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6m2l

Crystal structure of Plasmodium falciparum hexose transporter PfHT1 bound with C3361

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Hexose transporter 1

Plasmodium falciparum

UniProt O97467

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein monomer Monomer Protein 1 (2S,3R,4S,5R,6R)-6-(hydroxymethyl)-4-undec-10-enoxy-oxane-2,3,5-triol × 1 Consistent with protein count
2 Protein monomer Monomer Protein 1 (2S,3R,4S,5R,6R)-6-(hydroxymethyl)-4-undec-10-enoxy-oxane-2,3,5-triol × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
6m20 6m20 6m20 6m20 6m2l 6m2l 6rw3 6rw3 6rw3 6rw3

10 assemblies

Homodimer
9hkk 9hkk

2 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
9sdl

1 assemblies

View Construct and Data Evidence
UniProt name O97467_PLAFA
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–504； UniProt 1–504 Author chain B； PDBConstruct 1–504； UniProt 1–504

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id6m2l
Deposition date deposition_date2020-02-27
Structure title titleCrystal structure of Plasmodium falciparum hexose transporter PfHT1 bound with C3361
Keywords keywordsMFS, hexose transporter, inhibitor, Plasmodium falciparum, TRANSPORT PROTEIN; TRANSPORT PROTEIN
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6m2l__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6m2l__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

6m2l__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）23.22 Å
Rg (electron density)22.06 Å
Total Rg23.12 Å
Atom count3383
Residues447
Excluded volume62115 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 6m2l__assembly_1__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 6m2l__assembly_2__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (2)

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6. Fold Classification (SCOP + CATH) 2 domains

CATH v4.4 (2 domains)

Domain ID domain_id6m2lA01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1250 — Growth Hormone; Chain: A;
Homologous superfamily homologous superfamily20 — MFS general substrate transporter like domains
Domain ID domain_id6m2lB01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1250 — Growth Hormone; Chain: A;
Homologous superfamily homologous superfamily20 — MFS general substrate transporter like domains
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7. Citations (1)