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5s7q

XChem group deposition -- Crystal Structure of human ACVR1 in complex with FM010944a

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Activin receptor type-1

Homo sapiens

UniProt Q04771

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 2 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine × 4 1,2-ETHANEDIOL × 13 DIMETHYL SULFOXIDE × 2 SULFATE ION × 6 5-methyl-1H-tetrazole × 2 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
3mtf 3mtf 4bgg 4bgg 4bgg 4bgg 5oxg 5oxg 5oxg 5oxg 5oy6 5oy6

112 assemblies; showing the first 12

Homodimer
3oom 3q4u 3q4u 3q4u 4dym 5s7k 5s7l 5s7m 5s7n 5s7q 5s7t 5s7u

24 assemblies; showing the first 12

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
3h9r 4c02 6i1s 7yru 8pod 9n4k 9rda

7 assemblies

View Construct and Data Evidence
UniProt name ACVR1_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 3–301； UniProt 201–499 Author chain B； PDBConstruct 3–301； UniProt 201–499

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id5s7q
Deposition date deposition_date2020-12-11
Structure title titleXChem group deposition -- Crystal Structure of human ACVR1 in complex with FM010944a
Keywords keywordsSGC - Diamond I04-1 fragment screening, PanDDA, XChemExplorer, TRANSFERASE; TRANSFERASE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

5s7q__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

5s7q__assembly_1__model_1 | I(q)

10-2 10-1 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

5s7q__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）29.76 Å
Rg (electron density)29.38 Å
Total Rg30.04 Å
Atom count4771
Residues573
Excluded volume85426 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 5s7q__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (7)

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6. Fold Classification (SCOP + CATH) 2 domains

SCOP 2.08 (2 domains)

Domain ID domain_idd5s7qa_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.144 — Protein kinase-like (PK-like)
Superfamily Superfamily superfamilyd.144.1 — Protein kinase-like (PK-like)
Family Family familyd.144.1.7 — Protein kinases, catalytic subunit
Domain ID domain_idd5s7qb_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.144 — Protein kinase-like (PK-like)
Superfamily Superfamily superfamilyd.144.1 — Protein kinase-like (PK-like)
Family Family familyd.144.1.7 — Protein kinases, catalytic subunit
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7. Citations (1)