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6eny

Structure of the human PLC editing module

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Beta-2-microglobulin

OrganismNot specified

UniProt P61769

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Other combination Heteromer Protein 5 其他Polymer 2 Tapasin × 1 （O15533） Protein disulfide-isomerase A3 × 1 （P30101） HLA class I histocompatibility antigen, A-3 alpha chain × 1 （P04439） Calreticulin × 1 （P27797） 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 1 beta-D-glucopyranose-(1-3)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1jnj 1lds 1py4 1py4 1py4 1py4 2d4d 2d4f 2vb5 2xks 2xku 2yxf

61 assemblies; showing the first 12

Homodimer
2x89 2x89 2z9t 3low 4r9h 4r9h 4ra3 4ra3 4rah 6m1b

10 assemblies

Homotetramer
2e8d 2f8o 3tlr 3tm6 3tm6 7afv

6 assemblies

Other homooligomers
3ciq 3ciq 3loz 6gk3 8a7o 8a7p 8a7q 8a7t

8 assemblies

Heteromeric or nucleic-acid complex
1a1m 1a1n 1a1o 1a6z 1a6z 1a9b 1a9b 1a9e 1agb 1agc 1agd 1age

1914 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name B2MG_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain B； PDBConstruct 1–99； UniProt 21–119

Tapasin

OrganismNot specified

UniProt O15533

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Other combination Heteromer Protein 5 其他Polymer 2 Beta-2-microglobulin × 1 （P61769） Protein disulfide-isomerase A3 × 1 （P30101） HLA class I histocompatibility antigen, A-3 alpha chain × 1 （P04439） Calreticulin × 1 （P27797） 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 1 beta-D-glucopyranose-(1-3)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
3f8u 3f8u 3f8u 6eny 7qng 7qpd 7tue 7tuf 7tug 9rcv

10 assemblies

View Construct and Data Evidence
UniProt name TPSN_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain C； PDBConstruct 1–428； UniProt 21–448

Protein disulfide-isomerase A3

OrganismNot specified

UniProt P30101

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Other combination Heteromer Protein 5 其他Polymer 2 Beta-2-microglobulin × 1 （P61769） Tapasin × 1 （O15533） HLA class I histocompatibility antigen, A-3 alpha chain × 1 （P04439） Calreticulin × 1 （P27797） 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 1 beta-D-glucopyranose-(1-3)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
2alb 2dmm 2h8l 2h8l 2h8l 9wqu 9wqu 9wqu

8 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
3f8u 3f8u 3f8u 6eny 7qng 7qpd

6 assemblies

View Construct and Data Evidence
UniProt name PDIA3_HUMAN
Isoform —
PDB entities 3
Chains and sequence ranges Author chain D； PDBConstruct 1–481； UniProt 25–505

HLA class I histocompatibility antigen, A-3 alpha chain

OrganismNot specified

UniProt P04439

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Other combination Heteromer Protein 5 其他Polymer 2 Beta-2-microglobulin × 1 （P61769） Tapasin × 1 （O15533） Protein disulfide-isomerase A3 × 1 （P30101） Calreticulin × 1 （P27797） 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 1 beta-D-glucopyranose-(1-3)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2xpg 3rl1 3rl2 6eny 6o9b 6o9c 7l1b 7l1c 7l1d 7mle 7phr 7qpd

79 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name 1A03_HUMAN
Isoform —
PDB entities 4
Chains and sequence ranges Author chain F； PDBConstruct 1–341； UniProt 25–365

Calreticulin

OrganismNot specified

UniProt P27797

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Other combination Heteromer Protein 5 其他Polymer 2 Beta-2-microglobulin × 1 （P61769） Tapasin × 1 （O15533） Protein disulfide-isomerase A3 × 1 （P30101） HLA class I histocompatibility antigen, A-3 alpha chain × 1 （P04439） 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 1 beta-D-glucopyranose-(1-3)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
3pos 3pos 3pos 3pow

4 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers
5lk5

1 assemblies

Heteromeric or nucleic-acid complex
2clr 2clr 3dow 5v90 5v90 6eny 7qpd 8tzo 8tzr

9 assemblies

View Construct and Data Evidence
UniProt name CALR_HUMAN
Isoform —
PDB entities 5
Chains and sequence ranges Author chain G； PDBConstruct 1–400； UniProt 18–417

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id6eny
Deposition date deposition_date2017-10-07
Structure title titleStructure of the human PLC editing module
Keywords keywordsadaptive immunity, antigen processing, chaperone, MHC class I, IMMUNE SYSTEM; IMMUNE SYSTEM
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6eny__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6eny__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

6eny__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）42.25 Å
Rg (electron density)42.10 Å
Total Rg42.27 Å
Atom count7778
Residues1563
Excluded volume125360 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 6eny__assembly_1__model_1 pentameric （5） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (7)

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7. Citations (1)