6c1d

High-Resolution Cryo-EM Structures of Actin-bound Myosin States Reveal the Mechanism of Myosin Force Sensing

Method: ELECTRON MICROSCOPY
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1. 蛋白身份与相关结构 Protein Identity & Related Structures

Actin, alpha skeletal muscle

物种未注明

UniProt P68135

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 8 Unconventional myosin-Ib × 1 (Q05096) Calmodulin × 1 Phalloidin × 1 ADENOSINE-5'-DIPHOSPHATE × 6 MAGNESIUM ION × 6 待复核

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 ACTS_RABIT
Isoform —
PDB实体 1
链与序列区间 作者链 A; PDB构建体 1–375; UniProt 3–377 作者链 B; PDB构建体 1–375; UniProt 3–377 作者链 C; PDB构建体 1–375; UniProt 3–377 作者链 D; PDB构建体 1–375; UniProt 3–377 作者链 E; PDB构建体 1–375; UniProt 3–377

Unconventional myosin-Ib

物种未注明

UniProt Q05096

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 8 Actin, alpha skeletal muscle × 5 (P68135) Calmodulin × 1 Phalloidin × 1 ADENOSINE-5'-DIPHOSPHATE × 6 MAGNESIUM ION × 6 待复核

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 MYO1B_RAT
Isoform Q05096-2
PDB实体 2
链与序列区间 作者链 P; PDB构建体 1–723; UniProt 6–728

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中;数据库内部编号、导入时间和 assembly 操作表达式仅用于维护,因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id6c1d
沉积日期 deposition_date2018-01-04
结构标题 titleHigh-Resolution Cryo-EM Structures of Actin-bound Myosin States Reveal the Mechanism of Myosin Force Sensing
关键词 keywordsMechanochemistry, Mechanobiology, Structural Biology, Cytoskeleton, Molecular Motor, Myosin-I, STRUCTURAL PROTEIN; STRUCTURAL PROTEIN
实验方法 methodELECTRON MICROSCOPY
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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

6c1d__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

6c1d__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 q (1/Angstrom) I(q)
100 个绘图点;横轴和纵轴均采用对数尺度。

6c1d__assembly_1__model_1 | P(r) · Pending

新版 assembly/model P(r) 尚未计算 此处仅保留位置,不展示旧数据 r (Angstrom) P(r)
P(r) 将按相同 assembly/model 分别计算和展示。
Rg(Guinier)55.55 Å
Rg(电子密度)54.28 Å
总 Rg53.79 Å
原子数21049
残基数2755
排除体积370500 ų
最大 q0.500 Å⁻¹
Assembly Model 结构单元 聚集说明 状态 CRYSOL 操作
1 1 6c1d__assembly_1__model_1 heptameric (7) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (6)

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6. 折叠分类 (SCOP + CATH) 22 domains

CATH v4.4 (22 domains)

结构域编号 domain_id6c1dA01
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology420 — Nucleotidyltransferase; domain 5
同源超家族 H-superfamily homologous superfamily40 — ATPase, nucleotide binding domain
结构域编号 domain_id6c1dA02
类 Class class2 — Mainly Beta
架构 Architecture architecture30 — Roll
拓扑 Topology topology36 — Actin; Chain A, domain 2
同源超家族 H-superfamily homologous superfamily70 — Actin; Chain A, domain 2
结构域编号 domain_id6c1dA03
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology420 — Nucleotidyltransferase; domain 5
同源超家族 H-superfamily homologous superfamily40 — ATPase, nucleotide binding domain
结构域编号 domain_id6c1dA04
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology640 — Actin; Chain A, domain 4
同源超家族 H-superfamily homologous superfamily10 — ATPase, substrate binding domain, subdomain 4
结构域编号 domain_id6c1dB01
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology420 — Nucleotidyltransferase; domain 5
同源超家族 H-superfamily homologous superfamily40 — ATPase, nucleotide binding domain
结构域编号 domain_id6c1dB02
类 Class class2 — Mainly Beta
架构 Architecture architecture30 — Roll
拓扑 Topology topology36 — Actin; Chain A, domain 2
同源超家族 H-superfamily homologous superfamily70 — Actin; Chain A, domain 2
结构域编号 domain_id6c1dB03
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology420 — Nucleotidyltransferase; domain 5
同源超家族 H-superfamily homologous superfamily40 — ATPase, nucleotide binding domain
结构域编号 domain_id6c1dB04
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology640 — Actin; Chain A, domain 4
同源超家族 H-superfamily homologous superfamily10 — ATPase, substrate binding domain, subdomain 4
结构域编号 domain_id6c1dC01
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology420 — Nucleotidyltransferase; domain 5
同源超家族 H-superfamily homologous superfamily40 — ATPase, nucleotide binding domain
结构域编号 domain_id6c1dC02
类 Class class2 — Mainly Beta
架构 Architecture architecture30 — Roll
拓扑 Topology topology36 — Actin; Chain A, domain 2
同源超家族 H-superfamily homologous superfamily70 — Actin; Chain A, domain 2
结构域编号 domain_id6c1dC03
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology420 — Nucleotidyltransferase; domain 5
同源超家族 H-superfamily homologous superfamily40 — ATPase, nucleotide binding domain
结构域编号 domain_id6c1dC04
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology640 — Actin; Chain A, domain 4
同源超家族 H-superfamily homologous superfamily10 — ATPase, substrate binding domain, subdomain 4
结构域编号 domain_id6c1dD01
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology420 — Nucleotidyltransferase; domain 5
同源超家族 H-superfamily homologous superfamily40 — ATPase, nucleotide binding domain
结构域编号 domain_id6c1dD02
类 Class class2 — Mainly Beta
架构 Architecture architecture30 — Roll
拓扑 Topology topology36 — Actin; Chain A, domain 2
同源超家族 H-superfamily homologous superfamily70 — Actin; Chain A, domain 2
结构域编号 domain_id6c1dD03
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology420 — Nucleotidyltransferase; domain 5
同源超家族 H-superfamily homologous superfamily40 — ATPase, nucleotide binding domain
结构域编号 domain_id6c1dD04
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology640 — Actin; Chain A, domain 4
同源超家族 H-superfamily homologous superfamily10 — ATPase, substrate binding domain, subdomain 4
结构域编号 domain_id6c1dE01
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology420 — Nucleotidyltransferase; domain 5
同源超家族 H-superfamily homologous superfamily40 — ATPase, nucleotide binding domain
结构域编号 domain_id6c1dE02
类 Class class2 — Mainly Beta
架构 Architecture architecture30 — Roll
拓扑 Topology topology36 — Actin; Chain A, domain 2
同源超家族 H-superfamily homologous superfamily70 — Actin; Chain A, domain 2
结构域编号 domain_id6c1dE03
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology420 — Nucleotidyltransferase; domain 5
同源超家族 H-superfamily homologous superfamily40 — ATPase, nucleotide binding domain
结构域编号 domain_id6c1dE04
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology640 — Actin; Chain A, domain 4
同源超家族 H-superfamily homologous superfamily10 — ATPase, substrate binding domain, subdomain 4
结构域编号 domain_id6c1dP01
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
同源超家族 H-superfamily homologous superfamily4820 —
结构域编号 domain_id6c1dR01
类 Class class1 — Mainly Alpha
架构 Architecture architecture10 — Orthogonal Bundle
拓扑 Topology topology238 — Recoverin; domain 1
同源超家族 H-superfamily homologous superfamily10 — EF-hand
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7. 引用文献 (1)