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5cus

Crystal Structure of sErbB3-Fab3379 Complex

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Receptor tyrosine-protein kinase erbB-3

Homo sapiens

UniProt P21860

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 3 IgG H chain × 1 （S6B291） Fab LC region of KTN3379 × 1 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 3 IgG H chain × 1 （S6B291） Fab LC region of KTN3379 × 1 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 3 IgG H chain × 1 （S6B291） Fab LC region of KTN3379 × 1 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 3 IgG H chain × 1 （S6B291） Fab LC region of KTN3379 × 1 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
3lmg 3lmg 6op9

3 assemblies

Homodimer
2l9u 3kex 3kex

3 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1m6b 1m6b 3p11 4leo 4p59 4riw 4riw 4rix 4rix 4riy 4riy 5cus

30 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name ERBB3_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–622； UniProt 20–641 Author chain B； PDBConstruct 1–622； UniProt 20–641 Author chain C； PDBConstruct 1–622； UniProt 20–641 Author chain D； PDBConstruct 1–622； UniProt 20–641

IgG H chain

Homo sapiens

UniProt S6B291

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 3 Receptor tyrosine-protein kinase erbB-3 × 1 （P21860） Fab LC region of KTN3379 × 1 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 3 Receptor tyrosine-protein kinase erbB-3 × 1 （P21860） Fab LC region of KTN3379 × 1 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 3 Receptor tyrosine-protein kinase erbB-3 × 1 （P21860） Fab LC region of KTN3379 × 1 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 3 Receptor tyrosine-protein kinase erbB-3 × 1 （P21860） Fab LC region of KTN3379 × 1 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
3mnw 3mnw 3mnz 4eow 4ydv 4ydv 5c7k 5cus 5cus 5cus 5cus 5d9q

49 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name S6B291_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain H； PDBConstruct 1–221； UniProt 20–239 Author chain I； PDBConstruct 1–221； UniProt 20–239 Author chain J； PDBConstruct 1–221； UniProt 20–239 Author chain K； PDBConstruct 1–221； UniProt 20–239

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id5cus
Deposition date deposition_date2015-07-25
Structure title titleCrystal Structure of sErbB3-Fab3379 Complex
Keywords keywordsErbB3, Antibody, TRANSFERASE; TRANSFERASE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

5cus__assembly_2__model_1

Assembly 2 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

5cus__assembly_2__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

5cus__assembly_2__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）37.15 Å
Rg (electron density)36.48 Å
Total Rg36.87 Å
Atom count6603
Residues931
Excluded volume115820 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 5cus__assembly_1__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 5cus__assembly_2__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 5cus__assembly_3__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
4 1 5cus__assembly_4__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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6. Fold Classification (SCOP + CATH) 20 domains

CATH v4.4 (20 domains)

Domain ID domain_id5cusB01
Class class3 — Alpha Beta
Architecture architecture80 — Alpha-Beta Horseshoe
Topology topology20 — 24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a'; Chain A
Homologous superfamily homologous superfamily20 — Receptor L-domain
Domain ID domain_id5cusB02
Class class2 — Mainly Beta
Architecture architecture10 — Ribbon
Topology topology220 — Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A domain 2
Homologous superfamily homologous superfamily10 — Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2
Domain ID domain_id5cusB03
Class class3 — Alpha Beta
Architecture architecture80 — Alpha-Beta Horseshoe
Topology topology20 — 24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a'; Chain A
Homologous superfamily homologous superfamily20 — Receptor L-domain
Domain ID domain_id5cusB04
Class class2 — Mainly Beta
Architecture architecture10 — Ribbon
Topology topology220 — Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A domain 2
Homologous superfamily homologous superfamily10 — Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2
Domain ID domain_id5cusH01
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id5cusH02
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id5cusI01
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id5cusI02
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id5cusJ01
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id5cusJ02
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id5cusK01
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id5cusK02
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id5cusL01
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id5cusL02
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id5cusM01
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id5cusM02
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id5cusN01
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id5cusN02
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id5cusO01
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id5cusO02
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
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7. Citations (1)