SAXSdb — 6fln

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1. Protein Identity and Related Structures Protein Identity & Related Structures

E3 ubiquitin/ISG15 ligase TRIM25

Homo sapiens

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein homooligomer	Homooligomer	Protein 2	No other associated polymer	Consistent with protein count
2	Protein homooligomer	Homooligomer	Protein 2	No other associated polymer	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	TRI25_HUMAN
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 4–445； UniProt 189–630 Author chain B； PDBConstruct 4–445； UniProt 189–630 Author chain E； PDBConstruct 4–445； UniProt 189–630

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	6fln
Deposition date deposition_date	2018-01-26
Structure title title	Crystal structure of the human TRIM25 coiled-coil and PRYSPRY domains
Keywords keywords	Coiled-coil, PRYSPRY domain, TRIM proteins, E3 ligase, PROTEIN BINDING; PROTEIN BINDING
Experimental Method method	X-RAY DIFFRACTION

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6fln__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6fln__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

6fln__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	52.15 Å
Rg (electron density)	53.44 Å
Total Rg	52.99 Å
Atom count	5921
Residues	733
Excluded volume	105820 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`6fln__assembly_1__model_1`	dimeric （2）	Success	4.1.3-1-20251215 (887e7ef)	View Download
2	1	`6fln__assembly_2__model_1`	dimeric （2）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (1)

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Unit-cell length a length_a	89.920 Å
Unit-cell length b length_b	89.920 Å
Unit-cell length c length_c	827.090 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	90.00 °
Unit-cell angle γ angle_gamma	120.00 °
Molecules per unit cell Z z_pdb	36

Space group space_group	P 61 2 2
Space-group number int_tables_number	178
Crystal system crystal_system	—

Resolution resolution	3.600 Å
Low-resolution limit resolution_low	137.850 Å
R factor r_factor	0.2888
R_work r_work	0.2872
R_free r_free	0.3184

Description description	E3 ubiquitin/ISG15 ligase TRIM25
Molecular weight formula_weight	50288.5 kDa
EC 编号 ec_number	6.3.2.-,2.3.2.27
Source method src_method	man
Copy count entity_count	3

Polymer type type	polypeptide(L)
Chain IDs strand_id	A,B,E
Atom count atom_count	8861

Crystal structure of the human TRIM25 coiled-coil and PRYSPRY domains

1. Protein Identity and Related Structures Protein Identity & Related Structures

E3 ubiquitin/ISG15 ligase TRIM25

State in the Current Structure

Other States of the Same Protein in the Database

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

6fln__assembly_1__model_1

6fln__assembly_1__model_1 | I(q)

6fln__assembly_1__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

Refinement Refinement

Diffraction experiment Diffraction

5. Entities and Polymers Entities & Polymers (1)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

7. Citations (1)

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Crystal structure of the human TRIM25 coiled-coil and PRYSPRY domains

1. Protein Identity and Related Structures Protein Identity & Related Structures

E3 ubiquitin/ISG15 ligase TRIM25

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

6fln__assembly_1__model_1

6fln__assembly_1__model_1 | I(q)

6fln__assembly_1__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

Refinement Refinement

Diffraction experiment Diffraction

5. Entities and Polymers Entities & Polymers (1)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

7. Citations (1)