5g06

Cryo-EM structure of yeast cytoplasmic exosome

Method: ELECTRON MICROSCOPY

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1. Protein Identity and Related Structures Protein Identity & Related Structures

EXOSOME COMPLEX COMPONENT RRP45

OrganismNot specified

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 11	EXOSOME COMPLEX COMPONENT SKI6 × 1 （P46948） EXOSOME COMPLEX COMPONENT RRP43 × 1 （P25359） EXOSOME COMPLEX COMPONENT RRP46 × 1 （P53256） EXOSOME COMPLEX COMPONENT RRP42 × 1 （Q12277） EXOSOME COMPLEX COMPONENT MTR3 × 1 （P48240） EXOSOME COMPLEX COMPONENT RRP40 × 1 （Q08285） EXOSOME COMPLEX COMPONENT RRP4 × 1 （P38792） EXOSOME COMPLEX COMPONENT CSL4 × 1 （P53859） EXOSOME COMPLEX EXONUCLEASE DIS3 × 1 （Q08162） SUPERKILLER PROTEIN 7 × 1 （Q08491）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RRP45_YEAST
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 1–305； UniProt 1–305

EXOSOME COMPLEX COMPONENT SKI6

OrganismNot specified

UniProt P46948

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 11	EXOSOME COMPLEX COMPONENT RRP45 × 1 （Q05636） EXOSOME COMPLEX COMPONENT RRP43 × 1 （P25359） EXOSOME COMPLEX COMPONENT RRP46 × 1 （P53256） EXOSOME COMPLEX COMPONENT RRP42 × 1 （Q12277） EXOSOME COMPLEX COMPONENT MTR3 × 1 （P48240） EXOSOME COMPLEX COMPONENT RRP40 × 1 （Q08285） EXOSOME COMPLEX COMPONENT RRP4 × 1 （P38792） EXOSOME COMPLEX COMPONENT CSL4 × 1 （P53859） EXOSOME COMPLEX EXONUCLEASE DIS3 × 1 （Q08162） SUPERKILLER PROTEIN 7 × 1 （Q08491）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RRP41_YEAST
Isoform	—
PDB entities	2
Chains and sequence ranges	Author chain B； PDBConstruct 1–246； UniProt 1–246

EXOSOME COMPLEX COMPONENT RRP43

OrganismNot specified

UniProt P25359

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 11	EXOSOME COMPLEX COMPONENT RRP45 × 1 （Q05636） EXOSOME COMPLEX COMPONENT SKI6 × 1 （P46948） EXOSOME COMPLEX COMPONENT RRP46 × 1 （P53256） EXOSOME COMPLEX COMPONENT RRP42 × 1 （Q12277） EXOSOME COMPLEX COMPONENT MTR3 × 1 （P48240） EXOSOME COMPLEX COMPONENT RRP40 × 1 （Q08285） EXOSOME COMPLEX COMPONENT RRP4 × 1 （P38792） EXOSOME COMPLEX COMPONENT CSL4 × 1 （P53859） EXOSOME COMPLEX EXONUCLEASE DIS3 × 1 （Q08162） SUPERKILLER PROTEIN 7 × 1 （Q08491）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RRP43_YEAST
Isoform	—
PDB entities	3
Chains and sequence ranges	Author chain C； PDBConstruct 1–394； UniProt 1–394

EXOSOME COMPLEX COMPONENT RRP46

OrganismNot specified

UniProt P53256

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 11	EXOSOME COMPLEX COMPONENT RRP45 × 1 （Q05636） EXOSOME COMPLEX COMPONENT SKI6 × 1 （P46948） EXOSOME COMPLEX COMPONENT RRP43 × 1 （P25359） EXOSOME COMPLEX COMPONENT RRP42 × 1 （Q12277） EXOSOME COMPLEX COMPONENT MTR3 × 1 （P48240） EXOSOME COMPLEX COMPONENT RRP40 × 1 （Q08285） EXOSOME COMPLEX COMPONENT RRP4 × 1 （P38792） EXOSOME COMPLEX COMPONENT CSL4 × 1 （P53859） EXOSOME COMPLEX EXONUCLEASE DIS3 × 1 （Q08162） SUPERKILLER PROTEIN 7 × 1 （Q08491）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RRP46_YEAST
Isoform	—
PDB entities	4
Chains and sequence ranges	Author chain D； PDBConstruct 1–223； UniProt 1–223

EXOSOME COMPLEX COMPONENT RRP42

OrganismNot specified

UniProt Q12277

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 11	EXOSOME COMPLEX COMPONENT RRP45 × 1 （Q05636） EXOSOME COMPLEX COMPONENT SKI6 × 1 （P46948） EXOSOME COMPLEX COMPONENT RRP43 × 1 （P25359） EXOSOME COMPLEX COMPONENT RRP46 × 1 （P53256） EXOSOME COMPLEX COMPONENT MTR3 × 1 （P48240） EXOSOME COMPLEX COMPONENT RRP40 × 1 （Q08285） EXOSOME COMPLEX COMPONENT RRP4 × 1 （P38792） EXOSOME COMPLEX COMPONENT CSL4 × 1 （P53859） EXOSOME COMPLEX EXONUCLEASE DIS3 × 1 （Q08162） SUPERKILLER PROTEIN 7 × 1 （Q08491）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RRP42_YEAST
Isoform	—
PDB entities	5
Chains and sequence ranges	Author chain E； PDBConstruct 1–265； UniProt 1–265

EXOSOME COMPLEX COMPONENT MTR3

OrganismNot specified

UniProt P48240

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 11	EXOSOME COMPLEX COMPONENT RRP45 × 1 （Q05636） EXOSOME COMPLEX COMPONENT SKI6 × 1 （P46948） EXOSOME COMPLEX COMPONENT RRP43 × 1 （P25359） EXOSOME COMPLEX COMPONENT RRP46 × 1 （P53256） EXOSOME COMPLEX COMPONENT RRP42 × 1 （Q12277） EXOSOME COMPLEX COMPONENT RRP40 × 1 （Q08285） EXOSOME COMPLEX COMPONENT RRP4 × 1 （P38792） EXOSOME COMPLEX COMPONENT CSL4 × 1 （P53859） EXOSOME COMPLEX EXONUCLEASE DIS3 × 1 （Q08162） SUPERKILLER PROTEIN 7 × 1 （Q08491）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MTR3_YEAST
Isoform	—
PDB entities	6
Chains and sequence ranges	Author chain F； PDBConstruct 1–250； UniProt 1–250

EXOSOME COMPLEX COMPONENT RRP40

OrganismNot specified

UniProt Q08285

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 11	EXOSOME COMPLEX COMPONENT RRP45 × 1 （Q05636） EXOSOME COMPLEX COMPONENT SKI6 × 1 （P46948） EXOSOME COMPLEX COMPONENT RRP43 × 1 （P25359） EXOSOME COMPLEX COMPONENT RRP46 × 1 （P53256） EXOSOME COMPLEX COMPONENT RRP42 × 1 （Q12277） EXOSOME COMPLEX COMPONENT MTR3 × 1 （P48240） EXOSOME COMPLEX COMPONENT RRP4 × 1 （P38792） EXOSOME COMPLEX COMPONENT CSL4 × 1 （P53859） EXOSOME COMPLEX EXONUCLEASE DIS3 × 1 （Q08162） SUPERKILLER PROTEIN 7 × 1 （Q08491）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RRP40_YEAST
Isoform	—
PDB entities	7
Chains and sequence ranges	Author chain G； PDBConstruct 1–240； UniProt 1–240

EXOSOME COMPLEX COMPONENT RRP4

OrganismNot specified

UniProt P38792

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 11	EXOSOME COMPLEX COMPONENT RRP45 × 1 （Q05636） EXOSOME COMPLEX COMPONENT SKI6 × 1 （P46948） EXOSOME COMPLEX COMPONENT RRP43 × 1 （P25359） EXOSOME COMPLEX COMPONENT RRP46 × 1 （P53256） EXOSOME COMPLEX COMPONENT RRP42 × 1 （Q12277） EXOSOME COMPLEX COMPONENT MTR3 × 1 （P48240） EXOSOME COMPLEX COMPONENT RRP40 × 1 （Q08285） EXOSOME COMPLEX COMPONENT CSL4 × 1 （P53859） EXOSOME COMPLEX EXONUCLEASE DIS3 × 1 （Q08162） SUPERKILLER PROTEIN 7 × 1 （Q08491）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RRP4_YEAST
Isoform	—
PDB entities	8
Chains and sequence ranges	Author chain H； PDBConstruct 1–359； UniProt 1–359

EXOSOME COMPLEX COMPONENT CSL4

OrganismNot specified

UniProt P53859

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 11	EXOSOME COMPLEX COMPONENT RRP45 × 1 （Q05636） EXOSOME COMPLEX COMPONENT SKI6 × 1 （P46948） EXOSOME COMPLEX COMPONENT RRP43 × 1 （P25359） EXOSOME COMPLEX COMPONENT RRP46 × 1 （P53256） EXOSOME COMPLEX COMPONENT RRP42 × 1 （Q12277） EXOSOME COMPLEX COMPONENT MTR3 × 1 （P48240） EXOSOME COMPLEX COMPONENT RRP40 × 1 （Q08285） EXOSOME COMPLEX COMPONENT RRP4 × 1 （P38792） EXOSOME COMPLEX EXONUCLEASE DIS3 × 1 （Q08162） SUPERKILLER PROTEIN 7 × 1 （Q08491）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	CSL4_YEAST
Isoform	—
PDB entities	9
Chains and sequence ranges	Author chain I； PDBConstruct 1–292； UniProt 1–292

EXOSOME COMPLEX EXONUCLEASE DIS3

OrganismNot specified

UniProt Q08162

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 11	EXOSOME COMPLEX COMPONENT RRP45 × 1 （Q05636） EXOSOME COMPLEX COMPONENT SKI6 × 1 （P46948） EXOSOME COMPLEX COMPONENT RRP43 × 1 （P25359） EXOSOME COMPLEX COMPONENT RRP46 × 1 （P53256） EXOSOME COMPLEX COMPONENT RRP42 × 1 （Q12277） EXOSOME COMPLEX COMPONENT MTR3 × 1 （P48240） EXOSOME COMPLEX COMPONENT RRP40 × 1 （Q08285） EXOSOME COMPLEX COMPONENT RRP4 × 1 （P38792） EXOSOME COMPLEX COMPONENT CSL4 × 1 （P53859） SUPERKILLER PROTEIN 7 × 1 （Q08491）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RRP44_YEAST
Isoform	—
PDB entities	10
Chains and sequence ranges	Author chain J； PDBConstruct 1–1001； UniProt 1–1001

SUPERKILLER PROTEIN 7

OrganismNot specified

UniProt Q08491

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 11	EXOSOME COMPLEX COMPONENT RRP45 × 1 （Q05636） EXOSOME COMPLEX COMPONENT SKI6 × 1 （P46948） EXOSOME COMPLEX COMPONENT RRP43 × 1 （P25359） EXOSOME COMPLEX COMPONENT RRP46 × 1 （P53256） EXOSOME COMPLEX COMPONENT RRP42 × 1 （Q12277） EXOSOME COMPLEX COMPONENT MTR3 × 1 （P48240） EXOSOME COMPLEX COMPONENT RRP40 × 1 （Q08285） EXOSOME COMPLEX COMPONENT RRP4 × 1 （P38792） EXOSOME COMPLEX COMPONENT CSL4 × 1 （P53859） EXOSOME COMPLEX EXONUCLEASE DIS3 × 1 （Q08162）	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	SKI7_YEAST
Isoform	—
PDB entities	11
Chains and sequence ranges	Author chain P； PDBConstruct 1–747； UniProt 1–747

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	5g06
Deposition date deposition_date	2016-03-17
Structure title title	Cryo-EM structure of yeast cytoplasmic exosome
Keywords keywords	HYDROLASE, RNA DECAY, EXOSOME, RNA QUALITY CONTROL; HYDROLASE
Experimental Method method	ELECTRON MICROSCOPY

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

5g06__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

5g06__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

5g06__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	49.30 Å
Rg (electron density)	48.83 Å
Total Rg	49.04 Å
Atom count	26794
Residues	3420
Excluded volume	478040 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`5g06__assembly_1__model_1`	undecameric （11）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (11)

Entity 1 Entity 1 polymer

Description description	EXOSOME COMPLEX COMPONENT RRP45
Molecular weight formula_weight	34001.9 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	A
Atom count atom_count	26794

MAKDIEISASESKFILEALRQNYRLDGRSFDQFRDVEITFGKEFGDVSVKMGNTKVHCRISCQIAQPYEDRPFEGLFVISTEISPMAGSQFENGNITGEDEVLCSRIIEKSVRRSGALDVEGLCIVAGSKCWAVRADVHFLDCDGGFIDASCIAVMAGLMHFKKPDITVHGEQIIVHPVNEREPVPLGILHIPICVTFSFFNPQDTEENIKGETNSEISIIDATLKEELLRDGVLTVTLNKNREVVQVSKAGGLPMDALTLMKCCHEAYSIIEKITDQILQLLKEDSEKRNKYAAMLTSENAREI

Entity 2 Entity 2 polymer

Description description	EXOSOME COMPLEX COMPONENT SKI6
Molecular weight formula_weight	27599.7 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	B

MSRLEIYSPEGLRLDGRRWNELRRFESSINTHPHAADGSSYMEQGNNKIITLVKGPKEPRLKSQMDTSKALLNVSVNITKFSKFERSKSSHKNERRVLEIQTSLVRMFEKNVMLNIYPRTVIDIEIHVLEQDGGIMGSLINGITLALIDAGISMFDYISGISVGLYDTTPLLDTNSLEENAMSTVTLGVVGKSEKLSLLLVEDKIPLDRLENVLAIGIAGAHRVRDLMDEELRKHAQKRVSNASAR

Entity 3 Entity 3 polymer

Description description	EXOSOME COMPLEX COMPONENT RRP43
Molecular weight formula_weight	44093.0 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	C

MAESTTLETIEIHPITFPPEVLARISPELSLQRHLSLGIRPCLRKYEEFRDVAIENNTLSRYADAGNIDTKNNILGSNVLKSGKTIVITSITGGIIEETSAAIKDLDDFGEEELFEVTKEEDIIANYASVYPVVEVERGRVGACTDEEMTISQKLHDSILHSRILPKKALKVKAGVRSANEDGTFSVLYPDELEDDTLNETNLKMKRKWSYVLYAKIVVLSRTGPVFDLCWNSLMYALQSVKLPRAFIDERASDLRMTIRTRGRSATIRETYEIICDQTKSVPLMINAKNIAFASNYGIVELDPECQLQNSDNSEEEEVDIDMDKLNTVLIADLDTEAEETSIHSTISILAAPSGNYKQLTLMGGGAKITPEMIKRSLLLSRVRADDLSTRFNI

Entity 4 Entity 4 polymer

Description description	EXOSOME COMPLEX COMPONENT RRP46
Molecular weight formula_weight	24430.2 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	D

MSVQAEIGILDHVDGSSEFVSQDTKVICSVTGPIEPKARQELPTQLALEIIVRPAKGVATTREKVLEDKLRAVLTPLITRHCYPRQLCQITCQILESGEDEAEFSLRELSCCINAAFLALVDAGIALNSMCASIPIAIIKDTSDIIVDPTAEQLKISLSVHTLALEFVNGGKVVKNVLLLDSNGDFNEDQLFSLLELGEQKCQELVTNIRRIIQDNISPRLVV

Entity 5 Entity 5 polymer

Description description	EXOSOME COMPLEX COMPONENT RRP42
Molecular weight formula_weight	29099.2 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	E

MSLSVAEKSYLYDSLASTPSIRPDGRLPHQFRPIEIFTDFLPSSNGSSRIIASDGSECIVSIKSKVVDHHVENELLQVDVDIAGQRDDALVVETITSLLNKVLKSGSGVDSSKLQLTKKYSFKIFVDVLVISSHSHPISLISFAIYSALNSTYLPKLISAFDDLEVEELPTFHDYDMVKLDINPPLVFILAVVGNNMLLDPAANESEVANNGLIISWSNGKITSPIRSVALNDSNVKSFKPHLLKQGLAMVEKYAPDVVRSLENL

Entity 6 Entity 6 polymer

Description description	EXOSOME COMPLEX COMPONENT MTR3
Molecular weight formula_weight	27590.0 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	F

MNVQDRRRLLGPAAAKPMAFSNTTTHVPEKKSTDLTPKGNESEQELSLHTGFIENCNGSALVEARSLGHQTSLISAVYGPRSIRGSFTSQGTISIQLKNGLLEKYNTNELKEVSSFLMGIFNSVVNLSRYPKSGIDIFVYLTYDKDLTNNPQDDDSQSKMMSSQISSLIPHCITSITLALADAGIELVDMAGAGEANGTVVSFIKNGEEIVGFWKDDGDDEDLLECLDRCKEQYNRYRDLMISCLMNQET

Entity 7 Entity 7 polymer

Description description	EXOSOME COMPLEX COMPONENT RRP40
Molecular weight formula_weight	26583.4 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	G

MSTFIFPGDSFPVDPTTPVKLGPGIYCDPNTQEIRPVNTGVLHVSAKGKSGVQTAYIDYSSKRYIPSVNDFVIGVIIGTFSDSYKVSLQNFSSSVSLSYMAFPNASKKNRPTLQVGDLVYARVCTAEKELEAEIECFDSTTGRDAGFGILEDGMIIDVNLNFARQLLFNNDFPLLKVLAAHTKFEVAIGLNGKIWVKCEELSNTLACYRTIMECCQKNDTAAFKDIAKRQFKEILTVKEE

Entity 8 Entity 8 polymer

Description description	EXOSOME COMPLEX COMPONENT RRP4
Molecular weight formula_weight	39470.2 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	H

MSEVITITKRNGAFQNSSNLSYNNTGISDDENDEEDIYMHDVNSASKSESDSQIVTPGELVTDDPIWMRGHGTYFLDNMTYSSVAGTVSRVNRLLSVIPLKGRYAPETGDHVVGRIAEVGNKRWKVDIGGKQHAVLMLGSVNLPGGILRRKSESDELQMRSFLKEGDLLNAEVQSLFQDGSASLHTRSLKYGKLRNGMFCQVPSSLIVRAKNHTHNLPGNITVVLGVNGYIWLRKTSQMDLARDTPSANNSSSIKSTGPTGAVSLNPSITRLEEESSWQIYSDENDPSISNNIRQAICRYANVIKALAFCEIGITQQRIVSAYEASMVYSNVGELIEKNVMESIGSDILTAEKMRGNGN

Entity 9 Entity 9 polymer

Description description	EXOSOME COMPLEX COMPONENT CSL4
Molecular weight formula_weight	31619.3 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	I

MACNFQFPEIAYPGKLICPQYGTENKDGEDIIFNYVPGPGTKLIQYEHNGRTLEAITATLVGTVRCEEEKKTDQEEEREGTDQSTEEEKSVDASPNDVTRRTVKNILVSVLPGTEKGRKTNKYANNDFANNLPKEGDIVLTRVTRLSLQRANVEILAVEDKPSPIDSGIGSNGSGIVAAGGGSGAATFSVSQASSDLGETFRGIIRSQDVRSTDRDRVKVIECFKPGDIVRAQVLSLGDGTNYYLTTARNDLGVVFARAANGAGGLMYATDWQMMTSPVTGATEKRKCAKPF

Entity 10 Entity 10 polymer

Description description	EXOSOME COMPLEX EXONUCLEASE DIS3
Molecular weight formula_weight	113855.8 kDa
EC 编号 ec_number	3.1.13.1
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	J

MSVPAIAPRRKRLADGLSVTQKVFVRSRNGGATKIVREHYLRSDIPCLSRSCTKCPQIVVPDAQNELPKFILSDSPLELSAPIGKHYVVLDTNVVLQAIDLLENPNCFFDVIVPQIVLDEVRNKSYPVYTRLRTLCRDSDDHKRFIVFHNEFSEHTFVERLPNETINDRNNRAIRKTCQWYSEHLKPYDINVVLVTNDRLNREAATKEVESNIITKSLVQYIELLPNADDIRDSIPQMDSFDKDLERDTFSDFTFPEYYSTARVMGGLKNGVLYQGNIQISEYNFLEGSVSLPRFSKPVLIVGQKNLNRAFNGDQVIVELLPQSEWKAPSSIVLDSEHFDVNDNPDIEAGDDDDNNESSSNTTVISDKQRRLLAKDAMIAQRSKKIQPTAKVVYIQRRSWRQYVGQLAPSSVDPQSSSTQNVFVILMDKCLPKVRIRTRRAAELLDKRIVISIDSWPTTHKYPLGHFVRDLGTIESAQAETEALLLEHDVEYRPFSKKVLECLPAEGHDWKAPTKLDDPEAVSKDPLLTKRKDLRDKLICSIDPPGCVDINDALHAKKLPNGNWEVGVHIADVTHFVKPGTALDAEGAARGTSVYLVDKRIDMLPMLLGTDLCSLKPYVDRFAFSVIWELDDSANIVNVNFMKSVIRSREAFSYEQAQLRIDDKTQNDELTMGMRALLKLSVKLKQKRLEAGALNLASPEVKVHMDSETSDPNEVEIKKLLATNSLVEEFMLLANISVARKIYDAFPQTAMLRRHAAPPSTNFEILNEMLNTRKNMSISLESSKALADSLDRCVDPEDPYFNTLVRIMSTRCMMAAQYFYSGAYSYPDFRHYGLAVDIYTHFTSPIRRYCDVVAHRQLAGAIGYEPLSLTHRDKNKMDMICRNINRKHRNAQFAGRASIEYYVGQVMRNNESTETGYVIKVFNNGIVVLVPKFGVEGLIRLDNLTEDPNSAAFDEVEYKLTFVPTNSDKPRDVYVFDKVEVQVRSVMDPITSKRKAELLLK

Entity 11 Entity 11 polymer

Description description	SUPERKILLER PROTEIN 7
Molecular weight formula_weight	84888.7 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	P

MSLLEQLARKRIEKSKGLLSADQSHSTSKSASLLERLHKNRETKDNNAETKRKDLKTLLAKDKVKRSDFTPNQHSVSLSLKLSALKKSNSDLEKQGKSVTLDSKENELPTKRKSPDDKLNLEESWKAIKEMNHYCFLKNDPCINQTDDFAFTNFIIKDKKNSLSTSIPLSSQNSSFLSLKKHNNELLGIFVPCNLPKTTRKVAIENFNRPSPDDIIQSAQLNAFNEKLENLNIKSVPKAEKKEPINLQTPPTESIDIHSFIATHPLNLTCLFLGDTNAGKSTLLGHLLYDLNEISMSSMRELQKKSSNLDPSSSNSFKVILDNTKTERENGFSMFKKVIQVENDLLPPSSTLTLIDTPGSIKYFNKETLNSILTFDPEVYVLVIDCNYDSWEKSLDGPNNQIYEILKVISYLNKNSACKKHLIILLNKADLISWDKHRLEMIQSELNYVLKENFQWTDAEFQFIPCSGLLGSNLNKTENITKSKYKSEFDSINYVPEWYEGPTFFSQLYLLVEHNMNKIETTLEEPFVGTILQSSVLQPIAEINYVSLKVLINSGYIQSGQTIEIHTQYEDFHYYGIVSRMKNSKQILETNTKNNISVGLNPDILEVLVKIHNTEDFTKKQFHIRKGDIIIHSRKTNTLSPNLPNTLKLLALRLIKLSIQTHALSDPVDLGSELLLYHNLTHNAVKLVKILGTNDISINPNQSLIVEVEIIEPDFALNVIDSKYITNNIVLTSIDHKVIAVGRIACQ

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Unit-cell length a length_a	1.000 Å
Unit-cell length b length_b	1.000 Å
Unit-cell length c length_c	1.000 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	90.00 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	1

Space group space_group	P 1
Space-group number int_tables_number	1
Crystal system crystal_system	—

Resolution resolution	4.200 Å
Low-resolution limit resolution_low	— Å
R factor r_factor	—
R_work r_work	—
R_free r_free	—

Resolution resolution	4.20 Å
Resolution测定Method resolution_method	—
颗粒数 num_particles	25000

Cryo-EM structure of yeast cytoplasmic exosome

1. Protein Identity and Related Structures Protein Identity & Related Structures

EXOSOME COMPLEX COMPONENT RRP45

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

EXOSOME COMPLEX COMPONENT SKI6

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

EXOSOME COMPLEX COMPONENT RRP43

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

EXOSOME COMPLEX COMPONENT RRP46

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

EXOSOME COMPLEX COMPONENT RRP42

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

EXOSOME COMPLEX COMPONENT MTR3

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

EXOSOME COMPLEX COMPONENT RRP40

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

EXOSOME COMPLEX COMPONENT RRP4

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

EXOSOME COMPLEX COMPONENT CSL4

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

EXOSOME COMPLEX EXONUCLEASE DIS3

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer