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5tbk

Crystal structure of human importin a3 bound to RCC1

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Importin subunit alpha-3

Homo sapiens

UniProt O00629

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 Regulator of chromosome condensation × 1 （P18754） Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 Regulator of chromosome condensation × 1 （P18754） Consistent with protein count
3 Protein heterocomplex Heteromer Protein 2 Regulator of chromosome condensation × 1 （P18754） Consistent with protein count
4 Protein heterocomplex Heteromer Protein 2 Regulator of chromosome condensation × 1 （P18754） Consistent with protein count
5 Protein heterocomplex Heteromer Protein 2 Regulator of chromosome condensation × 1 （P18754） Consistent with protein count
6 Protein heterocomplex Heteromer Protein 2 Regulator of chromosome condensation × 1 （P18754） Consistent with protein count
7 Protein heterocomplex Heteromer Protein 2 Regulator of chromosome condensation × 1 （P18754） Consistent with protein count
8 Protein heterocomplex Heteromer Protein 2 Regulator of chromosome condensation × 1 （P18754） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
6bvz

1 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
4uae 5tbk 5tbk 5tbk 5tbk 5tbk 5tbk 5tbk 5tbk 5xzx 6bvv 6bw9

26 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name IMA3_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–521； UniProt 1–521 Author chain B； PDBConstruct 1–521； UniProt 1–521 Author chain C； PDBConstruct 1–521； UniProt 1–521 Author chain D； PDBConstruct 1–521； UniProt 1–521 Author chain E； PDBConstruct 1–521； UniProt 1–521 Author chain F； PDBConstruct 1–521； UniProt 1–521 Author chain G； PDBConstruct 1–521； UniProt 1–521 Author chain H； PDBConstruct 1–521； UniProt 1–521

Regulator of chromosome condensation

Homo sapiens

UniProt P18754

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 Importin subunit alpha-3 × 1 （O00629） Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 Importin subunit alpha-3 × 1 （O00629） Consistent with protein count
3 Protein heterocomplex Heteromer Protein 2 Importin subunit alpha-3 × 1 （O00629） Consistent with protein count
4 Protein heterocomplex Heteromer Protein 2 Importin subunit alpha-3 × 1 （O00629） Consistent with protein count
5 Protein heterocomplex Heteromer Protein 2 Importin subunit alpha-3 × 1 （O00629） Consistent with protein count
6 Protein heterocomplex Heteromer Protein 2 Importin subunit alpha-3 × 1 （O00629） Consistent with protein count
7 Protein heterocomplex Heteromer Protein 2 Importin subunit alpha-3 × 1 （O00629） Consistent with protein count
8 Protein heterocomplex Heteromer Protein 2 Importin subunit alpha-3 × 1 （O00629） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers
1a12

1 assemblies

Heteromeric or nucleic-acid complex
1i2m 1i2m 1i2m 5tbk 5tbk 5tbk 5tbk 5tbk 5tbk 5tbk 5tbk 8ux1

12 assemblies

View Construct and Data Evidence
UniProt name RCC1_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain I； PDBConstruct 1–421； UniProt 1–421 Author chain J； PDBConstruct 1–421； UniProt 1–421 Author chain K； PDBConstruct 1–421； UniProt 1–421 Author chain L； PDBConstruct 1–421； UniProt 1–421 Author chain M； PDBConstruct 1–421； UniProt 1–421 Author chain N； PDBConstruct 1–421； UniProt 1–421 Author chain O； PDBConstruct 1–421； UniProt 1–421 Author chain P； PDBConstruct 1–421； UniProt 1–421

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id5tbk
Deposition date deposition_date2016-09-12
Structure title titleCrystal structure of human importin a3 bound to RCC1
Keywords keywordsNuclear Import, Importin alpha, RCC1 like Domain (RLD), NLS, PROTEIN TRANSPORT - NUCLEAR PROTEIN complex; PROTEIN TRANSPORT / NUCLEAR PROTEIN
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

5tbk__assembly_2__model_1

Assembly 2 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

5tbk__assembly_2__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

5tbk__assembly_2__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）32.51 Å
Rg (electron density)31.93 Å
Total Rg32.44 Å
Atom count6326
Residues834
Excluded volume112480 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 5tbk__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 5tbk__assembly_2__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 5tbk__assembly_3__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
4 1 5tbk__assembly_4__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
5 1 5tbk__assembly_5__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
6 1 5tbk__assembly_6__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
7 1 5tbk__assembly_7__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
8 1 5tbk__assembly_8__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (2)

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6. Fold Classification (SCOP + CATH) 16 domains

CATH v4.4 (16 domains)

Domain ID domain_id5tbkA00
Class class1 — Mainly Alpha
Architecture architecture25 — Alpha Horseshoe
Topology topology10 — Leucine-rich Repeat Variant
Homologous superfamily homologous superfamily10 — Leucine-rich Repeat Variant
Domain ID domain_id5tbkB00
Class class1 — Mainly Alpha
Architecture architecture25 — Alpha Horseshoe
Topology topology10 — Leucine-rich Repeat Variant
Homologous superfamily homologous superfamily10 — Leucine-rich Repeat Variant
Domain ID domain_id5tbkC00
Class class1 — Mainly Alpha
Architecture architecture25 — Alpha Horseshoe
Topology topology10 — Leucine-rich Repeat Variant
Homologous superfamily homologous superfamily10 — Leucine-rich Repeat Variant
Domain ID domain_id5tbkD00
Class class1 — Mainly Alpha
Architecture architecture25 — Alpha Horseshoe
Topology topology10 — Leucine-rich Repeat Variant
Homologous superfamily homologous superfamily10 — Leucine-rich Repeat Variant
Domain ID domain_id5tbkE00
Class class1 — Mainly Alpha
Architecture architecture25 — Alpha Horseshoe
Topology topology10 — Leucine-rich Repeat Variant
Homologous superfamily homologous superfamily10 — Leucine-rich Repeat Variant
Domain ID domain_id5tbkF00
Class class1 — Mainly Alpha
Architecture architecture25 — Alpha Horseshoe
Topology topology10 — Leucine-rich Repeat Variant
Homologous superfamily homologous superfamily10 — Leucine-rich Repeat Variant
Domain ID domain_id5tbkG00
Class class1 — Mainly Alpha
Architecture architecture25 — Alpha Horseshoe
Topology topology10 — Leucine-rich Repeat Variant
Homologous superfamily homologous superfamily10 — Leucine-rich Repeat Variant
Domain ID domain_id5tbkH00
Class class1 — Mainly Alpha
Architecture architecture25 — Alpha Horseshoe
Topology topology10 — Leucine-rich Repeat Variant
Homologous superfamily homologous superfamily10 — Leucine-rich Repeat Variant
Domain ID domain_id5tbkI00
Class class2 — Mainly Beta
Architecture architecture130 — 7 Propeller
Topology topology10 — Methylamine Dehydrogenase; Chain H
Homologous superfamily homologous superfamily30 — Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
Domain ID domain_id5tbkJ00
Class class2 — Mainly Beta
Architecture architecture130 — 7 Propeller
Topology topology10 — Methylamine Dehydrogenase; Chain H
Homologous superfamily homologous superfamily30 — Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
Domain ID domain_id5tbkK00
Class class2 — Mainly Beta
Architecture architecture130 — 7 Propeller
Topology topology10 — Methylamine Dehydrogenase; Chain H
Homologous superfamily homologous superfamily30 — Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
Domain ID domain_id5tbkL00
Class class2 — Mainly Beta
Architecture architecture130 — 7 Propeller
Topology topology10 — Methylamine Dehydrogenase; Chain H
Homologous superfamily homologous superfamily30 — Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
Domain ID domain_id5tbkM00
Class class2 — Mainly Beta
Architecture architecture130 — 7 Propeller
Topology topology10 — Methylamine Dehydrogenase; Chain H
Homologous superfamily homologous superfamily30 — Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
Domain ID domain_id5tbkN00
Class class2 — Mainly Beta
Architecture architecture130 — 7 Propeller
Topology topology10 — Methylamine Dehydrogenase; Chain H
Homologous superfamily homologous superfamily30 — Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
Domain ID domain_id5tbkO00
Class class2 — Mainly Beta
Architecture architecture130 — 7 Propeller
Topology topology10 — Methylamine Dehydrogenase; Chain H
Homologous superfamily homologous superfamily30 — Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
Domain ID domain_id5tbkP00
Class class2 — Mainly Beta
Architecture architecture130 — 7 Propeller
Topology topology10 — Methylamine Dehydrogenase; Chain H
Homologous superfamily homologous superfamily30 — Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
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7. Citations (1)