5heu

Pentameric ligand-gated ion channel ELIC mutant A257Y

Method: X-RAY DIFFRACTION

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1. 蛋白身份与相关结构 Protein Identity & Related Structures

Gamma-aminobutyric-acid receptor subunit beta-1

Dickeya dadantii (strain 3937)

当前结构中的状态

Assembly	物理组成	蛋白状态	分子拷贝数	共同组分	数据核对
1	蛋白同源多聚体	同源多聚体	蛋白 5	无其他共同聚合物	与蛋白数一致
2	蛋白同源多聚体	同源多聚体	蛋白 5	无其他共同聚合物	与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据

UniProt名称	E0SJQ4_DICD3
Isoform	—
PDB实体	1
链与序列区间	作者链 A； PDB构建体 1–322； UniProt 22–343 作者链 B； PDB构建体 1–322； UniProt 22–343 作者链 C； PDB构建体 1–322； UniProt 22–343 作者链 D； PDB构建体 1–322； UniProt 22–343 作者链 E； PDB构建体 1–322； UniProt 22–343 作者链 F； PDB构建体 1–322； UniProt 22–343 作者链 G； PDB构建体 1–322； UniProt 22–343 作者链 H； PDB构建体 1–322； UniProt 22–343 作者链 I； PDB构建体 1–322； UniProt 22–343 作者链 J； PDB构建体 1–322； UniProt 22–343

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。链映射与序列区间收在“数据证据”中；数据库内部编号、导入时间和 assembly 操作表达式仅用于维护，因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id	5heu
沉积日期 deposition_date	2016-01-06
结构标题 title	Pentameric ligand-gated ion channel ELIC mutant A257Y
关键词 keywords	Pentameric ligand-gated ion channels, Membrane protein, Ligand-gated ion channel, transport protein; TRANSPORT PROTEIN
实验方法 method	X-RAY DIFFRACTION

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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

5heu__assembly_2__model_1

Assembly 2 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

5heu__assembly_2__model_1 | I(q)

100 个绘图点；横轴和纵轴均采用对数尺度。

5heu__assembly_2__model_1 | P(r) · Pending

P(r) 将按相同 assembly/model 分别计算和展示。

Rg（Guinier）	37.65 Å
Rg（电子密度）	36.69 Å
总 Rg	37.29 Å
原子数	12490
残基数	1535
排除体积	224000 Å³
最大 q	0.500 Å⁻¹

Assembly	Model	结构单元	聚集说明	状态	CRYSOL	操作
1	1	`5heu__assembly_1__model_1`	pentameric （5）	成功	4.1.3-1-20251215 (887e7ef)	查看下载
2	1	`5heu__assembly_2__model_1`	pentameric （5）	成功	4.1.3-1-20251215 (887e7ef)	查看下载

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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (1)

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6. 折叠分类 (SCOP + CATH) 20 domains

CATH v4.4 (20 domains)

结构域编号 domain_id	5heuA01
类 Class class	2 — Mainly Beta
架构 Architecture architecture	70 — Distorted Sandwich
拓扑 Topology topology	170 — Acetylcholine Binding Protein; Chain: A,
同源超家族 H-superfamily homologous superfamily	10 — Neurotransmitter-gated ion-channel ligand-binding domain

结构域编号 domain_id	5heuA02
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	20 — Up-down Bundle
拓扑 Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
同源超家族 H-superfamily homologous superfamily	390 — Neurotransmitter-gated ion-channel transmembrane domain

结构域编号 domain_id	5heuB01
类 Class class	2 — Mainly Beta
架构 Architecture architecture	70 — Distorted Sandwich
拓扑 Topology topology	170 — Acetylcholine Binding Protein; Chain: A,
同源超家族 H-superfamily homologous superfamily	10 — Neurotransmitter-gated ion-channel ligand-binding domain

结构域编号 domain_id	5heuB02
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	20 — Up-down Bundle
拓扑 Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
同源超家族 H-superfamily homologous superfamily	390 — Neurotransmitter-gated ion-channel transmembrane domain

结构域编号 domain_id	5heuC01
类 Class class	2 — Mainly Beta
架构 Architecture architecture	70 — Distorted Sandwich
拓扑 Topology topology	170 — Acetylcholine Binding Protein; Chain: A,
同源超家族 H-superfamily homologous superfamily	10 — Neurotransmitter-gated ion-channel ligand-binding domain

结构域编号 domain_id	5heuC02
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	20 — Up-down Bundle
拓扑 Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
同源超家族 H-superfamily homologous superfamily	390 — Neurotransmitter-gated ion-channel transmembrane domain

结构域编号 domain_id	5heuD01
类 Class class	2 — Mainly Beta
架构 Architecture architecture	70 — Distorted Sandwich
拓扑 Topology topology	170 — Acetylcholine Binding Protein; Chain: A,
同源超家族 H-superfamily homologous superfamily	10 — Neurotransmitter-gated ion-channel ligand-binding domain

结构域编号 domain_id	5heuD02
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	20 — Up-down Bundle
拓扑 Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
同源超家族 H-superfamily homologous superfamily	390 — Neurotransmitter-gated ion-channel transmembrane domain

结构域编号 domain_id	5heuE01
类 Class class	2 — Mainly Beta
架构 Architecture architecture	70 — Distorted Sandwich
拓扑 Topology topology	170 — Acetylcholine Binding Protein; Chain: A,
同源超家族 H-superfamily homologous superfamily	10 — Neurotransmitter-gated ion-channel ligand-binding domain

结构域编号 domain_id	5heuE02
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	20 — Up-down Bundle
拓扑 Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
同源超家族 H-superfamily homologous superfamily	390 — Neurotransmitter-gated ion-channel transmembrane domain

结构域编号 domain_id	5heuF01
类 Class class	2 — Mainly Beta
架构 Architecture architecture	70 — Distorted Sandwich
拓扑 Topology topology	170 — Acetylcholine Binding Protein; Chain: A,
同源超家族 H-superfamily homologous superfamily	10 — Neurotransmitter-gated ion-channel ligand-binding domain

结构域编号 domain_id	5heuF02
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	20 — Up-down Bundle
拓扑 Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
同源超家族 H-superfamily homologous superfamily	390 — Neurotransmitter-gated ion-channel transmembrane domain

结构域编号 domain_id	5heuG01
类 Class class	2 — Mainly Beta
架构 Architecture architecture	70 — Distorted Sandwich
拓扑 Topology topology	170 — Acetylcholine Binding Protein; Chain: A,
同源超家族 H-superfamily homologous superfamily	10 — Neurotransmitter-gated ion-channel ligand-binding domain

结构域编号 domain_id	5heuG02
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	20 — Up-down Bundle
拓扑 Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
同源超家族 H-superfamily homologous superfamily	390 — Neurotransmitter-gated ion-channel transmembrane domain

结构域编号 domain_id	5heuH01
类 Class class	2 — Mainly Beta
架构 Architecture architecture	70 — Distorted Sandwich
拓扑 Topology topology	170 — Acetylcholine Binding Protein; Chain: A,
同源超家族 H-superfamily homologous superfamily	10 — Neurotransmitter-gated ion-channel ligand-binding domain

结构域编号 domain_id	5heuH02
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	20 — Up-down Bundle
拓扑 Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
同源超家族 H-superfamily homologous superfamily	390 — Neurotransmitter-gated ion-channel transmembrane domain

结构域编号 domain_id	5heuI01
类 Class class	2 — Mainly Beta
架构 Architecture architecture	70 — Distorted Sandwich
拓扑 Topology topology	170 — Acetylcholine Binding Protein; Chain: A,
同源超家族 H-superfamily homologous superfamily	10 — Neurotransmitter-gated ion-channel ligand-binding domain

结构域编号 domain_id	5heuI02
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	20 — Up-down Bundle
拓扑 Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
同源超家族 H-superfamily homologous superfamily	390 — Neurotransmitter-gated ion-channel transmembrane domain

结构域编号 domain_id	5heuJ01
类 Class class	2 — Mainly Beta
架构 Architecture architecture	70 — Distorted Sandwich
拓扑 Topology topology	170 — Acetylcholine Binding Protein; Chain: A,
同源超家族 H-superfamily homologous superfamily	10 — Neurotransmitter-gated ion-channel ligand-binding domain

结构域编号 domain_id	5heuJ02
类 Class class	1 — Mainly Alpha
架构 Architecture architecture	20 — Up-down Bundle
拓扑 Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
同源超家族 H-superfamily homologous superfamily	390 — Neurotransmitter-gated ion-channel transmembrane domain

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晶胞边长 a length_a	105.000 Å
晶胞边长 b length_b	266.610 Å
晶胞边长 c length_c	110.710 Å
晶胞夹角 α angle_alpha	90.00 °
晶胞夹角 β angle_beta	110.47 °
晶胞夹角 γ angle_gamma	90.00 °
晶胞分子数 Z z_pdb	20

空间群 space_group	P 1 21 1
空间群编号 int_tables_number	4
晶系 crystal_system	—

分辨率 resolution	3.200 Å
最低分辨率 resolution_low	29.939 Å
R 因子 r_factor	0.2211
R_work r_work	0.2197
R_free r_free	0.2467

描述 description	Gamma-aminobutyric-acid receptor subunit beta-1
分子量 formula_weight	36786.9 kDa
突变 mutation	A257Y
来源方法 src_method	man
拷贝数 entity_count	10

聚合物类型 type	polypeptide(L)
链编号 strand_id	A,B,C,D,E,F,G,H,I,J
原子数 atom_count	24980

Pentameric ligand-gated ion channel ELIC mutant A257Y

1. 蛋白身份与相关结构 Protein Identity & Related Structures

Gamma-aminobutyric-acid receptor subunit beta-1

当前结构中的状态

数据库中的同蛋白其他状态

2. 结构基本信息 2. Structure Basics

3. Official assembly/model 理论 SAXS Official SAXS Profiles

5heu__assembly_2__model_1

5heu__assembly_2__model_1 | I(q)

5heu__assembly_2__model_1 | P(r) · Pending

4. 晶体学与实验 4. Crystallography & Experiment

晶胞参数 Unit Cell

对称性 Symmetry

精修参数 Refinement

衍射实验 Diffraction

5. 实体与聚合物信息 Entities & Polymers (1)

实体 1 Entity 1 polymer

聚合物 Polymer

来源 Source

6. 折叠分类 (SCOP + CATH) 20 domains

CATH v4.4 (20 domains)

7. 引用文献 (1)

来源生物 organism	Dickeya dadantii (strain 3937)
NCBI 分类编号 ncbi_taxonomy_id	198628
宿主生物 host_organism	Escherichia coli

Pentameric ligand-gated ion channel ELIC mutant A257Y

1. 蛋白身份与相关结构 Protein Identity & Related Structures

Gamma-aminobutyric-acid receptor subunit beta-1

当前结构中的状态

数据库中的同蛋白其他状态

单体

同源二聚体

同源四聚体

其他同源多聚体

异源或核酸复合物

2. 结构基本信息 2. Structure Basics

3. Official assembly/model 理论 SAXS Official SAXS Profiles

5heu__assembly_2__model_1

5heu__assembly_2__model_1 | I(q)

5heu__assembly_2__model_1 | P(r) · Pending

4. 晶体学与实验 4. Crystallography & Experiment

晶胞参数 Unit Cell

对称性 Symmetry

精修参数 Refinement

衍射实验 Diffraction

5. 实体与聚合物信息 Entities & Polymers (1)

实体 1 Entity 1 polymer

聚合物 Polymer

来源 Source

6. 折叠分类 (SCOP + CATH) 20 domains

CATH v4.4 (20 domains)

7. 引用文献 (1)