5vhh

Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle

Method: ELECTRON MICROSCOPY

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1. Protein Identity and Related Structures Protein Identity & Related Structures

26S proteasome regulatory subunit 7

Homo sapiens

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 19	26S proteasome regulatory subunit 4 × 1 （P62191） 26S proteasome regulatory subunit 8 × 1 （P62195） 26S proteasome regulatory subunit 6B × 1 （P43686） 26S proteasome regulatory subunit 10B × 1 （P62333） 26S proteasome regulatory subunit 6A × 1 （P17980） 26S proteasome non-ATPase regulatory subunit 1 × 1 （Q99460） 26S proteasome non-ATPase regulatory subunit 3 × 1 （O43242） 26S proteasome non-ATPase regulatory subunit 12 × 1 （O00232） 26S proteasome non-ATPase regulatory subunit 11 × 1 （O00231） 26S proteasome non-ATPase regulatory subunit 6 × 1 （Q15008） 26S proteasome non-ATPase regulatory subunit 7 × 1 （P51665） 26S proteasome non-ATPase regulatory subunit 13 × 1 （Q9UNM6） 26S proteasome non-ATPase regulatory subunit 4 × 1 （P55036） 26S proteasome non-ATPase regulatory subunit 14 × 1 （O00487） 26S proteasome non-ATPase regulatory subunit 8 × 1 （P48556） 26S proteasome complex subunit SEM1 × 1 （P60896） 26S proteasome non-ATPase regulatory subunit 10 × 1 （O75832） 26S proteasome non-ATPase regulatory subunit 2 × 1 （Q13200） ZINC ION × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PRS7_HUMAN
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 1–352； UniProt 73–424

26S proteasome regulatory subunit 4

Homo sapiens

UniProt P62191

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 19	26S proteasome regulatory subunit 7 × 1 （P35998） 26S proteasome regulatory subunit 8 × 1 （P62195） 26S proteasome regulatory subunit 6B × 1 （P43686） 26S proteasome regulatory subunit 10B × 1 （P62333） 26S proteasome regulatory subunit 6A × 1 （P17980） 26S proteasome non-ATPase regulatory subunit 1 × 1 （Q99460） 26S proteasome non-ATPase regulatory subunit 3 × 1 （O43242） 26S proteasome non-ATPase regulatory subunit 12 × 1 （O00232） 26S proteasome non-ATPase regulatory subunit 11 × 1 （O00231） 26S proteasome non-ATPase regulatory subunit 6 × 1 （Q15008） 26S proteasome non-ATPase regulatory subunit 7 × 1 （P51665） 26S proteasome non-ATPase regulatory subunit 13 × 1 （Q9UNM6） 26S proteasome non-ATPase regulatory subunit 4 × 1 （P55036） 26S proteasome non-ATPase regulatory subunit 14 × 1 （O00487） 26S proteasome non-ATPase regulatory subunit 8 × 1 （P48556） 26S proteasome complex subunit SEM1 × 1 （P60896） 26S proteasome non-ATPase regulatory subunit 10 × 1 （O75832） 26S proteasome non-ATPase regulatory subunit 2 × 1 （Q13200） ZINC ION × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PRS4_HUMAN
Isoform	—
PDB entities	2
Chains and sequence ranges	Author chain B； PDBConstruct 1–340； UniProt 93–432

26S proteasome regulatory subunit 8

Homo sapiens

UniProt P62195

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 19	26S proteasome regulatory subunit 7 × 1 （P35998） 26S proteasome regulatory subunit 4 × 1 （P62191） 26S proteasome regulatory subunit 6B × 1 （P43686） 26S proteasome regulatory subunit 10B × 1 （P62333） 26S proteasome regulatory subunit 6A × 1 （P17980） 26S proteasome non-ATPase regulatory subunit 1 × 1 （Q99460） 26S proteasome non-ATPase regulatory subunit 3 × 1 （O43242） 26S proteasome non-ATPase regulatory subunit 12 × 1 （O00232） 26S proteasome non-ATPase regulatory subunit 11 × 1 （O00231） 26S proteasome non-ATPase regulatory subunit 6 × 1 （Q15008） 26S proteasome non-ATPase regulatory subunit 7 × 1 （P51665） 26S proteasome non-ATPase regulatory subunit 13 × 1 （Q9UNM6） 26S proteasome non-ATPase regulatory subunit 4 × 1 （P55036） 26S proteasome non-ATPase regulatory subunit 14 × 1 （O00487） 26S proteasome non-ATPase regulatory subunit 8 × 1 （P48556） 26S proteasome complex subunit SEM1 × 1 （P60896） 26S proteasome non-ATPase regulatory subunit 10 × 1 （O75832） 26S proteasome non-ATPase regulatory subunit 2 × 1 （Q13200） ZINC ION × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PRS8_HUMAN
Isoform	—
PDB entities	3
Chains and sequence ranges	Author chain C； PDBConstruct 1–385； UniProt 11–395

26S proteasome regulatory subunit 6B

Homo sapiens

UniProt P43686

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 19	26S proteasome regulatory subunit 7 × 1 （P35998） 26S proteasome regulatory subunit 4 × 1 （P62191） 26S proteasome regulatory subunit 8 × 1 （P62195） 26S proteasome regulatory subunit 10B × 1 （P62333） 26S proteasome regulatory subunit 6A × 1 （P17980） 26S proteasome non-ATPase regulatory subunit 1 × 1 （Q99460） 26S proteasome non-ATPase regulatory subunit 3 × 1 （O43242） 26S proteasome non-ATPase regulatory subunit 12 × 1 （O00232） 26S proteasome non-ATPase regulatory subunit 11 × 1 （O00231） 26S proteasome non-ATPase regulatory subunit 6 × 1 （Q15008） 26S proteasome non-ATPase regulatory subunit 7 × 1 （P51665） 26S proteasome non-ATPase regulatory subunit 13 × 1 （Q9UNM6） 26S proteasome non-ATPase regulatory subunit 4 × 1 （P55036） 26S proteasome non-ATPase regulatory subunit 14 × 1 （O00487） 26S proteasome non-ATPase regulatory subunit 8 × 1 （P48556） 26S proteasome complex subunit SEM1 × 1 （P60896） 26S proteasome non-ATPase regulatory subunit 10 × 1 （O75832） 26S proteasome non-ATPase regulatory subunit 2 × 1 （Q13200） ZINC ION × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PRS6B_HUMAN
Isoform	—
PDB entities	4
Chains and sequence ranges	Author chain D； PDBConstruct 1–368； UniProt 39–406

26S proteasome regulatory subunit 10B

Homo sapiens

UniProt P62333

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 19	26S proteasome regulatory subunit 7 × 1 （P35998） 26S proteasome regulatory subunit 4 × 1 （P62191） 26S proteasome regulatory subunit 8 × 1 （P62195） 26S proteasome regulatory subunit 6B × 1 （P43686） 26S proteasome regulatory subunit 6A × 1 （P17980） 26S proteasome non-ATPase regulatory subunit 1 × 1 （Q99460） 26S proteasome non-ATPase regulatory subunit 3 × 1 （O43242） 26S proteasome non-ATPase regulatory subunit 12 × 1 （O00232） 26S proteasome non-ATPase regulatory subunit 11 × 1 （O00231） 26S proteasome non-ATPase regulatory subunit 6 × 1 （Q15008） 26S proteasome non-ATPase regulatory subunit 7 × 1 （P51665） 26S proteasome non-ATPase regulatory subunit 13 × 1 （Q9UNM6） 26S proteasome non-ATPase regulatory subunit 4 × 1 （P55036） 26S proteasome non-ATPase regulatory subunit 14 × 1 （O00487） 26S proteasome non-ATPase regulatory subunit 8 × 1 （P48556） 26S proteasome complex subunit SEM1 × 1 （P60896） 26S proteasome non-ATPase regulatory subunit 10 × 1 （O75832） 26S proteasome non-ATPase regulatory subunit 2 × 1 （Q13200） ZINC ION × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PRS10_HUMAN
Isoform	—
PDB entities	5
Chains and sequence ranges	Author chain E； PDBConstruct 1–379； UniProt 11–389

26S proteasome regulatory subunit 6A

Homo sapiens

UniProt P17980

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 19	26S proteasome regulatory subunit 7 × 1 （P35998） 26S proteasome regulatory subunit 4 × 1 （P62191） 26S proteasome regulatory subunit 8 × 1 （P62195） 26S proteasome regulatory subunit 6B × 1 （P43686） 26S proteasome regulatory subunit 10B × 1 （P62333） 26S proteasome non-ATPase regulatory subunit 1 × 1 （Q99460） 26S proteasome non-ATPase regulatory subunit 3 × 1 （O43242） 26S proteasome non-ATPase regulatory subunit 12 × 1 （O00232） 26S proteasome non-ATPase regulatory subunit 11 × 1 （O00231） 26S proteasome non-ATPase regulatory subunit 6 × 1 （Q15008） 26S proteasome non-ATPase regulatory subunit 7 × 1 （P51665） 26S proteasome non-ATPase regulatory subunit 13 × 1 （Q9UNM6） 26S proteasome non-ATPase regulatory subunit 4 × 1 （P55036） 26S proteasome non-ATPase regulatory subunit 14 × 1 （O00487） 26S proteasome non-ATPase regulatory subunit 8 × 1 （P48556） 26S proteasome complex subunit SEM1 × 1 （P60896） 26S proteasome non-ATPase regulatory subunit 10 × 1 （O75832） 26S proteasome non-ATPase regulatory subunit 2 × 1 （Q13200） ZINC ION × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PRS6A_HUMAN
Isoform	—
PDB entities	6
Chains and sequence ranges	Author chain F； PDBConstruct 1–380； UniProt 53–432

26S proteasome non-ATPase regulatory subunit 1

Homo sapiens

UniProt Q99460

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 19	26S proteasome regulatory subunit 7 × 1 （P35998） 26S proteasome regulatory subunit 4 × 1 （P62191） 26S proteasome regulatory subunit 8 × 1 （P62195） 26S proteasome regulatory subunit 6B × 1 （P43686） 26S proteasome regulatory subunit 10B × 1 （P62333） 26S proteasome regulatory subunit 6A × 1 （P17980） 26S proteasome non-ATPase regulatory subunit 3 × 1 （O43242） 26S proteasome non-ATPase regulatory subunit 12 × 1 （O00232） 26S proteasome non-ATPase regulatory subunit 11 × 1 （O00231） 26S proteasome non-ATPase regulatory subunit 6 × 1 （Q15008） 26S proteasome non-ATPase regulatory subunit 7 × 1 （P51665） 26S proteasome non-ATPase regulatory subunit 13 × 1 （Q9UNM6） 26S proteasome non-ATPase regulatory subunit 4 × 1 （P55036） 26S proteasome non-ATPase regulatory subunit 14 × 1 （O00487） 26S proteasome non-ATPase regulatory subunit 8 × 1 （P48556） 26S proteasome complex subunit SEM1 × 1 （P60896） 26S proteasome non-ATPase regulatory subunit 10 × 1 （O75832） 26S proteasome non-ATPase regulatory subunit 2 × 1 （Q13200） ZINC ION × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSMD1_HUMAN
Isoform	—
PDB entities	7
Chains and sequence ranges	Author chain U； PDBConstruct 1–935； UniProt 1–935

26S proteasome non-ATPase regulatory subunit 3

Homo sapiens

UniProt O43242

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 19	26S proteasome regulatory subunit 7 × 1 （P35998） 26S proteasome regulatory subunit 4 × 1 （P62191） 26S proteasome regulatory subunit 8 × 1 （P62195） 26S proteasome regulatory subunit 6B × 1 （P43686） 26S proteasome regulatory subunit 10B × 1 （P62333） 26S proteasome regulatory subunit 6A × 1 （P17980） 26S proteasome non-ATPase regulatory subunit 1 × 1 （Q99460） 26S proteasome non-ATPase regulatory subunit 12 × 1 （O00232） 26S proteasome non-ATPase regulatory subunit 11 × 1 （O00231） 26S proteasome non-ATPase regulatory subunit 6 × 1 （Q15008） 26S proteasome non-ATPase regulatory subunit 7 × 1 （P51665） 26S proteasome non-ATPase regulatory subunit 13 × 1 （Q9UNM6） 26S proteasome non-ATPase regulatory subunit 4 × 1 （P55036） 26S proteasome non-ATPase regulatory subunit 14 × 1 （O00487） 26S proteasome non-ATPase regulatory subunit 8 × 1 （P48556） 26S proteasome complex subunit SEM1 × 1 （P60896） 26S proteasome non-ATPase regulatory subunit 10 × 1 （O75832） 26S proteasome non-ATPase regulatory subunit 2 × 1 （Q13200） ZINC ION × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSMD3_HUMAN
Isoform	—
PDB entities	8
Chains and sequence ranges	Author chain V； PDBConstruct 1–488； UniProt 18–505

26S proteasome non-ATPase regulatory subunit 12

Homo sapiens

UniProt O00232

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 19	26S proteasome regulatory subunit 7 × 1 （P35998） 26S proteasome regulatory subunit 4 × 1 （P62191） 26S proteasome regulatory subunit 8 × 1 （P62195） 26S proteasome regulatory subunit 6B × 1 （P43686） 26S proteasome regulatory subunit 10B × 1 （P62333） 26S proteasome regulatory subunit 6A × 1 （P17980） 26S proteasome non-ATPase regulatory subunit 1 × 1 （Q99460） 26S proteasome non-ATPase regulatory subunit 3 × 1 （O43242） 26S proteasome non-ATPase regulatory subunit 11 × 1 （O00231） 26S proteasome non-ATPase regulatory subunit 6 × 1 （Q15008） 26S proteasome non-ATPase regulatory subunit 7 × 1 （P51665） 26S proteasome non-ATPase regulatory subunit 13 × 1 （Q9UNM6） 26S proteasome non-ATPase regulatory subunit 4 × 1 （P55036） 26S proteasome non-ATPase regulatory subunit 14 × 1 （O00487） 26S proteasome non-ATPase regulatory subunit 8 × 1 （P48556） 26S proteasome complex subunit SEM1 × 1 （P60896） 26S proteasome non-ATPase regulatory subunit 10 × 1 （O75832） 26S proteasome non-ATPase regulatory subunit 2 × 1 （Q13200） ZINC ION × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSD12_HUMAN
Isoform	—
PDB entities	9
Chains and sequence ranges	Author chain W； PDBConstruct 1–456； UniProt 1–456

26S proteasome non-ATPase regulatory subunit 11

Homo sapiens

UniProt O00231

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 19	26S proteasome regulatory subunit 7 × 1 （P35998） 26S proteasome regulatory subunit 4 × 1 （P62191） 26S proteasome regulatory subunit 8 × 1 （P62195） 26S proteasome regulatory subunit 6B × 1 （P43686） 26S proteasome regulatory subunit 10B × 1 （P62333） 26S proteasome regulatory subunit 6A × 1 （P17980） 26S proteasome non-ATPase regulatory subunit 1 × 1 （Q99460） 26S proteasome non-ATPase regulatory subunit 3 × 1 （O43242） 26S proteasome non-ATPase regulatory subunit 12 × 1 （O00232） 26S proteasome non-ATPase regulatory subunit 6 × 1 （Q15008） 26S proteasome non-ATPase regulatory subunit 7 × 1 （P51665） 26S proteasome non-ATPase regulatory subunit 13 × 1 （Q9UNM6） 26S proteasome non-ATPase regulatory subunit 4 × 1 （P55036） 26S proteasome non-ATPase regulatory subunit 14 × 1 （O00487） 26S proteasome non-ATPase regulatory subunit 8 × 1 （P48556） 26S proteasome complex subunit SEM1 × 1 （P60896） 26S proteasome non-ATPase regulatory subunit 10 × 1 （O75832） 26S proteasome non-ATPase regulatory subunit 2 × 1 （Q13200） ZINC ION × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSD11_HUMAN
Isoform	—
PDB entities	10
Chains and sequence ranges	Author chain X； PDBConstruct 1–385； UniProt 38–422

26S proteasome non-ATPase regulatory subunit 6

Homo sapiens

UniProt Q15008

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 19	26S proteasome regulatory subunit 7 × 1 （P35998） 26S proteasome regulatory subunit 4 × 1 （P62191） 26S proteasome regulatory subunit 8 × 1 （P62195） 26S proteasome regulatory subunit 6B × 1 （P43686） 26S proteasome regulatory subunit 10B × 1 （P62333） 26S proteasome regulatory subunit 6A × 1 （P17980） 26S proteasome non-ATPase regulatory subunit 1 × 1 （Q99460） 26S proteasome non-ATPase regulatory subunit 3 × 1 （O43242） 26S proteasome non-ATPase regulatory subunit 12 × 1 （O00232） 26S proteasome non-ATPase regulatory subunit 11 × 1 （O00231） 26S proteasome non-ATPase regulatory subunit 7 × 1 （P51665） 26S proteasome non-ATPase regulatory subunit 13 × 1 （Q9UNM6） 26S proteasome non-ATPase regulatory subunit 4 × 1 （P55036） 26S proteasome non-ATPase regulatory subunit 14 × 1 （O00487） 26S proteasome non-ATPase regulatory subunit 8 × 1 （P48556） 26S proteasome complex subunit SEM1 × 1 （P60896） 26S proteasome non-ATPase regulatory subunit 10 × 1 （O75832） 26S proteasome non-ATPase regulatory subunit 2 × 1 （Q13200） ZINC ION × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSMD6_HUMAN
Isoform	—
PDB entities	11
Chains and sequence ranges	Author chain Y； PDBConstruct 1–378； UniProt 12–389

26S proteasome non-ATPase regulatory subunit 7

Homo sapiens

UniProt P51665

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 19	26S proteasome regulatory subunit 7 × 1 （P35998） 26S proteasome regulatory subunit 4 × 1 （P62191） 26S proteasome regulatory subunit 8 × 1 （P62195） 26S proteasome regulatory subunit 6B × 1 （P43686） 26S proteasome regulatory subunit 10B × 1 （P62333） 26S proteasome regulatory subunit 6A × 1 （P17980） 26S proteasome non-ATPase regulatory subunit 1 × 1 （Q99460） 26S proteasome non-ATPase regulatory subunit 3 × 1 （O43242） 26S proteasome non-ATPase regulatory subunit 12 × 1 （O00232） 26S proteasome non-ATPase regulatory subunit 11 × 1 （O00231） 26S proteasome non-ATPase regulatory subunit 6 × 1 （Q15008） 26S proteasome non-ATPase regulatory subunit 13 × 1 （Q9UNM6） 26S proteasome non-ATPase regulatory subunit 4 × 1 （P55036） 26S proteasome non-ATPase regulatory subunit 14 × 1 （O00487） 26S proteasome non-ATPase regulatory subunit 8 × 1 （P48556） 26S proteasome complex subunit SEM1 × 1 （P60896） 26S proteasome non-ATPase regulatory subunit 10 × 1 （O75832） 26S proteasome non-ATPase regulatory subunit 2 × 1 （Q13200） ZINC ION × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSMD7_HUMAN
Isoform	—
PDB entities	12
Chains and sequence ranges	Author chain Z； PDBConstruct 1–286； UniProt 5–290

26S proteasome non-ATPase regulatory subunit 13

Homo sapiens

UniProt Q9UNM6

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 19	26S proteasome regulatory subunit 7 × 1 （P35998） 26S proteasome regulatory subunit 4 × 1 （P62191） 26S proteasome regulatory subunit 8 × 1 （P62195） 26S proteasome regulatory subunit 6B × 1 （P43686） 26S proteasome regulatory subunit 10B × 1 （P62333） 26S proteasome regulatory subunit 6A × 1 （P17980） 26S proteasome non-ATPase regulatory subunit 1 × 1 （Q99460） 26S proteasome non-ATPase regulatory subunit 3 × 1 （O43242） 26S proteasome non-ATPase regulatory subunit 12 × 1 （O00232） 26S proteasome non-ATPase regulatory subunit 11 × 1 （O00231） 26S proteasome non-ATPase regulatory subunit 6 × 1 （Q15008） 26S proteasome non-ATPase regulatory subunit 7 × 1 （P51665） 26S proteasome non-ATPase regulatory subunit 4 × 1 （P55036） 26S proteasome non-ATPase regulatory subunit 14 × 1 （O00487） 26S proteasome non-ATPase regulatory subunit 8 × 1 （P48556） 26S proteasome complex subunit SEM1 × 1 （P60896） 26S proteasome non-ATPase regulatory subunit 10 × 1 （O75832） 26S proteasome non-ATPase regulatory subunit 2 × 1 （Q13200） ZINC ION × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSD13_HUMAN
Isoform	—
PDB entities	13
Chains and sequence ranges	Author chain a； PDBConstruct 1–374； UniProt 3–376

26S proteasome non-ATPase regulatory subunit 4

Homo sapiens

UniProt P55036

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 19	26S proteasome regulatory subunit 7 × 1 （P35998） 26S proteasome regulatory subunit 4 × 1 （P62191） 26S proteasome regulatory subunit 8 × 1 （P62195） 26S proteasome regulatory subunit 6B × 1 （P43686） 26S proteasome regulatory subunit 10B × 1 （P62333） 26S proteasome regulatory subunit 6A × 1 （P17980） 26S proteasome non-ATPase regulatory subunit 1 × 1 （Q99460） 26S proteasome non-ATPase regulatory subunit 3 × 1 （O43242） 26S proteasome non-ATPase regulatory subunit 12 × 1 （O00232） 26S proteasome non-ATPase regulatory subunit 11 × 1 （O00231） 26S proteasome non-ATPase regulatory subunit 6 × 1 （Q15008） 26S proteasome non-ATPase regulatory subunit 7 × 1 （P51665） 26S proteasome non-ATPase regulatory subunit 13 × 1 （Q9UNM6） 26S proteasome non-ATPase regulatory subunit 14 × 1 （O00487） 26S proteasome non-ATPase regulatory subunit 8 × 1 （P48556） 26S proteasome complex subunit SEM1 × 1 （P60896） 26S proteasome non-ATPase regulatory subunit 10 × 1 （O75832） 26S proteasome non-ATPase regulatory subunit 2 × 1 （Q13200） ZINC ION × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSMD4_HUMAN
Isoform	P55036-2
PDB entities	14
Chains and sequence ranges	Author chain b； PDBConstruct 1–191； UniProt 1–191

26S proteasome non-ATPase regulatory subunit 14

Homo sapiens

UniProt O00487

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 19	26S proteasome regulatory subunit 7 × 1 （P35998） 26S proteasome regulatory subunit 4 × 1 （P62191） 26S proteasome regulatory subunit 8 × 1 （P62195） 26S proteasome regulatory subunit 6B × 1 （P43686） 26S proteasome regulatory subunit 10B × 1 （P62333） 26S proteasome regulatory subunit 6A × 1 （P17980） 26S proteasome non-ATPase regulatory subunit 1 × 1 （Q99460） 26S proteasome non-ATPase regulatory subunit 3 × 1 （O43242） 26S proteasome non-ATPase regulatory subunit 12 × 1 （O00232） 26S proteasome non-ATPase regulatory subunit 11 × 1 （O00231） 26S proteasome non-ATPase regulatory subunit 6 × 1 （Q15008） 26S proteasome non-ATPase regulatory subunit 7 × 1 （P51665） 26S proteasome non-ATPase regulatory subunit 13 × 1 （Q9UNM6） 26S proteasome non-ATPase regulatory subunit 4 × 1 （P55036） 26S proteasome non-ATPase regulatory subunit 8 × 1 （P48556） 26S proteasome complex subunit SEM1 × 1 （P60896） 26S proteasome non-ATPase regulatory subunit 10 × 1 （O75832） 26S proteasome non-ATPase regulatory subunit 2 × 1 （Q13200） ZINC ION × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSDE_HUMAN
Isoform	—
PDB entities	15
Chains and sequence ranges	Author chain c； PDBConstruct 1–287； UniProt 24–310

26S proteasome non-ATPase regulatory subunit 8

Homo sapiens

UniProt P48556

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 19	26S proteasome regulatory subunit 7 × 1 （P35998） 26S proteasome regulatory subunit 4 × 1 （P62191） 26S proteasome regulatory subunit 8 × 1 （P62195） 26S proteasome regulatory subunit 6B × 1 （P43686） 26S proteasome regulatory subunit 10B × 1 （P62333） 26S proteasome regulatory subunit 6A × 1 （P17980） 26S proteasome non-ATPase regulatory subunit 1 × 1 （Q99460） 26S proteasome non-ATPase regulatory subunit 3 × 1 （O43242） 26S proteasome non-ATPase regulatory subunit 12 × 1 （O00232） 26S proteasome non-ATPase regulatory subunit 11 × 1 （O00231） 26S proteasome non-ATPase regulatory subunit 6 × 1 （Q15008） 26S proteasome non-ATPase regulatory subunit 7 × 1 （P51665） 26S proteasome non-ATPase regulatory subunit 13 × 1 （Q9UNM6） 26S proteasome non-ATPase regulatory subunit 4 × 1 （P55036） 26S proteasome non-ATPase regulatory subunit 14 × 1 （O00487） 26S proteasome complex subunit SEM1 × 1 （P60896） 26S proteasome non-ATPase regulatory subunit 10 × 1 （O75832） 26S proteasome non-ATPase regulatory subunit 2 × 1 （Q13200） ZINC ION × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSMD8_HUMAN
Isoform	—
PDB entities	16
Chains and sequence ranges	Author chain d； PDBConstruct 1–257； UniProt 94–350

26S proteasome complex subunit SEM1

Homo sapiens

UniProt P60896

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 19	26S proteasome regulatory subunit 7 × 1 （P35998） 26S proteasome regulatory subunit 4 × 1 （P62191） 26S proteasome regulatory subunit 8 × 1 （P62195） 26S proteasome regulatory subunit 6B × 1 （P43686） 26S proteasome regulatory subunit 10B × 1 （P62333） 26S proteasome regulatory subunit 6A × 1 （P17980） 26S proteasome non-ATPase regulatory subunit 1 × 1 （Q99460） 26S proteasome non-ATPase regulatory subunit 3 × 1 （O43242） 26S proteasome non-ATPase regulatory subunit 12 × 1 （O00232） 26S proteasome non-ATPase regulatory subunit 11 × 1 （O00231） 26S proteasome non-ATPase regulatory subunit 6 × 1 （Q15008） 26S proteasome non-ATPase regulatory subunit 7 × 1 （P51665） 26S proteasome non-ATPase regulatory subunit 13 × 1 （Q9UNM6） 26S proteasome non-ATPase regulatory subunit 4 × 1 （P55036） 26S proteasome non-ATPase regulatory subunit 14 × 1 （O00487） 26S proteasome non-ATPase regulatory subunit 8 × 1 （P48556） 26S proteasome non-ATPase regulatory subunit 10 × 1 （O75832） 26S proteasome non-ATPase regulatory subunit 2 × 1 （Q13200） ZINC ION × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	SEM1_HUMAN
Isoform	—
PDB entities	17
Chains and sequence ranges	Author chain e； PDBConstruct 1–70； UniProt 1–70

26S proteasome non-ATPase regulatory subunit 10

Homo sapiens

UniProt O75832

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 19	26S proteasome regulatory subunit 7 × 1 （P35998） 26S proteasome regulatory subunit 4 × 1 （P62191） 26S proteasome regulatory subunit 8 × 1 （P62195） 26S proteasome regulatory subunit 6B × 1 （P43686） 26S proteasome regulatory subunit 10B × 1 （P62333） 26S proteasome regulatory subunit 6A × 1 （P17980） 26S proteasome non-ATPase regulatory subunit 1 × 1 （Q99460） 26S proteasome non-ATPase regulatory subunit 3 × 1 （O43242） 26S proteasome non-ATPase regulatory subunit 12 × 1 （O00232） 26S proteasome non-ATPase regulatory subunit 11 × 1 （O00231） 26S proteasome non-ATPase regulatory subunit 6 × 1 （Q15008） 26S proteasome non-ATPase regulatory subunit 7 × 1 （P51665） 26S proteasome non-ATPase regulatory subunit 13 × 1 （Q9UNM6） 26S proteasome non-ATPase regulatory subunit 4 × 1 （P55036） 26S proteasome non-ATPase regulatory subunit 14 × 1 （O00487） 26S proteasome non-ATPase regulatory subunit 8 × 1 （P48556） 26S proteasome complex subunit SEM1 × 1 （P60896） 26S proteasome non-ATPase regulatory subunit 2 × 1 （Q13200） ZINC ION × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSD10_HUMAN
Isoform	—
PDB entities	18
Chains and sequence ranges	Author chain G； PDBConstruct 1–223； UniProt 4–226

26S proteasome non-ATPase regulatory subunit 2

Homo sapiens

UniProt Q13200

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 19	26S proteasome regulatory subunit 7 × 1 （P35998） 26S proteasome regulatory subunit 4 × 1 （P62191） 26S proteasome regulatory subunit 8 × 1 （P62195） 26S proteasome regulatory subunit 6B × 1 （P43686） 26S proteasome regulatory subunit 10B × 1 （P62333） 26S proteasome regulatory subunit 6A × 1 （P17980） 26S proteasome non-ATPase regulatory subunit 1 × 1 （Q99460） 26S proteasome non-ATPase regulatory subunit 3 × 1 （O43242） 26S proteasome non-ATPase regulatory subunit 12 × 1 （O00232） 26S proteasome non-ATPase regulatory subunit 11 × 1 （O00231） 26S proteasome non-ATPase regulatory subunit 6 × 1 （Q15008） 26S proteasome non-ATPase regulatory subunit 7 × 1 （P51665） 26S proteasome non-ATPase regulatory subunit 13 × 1 （Q9UNM6） 26S proteasome non-ATPase regulatory subunit 4 × 1 （P55036） 26S proteasome non-ATPase regulatory subunit 14 × 1 （O00487） 26S proteasome non-ATPase regulatory subunit 8 × 1 （P48556） 26S proteasome complex subunit SEM1 × 1 （P60896） 26S proteasome non-ATPase regulatory subunit 10 × 1 （O75832） ZINC ION × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSMD2_HUMAN
Isoform	—
PDB entities	19
Chains and sequence ranges	Author chain f； PDBConstruct 1–848； UniProt 6–853

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	5vhh
Deposition date deposition_date	2017-04-13
Structure title title	Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle
Keywords keywords	p28, 26S proteasome, regulatory particle, 19S, gankyrin, HYDROLASE; HYDROLASE
Experimental Method method	ELECTRON MICROSCOPY

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

5vhh__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

5vhh__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

5vhh__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	71.00 Å
Rg (electron density)	70.66 Å
Total Rg	70.73 Å
Atom count	55279
Residues	6982
Excluded volume	990170 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`5vhh__assembly_1__model_1`	nonadecameric （19）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (20)

Entity 1 Entity 1 polymer

Description description	26S proteasome regulatory subunit 7
Molecular weight formula_weight	39395.4 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	A
Atom count atom_count	55280

APPALWDLAADKQTLQSEQPLQVARCTKIINADSEDPKYIINVKQFAKFVVDLSDQVAPTDIEEGMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEKPDVTYSDVGGCKEQIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLCARAVANRTDACFIRVIGSELVQKYVGEGARMVRELFEMARTKKACLIFFDEIDAIGGARFDDGAGGDNEVQRTMLELINQLDGFDPRGNIKVLMATNRPDTLDPALMRPGRLDRKIEFSLPDLEGRTHIFKIHARSMSVERDIRFELLARLCPNSTGAEIRSVCTEAGMFAIRARRKIATEKDFLEAVNKVIKSYAKFS

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 2 Entity 2 polymer

Description description	26S proteasome regulatory subunit 4
Molecular weight formula_weight	37968.3 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	B

EEERSKVDDLRGTPMSVGTLEEIIDDNHAIVSTSVGSEHYVSILSFVDKDLLEPGCSVLLNHKVHAVIGVLMDDTDPLVTVMKVEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKTKKRIFQIHTSRMTLADDVTLDDLIMAKDDLSGADIKAICTEAGLMALRERRMKVTNEDFKKSKENVLYKKQE

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 3 Entity 3 polymer

Description description	26S proteasome regulatory subunit 8
Molecular weight formula_weight	43201.1 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	C

LEEGKAGSGLRQYYLSKIEELQLIVNDKSQNLRRLQAQRNELNAKVRLLREELQLLQEQGSYVGEVVRAMDKKKVLVKVHPEGKFVVDVDKNIDINDVTPNCRVALRNDSYTLHKILPNKVDPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIGEGARMVRELFVMAREHAPSIIFMDEIDSIGSSRLEGGSGGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDILDSALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAELMPGASGAEVKGVCTEAGMYALRERRVHVTQEDFEMAVAKVMQKDS

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 4 Entity 4 polymer

Description description	26S proteasome regulatory subunit 6B
Molecular weight formula_weight	41723.8 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	D

DLYSRYKKLQQELEFLEVQEEYIKDEQKNLKKEFLHAQEEVKRIQSIPLVIGQFLEAVDQNTAIVGSTTGSNYYVRILSTIDRELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVRENRYIVLAKDFEKAYKTV

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 5 Entity 5 polymer

Description description	26S proteasome regulatory subunit 10B
Molecular weight formula_weight	43112.7 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	E

DYRKKLLEHKEIDGRLKELREQLKELTKQYEKSENDLKALQSVGQIVGEVLKQLTEEKFIVKATNGPRYVVGCRRQLDKSKLKPGTRVALDMTTLTIMRYLPREVDPLVYNMSHEDPGNVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVASQLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLDPALLRPGRLDRKIHIDLPNEQARLDILKIHAGPITKHGEIDYEAIVKLSDGFNGADLRNVCTEAGMFAIRADHDFVVQEDFMKAVRKVADSKKLESKLDYKPV

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 6 Entity 6 polymer

Description description	26S proteasome regulatory subunit 6A
Molecular weight formula_weight	42467.9 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	F

KIMKSEVLRVTHELQAMKDKIKENSEKIKVNKTLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKGKCAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGATELTHEDYMEGILEVQAKKK

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 7 Entity 7 polymer

Description description	26S proteasome non-ATPase regulatory subunit 1
Molecular weight formula_weight	103755.0 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	U

MITSAAGIISLLDEDEPQLKEFALHKLNAVVNDFWAEISESVDKIEVLYEDEGFRSRQFAALVASKVFYHLGAFEESLNYALGAGDLFNVNDNSEYVETIIAKCIDHYTKQCVENADLPEGEKKPIDQRLEGIVNKMFQRCLDDHKYKQAIGIALETRRLDVFEKTILESNDVPGMLAYSLKLCMSLMQNKQFRNKVLRVLVKIYMNLEKPDFINVCQCLIFLDDPQAVSDILEKLVKEDNLLMAYQICFDLYESASQQFLSSVIQNLRTVGTPIASVPGSTNTGTVPGSEKDSDSMETEEKTSSAFVGKTPEASPEPKDQTLKMIKILSGEMAIELHLQFLIRNNNTDLMILKNTKDAVRNSVCHTATVIANSFMHCGTTSDQFLRDNLEWLARATNWAKFTATASLGVIHKGHEKEALQLMATYLPKDTSPGSAYQEGGGLYALGLIHANHGGDIIDYLLNQLKNASNDIVRHGGSLGLGLAAMGTARQDVYDLLKTNLYQDDAVTGEAAGLALGLVMLGSKNAQAIEDMVGYAQETQHEKILRGLAVGIALVMYGRMEEADALIESLCRDKDPILRRSGMYTVAMAYCGSGNNKAIRRLLHVAVSDVNDDVRRAAVESLGFILFRTPEQCPSVVSLLSESYNPHVRYGAAMALGICCAGTGNKEAINLLEPMTNDPVNYVRQGALIASALIMIQQTEITCPKVNQFRQLYSKVINDKHDDVMAKFGAILAQGILDAGGHNVTISLQSRTGHTHMPSVVGVLVFTQFWFWFPLSHFLSLAYTPTCVIGLNKDLKMPKVQYKSNCKPSTFAYPAPLEVPKEKEKEKVSTAVLSITAKAKKKEKEKEKKEEEKMEVDEAEKKEEKEKKKEPEPNFQLLDNPARVMPAQLKVLTMPETCRYQPFKPLSIGGIIILKDTSEDIEELVEPVAAHGPKI

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 8 Entity 8 polymer

Description description	26S proteasome non-ATPase regulatory subunit 3
Molecular weight formula_weight	55703.7 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	V

PPGGGEQEPPPPPAPQDVEMKEEAATGGGSTGEADGKTAAAAAEHSQRELDTVTLEDIKEHVKQLEKAVSGKEPRFVLRALRMLPSTSRRLNHYVLYKAVQGFFTSNNATRDFLLPFLEEPMDTEADLQFRPRTGKAASTPLLPEVEAYLQLLVVIFMMNSKRYKEAQKISDDLMQKISTQNRRALDLVAAKCYYYHARVYEFLDKLDVVRSFLHARLRTATLRHDADGQATLLNLLLRNYLHYSLYDQAEKLVSKSVFPEQANNNEWARYLYYTGRIKAIQLEYSEARRTMTNALRKAPQHTAVGFKQTVHKLLIVVELLLGEIPDRLQFRQPSLKRSLMPYFLLTQAVRTGNLAKFNQVLDQFGEKFQADGTYTLIIRLRHNVIKTGVRMISLSYSRISLADIAQKLQLDSPEDAEFIVAKAIRDGVIEASINHEKGYVQSKEMIDIYSTREPQLAFHQRISFCLDIHNMSVKAMRFPPKSYNKDL

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 9 Entity 9 polymer

Description description	26S proteasome non-ATPase regulatory subunit 12
Molecular weight formula_weight	52979.4 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	W

MADGGSERADGRIVKMEVDYSATVDQRLPECAKLAKEGRLQEVIETLLSLEKQTRTASDMVSTSRILVAVVKMCYEAKEWDLLNENIMLLSKRRSQLKQAVAKMVQQCCTYVEEITDLPIKLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVKEAASILQELQVETYGSMEKKERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTEKLKLKYYNLMIQLDQHEGSYLSICKHYRAIYDTPCIQAESEKWQQALKSVVLYVILAPFDNEQSDLVHRISGDKKLEEIPKYKDLLKLFTTMELMRWSTLVEDYGMELRKGSLESPATDVFGSTEEGEKRWKDLKNRVVEHNIRIMAKYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGIINFQRPKDPNNLLNDWSQKLNSLMSLVNKTTHLIAKEEMIHNLQ

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 10 Entity 10 polymer

Description description	26S proteasome non-ATPase regulatory subunit 11
Molecular weight formula_weight	43427.1 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	X

NDEEAVQVKEQSILELGSLLAKTGQAAELGGLLKYVRPFLNSISKAKAARLVRSLLDLFLDMEAATGQEVELCLECIEWAKSEKRTFLRQALEARLVSLYFDTKRYQEALHLGSQLLRELKKMDDKALLVEVQLLESKTYHALSNLPKARAALTSARTTANAIYCPPKLQATLDMQSGIIHAAEEKDWKTAYSYFYEAFEGYDSIDSPKAITSLKYMLLCKIMLNTPEDVQALVSGKLALRYAGRQTEALKCVAQASKNRSLADFEKALTDYRAELRDDPIISTHLAKLYDNLLEQNLIRVIEPFSRVQIEHISSLIKLSKADVERKLSQMILDKKFHGILDQGEGVLIIFDEPPVDKTYEAALETIQNMSKVVDSLYNKAKKLT

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 11 Entity 11 polymer

Description description	26S proteasome non-ATPase regulatory subunit 6
Molecular weight formula_weight	44336.9 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	Y

PKNPDLRIAQLRFLLSLPEHRGDAAVRDELMAAVRDNNMAPYYEALCKSLDWQIDVDLLNKMKKANEDELKRLDEELEDAEKNLGESEIRDAMMAKAEYLCRIGDKEGALTAFRKTYDKTVALGHRLDIVFYLLRIGLFYMDNDLITRNTEKAKSLIEEGGDWDRRNRLKVYQGLYCVAIRDFKQAAELFLDTVSTFTSYELMDYKTFVTYTVYVSMIALERPDLREKVIKGAEILEVLHSLPAVRQYLFSLYECRYSVFFQSLAVVEQEMKKDWLFAPHYRYYVREMRIHAYSQLLESYRSLTLGYMAEAFGVGVEFIDQELSRFIAAGRLHCKIDKVNEIVETNRPDSKNWQYQETIKKGDLLLNRVQKLSRVINM

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 12 Entity 12 polymer

Description description	26S proteasome non-ATPase regulatory subunit 7
Molecular weight formula_weight	32382.1 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	Z

AVQKVVVHPLVLLSVVDHFNRIGKVGNQKRVVGVLLGSWQKKVLDVSNSFAVPFDEDDKDDSVWFLDHDYLENMYGMFKKVNARERIVGWYHTGPKLHKNDIAINELMKRYCPNSVLVIIDVKPKDLGLPTEAYISVEEVHDDGTPTSKTFEHVTSEIGAEEAEEVGVEHLLRDIKDTTVGTLSQRITNQVHGLKGLNSKLLDIRSYLEKVATGKLPINHQIIYQLQDVFNLLPDVSLQEFVKAFYLKTNDQMVVVYLASLIRSVVALHNLINNKIANRDAEKKEG

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 13 Entity 13 polymer

Description description	26S proteasome non-ATPase regulatory subunit 13
Molecular weight formula_weight	42735.0 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	a

DVPGFLQQSQNSGPGQPAVWHRLEELYTKKLWHQLTLQVLDFVQDPCFAQGDGLIKLYENFISEFEHRVNPLSLVEIILHVVRQMTDPNVALTFLEKTREKVKSSDEAVILCKTAIGALKLNIGDLQVTKETIEDVEEMLNNLPGVTSVHSRFYDLSSKYYQTIGNHASYYKDALRFLGCVDIKDLPVSEQQERAFTLGLAGLLGEGVFNFGELLMHPVLESLRNTDRQWLIDTLYAFNSGNVERFQTLKTAWGQQPDLAANEAQLLRKIQLLCLMEMTFTRPANHRQLTFEEIAKSAKITVNEVELLVMKALSVGLVKGSIDEVDKRVHMTWVQPRVLDLQQIKGMKDRLEFWCTDVKSMEMLVEHQAHDILT

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 14 Entity 14 polymer

Description description	26S proteasome non-ATPase regulatory subunit 4
Molecular weight formula_weight	20866.0 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	b

MVLESTMVCVDNSEYMRNGDFLPTRLQAQQDAVNIVCHSKTRSNPENNVGLITLANDCEVLTTLTPDTGRILSKLHTVQPKGKITFCTGIRVAHLALKHRQGKNHKMRIIAFVGSPVEDNEKDLVKLAKRLKKEKVNVDIINFGEEEVNTEKLTAFVNTLNGKDGTGSHLVTVPPGPSLADALISSPILAG

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 15 Entity 15 polymer

Description description	26S proteasome non-ATPase regulatory subunit 14
Molecular weight formula_weight	32329.4 kDa
EC 编号 ec_number	3.4.19.-
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	c

AVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSNLGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKHNESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCLAAMLDTVVFK

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 16 Entity 16 polymer

Description description	26S proteasome non-ATPase regulatory subunit 8
Molecular weight formula_weight	30039.7 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	d

MYEQLKGEWNRKSPNLSKCGEELGRLKLVLLELNFLPTTGTKLTKQQLILARDILEIGAQWSILRKDIPSFERYMAQLKCYYFDYKEQLPESAYMHQLLGLNLLFLLSQNRVAEFHTELERLPAKDIQTNVYIKHPVSLEQYLMEGSYNKVFLAKGNIPAESYTFFIDILLDTIRDEIAGCIEKAYEKILFTEATRILFFNTPKKMTDYAKKRGWVLGPNNYYSFASQQQKPEDTTIPSTELAKQVIEYARQLEMIV

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 17 Entity 17 polymer

Description description	26S proteasome complex subunit SEM1
Molecular weight formula_weight	8284.6 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	e

MSEKKQPVDLGLLEEDDEFEEFPAEDWAGLDEDEDAHVWEDNWDDDNVEDDFSNQLRAELEKHGYKMETS

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 18 Entity 18 polymer

Description description	26S proteasome non-ATPase regulatory subunit 10
Molecular weight formula_weight	24142.5 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	G

CVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMVEG

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 19 Entity 19 polymer

Description description	26S proteasome non-ATPase regulatory subunit 2
Molecular weight formula_weight	93790.2 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	f

RDKAPVQPQQSPAAAPGGTDEKPSGKERRDAGDKDKEQELSEEDKQLQDELEMLVERLGEKDTSLYRPALEELRRQIRSSTTSMTSVPKPLKFLRPHYGKLKEIYENMAPGENKRFAADIISVLAMTMSGERECLKYRLVGSQEELASWGHEYVRHLAGEVAKEWQELDDAEKVQREPLLTLVKEIVPYNMAHNAEHEACDLLMEIEQVDMLEKDIDENAYAKVCLYLTSCVNYVPEPENSALLRCALGVFRKFSRFPEALRLALMLNDMELVEDIFTSCKDVVVQKQMAFMLGRHGVFLELSEDVEEYEDLTEIMSNVQLNSNFLALARELDIMEPKVPDDIYKTHLENNRFGGSGSQVDSARMNLASSFVNGFVNAAFGQDKLLTDDGNKWLYKNKDHGMLSAAASLGMILLWDVDGGLTQIDKYLYSSEDYIKSGALLACGIVNSGVRNECDPALALLSDYVLHNSNTMRLGSIFGLGLAYAGSNREDVLTLLLPVMGDSKSSMEVAGVTALACGMIAVGSCNGDVTSTILQTIMEKSETELKDTYARWLPLGLGLNHLGKGEAIEAILAALEVVSEPFRSFANTLVDVCAYAGSGNVLKVQQLLHICSEHFDSKEKEEDKDKKEKKDKDKKEAPADMGAHQGVAVLGIALIAMGEEIGAEMALRTFGHLLRYGEPTLRRAVPLALALISVSNPRLNILDTLSKFSHDADPEVSYNSIFAMGMVGSGTNNARLAAMLRQLAQYHAKDPNNLFMVRLAQGLTHLGKGTLTLCPYHSDRQLMSQVAVAGLLTVLVSFLDVRNIILGKSHYVLYGLVAAMQPRMLVTFDEELRPLPVSVRVGQAVDVV

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 20 Entity 20 non-polymer

Description description	ZINC ION
Molecular weight formula_weight	65.4 kDa
Source method src_method	syn
Copy count entity_count	1

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Resolution resolution	6.10 Å
Resolution测定Method resolution_method	—
颗粒数 num_particles	27629

Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle

1. Protein Identity and Related Structures Protein Identity & Related Structures

26S proteasome regulatory subunit 7

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

26S proteasome regulatory subunit 4

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

26S proteasome regulatory subunit 8

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

26S proteasome regulatory subunit 6B

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

26S proteasome regulatory subunit 10B

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

26S proteasome regulatory subunit 6A

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

26S proteasome non-ATPase regulatory subunit 1

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

26S proteasome non-ATPase regulatory subunit 3

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

26S proteasome non-ATPase regulatory subunit 12

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

26S proteasome non-ATPase regulatory subunit 11

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer