6lxd

Pri-miRNA bound DROSHA-DGCR8 complex

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Ribonuclease 3

Homo sapiens

UniProt Q9NRR4

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 3 RNA 1 Microprocessor complex subunit DGCR8 × 2 (Q8WYQ5) RNA (102-mer) × 1 ZINC ION × 2 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name RNC_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A; PDBConstruct 1–984; UniProt 391–1374

Microprocessor complex subunit DGCR8

Homo sapiens

UniProt Q8WYQ5

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein–RNA Heteromer Protein 3 RNA 1 Ribonuclease 3 × 1 (Q9NRR4) RNA (102-mer) × 1 ZINC ION × 2 Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name DGCR8_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B; PDBConstruct 1–773; UniProt 1–773 Author chain C; PDBConstruct 1–773; UniProt 1–773

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id6lxd
Deposition date deposition_date2020-02-10
Structure title titlePri-miRNA bound DROSHA-DGCR8 complex
Keywords keywordsRibonuclease, RNA BINDING PROTEIN, HYDROLASE-RNA BINDING PROTEIN-RNA complex; HYDROLASE/RNA BINDING PROTEIN/RNA
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6lxd__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6lxd__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

6lxd__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg(Guinier)37.05 Å
Rg (electron density)36.94 Å
Total Rg37.22 Å
Atom count9435
Residues1035
Excluded volume162250 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 6lxd__assembly_1__model_1 tetrameric (4) Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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7. Citations (1)