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6mo0

Structure of dengue virus protease with an allosteric Inhibitor that blocks replication

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

FLAVIVIRUS_NS2B/Peptidase S7

Dengue virus 2

UniProt A0A0B4L2Y4

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Monomer Protein 1 1-(4-{3-[4-(furan-3-yl)phenyl]-5-[(piperidin-4-yl)methoxy]pyrazin-2-yl}phenyl)methanamine × 1 Consistent with protein count
2 Insufficient information Monomer Protein 1 1-(4-{3-[4-(furan-3-yl)phenyl]-5-[(piperidin-4-yl)methoxy]pyrazin-2-yl}phenyl)methanamine × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
6mo0 6mo0 6mo2 6mo2

4 assemblies

View Construct and Data Evidence
UniProt name A0A0B4L2Y4_9FLAV
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 7–53； UniProt 1394–1440 Author chain B； PDBConstruct 7–53； UniProt 1394–1440

FLAVIVIRUS_NS2B/Peptidase S7

Dengue virus 2

UniProt Q91H74

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Monomer Protein 1 1-(4-{3-[4-(furan-3-yl)phenyl]-5-[(piperidin-4-yl)methoxy]pyrazin-2-yl}phenyl)methanamine × 1 Consistent with protein count
2 Insufficient information Monomer Protein 1 1-(4-{3-[4-(furan-3-yl)phenyl]-5-[(piperidin-4-yl)methoxy]pyrazin-2-yl}phenyl)methanamine × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
2bhr 2bhr 2bmf 2bmf 4m9f 4m9i 4m9k 4m9m 4m9t 6kr2 6kr2 6kr3

74 assemblies; showing the first 12

Homodimer
2fom

1 assemblies

Homotetramer
2fom

1 assemblies

Other homooligomers

None

Heteromeric or nucleic-acid complex
6mo0 6mo0 6mo1 6mo1 6mo2 6mo2 7xd8 7xd8 7xd8 7xd8 7xd8 7xd8

20 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name Q91H74_9FLAV
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 63–247； UniProt 1476–1660 Author chain B； PDBConstruct 63–247； UniProt 1476–1660

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id6mo0
Deposition date deposition_date2018-10-03
Structure title titleStructure of dengue virus protease with an allosteric Inhibitor that blocks replication
Keywords keywordsAllosteric Inhibitor, Inhibitor, Complex, Protease, VIRAL PROTEIN, VIRAL PROTEIN-INHIBITOR complex; VIRAL PROTEIN/INHIBITOR
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6mo0__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6mo0__assembly_1__model_1 | I(q)

10-2 10-1 105 106 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

6mo0__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）16.76 Å
Rg (electron density)15.61 Å
Total Rg16.92 Å
Atom count1289
Residues164
Excluded volume22973 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 6mo0__assembly_1__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 6mo0__assembly_2__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (2)

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7. Citations (1)