein 1	water × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	VP35_EBOZ5
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 1–124； UniProt 217–340 Author chain B； PDBConstruct 1–124； UniProt 217–340

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	5bpv
Deposition date deposition_date	2015-05-28
Structure title title	Crystal Structure of Zaire ebolavirus VP35 RNA binding domain mutant I278A
Keywords keywords	Polymerase cofactor, Interferon inhibitor, viral protein; VIRAL PROTEIN
Experimental Method method	X-RAY DIFFRACTION

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

5bpv__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

5bpv__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

5bpv__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	15.72 Å
Rg (electron density)	14.28 Å
Total Rg	15.38 Å
Atom count	1931
Residues	124
Excluded volume	17124 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`5bpv__assembly_1__model_1`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
2	1	`5bpv__assembly_2__model_1`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (2)

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6. Fold Classification (SCOP + CATH) 6 domains

SCOP 2.08 (2 domains)

Domain ID domain_id	d5bpva_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.388 — Filoviridae VP35-like
Superfamily Superfamily superfamily	d.388.1 — Filoviridae VP35-like
Family Family family	d.388.1.1 — Filoviridae VP35

Domain ID domain_id	d5bpvb_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.388 — Filoviridae VP35-like
Superfamily Superfamily superfamily	d.388.1 — Filoviridae VP35-like
Family Family family	d.388.1.1 — Filoviridae VP35

CATH v4.4 (4 domains)

Domain ID domain_id	5bpvA01
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	8 — Helicase, Ruva Protein; domain 3
Homologous superfamily homologous superfamily	950 — Filoviridae VP35, C-terminal inhibitory domain, helical subdomain

Domain ID domain_id	5bpvA02
Class class	2 — Mainly Beta
Architecture architecture	10 — Ribbon
Topology topology	10 — Seminal Fluid Protein PDC-109 (Domain B)
Homologous superfamily homologous superfamily	70 — Filoviridae VP35, C-terminal inhibitory domain, beta-sheet subdomain

Domain ID domain_id	5bpvB01
Class class	1 — Mainly Alpha
Architecture architecture	10 — Orthogonal Bundle
Topology topology	8 — Helicase, Ruva Protein; domain 3
Homologous superfamily homologous superfamily	950 — Filoviridae VP35, C-terminal inhibitory domain, helical subdomain

Domain ID domain_id	5bpvB02
Class class	2 — Mainly Beta
Architecture architecture	10 — Ribbon
Topology topology	10 — Seminal Fluid Protein PDC-109 (Domain B)
Homologous superfamily homologous superfamily	70 — Filoviridae VP35, C-terminal inhibitory domain, beta-sheet subdomain

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Unit-cell length a length_a	51.750 Å
Unit-cell length b length_b	65.660 Å
Unit-cell length c length_c	72.020 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	90.00 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	8

Space group space_group	P 21 21 21
Space-group number int_tables_number	19
Crystal system crystal_system	—

Resolution resolution	1.952 Å
Low-resolution limit resolution_low	13.905 Å
R factor r_factor	0.1821
R_work r_work	0.1802
R_free r_free	0.2184

Description description	Polymerase cofactor VP35
Molecular weight formula_weight	13655.8 kDa
Mutation mutation	I278A
Source method src_method	man
Copy count entity_count	2

Polymer type type	polypeptide(L)
Chain IDs strand_id	A,B
Atom count atom_count	4188

Crystal Structure of Zaire ebolavirus VP35 RNA binding domain mutant I278A

1. Protein Identity and Related Structures Protein Identity & Related Structures

Polymerase cofactor VP35

State in the Current Structure

Other States of the Same Protein in the Database

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

5bpv__assembly_1__model_1

5bpv__assembly_1__model_1 | I(q)

5bpv__assembly_1__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

Refinement Refinement

Diffraction experiment Diffraction

5. Entities and Polymers Entities & Polymers (2)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

Entity 2 Entity 2 water

6. Fold Classification (SCOP + CATH) 6 domains

SCOP 2.08 (2 domains)

CATH v4.4 (4 domains)

7. Citations (1)

Source organism organism	Zaire ebolavirus
Common name common_name	ZEBOV
NCBI taxonomy ID ncbi_taxonomy_id	186538
Host organism host_organism	Escherichia coli

Description description	water
Molecular weight formula_weight	18.0 kDa
Source method src_method	nat
Copy count entity_count	263

Crystal Structure of Zaire ebolavirus VP35 RNA binding domain mutant I278A

1. Protein Identity and Related Structures Protein Identity & Related Structures

Polymerase cofactor VP35

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

5bpv__assembly_1__model_1

5bpv__assembly_1__model_1 | I(q)

5bpv__assembly_1__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

Refinement Refinement

Diffraction experiment Diffraction

5. Entities and Polymers Entities & Polymers (2)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

Entity 2 Entity 2 water

6. Fold Classification (SCOP + CATH) 6 domains

SCOP 2.08 (2 domains)

CATH v4.4 (4 domains)

7. Citations (1)