6mj6

Crystal structure of the mCD1d/xxx (JJ166) /iNKTCR ternary complex

Method: X-RAY DIFFRACTION
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1. 蛋白身份与相关结构 Protein Identity & Related Structures

;T cell receptor alpha variable 11,T cell receptor alpha variable 11,T cell receptor alpha joining 18,Human nkt tcr alpha chain, CHIMERIC PROTEIN,Human nkt tcr alpha chain ;

Homo sapiens

UniProt A0A0B4J1J9

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 信息不足 异源复合物 蛋白 4 其他聚合物 2 Beta-chain,T cell receptor chain,T cell receptor beta constant 2, CHIMERIC PROTEIN × 1 (A0A5B9,A0N8J3,A2NTY6) Antigen-presenting glycoprotein CD1d1 × 1 (A0A0R4J090) Beta-2-microglobulin × 1 (P01887) 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 1 ;beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 GLYCEROL × 7 SODIUM ION × 3 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 N-[(2S,3S,4R)-1-({4-O-[(4-chlorophenyl)methyl]-alpha-D-galactopyranosyl}oxy)-3,4-dihydroxyoctadecan-2-yl]hexacosanamide × 1 water × 4 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 A0A0B4J1J9_MOUSE
Isoform —
PDB实体 1
链与序列区间 作者链 C; PDB构建体 2–93; UniProt 22–113

;T cell receptor alpha variable 11,T cell receptor alpha variable 11,T cell receptor alpha joining 18,Human nkt tcr alpha chain, CHIMERIC PROTEIN,Human nkt tcr alpha chain ;

Homo sapiens

UniProt K7N5M3

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 信息不足 异源复合物 蛋白 4 其他聚合物 2 Beta-chain,T cell receptor chain,T cell receptor beta constant 2, CHIMERIC PROTEIN × 1 (A0A5B9,A0N8J3,A2NTY6) Antigen-presenting glycoprotein CD1d1 × 1 (A0A0R4J090) Beta-2-microglobulin × 1 (P01887) 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 1 ;beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 GLYCEROL × 7 SODIUM ION × 3 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 N-[(2S,3S,4R)-1-({4-O-[(4-chlorophenyl)methyl]-alpha-D-galactopyranosyl}oxy)-3,4-dihydroxyoctadecan-2-yl]hexacosanamide × 1 water × 4 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 K7N5M3_HUMAN
Isoform —
PDB实体 1
链与序列区间 作者链 C; PDB构建体 115–209; UniProt 116–210

Beta-chain,T cell receptor chain,T cell receptor beta constant 2, CHIMERIC PROTEIN

Homo sapiens

UniProt A0A5B9

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 信息不足 异源复合物 蛋白 4 其他聚合物 2 ;T cell receptor alpha variable 11,T cell receptor alpha variable 11,T cell receptor alpha joining 18,Human nkt tcr alpha chain, CHIMERIC PROTEIN,Human nkt tcr alpha chain ; × 1 (A0A0B4J1J9,K7N5M3) Antigen-presenting glycoprotein CD1d1 × 1 (A0A0R4J090) Beta-2-microglobulin × 1 (P01887) 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 1 ;beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 GLYCEROL × 7 SODIUM ION × 3 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 N-[(2S,3S,4R)-1-({4-O-[(4-chlorophenyl)methyl]-alpha-D-galactopyranosyl}oxy)-3,4-dihydroxyoctadecan-2-yl]hexacosanamide × 1 water × 4 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 TRBC2_HUMAN
Isoform —
PDB实体 2
链与序列区间 作者链 D; PDB构建体 132–241; UniProt 19–128

Beta-chain,T cell receptor chain,T cell receptor beta constant 2, CHIMERIC PROTEIN

Homo sapiens

UniProt A0N8J3

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 信息不足 异源复合物 蛋白 4 其他聚合物 2 ;T cell receptor alpha variable 11,T cell receptor alpha variable 11,T cell receptor alpha joining 18,Human nkt tcr alpha chain, CHIMERIC PROTEIN,Human nkt tcr alpha chain ; × 1 (A0A0B4J1J9,K7N5M3) Antigen-presenting glycoprotein CD1d1 × 1 (A0A0R4J090) Beta-2-microglobulin × 1 (P01887) 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 1 ;beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 GLYCEROL × 7 SODIUM ION × 3 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 N-[(2S,3S,4R)-1-({4-O-[(4-chlorophenyl)methyl]-alpha-D-galactopyranosyl}oxy)-3,4-dihydroxyoctadecan-2-yl]hexacosanamide × 1 water × 4 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 A0N8J3_MOUSE
Isoform —
PDB实体 2
链与序列区间 作者链 D; PDB构建体 100–131; UniProt 96–127

Beta-chain,T cell receptor chain,T cell receptor beta constant 2, CHIMERIC PROTEIN

Homo sapiens

UniProt A2NTY6

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 信息不足 异源复合物 蛋白 4 其他聚合物 2 ;T cell receptor alpha variable 11,T cell receptor alpha variable 11,T cell receptor alpha joining 18,Human nkt tcr alpha chain, CHIMERIC PROTEIN,Human nkt tcr alpha chain ; × 1 (A0A0B4J1J9,K7N5M3) Antigen-presenting glycoprotein CD1d1 × 1 (A0A0R4J090) Beta-2-microglobulin × 1 (P01887) 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 1 ;beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 GLYCEROL × 7 SODIUM ION × 3 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 N-[(2S,3S,4R)-1-({4-O-[(4-chlorophenyl)methyl]-alpha-D-galactopyranosyl}oxy)-3,4-dihydroxyoctadecan-2-yl]hexacosanamide × 1 water × 4 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 A2NTY6_MOUSE
Isoform —
PDB实体 2
链与序列区间 作者链 D; PDB构建体 1–95; UniProt 29–123

Antigen-presenting glycoprotein CD1d1

Mus musculus

UniProt A0A0R4J090

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 信息不足 异源复合物 蛋白 4 其他聚合物 2 ;T cell receptor alpha variable 11,T cell receptor alpha variable 11,T cell receptor alpha joining 18,Human nkt tcr alpha chain, CHIMERIC PROTEIN,Human nkt tcr alpha chain ; × 1 (A0A0B4J1J9,K7N5M3) Beta-chain,T cell receptor chain,T cell receptor beta constant 2, CHIMERIC PROTEIN × 1 (A0A5B9,A0N8J3,A2NTY6) Beta-2-microglobulin × 1 (P01887) 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 1 ;beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 GLYCEROL × 7 SODIUM ION × 3 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 N-[(2S,3S,4R)-1-({4-O-[(4-chlorophenyl)methyl]-alpha-D-galactopyranosyl}oxy)-3,4-dihydroxyoctadecan-2-yl]hexacosanamide × 1 water × 4 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 A0A0R4J090_MOUSE
Isoform —
PDB实体 3
链与序列区间 作者链 A; PDB构建体 1–279; UniProt 19–297

Beta-2-microglobulin

Mus musculus

UniProt P01887

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 信息不足 异源复合物 蛋白 4 其他聚合物 2 ;T cell receptor alpha variable 11,T cell receptor alpha variable 11,T cell receptor alpha joining 18,Human nkt tcr alpha chain, CHIMERIC PROTEIN,Human nkt tcr alpha chain ; × 1 (A0A0B4J1J9,K7N5M3) Beta-chain,T cell receptor chain,T cell receptor beta constant 2, CHIMERIC PROTEIN × 1 (A0A5B9,A0N8J3,A2NTY6) Antigen-presenting glycoprotein CD1d1 × 1 (A0A0R4J090) 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 1 ;beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 GLYCEROL × 7 SODIUM ION × 3 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 N-[(2S,3S,4R)-1-({4-O-[(4-chlorophenyl)methyl]-alpha-D-galactopyranosyl}oxy)-3,4-dihydroxyoctadecan-2-yl]hexacosanamide × 1 water × 4 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 B2MG_MOUSE
Isoform —
PDB实体 4
链与序列区间 作者链 B; PDB构建体 1–99; UniProt 21–119

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中;数据库内部编号、导入时间和 assembly 操作表达式仅用于维护,因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id6mj6
沉积日期 deposition_date2018-09-20
结构标题 titleCrystal structure of the mCD1d/xxx (JJ166) /iNKTCR ternary complex
关键词 keywordsMHC-fold, Ig-fold, glycolipid antigen presentation, T cell receptor, IMMUNE SYSTEM; IMMUNE SYSTEM
实验方法 methodX-RAY DIFFRACTION
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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

6mj6__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

6mj6__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 个绘图点;横轴和纵轴均采用对数尺度。

6mj6__assembly_1__model_1 | P(r) · Pending

新版 assembly/model P(r) 尚未计算 此处仅保留位置,不展示旧数据 r (Angstrom) P(r)
P(r) 将按相同 assembly/model 分别计算和展示。
Rg(Guinier)39.35 Å
Rg(电子密度)39.88 Å
总 Rg39.82 Å
原子数6589
残基数809
排除体积116600 ų
最大 q0.500 Å⁻¹
Assembly Model 结构单元 聚集说明 状态 CRYSOL 操作
1 1 6mj6__assembly_1__model_1 tetrameric (4) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (11)

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6. 折叠分类 (SCOP + CATH) 13 domains

SCOP 2.08 (7 domains)

结构域编号 domain_idd6mj6a1
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.19 — MHC antigen-recognition domain
超家族 Superfamily superfamilyd.19.1 — MHC antigen-recognition domain
家族 Family familyd.19.1.0 — automated matches
结构域编号 domain_idd6mj6a2
类 Class classb — All beta proteins
折叠类型 Fold foldb.1 — Immunoglobulin-like beta-sandwich
超家族 Superfamily superfamilyb.1.1 — Immunoglobulin
家族 Family familyb.1.1.0 — automated matches
结构域编号 domain_idd6mj6b_
类 Class classb — All beta proteins
折叠类型 Fold foldb.1 — Immunoglobulin-like beta-sandwich
超家族 Superfamily superfamilyb.1.1 — Immunoglobulin
家族 Family familyb.1.1.2 — C1 set domains (antibody constant domain-like)
结构域编号 domain_idd6mj6c1
类 Class classb — All beta proteins
折叠类型 Fold foldb.1 — Immunoglobulin-like beta-sandwich
超家族 Superfamily superfamilyb.1.1 — Immunoglobulin
家族 Family familyb.1.1.0 — automated matches
结构域编号 domain_idd6mj6c2
类 Class classb — All beta proteins
折叠类型 Fold foldb.1 — Immunoglobulin-like beta-sandwich
超家族 Superfamily superfamilyb.1.1 — Immunoglobulin
家族 Family familyb.1.1.2 — C1 set domains (antibody constant domain-like)
结构域编号 domain_idd6mj6d1
类 Class classb — All beta proteins
折叠类型 Fold foldb.1 — Immunoglobulin-like beta-sandwich
超家族 Superfamily superfamilyb.1.1 — Immunoglobulin
家族 Family familyb.1.1.0 — automated matches
结构域编号 domain_idd6mj6d2
类 Class classb — All beta proteins
折叠类型 Fold foldb.1 — Immunoglobulin-like beta-sandwich
超家族 Superfamily superfamilyb.1.1 — Immunoglobulin
家族 Family familyb.1.1.0 — automated matches

CATH v4.4 (6 domains)

结构域编号 domain_id6mj6A01
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology500 — Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily10 — MHC class I-like antigen recognition-like
结构域编号 domain_id6mj6A02
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id6mj6B00
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id6mj6C01
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id6mj6D01
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id6mj6D02
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
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7. 引用文献 (1)