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6gvc

Structure of ArhGAP12 bound to G-Actin

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Actin, alpha skeletal muscle

OrganismNot specified

UniProt P68135

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 Rho GTPase-activating protein 12 × 1 （Q8C0D4） 1,2-ETHANEDIOL × 2 LATRUNCULIN B × 1 ADENOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 1 water × 2 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 Rho GTPase-activating protein 12 × 1 （Q8C0D4） 1,2-ETHANEDIOL × 3 LATRUNCULIN B × 1 ADENOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 1 water × 2 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 2 Rho GTPase-activating protein 12 × 1 （Q8C0D4） 1,2-ETHANEDIOL × 1 LATRUNCULIN B × 1 ADENOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 1 water × 2 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 2 Rho GTPase-activating protein 12 × 1 （Q8C0D4） 1,2-ETHANEDIOL × 2 LATRUNCULIN B × 1 ADENOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 1 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1ijj 1ijj 1j6z 1nwk 1qz5 1s22 1wua 2asm 2aso 2asp 2fxu 2gwj

40 assemblies; showing the first 12

Homodimer
1lcu 1rdw 1rfq 1yxq 2a5x 2gwk 2hmp 2q1n 2q1n 2q31 2q31 2q36

14 assemblies; showing the first 12

Homotetramer
8dmx 8ru0 9fjo

3 assemblies

Other homooligomers
2y83 3b5u 3g37 3j8i 3j8j 3j8k 3mfp 4a7n 5mva 5mvy 5onv 5ooc

42 assemblies; showing the first 12

Heteromeric or nucleic-acid complex
1eqy 1esv 1kxp 1lot 1m8q 1ma9 1mvw 1o18 1o19 1o1a 1o1b 1o1c

255 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name ACTS_RABIT
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–377； UniProt 1–377 Author chain B； PDBConstruct 1–377； UniProt 1–377 Author chain C； PDBConstruct 1–377； UniProt 1–377 Author chain D； PDBConstruct 1–377； UniProt 1–377

Rho GTPase-activating protein 12

Mus musculus

UniProt Q8C0D4

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 Actin, alpha skeletal muscle × 1 （P68135） 1,2-ETHANEDIOL × 2 LATRUNCULIN B × 1 ADENOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 1 water × 2 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 Actin, alpha skeletal muscle × 1 （P68135） 1,2-ETHANEDIOL × 3 LATRUNCULIN B × 1 ADENOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 1 water × 2 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 2 Actin, alpha skeletal muscle × 1 （P68135） 1,2-ETHANEDIOL × 1 LATRUNCULIN B × 1 ADENOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 1 water × 2 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 2 Actin, alpha skeletal muscle × 1 （P68135） 1,2-ETHANEDIOL × 2 LATRUNCULIN B × 1 ADENOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 1 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
6gvc 6gvc 6gvc 6gvc

4 assemblies

View Construct and Data Evidence
UniProt name RHG12_MOUSE
Isoform —
PDB entities 2
Chains and sequence ranges Author chain Q； PDBConstruct 8–231； UniProt 615–838 Author chain R； PDBConstruct 8–231； UniProt 615–838 Author chain S； PDBConstruct 8–231； UniProt 615–838 Author chain T； PDBConstruct 8–231； UniProt 615–838

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id6gvc
Deposition date deposition_date2018-06-20
Structure title titleStructure of ArhGAP12 bound to G-Actin
Keywords keywordsGAP, RAC, Actin, HYDROLASE; HYDROLASE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6gvc__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6gvc__assembly_1__model_1 | I(q)

10-2 10-1 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

6gvc__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）26.31 Å
Rg (electron density)25.45 Å
Total Rg26.18 Å
Atom count4531
Residues575
Excluded volume80994 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 6gvc__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 6gvc__assembly_2__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 6gvc__assembly_3__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
4 1 6gvc__assembly_4__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (7)

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6. Fold Classification (SCOP + CATH) 25 domains

SCOP 2.08 (9 domains)

Domain ID domain_idd6gvca1
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.55 — Ribonuclease H-like motif
Superfamily Superfamily superfamilyc.55.1 — Actin-like ATPase domain
Family Family familyc.55.1.1 — Actin/HSP70
Domain ID domain_idd6gvca2
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.55 — Ribonuclease H-like motif
Superfamily Superfamily superfamilyc.55.1 — Actin-like ATPase domain
Family Family familyc.55.1.1 — Actin/HSP70
Domain ID domain_idd6gvcb1
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.55 — Ribonuclease H-like motif
Superfamily Superfamily superfamilyc.55.1 — Actin-like ATPase domain
Family Family familyc.55.1.1 — Actin/HSP70
Domain ID domain_idd6gvcb2
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.55 — Ribonuclease H-like motif
Superfamily Superfamily superfamilyc.55.1 — Actin-like ATPase domain
Family Family familyc.55.1.1 — Actin/HSP70
Domain ID domain_idd6gvcc1
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.55 — Ribonuclease H-like motif
Superfamily Superfamily superfamilyc.55.1 — Actin-like ATPase domain
Family Family familyc.55.1.1 — Actin/HSP70
Domain ID domain_idd6gvcc2
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.55 — Ribonuclease H-like motif
Superfamily Superfamily superfamilyc.55.1 — Actin-like ATPase domain
Family Family familyc.55.1.1 — Actin/HSP70
Domain ID domain_idd6gvcd1
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.55 — Ribonuclease H-like motif
Superfamily Superfamily superfamilyc.55.1 — Actin-like ATPase domain
Family Family familyc.55.1.1 — Actin/HSP70
Domain ID domain_idd6gvcd2
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.55 — Ribonuclease H-like motif
Superfamily Superfamily superfamilyc.55.1 — Actin-like ATPase domain
Family Family familyc.55.1.1 — Actin/HSP70
Domain ID domain_idd6gvcr_
Class classa — All alpha proteins
Fold Fold folda.116 — GTPase activation domain, GAP
Superfamily Superfamily superfamilya.116.1 — GTPase activation domain, GAP
Family Family familya.116.1.0 — automated matches

CATH v4.4 (16 domains)

Domain ID domain_id6gvcA01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology420 — Nucleotidyltransferase; domain 5
Homologous superfamily homologous superfamily40 — ATPase, nucleotide binding domain
Domain ID domain_id6gvcA02
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology420 — Nucleotidyltransferase; domain 5
Homologous superfamily homologous superfamily40 — ATPase, nucleotide binding domain
Domain ID domain_id6gvcA03
Class class3 — Alpha Beta
Architecture architecture90 — Alpha-Beta Complex
Topology topology640 — Actin; Chain A, domain 4
Homologous superfamily homologous superfamily10 — ATPase, substrate binding domain, subdomain 4
Domain ID domain_id6gvcB01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology420 — Nucleotidyltransferase; domain 5
Homologous superfamily homologous superfamily40 — ATPase, nucleotide binding domain
Domain ID domain_id6gvcB02
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology420 — Nucleotidyltransferase; domain 5
Homologous superfamily homologous superfamily40 — ATPase, nucleotide binding domain
Domain ID domain_id6gvcB03
Class class3 — Alpha Beta
Architecture architecture90 — Alpha-Beta Complex
Topology topology640 — Actin; Chain A, domain 4
Homologous superfamily homologous superfamily10 — ATPase, substrate binding domain, subdomain 4
Domain ID domain_id6gvcC01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology420 — Nucleotidyltransferase; domain 5
Homologous superfamily homologous superfamily40 — ATPase, nucleotide binding domain
Domain ID domain_id6gvcC02
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology420 — Nucleotidyltransferase; domain 5
Homologous superfamily homologous superfamily40 — ATPase, nucleotide binding domain
Domain ID domain_id6gvcC03
Class class3 — Alpha Beta
Architecture architecture90 — Alpha-Beta Complex
Topology topology640 — Actin; Chain A, domain 4
Homologous superfamily homologous superfamily10 — ATPase, substrate binding domain, subdomain 4
Domain ID domain_id6gvcD01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology420 — Nucleotidyltransferase; domain 5
Homologous superfamily homologous superfamily40 — ATPase, nucleotide binding domain
Domain ID domain_id6gvcD02
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology420 — Nucleotidyltransferase; domain 5
Homologous superfamily homologous superfamily40 — ATPase, nucleotide binding domain
Domain ID domain_id6gvcD03
Class class3 — Alpha Beta
Architecture architecture90 — Alpha-Beta Complex
Topology topology640 — Actin; Chain A, domain 4
Homologous superfamily homologous superfamily10 — ATPase, substrate binding domain, subdomain 4
Domain ID domain_id6gvcQ00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology555 — Phosphatidylinositol 3-kinase; Chain A
Homologous superfamily homologous superfamily10 — Rho GTPase activation protein
Domain ID domain_id6gvcR00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology555 — Phosphatidylinositol 3-kinase; Chain A
Homologous superfamily homologous superfamily10 — Rho GTPase activation protein
Domain ID domain_id6gvcS00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology555 — Phosphatidylinositol 3-kinase; Chain A
Homologous superfamily homologous superfamily10 — Rho GTPase activation protein
Domain ID domain_id6gvcT00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology555 — Phosphatidylinositol 3-kinase; Chain A
Homologous superfamily homologous superfamily10 — Rho GTPase activation protein
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7. Citations (1)