6mox

Crystal Structure of the All-trans Retinal-Bound R111K:Y134F:T54V:R132Q:P39Q:R59Y:L121E Human Cellular Retinoic Acid Binding Protein II Mutant in the Dark at 2.18 Angstrom Resolution

Method: X-RAY DIFFRACTION D_max: 50.0 Å Quality: GOOD

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1. 蛋白身份与相关结构 Protein Identity & Related Structures

Cellular retinoic acid-binding protein 2

Homo sapiens

当前结构中的状态

Assembly	聚集状态	构建体	突变与修饰	配体、离子与共同组分	实验方法与环境	结构质量
1	蛋白单体单体蛋白 × 1 PDB 声明：monomeric（1）与蛋白拷贝数一致	链 A； UniProt 2–138	突变：R111K, Y134F, T54V, R132Q, P39Q, R59Y, L121E	RET RETINAL × 1	X-RAY DIFFRACTION X-ray结晶条件：VAPOR DIFFUSION, HANGING DROP；277 K；PEG 3350, BTP, Sodium Fluoride	分辨率 2.18 Å R-free 0.250
2	蛋白同源多聚体同源多聚体蛋白 × 2 PDB 声明：dimeric（2）与蛋白拷贝数一致	链 A； UniProt 2–138	突变：R111K, Y134F, T54V, R132Q, P39Q, R59Y, L121E	RET RETINAL × 2	X-RAY DIFFRACTION X-ray结晶条件：VAPOR DIFFUSION, HANGING DROP；277 K；PEG 3350, BTP, Sodium Fluoride	分辨率 2.18 Å R-free 0.250

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB	相对当前条目 6MOX	Assembly / 聚集状态	构建体	突变与修饰	配体、离子与非聚合物	实验方法与环境	结构质量
1BLR NMR SOLUTION STRUCTURE OF HUMAN CELLULAR RETINOIC ACID BINDING PROTEIN-TYPE II, 22 STRUCTURES 提交 1998-07-20	构建体不同突变/修饰不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 1–137（137 aa）	未记录	未记录非水小分子	SOLUTION NMR NMR测量条件 pH 7.3；298 K NMR样品组成 H2O	分辨率未提供
1BM5 THE SOLUTION STRUCTURE OF A SITE-DIRECTED MUTANT (R111M) OF HUMAN CELLULAR RETIONIC ACID BINDING PROTEIN-TYPE II, NMR, 31 STRUCTURES 提交 1998-07-28	构建体不同突变/修饰不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 1–137（137 aa）	突变：R111M	未记录非水小分子	SOLUTION NMR NMR测量条件 pH 7.3；300 K NMR样品组成 PBS	分辨率未提供
1CBQ CRYSTAL STRUCTURE OF CELLULAR RETINOIC-ACID-BINDING PROTEINS I AND II IN COMPLEX WITH ALL-TRANS-RETINOIC ACID AND A SYNTHETIC RETINOID 提交 1994-09-28	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 3 PDB 声明：trimeric	链 A 1–137（137 aa）	未记录	PO4 PHOSPHATE ION × 3 RE9 6-(2,3,4,5,6,7-HEXAHYDRO-2,4,4-TRIMETHYL-1-METYLENEINDEN-2-YL)-3-METHYLHEXA-2,4-DIENOIC ACID × 3	X-RAY DIFFRACTION mmCIF 未提供已读取条件	分辨率 2.20 Å R-free 0.264
1CBS CRYSTAL STRUCTURE OF CELLULAR RETINOIC-ACID-BINDING PROTEINS I AND II IN COMPLEX WITH ALL-TRANS-RETINOIC ACID AND A SYNTHETIC RETINOID 提交 1994-09-28	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 1–137（137 aa）	未记录	REA RETINOIC ACID × 1	X-RAY DIFFRACTION mmCIF 未提供已读取条件	分辨率 1.80 Å R-free 0.237
1XCA APO-CELLULAR RETINOIC ACID BINDING PROTEIN II 提交 1996-12-31	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 1–137（137 aa）	突变：R111M	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 8；PROTEIN CONC, 30MG/ML BUFFER 0.1M TRIS, PH 8.0 SALT 0.2M SODIUM ACETATE PRECIPITANT 30% PEG 8000	分辨率 2.30 Å R-free 0.282
1XCA APO-CELLULAR RETINOIC ACID BINDING PROTEIN II 提交 1996-12-31	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 2 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 B 1–137（137 aa）	突变：R111M	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 pH 8；PROTEIN CONC, 30MG/ML BUFFER 0.1M TRIS, PH 8.0 SALT 0.2M SODIUM ACETATE PRECIPITANT 30% PEG 8000	分辨率 2.30 Å R-free 0.282
2CBS CELLULAR RETINOIC ACID BINDING PROTEIN II IN COMPLEX WITH A SYNTHETIC RETINOIC ACID (RO-13 6307) 提交 1999-02-22	突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	未记录	R13 3-METHYL-7-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL) -OCTA-2,4,6-TRIENOIC ACID × 1	X-RAY DIFFRACTION X-ray结晶条件 pH 5.5；20% MONOMETHYL PEG 5000 0.1 M SODIUM ACETATE PH 5.5	分辨率 2.10 Å R-free 0.233
2FR3 Crystal Structure of Cellular Retinoic Acid Binding Protein Type II in Complex with All-Trans-Retinoic Acid at 1.48 Angstroms Resolution 提交 2006-01-18	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 1–137（137 aa）	未记录	ACT ACETATE ION × 1 REA RETINOIC ACID × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.4；298 K；30% (w/v) PEG 4000, 0.1 M sodium citrate/citric acid pH 5.4, and 0.2 ammonium acetate (crystallization performed in dark room and under red light), VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 1.48 Å R-free 0.174
2FRS Crystal structure of the f15w mutant of apo-cellular retinoic acid binding protein type ii at 1.51 angstroms resolution 提交 2006-01-20	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 1–137（137 aa）	突变：F15W	NA SODIUM ION × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；30% (w/v) PEG 4000, 0.2 M Bis-Tris-Propane pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 1.51 Å R-free 0.240
2FRS Crystal structure of the f15w mutant of apo-cellular retinoic acid binding protein type ii at 1.51 angstroms resolution 提交 2006-01-20	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 2 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 B 1–137（137 aa）	突变：F15W	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；30% (w/v) PEG 4000, 0.2 M Bis-Tris-Propane pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 1.51 Å R-free 0.240
2FS6 Crystal Structure of Apo-Cellular Retinoic Acid Binding Protein Type II At 1.35 Angstroms Resolution 提交 2006-01-21	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 1–137（137 aa）	未记录	ACT ACETATE ION × 5 NA SODIUM ION × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 8；298 K；30% (w/v) PEG 8000 (4000), 0.1 M TRIS-HCl pH 8.0 (8.5), and 0.2 M Sodium Acetate, vapor diffusion, hanging drop, temperature 298K	分辨率 1.35 Å R-free 0.204
2FS6 Crystal Structure of Apo-Cellular Retinoic Acid Binding Protein Type II At 1.35 Angstroms Resolution 提交 2006-01-21	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 2 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 B 1–137（137 aa）	未记录	ACT ACETATE ION × 2 CL CHLORIDE ION × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 8；298 K；30% (w/v) PEG 8000 (4000), 0.1 M TRIS-HCl pH 8.0 (8.5), and 0.2 M Sodium Acetate, vapor diffusion, hanging drop, temperature 298K	分辨率 1.35 Å R-free 0.204
2FS7 Crystal Structure of Apo-Cellular Retinoic Acid Binding Protein Type II At 1.55 Angstroms Resolution 提交 2006-01-21	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 1–137（137 aa）	未记录	CL CHLORIDE ION × 2 ACT ACETATE ION × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 8；298 K；30% (w/v) PEG 8000, 0.1 M Tris-HCl pH 8.0, and 0.2 M Sodium Acetate, vapor diffusion, hanging drop, temperature 298K	分辨率 1.55 Å R-free 0.201
2FS7 Crystal Structure of Apo-Cellular Retinoic Acid Binding Protein Type II At 1.55 Angstroms Resolution 提交 2006-01-21	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 2 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 B 1–137（137 aa）	未记录	CL CHLORIDE ION × 2 ACT ACETATE ION × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 8；298 K；30% (w/v) PEG 8000, 0.1 M Tris-HCl pH 8.0, and 0.2 M Sodium Acetate, vapor diffusion, hanging drop, temperature 298K	分辨率 1.55 Å R-free 0.201
2G78 Crystal Structure of the R132K:Y134F Mutant of Cellular Retinoic Acid Binding Protein Type II in Complex with All-Trans-Retinoic Acid at 1.70 Angstroms Resolution 提交 2006-02-27	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 1–137（137 aa）	突变：R132K, Y134F	NA SODIUM ION × 1 REA RETINOIC ACID × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4.8；298 K；0.1 M sodium citrate pH 4.8, 20% PEG 5000 and 10% DMSO, VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 1.70 Å R-free 0.203
2G79 Crystal Structure of the R132K:Y134F Mutant of Cellular Retinoic Acid Binding Protein Type II in Complex with All-Trans-Retinal at 1.69 Angstroms Resolution 提交 2006-02-27	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 1–137（137 aa）	突变：R132K, Y134F	NA SODIUM ION × 3 SO4 SULFATE ION × 2 RET RETINAL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；30% (w/v) PEG 8000 and 0.2 M ammonium sulfate, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.69 Å R-free 0.214
2G7B Crystal Structure of the R132K:R111L:L121E mutant of Cellular Retinoic Acid Binding Protein Type II In Complex With All-Trans-Retinal At 1.18 Angstroms Resolution 提交 2006-02-27	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 1–137（137 aa）	突变：R132K, R111L, L121E	NA SODIUM ION × 2 RET RETINAL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.8；277 K；18% (w/v) PEG 6000 and 0.1 M sodium acetate pH 5.8, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.18 Å R-free 0.155
3CBS CELLULAR RETINOIC ACID BINDING PROTEIN II IN COMPLEX WITH A SYNTHETIC RETINOIC ACID (RO-12 7310) 提交 1999-02-22	突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	未记录	R12 (2E,4E,6E,8E)-9-(4-hydroxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid × 1	X-RAY DIFFRACTION X-ray结晶条件 pH 8.5；20% MONOMETHYL PEG 5000 0.2 M TRIS-HCL 0.2 M LICL , pH 8.5	分辨率 2.00 Å R-free 0.244
3CR6 Crystal Structure of the R132K:R111L:A32E Mutant of Cellular Retinoic Acid Binding Protein Type II Complexed with C15-aldehyde (a retinal analog) at 1.22 Angstrom resolution. 提交 2008-04-04	突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	突变：R132K, R111L, A32E	LSR 1,3,3-trimethyl-2-[(1E,3E)-3-methylpenta-1,3-dien-1-yl]cyclohexene × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 7.5；277 K；0.1M sodium citrate, 0.2M ammonium acetate, 26% PEG 4000, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.22 Å R-free 0.185
3CWK Crystal Structure of the R132K:Y134F:R111L:T54V:L121E Mutant of Cellular Retinoic Acid Binding Protein Type II in Complex with All-trans-Retinoic Acid at 1.57 Angstroms Resolution 提交 2008-04-22	突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	突变：T54V, R111L, L121E, R132K, Y134F	SO4 SULFATE ION × 1 REA RETINOIC ACID × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；0.1 M MES, 30% (W/V) PEG 5000, 0.2 M AMMONIUM SULFATE, pH 6.50, VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 1.60 Å R-free 0.167
3D95 Crystal Structure of the R132K:Y134F:R111L:L121E:T54V Mutant of Apo-Cellular Retinoic Acid Binding Protein Type II at 1.20 Angstroms Resolution 提交 2008-05-26	突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	突变：R132K, Y134F, R111L, L121E, T54V	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.8；298 K；20% (W/V) PEG 6000, 0.1 M SODIUM ACETATE, 5% ETHANOL, pH 5.8, VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 1.20 Å R-free 0.176
3D95 Crystal Structure of the R132K:Y134F:R111L:L121E:T54V Mutant of Apo-Cellular Retinoic Acid Binding Protein Type II at 1.20 Angstroms Resolution 提交 2008-05-26	突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 2 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 B 2–138（137 aa）	突变：R132K, Y134F, R111L, L121E, T54V	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.8；298 K；20% (W/V) PEG 6000, 0.1 M SODIUM ACETATE, 5% ETHANOL, pH 5.8, VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 1.20 Å R-free 0.176
3D96 Crystal Structure of the R132K:Y134F Mutant of Apo-Cellular Retinoic Acid Binding Protein Type II at 1.71 Angstroms Resolution 提交 2008-05-26	突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	突变：R132K, Y134F	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 8.5；298 K；30% (W/V) PEG 4000, 0.1 M TRIS-HCL, 0.2 M SODIUM ACETATE, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 1.71 Å R-free 0.222
3D96 Crystal Structure of the R132K:Y134F Mutant of Apo-Cellular Retinoic Acid Binding Protein Type II at 1.71 Angstroms Resolution 提交 2008-05-26	突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 2 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 B 2–138（137 aa）	突变：R132K, Y134F	ACT ACETATE ION × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 8.5；298 K；30% (W/V) PEG 4000, 0.1 M TRIS-HCL, 0.2 M SODIUM ACETATE, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 1.71 Å R-free 0.222
3D97 Crystal Structure of the R132K:R111L:L121E Mutant of Apo-Cellular Retinoic Acid Binding Protein Type II At 1.50 Angstroms Resolution 提交 2008-05-26	突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	突变：R111L, L121E, R132K	B3P 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；30% (w/v) PEG 4000, 0.1 M Bis-TRIS Propane, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 1.50 Å R-free 0.227
3D97 Crystal Structure of the R132K:R111L:L121E Mutant of Apo-Cellular Retinoic Acid Binding Protein Type II At 1.50 Angstroms Resolution 提交 2008-05-26	突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 2 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 B 2–138（137 aa）	突变：R111L, L121E, R132K	NA SODIUM ION × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；30% (w/v) PEG 4000, 0.1 M Bis-TRIS Propane, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 1.50 Å R-free 0.227
3F8A Crystal Structure of the R132K:R111L:L121E:R59W Mutant of Cellular Retinoic Acid-Binding Protein Type II Complexed with C15-aldehyde (a retinal analog) at 1.95 Angstrom resolution. 提交 2008-11-12	突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	突变：R132K, R111L, L121E, R59W	B3P 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 LSR 1,3,3-trimethyl-2-[(1E,3E)-3-methylpenta-1,3-dien-1-yl]cyclohexene × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 7.5；277 K；0.1M bis-tris-propane, 30% PEG400, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.95 Å R-free 0.246
3F9D Crystal structure of the R132K:R111L:T54E mutant of cellular retinoic acid-binding protein II complexed with C15-aldehyde (a retinal analog) at 2.00 angstrom resolution 提交 2008-11-13	突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	突变：R132K, R111L, T54E	LSR 1,3,3-trimethyl-2-[(1E,3E)-3-methylpenta-1,3-dien-1-yl]cyclohexene × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.8；277 K；0.1M sodium acetate, 18% PEG6000, pH 5.8, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 2.00 Å R-free 0.233
3F9D Crystal structure of the R132K:R111L:T54E mutant of cellular retinoic acid-binding protein II complexed with C15-aldehyde (a retinal analog) at 2.00 angstrom resolution 提交 2008-11-13	突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 2 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 B 2–138（137 aa）	突变：R132K, R111L, T54E	LSR 1,3,3-trimethyl-2-[(1E,3E)-3-methylpenta-1,3-dien-1-yl]cyclohexene × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.8；277 K；0.1M sodium acetate, 18% PEG6000, pH 5.8, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 2.00 Å R-free 0.233
3FA6 Crystal structure of the R132K:Y134F:R111L:L121D:T54V mutant of cellular retinoic acid-binding protein II complexed with C15-aldehyde (a retinal analog) at 1.54 angstrom resolution 提交 2008-11-15	突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	突变：R132K, Y134F, R111L, L121D, T54V	LSR 1,3,3-trimethyl-2-[(1E,3E)-3-methylpenta-1,3-dien-1-yl]cyclohexene × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.8；277 K；0.1M sodium acetate, 18% PEG6000, pH 5.8, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.54 Å R-free 0.221
3FA6 Crystal structure of the R132K:Y134F:R111L:L121D:T54V mutant of cellular retinoic acid-binding protein II complexed with C15-aldehyde (a retinal analog) at 1.54 angstrom resolution 提交 2008-11-15	突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 2 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 B 2–138（137 aa）	突变：R132K, Y134F, R111L, L121D, T54V	LSR 1,3,3-trimethyl-2-[(1E,3E)-3-methylpenta-1,3-dien-1-yl]cyclohexene × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.8；277 K；0.1M sodium acetate, 18% PEG6000, pH 5.8, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.54 Å R-free 0.221
3FA7 Crystal structure of the apo R132K:R111L:L121E:R59E mutant of cellular retinoic acid-binding protein II at 1.90 angstrom resolution 提交 2008-11-15	突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	突变：R132K, R111L, L121E, R59E	B3P 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；0.1M BTP, 22% PEG8000, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 1.90 Å R-free 0.249
3FA7 Crystal structure of the apo R132K:R111L:L121E:R59E mutant of cellular retinoic acid-binding protein II at 1.90 angstrom resolution 提交 2008-11-15	突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 2 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 B 2–138（137 aa）	突变：R132K, R111L, L121E, R59E	B3P 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；0.1M BTP, 22% PEG8000, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 1.90 Å R-free 0.249
3FA8 Crystal structure of the apo R132K:Y134F:R111L:L121E mutant of cellular retinoic acid-binding protein II at 1.78 angstrom resolution 提交 2008-11-16	突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	突变：R132K, Y134F, R111L, L121E	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；0.1M BTP, 25% PEG4000, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 1.78 Å R-free 0.234
3FA8 Crystal structure of the apo R132K:Y134F:R111L:L121E mutant of cellular retinoic acid-binding protein II at 1.78 angstrom resolution 提交 2008-11-16	突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 2 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 B 2–138（137 aa）	突变：R132K, Y134F, R111L, L121E	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；0.1M BTP, 25% PEG4000, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 1.78 Å R-free 0.234
3FA9 Crystal structure of the apo R132K:Y134F:R111L:L121D mutant of cellular retinoic acid-binding protein II at 1.94 angstrom resolution 提交 2008-11-16	突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	突变：R132K, Y134F, R111L, L121D	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 8.1；298 K；0.1M BTP, 22% PEG4000, pH 8.1, VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 1.94 Å R-free 0.276
3FA9 Crystal structure of the apo R132K:Y134F:R111L:L121D mutant of cellular retinoic acid-binding protein II at 1.94 angstrom resolution 提交 2008-11-16	突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 2 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 B 2–138（137 aa）	突变：R132K, Y134F, R111L, L121D	ACT ACETATE ION × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 8.1；298 K；0.1M BTP, 22% PEG4000, pH 8.1, VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 1.94 Å R-free 0.276
3FEK Crystal structure of the R132K:Y134F:R111L:L121D:T54V mutant of cellular retinoic acid-binding protein II at 1.51 angstrom resolution 提交 2008-11-30	突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	突变：R132K, Y134F, R111, L121D, T54V	ACT ACETATE ION × 1 PEG DI(HYDROXYETHYL)ETHER × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；0.1M Tris, 0.2M NaOAc, 24% PEG4000, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 1.51 Å R-free 0.210
3FEK Crystal structure of the R132K:Y134F:R111L:L121D:T54V mutant of cellular retinoic acid-binding protein II at 1.51 angstrom resolution 提交 2008-11-30	突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 2 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 B 2–138（137 aa）	突变：R132K, Y134F, R111, L121D, T54V	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；0.1M Tris, 0.2M NaOAc, 24% PEG4000, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 1.51 Å R-free 0.210
3FEL Crystal structure of the R132K:R111L:T54E mutant of cellular retinoic acid-binding protein II at 1.85 angstrom resolution 提交 2008-11-30	突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	突变：R132K, R111L, T54E	B3P 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；0.1M BTP, 30% PEG4000, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 1.85 Å R-free 0.248
3FEL Crystal structure of the R132K:R111L:T54E mutant of cellular retinoic acid-binding protein II at 1.85 angstrom resolution 提交 2008-11-30	突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 2 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 B 2–138（137 aa）	突变：R132K, R111L, T54E	B3P 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；0.1M BTP, 30% PEG4000, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 1.85 Å R-free 0.248
3FEN Crystal structure of the R132K:R111L:A32E mutant of cellular retinoic acid-binding protein II at 1.56 angstrom resolution 提交 2008-11-30	突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	突变：R132K, R111L, A32E	CL CHLORIDE ION × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 8.5；298 K；0.1M Tris, 0.2M NaOAc, 26% PEG4000, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 1.56 Å R-free 0.198
3FEN Crystal structure of the R132K:R111L:A32E mutant of cellular retinoic acid-binding protein II at 1.56 angstrom resolution 提交 2008-11-30	突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 2 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 B 2–138（137 aa）	突变：R132K, R111L, A32E	CL CHLORIDE ION × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 8.5；298 K；0.1M Tris, 0.2M NaOAc, 26% PEG4000, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 1.56 Å R-free 0.198
3FEP Crystal structure of the R132K:R111L:L121E:R59W-CRABPII mutant complexed with a synthetic ligand (merocyanin) at 2.60 angstrom resolution. 提交 2008-11-30	突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	突变：R132K, R111L, L121E, R59W	LMC (2E,4E,6E)-3-methyl-6-(1,3,3-trimethyl-1,3-dihydro-2H-indol-2-ylidene)hexa-2,4-dienal × 1 MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.3；277 K；0.1M MES, 0.2M ammonium sulfate, 30% PEGMME 5000, pH 6.3, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 2.60 Å R-free 0.293
3I17 Crystal structure of the apo R132K:L121E mutant of cellular retinoic acid-binding protein II at 1.68 angstrom resolution 提交 2009-06-25	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 2–138（137 aa）链 B 2–138（137 aa）	突变：R132K, L121E 突变：R132K, L121E	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 9.5；298 K；0.1 M Bis-tris-propane, pH 9.5, 30% PEG4000, VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 1.68 Å R-free 0.231
4I9R Crystal Structure of the R111K:R132L:Y134F:T54V:R59W:A32W Mutant of the Cellular Retinoic Acid Binding Protein Type II in Complex with All-Trans Retinal at 2.6 Angstrom Resolution 提交 2012-12-05	突变/修饰不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	突变：R111K:R132L:Y134F:T54V:R59W:A32W	RET RETINAL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；pH 7.5；277 K；0.1 M HEPES, pH 7.5, 2% PEG400, VAPOR DIFFUSION, SITTING DROP, temperature 277K	分辨率 2.60 Å R-free 0.276
4I9S Crystal Structure of the R111K:R132L:Y134F:T54V:R59W Mutant of the Cellular Retinoic Acid Binding Protein Type II in Complex with All-Trans Retinal at 2.58 Angstrom Resolution 提交 2012-12-05	突变/修饰不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	突变：R111K:R132L:Y134F:T54V:R59W	RET RETINAL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；pH 4.6；277 K；16% w/v PEG8000, 0.04 M potassium phosphate monobasic, 20% v/v glycerol, pH 4.6, VAPOR DIFFUSION, SITTING DROP, temperature 277K	分辨率 2.58 Å R-free 0.288
4M6S Crystal structure of the R111K:R132Y:Y134F:T54V:R59W:A32W mutant of the Cellular Retinoic Acid Binding Protein Type II in complex with All-Trans Retinal at 2.38 Angstrom Resolution 提交 2013-08-10	突变/修饰不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	突变：R111K:R132Y:Y134F:T54V:R59W:A32W	RET RETINAL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；pH 6；277 K；0.1 M malonate, pH 6.0, 12% PEG3350, VAPOR DIFFUSION, SITTING DROP, temperature 277K	分辨率 2.47 Å R-free 0.235
4M7M Crystal structure of the R111K:R132Q:Y134F:T54V:R59W:A32W mutant of the Cellular Retinoic Acid Binding Protein Type II in complex with All-Trans Retinal at 2.57 Angstrom Resolution 提交 2013-08-12	突变/修饰不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	突变：R111K:R132Q:Y134F:T54V:R59W:A32W	RET RETINAL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；pH 7；277 K；0.1 M malonate, pH 7.0, 12% PEG3350, VAPOR DIFFUSION, SITTING DROP, temperature 277K	分辨率 2.57 Å R-free 0.253
4QGV Crystal structure of the R132K:R111L mutant of Cellular Retinoic Acid Binding ProteinII complexed with a synthetic ligand (Merocyanine) at 1.73 angstrom resolution. 提交 2014-05-25	突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 B 2–138（137 aa）	突变：R132K, R111L	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；0.1M Bis Tris Propane, 0.2 M Sodium Fluoride, 16% PEG 3350, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.73 Å R-free 0.240
4QGV Crystal structure of the R132K:R111L mutant of Cellular Retinoic Acid Binding ProteinII complexed with a synthetic ligand (Merocyanine) at 1.73 angstrom resolution. 提交 2014-05-25	突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 2 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	突变：R132K, R111L	LMC (2E,4E,6E)-3-methyl-6-(1,3,3-trimethyl-1,3-dihydro-2H-indol-2-ylidene)hexa-2,4-dienal × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；0.1M Bis Tris Propane, 0.2 M Sodium Fluoride, 16% PEG 3350, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.73 Å R-free 0.240
4QGV Crystal structure of the R132K:R111L mutant of Cellular Retinoic Acid Binding ProteinII complexed with a synthetic ligand (Merocyanine) at 1.73 angstrom resolution. 提交 2014-05-25	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 3 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 2–138（137 aa）链 B 2–138（137 aa）	突变：R132K, R111L 突变：R132K, R111L	LMC (2E,4E,6E)-3-methyl-6-(1,3,3-trimethyl-1,3-dihydro-2H-indol-2-ylidene)hexa-2,4-dienal × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；0.1M Bis Tris Propane, 0.2 M Sodium Fluoride, 16% PEG 3350, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.73 Å R-free 0.240
4QGW Crystal structure of the R132K:R111L:L121D mutant of Cellular Retinoic Acid Binding ProteinII complexed with a synthetic ligand (Merocyanine) at 1.77 angstrom resolution 提交 2014-05-26	突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	突变：R132K, R111L, L121D	LMC (2E,4E,6E)-3-methyl-6-(1,3,3-trimethyl-1,3-dihydro-2H-indol-2-ylidene)hexa-2,4-dienal × 1 B3P 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；0.1M Bis Tris Propane, 0.2M Sodium Floride, 16% PEG3350, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.77 Å R-free 0.243
4QGW Crystal structure of the R132K:R111L:L121D mutant of Cellular Retinoic Acid Binding ProteinII complexed with a synthetic ligand (Merocyanine) at 1.77 angstrom resolution 提交 2014-05-26	突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 2 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 B 2–138（137 aa）	突变：R132K, R111L, L121D	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；0.1M Bis Tris Propane, 0.2M Sodium Floride, 16% PEG3350, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.77 Å R-free 0.243
4QGX Crystal structure of the R132K:R111L:L121E mutant of Cellular Retinoic Acid Binding ProteinII complexed with a synthetic ligand (Merocyanine) at 1.47 angstrom resolution 提交 2014-05-26	突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	突变：R132K, R111L, L121E	LMC (2E,4E,6E)-3-methyl-6-(1,3,3-trimethyl-1,3-dihydro-2H-indol-2-ylidene)hexa-2,4-dienal × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；0.1M bis Tris Propane, 0.2M Sodium Floride, 16% PEG3350, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.47 Å R-free 0.220
4QGX Crystal structure of the R132K:R111L:L121E mutant of Cellular Retinoic Acid Binding ProteinII complexed with a synthetic ligand (Merocyanine) at 1.47 angstrom resolution 提交 2014-05-26	突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 2 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 B 2–138（137 aa）	突变：R132K, R111L, L121E	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；0.1M bis Tris Propane, 0.2M Sodium Floride, 16% PEG3350, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.47 Å R-free 0.220
4QGX Crystal structure of the R132K:R111L:L121E mutant of Cellular Retinoic Acid Binding ProteinII complexed with a synthetic ligand (Merocyanine) at 1.47 angstrom resolution 提交 2014-05-26	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 3 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 2–138（137 aa）链 B 2–138（137 aa）	突变：R132K, R111L, L121E 突变：R132K, R111L, L121E	LMC (2E,4E,6E)-3-methyl-6-(1,3,3-trimethyl-1,3-dihydro-2H-indol-2-ylidene)hexa-2,4-dienal × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；0.1M bis Tris Propane, 0.2M Sodium Floride, 16% PEG3350, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.47 Å R-free 0.220
4YBP Crystal structure of the R111K:Y134F:T54V:R132Q:P39Q:R59Y mutant of human cellular retinoic acid binding proteinii with retinal after 24 hour incubation at 1.83 angstrom resolution - thermodynamic product - 1st cycle 提交 2015-02-19	突变/修饰不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	突变：R111K, Y134F, T54V, P39Q, R132Q, R59Y	RET RETINAL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION；pH 6；277 K；12% PEG3350, 8% Tacsimate pH = 6.0.	分辨率 1.83 Å R-free 0.238
4YBP Crystal structure of the R111K:Y134F:T54V:R132Q:P39Q:R59Y mutant of human cellular retinoic acid binding proteinii with retinal after 24 hour incubation at 1.83 angstrom resolution - thermodynamic product - 1st cycle 提交 2015-02-19	突变/修饰不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 2–138（137 aa）	突变：R111K, Y134F, T54V, P39Q, R132Q, R59Y	RET RETINAL × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION；pH 6；277 K；12% PEG3350, 8% Tacsimate pH = 6.0.	分辨率 1.83 Å R-free 0.238
4YBU Crystal structure of the R111K:Y134F:T54V:R132Q:P39Q:R59Y mutant of human Cellular Retinoic Acid Binding ProteinII in complex with Retinal after 24 h incubation and 1 hour UV irradiation at 1.92 angstrom - 1st cycle 提交 2015-02-19	突变/修饰不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	突变：R111K, Y134F, T54V, P39Q, R132Q, R59Y	RET RETINAL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION；pH 6；277 K；12% PEG3350, 8% Tacsimate, pH = 6.0	分辨率 1.92 Å R-free 0.244
4YBU Crystal structure of the R111K:Y134F:T54V:R132Q:P39Q:R59Y mutant of human Cellular Retinoic Acid Binding ProteinII in complex with Retinal after 24 h incubation and 1 hour UV irradiation at 1.92 angstrom - 1st cycle 提交 2015-02-19	突变/修饰不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 2–138（137 aa）	突变：R111K, Y134F, T54V, P39Q, R132Q, R59Y	RET RETINAL × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION；pH 6；277 K；12% PEG3350, 8% Tacsimate, pH = 6.0	分辨率 1.92 Å R-free 0.244
4YCE Crystal structure of the R111K:Y134F:T54V:R132Q:P39Q:R59Y mutant of human cellular retinoic acid binding proteinii with retinal at 1.95 angstrom- visible light irradiated crystal for 1 hour - 2nd cycle 提交 2015-02-19	突变/修饰不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	突变：R111K, Y134F, T54V, P39Q, R132Q, R59Y	RET RETINAL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION；pH 6；277 K；12% PEG3350, 8% Tacsimate pH 6.0	分辨率 1.95 Å R-free 0.238
4YCE Crystal structure of the R111K:Y134F:T54V:R132Q:P39Q:R59Y mutant of human cellular retinoic acid binding proteinii with retinal at 1.95 angstrom- visible light irradiated crystal for 1 hour - 2nd cycle 提交 2015-02-19	突变/修饰不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 2–138（137 aa）	突变：R111K, Y134F, T54V, P39Q, R132Q, R59Y	RET RETINAL × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION；pH 6；277 K；12% PEG3350, 8% Tacsimate pH 6.0	分辨率 1.95 Å R-free 0.238
4YCH Crystal Structure of R111K:Y134F:T54V:R132Q:P39Q:R59Y mutant of human Cellular Retinoic Acid Binding ProteinII with Retinal at 1.96 Angstrom - UV irradiated Crystal for 1 hour - 2nd cycle 提交 2015-02-20	突变/修饰不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	突变：R111K, Y134F, T54V, R132Q, P39Q, R59Y	RET RETINAL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION；pH 6；277 K；12% PEG 3350, 8% Tacsimate pH 6.0	分辨率 1.96 Å R-free 0.249
4YCH Crystal Structure of R111K:Y134F:T54V:R132Q:P39Q:R59Y mutant of human Cellular Retinoic Acid Binding ProteinII with Retinal at 1.96 Angstrom - UV irradiated Crystal for 1 hour - 2nd cycle 提交 2015-02-20	突变/修饰不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 2–138（137 aa）	突变：R111K, Y134F, T54V, R132Q, P39Q, R59Y	RET RETINAL × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION；pH 6；277 K；12% PEG 3350, 8% Tacsimate pH 6.0	分辨率 1.96 Å R-free 0.249
4YDA Crystal structure of R111K:Y134F:T54V:R132Q:P39Q:R59Y mutant of human cellular retinoic acid binding proteinii with retinal at 1.95 angstrom - after 1hour visible light irradiation - 3rd cycle 提交 2015-02-21	突变/修饰不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	突变：R111K, Y134F, T54V, R132Q, P39Q, R59Y	RET RETINAL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6；277 K；12% PEG3350, 8% Tacsimate pH 6.0	分辨率 1.95 Å R-free 0.240
4YDA Crystal structure of R111K:Y134F:T54V:R132Q:P39Q:R59Y mutant of human cellular retinoic acid binding proteinii with retinal at 1.95 angstrom - after 1hour visible light irradiation - 3rd cycle 提交 2015-02-21	突变/修饰不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 2–138（137 aa）	突变：R111K, Y134F, T54V, R132Q, P39Q, R59Y	RET RETINAL × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6；277 K；12% PEG3350, 8% Tacsimate pH 6.0	分辨率 1.95 Å R-free 0.240
4YDB Crystal structure of the R111K:Y134F:T54V:R132Q:P39Q:R59Y mutant of human Cellular Retinoic Acid Binding Protein II in complex with Retinal at 2.03 angstrom -UV irradiated crystal- 3rd cycle 提交 2015-02-21	突变/修饰不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	突变：R111K, Y134F, T54V, R132Q, P39Q, R59Y	RET RETINAL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6；277 K；12% PEG3350, 8% Tacsimate pH 6.0	分辨率 2.03 Å R-free 0.252
4YDB Crystal structure of the R111K:Y134F:T54V:R132Q:P39Q:R59Y mutant of human Cellular Retinoic Acid Binding Protein II in complex with Retinal at 2.03 angstrom -UV irradiated crystal- 3rd cycle 提交 2015-02-21	突变/修饰不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 2–138（137 aa）	突变：R111K, Y134F, T54V, R132Q, P39Q, R59Y	RET RETINAL × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6；277 K；12% PEG3350, 8% Tacsimate pH 6.0	分辨率 2.03 Å R-free 0.252
4YFP CRYSTAL STRUCTURE OF THE R111K:Y134F:T54V:R132Q:P39Y:R59Y MUTANT OF HUMAN CELLULAR RETINOIC ACID BINDING PROTEIN II WITH RETINAL AFTER 20 MINUTES INCUBATION AT 1.95 ANGSTROM RESOLUTION-Kinetic Product 提交 2015-02-25	突变/修饰不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	突变：R111K, Y134F, T54V, R132Q, P39Y, R59Y	RET RETINAL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6；277 K；12% PEG3350, 0.1M Malonate pH 6.0	分辨率 1.95 Å R-free 0.234
4YFP CRYSTAL STRUCTURE OF THE R111K:Y134F:T54V:R132Q:P39Y:R59Y MUTANT OF HUMAN CELLULAR RETINOIC ACID BINDING PROTEIN II WITH RETINAL AFTER 20 MINUTES INCUBATION AT 1.95 ANGSTROM RESOLUTION-Kinetic Product 提交 2015-02-25	突变/修饰不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 2–138（137 aa）	突变：R111K, Y134F, T54V, R132Q, P39Y, R59Y	RET RETINAL × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6；277 K；12% PEG3350, 0.1M Malonate pH 6.0	分辨率 1.95 Å R-free 0.234
4YFQ CRYSTAL STRUCTURE OF THE R111K:Y134F:T54V:R132Q:P39Y:R59Y MUTANT OF HUMAN CELLULAR RETINOIC ACID BINDING PROTEINII WITH RETINAL AFTER 24 HOURS INCUBATION AT 1.62 ANGSTROM RESOLUTION - Thermodynamic product - 1st cycle 提交 2015-02-25	突变/修饰不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	突变：R111K, Y134F, T54V, R132Q, P39Y, R59Y	RET RETINAL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；12% PEG3350, 0.1M Malonate pH 6.0	分辨率 1.62 Å R-free 0.225
4YFQ CRYSTAL STRUCTURE OF THE R111K:Y134F:T54V:R132Q:P39Y:R59Y MUTANT OF HUMAN CELLULAR RETINOIC ACID BINDING PROTEINII WITH RETINAL AFTER 24 HOURS INCUBATION AT 1.62 ANGSTROM RESOLUTION - Thermodynamic product - 1st cycle 提交 2015-02-25	突变/修饰不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 2–138（137 aa）	突变：R111K, Y134F, T54V, R132Q, P39Y, R59Y	RET RETINAL × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；12% PEG3350, 0.1M Malonate pH 6.0	分辨率 1.62 Å R-free 0.225
4YFR Crystal structure of the R111K:Y134F:T54V:R132Q:P39Y:R59Y mutant of human Cellular Retinoic Acid Binding Protein II with Retinal at 1.95 Angstrom Resolution - UV irradiated crystal for 30 minutes - 1st Cycle 提交 2015-02-25	突变/修饰不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	突变：R111K, Y134F, T54V, R132Q, P39Y, R59Y	RET RETINAL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；12% PEG3350, 0.1M Malonate pH 6.0	分辨率 1.95 Å R-free 0.265
4YFR Crystal structure of the R111K:Y134F:T54V:R132Q:P39Y:R59Y mutant of human Cellular Retinoic Acid Binding Protein II with Retinal at 1.95 Angstrom Resolution - UV irradiated crystal for 30 minutes - 1st Cycle 提交 2015-02-25	突变/修饰不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 2–138（137 aa）	突变：R111K, Y134F, T54V, R132Q, P39Y, R59Y	RET RETINAL × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；12% PEG3350, 0.1M Malonate pH 6.0	分辨率 1.95 Å R-free 0.265
4YGG CRYSTAL STRUCTURE OF R111K:Y134F:T54V:R132Q:P39Y:R59Y MUTANT OF HUMAN CELLULAR RETINOIC ACID BINDING PROTEIN II WITH RETINAL AT 1.9 ANGSTROM RESOLUTION - VISIBLE LIGHT IRRADIATED CRYSTAL - 2ND CYCLE 提交 2015-02-26	突变/修饰不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	突变：R111K, Y134F, T54V, R132Q, P39Y, R59Y	RET RETINAL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6；277 K；12% PEG3350, 0.1M Malonate pH 6.0	分辨率 1.90 Å R-free 0.238
4YGG CRYSTAL STRUCTURE OF R111K:Y134F:T54V:R132Q:P39Y:R59Y MUTANT OF HUMAN CELLULAR RETINOIC ACID BINDING PROTEIN II WITH RETINAL AT 1.9 ANGSTROM RESOLUTION - VISIBLE LIGHT IRRADIATED CRYSTAL - 2ND CYCLE 提交 2015-02-26	突变/修饰不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 2–138（137 aa）	突变：R111K, Y134F, T54V, R132Q, P39Y, R59Y	RET RETINAL × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6；277 K；12% PEG3350, 0.1M Malonate pH 6.0	分辨率 1.90 Å R-free 0.238
4YGH Crystal Structure of R111K:Y134F:T54V:R132Q:P39Y:R59Y mutant of human Cellular Retinoic Acid Binding Protein II with Retinal at 2.1 Angstrom resolution - UV irradiated crystal - 2nd cycle 提交 2015-02-26	突变/修饰不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	突变：R111K, Y134F, T54V, R132Q, P39Y, R59Y	RET RETINAL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；12% PEG3350, 0.1M Malonate pH 6.0	分辨率 2.10 Å R-free 0.236
4YGH Crystal Structure of R111K:Y134F:T54V:R132Q:P39Y:R59Y mutant of human Cellular Retinoic Acid Binding Protein II with Retinal at 2.1 Angstrom resolution - UV irradiated crystal - 2nd cycle 提交 2015-02-26	突变/修饰不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 2–138（137 aa）	突变：R111K, Y134F, T54V, R132Q, P39Y, R59Y	RET RETINAL × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；12% PEG3350, 0.1M Malonate pH 6.0	分辨率 2.10 Å R-free 0.236
4YGZ CRYSTAL STRUCTURE OF THE R111K:Y134F:T54V:R132Q:P39Y:R59Y MUTANT OF HUMAN CELLULAR RETINOIC ACID BINDING PROTEIN II WITH RETINAL AT 2.06 ANGSTROM RESOLUTION - VISIBLE LIGHT IRRADIATED CRYSTAL -3RD CYCLE 提交 2015-02-26	突变/修饰不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	突变：R111K, Y134F, T54V, R132Q, P39Y, R59Y	RET RETINAL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；12% PEG3350, 0.1M Malonate pH=6.0	分辨率 2.06 Å R-free 0.255
4YGZ CRYSTAL STRUCTURE OF THE R111K:Y134F:T54V:R132Q:P39Y:R59Y MUTANT OF HUMAN CELLULAR RETINOIC ACID BINDING PROTEIN II WITH RETINAL AT 2.06 ANGSTROM RESOLUTION - VISIBLE LIGHT IRRADIATED CRYSTAL -3RD CYCLE 提交 2015-02-26	突变/修饰不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 2–138（137 aa）	突变：R111K, Y134F, T54V, R132Q, P39Y, R59Y	RET RETINAL × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；12% PEG3350, 0.1M Malonate pH=6.0	分辨率 2.06 Å R-free 0.255
4YH0 Crystal structure of the R111K:Y134F:T54V:R132Q:P39Y:R59Y mutant of human Cellular Retinoic Acid Binding Protein II in complex with Retinal at 2.14 angstrom resolution - UV irradiated crystal - 3rd cycle 提交 2015-02-26	突变/修饰不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	突变：R111K, Y134F, T54V, R132Q, P39Y, R59Y	RET RETINAL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；12% PEG3350, 0.1M Malonate pH=6.0	分辨率 2.14 Å R-free 0.235
4YH0 Crystal structure of the R111K:Y134F:T54V:R132Q:P39Y:R59Y mutant of human Cellular Retinoic Acid Binding Protein II in complex with Retinal at 2.14 angstrom resolution - UV irradiated crystal - 3rd cycle 提交 2015-02-26	突变/修饰不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 2–138（137 aa）	突变：R111K, Y134F, T54V, R132Q, P39Y, R59Y	RET RETINAL × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；12% PEG3350, 0.1M Malonate pH=6.0	分辨率 2.14 Å R-free 0.235
4YKM Crystal structure of the R111K:Y134F:T54V:R132Q:P39Q:R59Y:A32W:F3Q mutant of human Cellular Retinoic Acid Binding Protein II with Retinal at 1.58 angstrom resolution 提交 2015-03-04	突变/修饰不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	突变：R111K, Y134F, T54V, R132Q, P39Q, R59Y, A32W, F3Q	RET RETINAL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；20% PEG3350, 0.1M Bis Tris Propane pH=6.0, 0.2M Sodium Floride	分辨率 1.58 Å R-free 0.216
4YKM Crystal structure of the R111K:Y134F:T54V:R132Q:P39Q:R59Y:A32W:F3Q mutant of human Cellular Retinoic Acid Binding Protein II with Retinal at 1.58 angstrom resolution 提交 2015-03-04	突变/修饰不同实验环境不同结构质量不同	Assembly 2 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 B 2–138（137 aa）	突变：R111K, Y134F, T54V, R132Q, P39Q, R59Y, A32W, F3Q	RET RETINAL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；20% PEG3350, 0.1M Bis Tris Propane pH=6.0, 0.2M Sodium Floride	分辨率 1.58 Å R-free 0.216
4YKO Crystal structure of the R111K:Y134F:T54V:R132Q:P39Q:R59Y:A32Y:F3Q mutant of human Cellular Retinoic Acid Binding Protein II with Retinal at 1.58 angstrom resolution 提交 2015-03-04	突变/修饰不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	突变：R111K, Y134F, T54V, R132Q, P39Q, R59Y, A32W, F3Q	RET RETINAL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；20% PEG3350, 0.1M Malonate pH=6.0	分辨率 1.57 Å R-free 0.224
4YKO Crystal structure of the R111K:Y134F:T54V:R132Q:P39Q:R59Y:A32Y:F3Q mutant of human Cellular Retinoic Acid Binding Protein II with Retinal at 1.58 angstrom resolution 提交 2015-03-04	突变/修饰不同实验环境不同结构质量不同	Assembly 2 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 B 2–138（137 aa）	突变：R111K, Y134F, T54V, R132Q, P39Q, R59Y, A32W, F3Q	RET RETINAL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；20% PEG3350, 0.1M Malonate pH=6.0	分辨率 1.57 Å R-free 0.224
5HZQ Crystal structure of cellular retinoic acid binding protein 2 (CRABP2)-aryl fluorosulfate covalent conjugate 提交 2016-02-02	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 1–138（138 aa）	未记录	YWZ 4'-[(3,6,9,12-tetraoxapentadec-14-yn-1-yl)oxy][1,1'-biphenyl]-4-yl sulfurofluoridate × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；293 K；20% (w/v) PEG3350 and 200 mM KH2PO4, cryoprotected using solution of same condition diluted with glycerol to 30% final glycerol concentration	分辨率 1.75 Å R-free 0.228
5HZQ Crystal structure of cellular retinoic acid binding protein 2 (CRABP2)-aryl fluorosulfate covalent conjugate 提交 2016-02-02	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 2 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 B 1–138（138 aa）	未记录	YWZ 4'-[(3,6,9,12-tetraoxapentadec-14-yn-1-yl)oxy][1,1'-biphenyl]-4-yl sulfurofluoridate × 1 GOL GLYCEROL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；293 K；20% (w/v) PEG3350 and 200 mM KH2PO4, cryoprotected using solution of same condition diluted with glycerol to 30% final glycerol concentration	分辨率 1.75 Å R-free 0.228
5OGB Human Cellular Retinoic Acid Binding Protein II (CRABPII) with bound synthetic retinoid DC360. 提交 2017-07-12	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 1–138（138 aa）	未记录	9U5 4-[2-(4,4-dimethyl-1-propan-2-yl-quinolin-6-yl)ethynyl]benzoic acid × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；293 K；PEG 4000, Na Acetate	分辨率 1.80 Å R-free 0.236
6HKR Human Cellular Retinoic Acid Binding Protein II (CRABPII) with bound synthetic retinoid DC271. 提交 2018-09-07	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 1–138（138 aa）	未记录	EDO 1,2-ETHANEDIOL × 1 G9Q 4-[2-(4,4-dimethyl-1-propan-2-yl-2,3-dihydroquinolin-6-yl)ethynyl]benzoic acid × 1 GOL GLYCEROL × 2 PG4 TETRAETHYLENE GLYCOL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；293 K；PEG5000, TRIS HCL, Sodium Acetate	分辨率 1.50 Å R-free 0.175
6MOP Crystal Structure of the All-trans Retinal-Bound R111K:Y134F:T54V:R132Q:P39Y:R59Y:L121E Mutant of Human Cellular Retinoic Acid Binding Protein II in the Dark at 1.9 Angstrom Resolution 提交 2018-10-04	突变/修饰不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	突变：R111K, Y134F, T54V, R132Q, P39Y, R59Y, L121E	RET RETINAL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG 3350, DL-malic acid	分辨率 1.90 Å R-free 0.228
6MOP Crystal Structure of the All-trans Retinal-Bound R111K:Y134F:T54V:R132Q:P39Y:R59Y:L121E Mutant of Human Cellular Retinoic Acid Binding Protein II in the Dark at 1.9 Angstrom Resolution 提交 2018-10-04	突变/修饰不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 2–138（137 aa）	突变：R111K, Y134F, T54V, R132Q, P39Y, R59Y, L121E	RET RETINAL × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG 3350, DL-malic acid	分辨率 1.90 Å R-free 0.228
6MOQ Crystal Structure of the All-trans Retinal-Bound R111K:Y134F:T54V:R132Q:P39Y:R59Y:L121W Mutant of Human Cellular Retinoic Acid Binding Protein II in the Dark at 2.2 Angstrom Resolution 提交 2018-10-04	突变/修饰不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	突变：R111K, Y134F, T54V, R132Q, P39Y, R59Y, L121W	RET RETINAL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；PEG 3350, sodium Malonate	分辨率 2.20 Å R-free 0.277
6MOQ Crystal Structure of the All-trans Retinal-Bound R111K:Y134F:T54V:R132Q:P39Y:R59Y:L121W Mutant of Human Cellular Retinoic Acid Binding Protein II in the Dark at 2.2 Angstrom Resolution 提交 2018-10-04	突变/修饰不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 2–138（137 aa）	突变：R111K, Y134F, T54V, R132Q, P39Y, R59Y, L121W	RET RETINAL × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；PEG 3350, sodium Malonate	分辨率 2.20 Å R-free 0.277
6MOR Crystal Structure of the All-Trans Retinal-Bound R111K:Y134F:T54V:R132Q:P39Y:R59Y:L121Y Mutant of Human Cellular Retinoic Acid Binding Protein II in the Dark at 1.79 Angstrom Resolution 提交 2018-10-04	突变/修饰不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	突变：R111K, Y134F, T54V, R132Q, P39Y, R59Y, L121Y	RET RETINAL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION；277 K；PEG 3350, Sodium Malonate	分辨率 1.79 Å R-free 0.247
6MOR Crystal Structure of the All-Trans Retinal-Bound R111K:Y134F:T54V:R132Q:P39Y:R59Y:L121Y Mutant of Human Cellular Retinoic Acid Binding Protein II in the Dark at 1.79 Angstrom Resolution 提交 2018-10-04	突变/修饰不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 2–138（137 aa）	突变：R111K, Y134F, T54V, R132Q, P39Y, R59Y, L121Y	RET RETINAL × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION；277 K；PEG 3350, Sodium Malonate	分辨率 1.79 Å R-free 0.247
6MOV Crystal Structure of the All-trans Retinal bound R111K:Y134F:T54V:R132Q:P39Y:R59Y:L121Q Human Cellular Retinoic Acid Binding Protein II in the Dark at 1.75 Angstrom Resolution 提交 2018-10-04	突变/修饰不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	突变：R111K, Y134F, T54V, R132Q, P39Y, R59Y, L121Q	RET RETINAL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；PEG 3350, DL-malic acid	分辨率 1.75 Å R-free 0.238
6MOV Crystal Structure of the All-trans Retinal bound R111K:Y134F:T54V:R132Q:P39Y:R59Y:L121Q Human Cellular Retinoic Acid Binding Protein II in the Dark at 1.75 Angstrom Resolution 提交 2018-10-04	突变/修饰不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 2–138（137 aa）	突变：R111K, Y134F, T54V, R132Q, P39Y, R59Y, L121Q	RET RETINAL × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；PEG 3350, DL-malic acid	分辨率 1.75 Å R-free 0.238
6MOW Crystal Structure of the apo R111K:Y134F:T54V:R132Q:P39Y:R59Y:L121Q mutant of Human Cellular Retinoic Acid Binding Protein II at 2.3 Angstrom Resolution 提交 2018-10-04	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）片段：R111K, Y134F, T54V, R132Q, P39Y, R59Y, L121Q	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；PEG3350, Sodium Malonate	分辨率 2.35 Å R-free 0.259
6MOW Crystal Structure of the apo R111K:Y134F:T54V:R132Q:P39Y:R59Y:L121Q mutant of Human Cellular Retinoic Acid Binding Protein II at 2.3 Angstrom Resolution 提交 2018-10-04	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 2–138（137 aa）片段：R111K, Y134F, T54V, R132Q, P39Y, R59Y, L121Q	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；PEG3350, Sodium Malonate	分辨率 2.35 Å R-free 0.259
6MPK Crystal Structure of the 13-cis Retinal-Bound R111K:Y134F:T54V:R132Q:P39Y:R59Y:L121E:A32Y Mutant of Human Cellular Retinoic Acid Binding Protein II in the Dark at 1.58 Angstrom Resolution 提交 2018-10-07	突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	未记录	RET RETINAL × 1 GOL GLYCEROL × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；PEG 3350, D-Malic acid	分辨率 1.58 Å R-free 0.222
6MQI Crystal Structure of the All-trans Retinal bound R111K:Y134F:T54V:R132Q:P39Y:R59Y:L121Q mutant of Human Cellular Retinoic Acid Binding Protein II Irradiated with 400 nm Laser for 5 minutes at 1.87 Angstrom Resolution 提交 2018-10-09	突变/修饰不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	突变：R111K, Y134F, T54V, R132Q, P39Y, R59Y, L121Q	RET RETINAL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；PEG 3350, DL-malic acid	分辨率 1.87 Å R-free 0.259
6MQI Crystal Structure of the All-trans Retinal bound R111K:Y134F:T54V:R132Q:P39Y:R59Y:L121Q mutant of Human Cellular Retinoic Acid Binding Protein II Irradiated with 400 nm Laser for 5 minutes at 1.87 Angstrom Resolution 提交 2018-10-09	突变/修饰不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 2–138（137 aa）	突变：R111K, Y134F, T54V, R132Q, P39Y, R59Y, L121Q	RET RETINAL × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；PEG 3350, DL-malic acid	分辨率 1.87 Å R-free 0.259
6MQJ Crystal Structure of the All-Trans Retinal bound R111K:Y134F:T54V:R132Q:P39Y:R59Y:L121Q mutant of Human Cellular Retinoic Acid Binding Protein II Irradiated with 532 nm Laser for 10 minutes at 2.1 Angstrom Resolution 提交 2018-10-09	突变/修饰不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	突变：R111K,Y134F,T54V,R132Q,P39Y,R59Y,L121Q	RET RETINAL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；PEG3350, DL-malic acid	分辨率 2.12 Å R-free 0.243
6MQJ Crystal Structure of the All-Trans Retinal bound R111K:Y134F:T54V:R132Q:P39Y:R59Y:L121Q mutant of Human Cellular Retinoic Acid Binding Protein II Irradiated with 532 nm Laser for 10 minutes at 2.1 Angstrom Resolution 提交 2018-10-09	突变/修饰不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 2–138（137 aa）	突变：R111K,Y134F,T54V,R132Q,P39Y,R59Y,L121Q	RET RETINAL × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；PEG3350, DL-malic acid	分辨率 2.12 Å R-free 0.243
6MQW Crystal Structure of All-trans Retinal-Bound R111K:Y134F:T54V:R132Q:P39Y:R59Y:L121E Human Cellular Retinoic Acid Binding Protein II Irradiated with 400 nm laser (30 seconds) and subsequently dark adapted (10 minutes) at 2.1 Angstrom Resolution 提交 2018-10-11	突变/修饰不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	未记录	RET RETINAL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG 3350, DL-malic acid	分辨率 2.09 Å R-free 0.220
6MQW Crystal Structure of All-trans Retinal-Bound R111K:Y134F:T54V:R132Q:P39Y:R59Y:L121E Human Cellular Retinoic Acid Binding Protein II Irradiated with 400 nm laser (30 seconds) and subsequently dark adapted (10 minutes) at 2.1 Angstrom Resolution 提交 2018-10-11	突变/修饰不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 2–138（137 aa）	未记录	RET RETINAL × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG 3350, DL-malic acid	分辨率 2.09 Å R-free 0.220
6MQX Crystal Structure of All-trans Retinal-Bound R111K:Y134F:T54V:R132Q:P39Y:R59Y:L121E Human Cellular Retinoic Acid Binding Protein II Irradiated with 400 nm Laser (30 seconds) and Subsequently Dark Adapted (25 minutes) at 2.0 Angstrom Resolution 提交 2018-10-11	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）片段：R111K, Y134F, T54V, R132Q, P39Y, R59Y, L121E	未记录	GOL GLYCEROL × 2 RET RETINAL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；PEG 3350, DL-malic acid	分辨率 2.01 Å R-free 0.233
6MQX Crystal Structure of All-trans Retinal-Bound R111K:Y134F:T54V:R132Q:P39Y:R59Y:L121E Human Cellular Retinoic Acid Binding Protein II Irradiated with 400 nm Laser (30 seconds) and Subsequently Dark Adapted (25 minutes) at 2.0 Angstrom Resolution 提交 2018-10-11	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 2–138（137 aa）片段：R111K, Y134F, T54V, R132Q, P39Y, R59Y, L121E	未记录	GOL GLYCEROL × 4 RET RETINAL × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；PEG 3350, DL-malic acid	分辨率 2.01 Å R-free 0.233
6MQY Crystal Structure of the 13-cis Product of All-trans Retinal-Bound R111K:Y134F:T54V:R132Q:P39Y:R59Y:L121E Mutant of Human Cellular Retinoic Acid Binding Protein II Irradiated with 400 nm Laser (30 seconds) at 1.9 Angstrom 提交 2018-10-11	突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	突变：R111K, Y134F, T54V, R132Q, P39Y, R59Y, L121E	GOL GLYCEROL × 3 RET RETINAL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG 3350, D-Malic acid	分辨率 1.90 Å R-free 0.217
6MQY Crystal Structure of the 13-cis Product of All-trans Retinal-Bound R111K:Y134F:T54V:R132Q:P39Y:R59Y:L121E Mutant of Human Cellular Retinoic Acid Binding Protein II Irradiated with 400 nm Laser (30 seconds) at 1.9 Angstrom 提交 2018-10-11	突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 2–138（137 aa）	突变：R111K, Y134F, T54V, R132Q, P39Y, R59Y, L121E	GOL GLYCEROL × 6 RET RETINAL × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG 3350, D-Malic acid	分辨率 1.90 Å R-free 0.217
6MQZ Crystal Structure of the 13-cis Product of the All-trans Retinal-Bound R111K:Y134F:T54V:R132Q:P39Y:R59Y:L121E Mutant of Human Cellular Retinoic Acid Binding Protein II Irradiated with 400 nm Laser (5 minutes) at 2.07 Angstrom 提交 2018-10-11	突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	突变：R111K, Y134F, T54V, R132Q, P39Y, R59Y, L121E	GOL GLYCEROL × 1 RET RETINAL × 1	X-RAY DIFFRACTION X-ray结晶条件 EVAPORATION, RECRYSTALLIZATION；pH 6.5；277 K；PEG 3350, DL-malic acid	分辨率 2.07 Å R-free 0.252
6MQZ Crystal Structure of the 13-cis Product of the All-trans Retinal-Bound R111K:Y134F:T54V:R132Q:P39Y:R59Y:L121E Mutant of Human Cellular Retinoic Acid Binding Protein II Irradiated with 400 nm Laser (5 minutes) at 2.07 Angstrom 提交 2018-10-11	突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 2–138（137 aa）	突变：R111K, Y134F, T54V, R132Q, P39Y, R59Y, L121E	GOL GLYCEROL × 2 RET RETINAL × 2	X-RAY DIFFRACTION X-ray结晶条件 EVAPORATION, RECRYSTALLIZATION；pH 6.5；277 K；PEG 3350, DL-malic acid	分辨率 2.07 Å R-free 0.252
6MR0 Crystal Structure of the All-trans Retinal Bound R111K:Y134F:T54V:R132Q:P39Q:R59Y:L121E Human Cellular Retinoic Acid Binding Protein II Mutant After 5 Minutes UV irradiation at 2.6 Angstrom Resolution 提交 2018-10-11	结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	突变：R111K, Y134F, T54V, R132Q, P39Q, R59Y, L121E	RET RETINAL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；PEG 3350, BTP, Sodium Fluoride	分辨率 2.65 Å R-free 0.274
6MR0 Crystal Structure of the All-trans Retinal Bound R111K:Y134F:T54V:R132Q:P39Q:R59Y:L121E Human Cellular Retinoic Acid Binding Protein II Mutant After 5 Minutes UV irradiation at 2.6 Angstrom Resolution 提交 2018-10-11	结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 2–138（137 aa）	突变：R111K, Y134F, T54V, R132Q, P39Q, R59Y, L121E	RET RETINAL × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；PEG 3350, BTP, Sodium Fluoride	分辨率 2.65 Å R-free 0.274
6NNX Crystal Structure of the All-Trans Retinal-Bound R111K:Y134F:T54V:R132Q:P39Y:R59Y:L121M Mutant of Human Cellular Retinoic Acid Binding Protein II in the Dark at 1.87 Angstrom Resolution 提交 2019-01-15	突变/修饰不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	突变：R111K, Y134F, T54V, R132Q, P39Y, R59Y, L121M	RET RETINAL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；298 K；PEG 3350, Sodium Malonate	分辨率 1.87 Å R-free 0.240
6NNX Crystal Structure of the All-Trans Retinal-Bound R111K:Y134F:T54V:R132Q:P39Y:R59Y:L121M Mutant of Human Cellular Retinoic Acid Binding Protein II in the Dark at 1.87 Angstrom Resolution 提交 2019-01-15	突变/修饰不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 2–138（137 aa）	突变：R111K, Y134F, T54V, R132Q, P39Y, R59Y, L121M	RET RETINAL × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；298 K；PEG 3350, Sodium Malonate	分辨率 1.87 Å R-free 0.240
6NNY Crystal Structure of the All-Trans Retinal-Bound R111K:Y134F:T54V:R132Q:P39E:R59Y:L121E Mutant of Human Cellular Retinoic Acid Binding Protein II in the Dark at 1.67 Angstrom Resolution 提交 2019-01-15	突变/修饰不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	突变：R111K, Y134F, T54V, R132Q, P39E, R59Y, L121E	RET RETINAL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；PEG 3350, Tacsimate	分辨率 1.67 Å R-free 0.248
6NNY Crystal Structure of the All-Trans Retinal-Bound R111K:Y134F:T54V:R132Q:P39E:R59Y:L121E Mutant of Human Cellular Retinoic Acid Binding Protein II in the Dark at 1.67 Angstrom Resolution 提交 2019-01-15	突变/修饰不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 2–138（137 aa）	突变：R111K, Y134F, T54V, R132Q, P39E, R59Y, L121E	RET RETINAL × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；PEG 3350, Tacsimate	分辨率 1.67 Å R-free 0.248
6NOE Crystal Structure of the All-Trans Retinal-Bound R111K:Y134F:T54V:R132Q:P39Y:R59Y:L121E:I63D Mutant of Human Cellular Retinoic Acid Binding Protein II in the Dark at 1.97 Angstrom Resolution 提交 2019-01-16	突变/修饰不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 2–138（137 aa）	突变：R111K, Y134F, T54V, R132Q, P39Y, R59Y, L121E, I63D	RET RETINAL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；PEG 3350,Sodium Malonate	分辨率 1.97 Å R-free 0.255
6NOE Crystal Structure of the All-Trans Retinal-Bound R111K:Y134F:T54V:R132Q:P39Y:R59Y:L121E:I63D Mutant of Human Cellular Retinoic Acid Binding Protein II in the Dark at 1.97 Angstrom Resolution 提交 2019-01-16	突变/修饰不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 2–138（137 aa）	突变：R111K, Y134F, T54V, R132Q, P39Y, R59Y, L121E, I63D	RET RETINAL × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；PEG 3350,Sodium Malonate	分辨率 1.97 Å R-free 0.255
6Z2U M2 mutant (R111K:Y134F:T54V:R132Q:P39Y:R59Y) of human cellular retinoic acid binding protein II 提交 2020-05-18	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 1–138（138 aa）	突变：R111K, Y134F, T54V, R132Q, P39Y, R59Y	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；281 K；0.2 M sodium malonate pH 6 and 20% w/v polyethylene glycol 3,350	分辨率 2.40 Å R-free 0.254
6Z2Z M2 mutant (R111K:Y134F:T54V:R132Q:P39Y:R59Y) of human cellular retinoic acid binding protein II - 2a conjugate 提交 2020-05-19	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 1–138（138 aa）	突变：R111K, Y134F, T54V, R132Q, P39Y, R59Y	Q5W methyl (~{Z})-3-(6-ethynylnaphthalen-2-yl)-2-methyl-prop-2-enoate × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；281 K；0.2 M sodium malonate pH 7 and 20% w/v polyethylene glycol 3,350	分辨率 2.55 Å R-free 0.265
6ZSW M2 mutant (R111K:Y134F:T54V:R132Q:P39Y:R59Y) of human cellular retinoic acid binding protein II - 6 conjugate 提交 2020-07-16	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 1–138（138 aa）	突变：R111K, Y134F, T54V, R132Q, P39Y, R59Y	QPB methyl (~{Z})-3-(4-hydroxyphenyl)-2-methyl-prop-2-enoate × 1 ACT ACETATE ION × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；pH 7；281 K；0.2 M sodium malonate pH 7 and 20 % w/v PEG 3350	分辨率 2.08 Å R-free 0.228
6ZSX M2 mutant (R111K:Y134F:T54V:R132Q:P39Y:R59Y) of human cellular retinoic acid binding protein II - 4 conjugate 提交 2020-07-16	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 1–138（138 aa）	突变：R111K, Y134F, T54V, R132Q, P39Y, R59Y	QPE methyl (~{Z})-2-methyl-3-phenyl-prop-2-enoate × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；pH 7；281 K；0.1 M sodium malonate pH 7 and 20 % w/v PEG 3350	分辨率 2.40 Å R-free 0.249
7AA0 Structural comparison of cellular retinoic acid binding protein I and II in the presence and absence of natural and synthetic ligands 提交 2020-09-02	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 BBB 1–138（138 aa）	未记录	R6B (~{E})-3-[4-(4,4-dimethyl-1-propan-2-yl-2,3-dihydroquinolin-6-yl)phenyl]prop-2-enoic acid × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；298 K；PEG based	分辨率 1.82 Å R-free 0.245
7AA0 Structural comparison of cellular retinoic acid binding protein I and II in the presence and absence of natural and synthetic ligands 提交 2020-09-02	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 2 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 AAA 1–138（138 aa）	未记录	R6B (~{E})-3-[4-(4,4-dimethyl-1-propan-2-yl-2,3-dihydroquinolin-6-yl)phenyl]prop-2-enoic acid × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；298 K；PEG based	分辨率 1.82 Å R-free 0.245
7AA1 Structural comparison of cellular retinoic acid binding proteins I and II in the presence and absence of natural and synthetic ligands 提交 2020-09-02	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 AAA 1–138（138 aa）	未记录	R62 4-[2-(5,5,8,8-tetramethyl-6,7-dihydroquinoxalin-2-yl)ethynyl]benzoic acid × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；298 K；PEG based vapor diffusion	分辨率 1.71 Å R-free 0.201
7OXW CrabP2 mutant R30DK31D 提交 2021-06-23	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 1–138（138 aa）	未记录	ACT ACETATE ION × 1 SO4 SULFATE ION × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；293.15 K；100 mM Sodium acetate pH 4.5 and 2.0 M ammonium sulfate	分辨率 1.16 Å R-free 0.174
7OXX CrabP2 mutant R30AK31A 提交 2021-06-23	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 1–138（138 aa）链 B 1–138（138 aa）链 C 1–138（138 aa）链 D 1–138（138 aa）	未记录	NA SODIUM ION × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；293.15 K；150 mM MgCl2, 100 mM Bis-Tris pH 6.5 and 25% PEG 3350.	分辨率 1.33 Å R-free 0.200
7RY5 Cellular Retinoic Acid Binding Protein II with Bound Inhibitor 4-[6-({4-[(fluorosulfonyl)oxy]phenyl}ethynyl)-4,4-dimethyl-3,4-dihydroquinolin-1(2H)-yl]-4-oxobutanoic acid 提交 2021-08-24	突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 AAA 2–138（137 aa）	未记录	80V 4-[6-({4-[(fluorosulfonyl)oxy]phenyl}ethynyl)-4,4-dimethyl-3,4-dihydroquinolin-1(2H)-yl]-4-oxobutanoic acid × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；0.1M Sodium Acetate, 18% PEG4000	分辨率 2.00 Å R-free 0.233
7RY5 Cellular Retinoic Acid Binding Protein II with Bound Inhibitor 4-[6-({4-[(fluorosulfonyl)oxy]phenyl}ethynyl)-4,4-dimethyl-3,4-dihydroquinolin-1(2H)-yl]-4-oxobutanoic acid 提交 2021-08-24	突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 2 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 BBB 2–138（137 aa）	未记录	80V 4-[6-({4-[(fluorosulfonyl)oxy]phenyl}ethynyl)-4,4-dimethyl-3,4-dihydroquinolin-1(2H)-yl]-4-oxobutanoic acid × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；0.1M Sodium Acetate, 18% PEG4000	分辨率 2.00 Å R-free 0.233
9GVX M2 mutant (R111K:Y134F:T54V:R132Q:P39Y:R59Y) of human cellular retinoic acid binding protein II - 1e conjugate 提交 2024-09-26	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 1–138（138 aa）	突变：R111K, Y134F, T54V, R132Q, P39Y, R59Y	A1IQZ methyl (~{Z})-3-(4-ethynylphenyl)-2-methyl-prop-2-enoate × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；pH 7；281 K；0.2 M sodium malonate pH 7 and 20% w/v polyethylene glycol 3.350	分辨率 2.10 Å R-free 0.254
9GVY M2 mutant (R111K:Y134F:T54V:R132Q:P39Y:R59Y) of human cellular retinoic acid binding protein II - 1m conjugate 提交 2024-09-26	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 1–138（138 aa）	突变：R111K, Y134F, T54V, R132Q, P39Y, R59Y	A1IQY methyl (~{Z})-2-methyl-3-(4-nitrophenyl)prop-2-enoate × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；pH 7；281 K；0.2 M sodium malonate pH 7 and 20% w/v polyethylene glycol 3.350	分辨率 2.05 Å R-free 0.251
9GVZ M2 mutant (R111K:Y134F:T54V:R132Q:P39Y:R59Y) of human cellular retinoic acid binding protein II - 1j conjugate 提交 2024-09-26	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 1–138（138 aa）	突变：R111K, Y134F, T54V, R132Q, P39Y, R59Y	A1IQ0 methyl (~{Z})-3-(4-ethynoxy-3,5-dimethoxy-phenyl)-2-methyl-prop-2-enoate × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；281 K；0.2 M sodium malonate pH 7 and 20% w/v polyethylene glycol 3.350	分辨率 3.00 Å R-free 0.271
9GW0 M2 mutant (R111K:Y134F:T54V:R132Q:P39Y:R59Y) of human cellular retinoic acid binding protein II - 1l conjugate 提交 2024-09-26	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 1–138（138 aa）	突变：R111K, Y134F, T54V, R132Q, P39Y, R59Y	A1IQ1 methyl (~{Z})-3-(4-acetamidophenyl)-2-methyl-prop-2-enoate × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 7；281 K；0.2 M sodium malonate pH 7 and 20% w/v polyethylene glycol 3.350	分辨率 2.40 Å R-free 0.281

共 84 个其他 PDB 条目、137 个 assembly。打开独立比较页并筛选聚集状态

查看构建体与数据证据

UniProt名称	RABP2_HUMAN
Isoform	—
PDB实体	1
链与序列区间	作者链 A； PDB构建体 1–137； UniProt 2–138

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。链映射与序列区间收在“数据证据”中；数据库内部编号、导入时间和 assembly 操作表达式仅用于维护，因此不在读者页面展示。

SAXS 散射曲线 SAXS Profile

P(r) 距离分布 P(r) Distribution

下载 Download SAXS (.dat) P(r) (.pr.out) CIF

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id	6mox
沉积日期 deposition_date	2018-10-04
结构标题 title	Crystal Structure of the All-trans Retinal-Bound R111K:Y134F:T54V:R132Q:P39Q:R59Y:L121E Human Cellular Retinoic Acid Binding Protein II Mutant in the Dark at 2.18 Angstrom Resolution
关键词 keywords	iLBP, Rhodopsin mimic, LIPID BINDING PROTEIN; LIPID BINDING PROTEIN
实验方法 method	X-RAY DIFFRACTION

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3. SAXS 参数 (CRYSOL 理论计算) 3. SAXS Parameters (CRYSOL)

回转半径 Rg (Guinier) rg_guinier	15.64 Å
回转半径 Rg (电子) rg_electron	14.40 Å
零角强度 I(0) i0	4579960.00
分子量 molecular_weight	15744.0 kDa
排除体积 excluded_volume	19944 Å³
包络体积 envelope_volume	22241 Å³
水化壳体积 shell_volume	13092 Å³
包络直径 envelope_diameter	49.3 Å
壳层 Rg shell_rg	20.18 Å
包络 Rg envelope_rg	14.59 Å
形状 Rg shape_rg	14.37 Å
总 Rg total_rg	15.67 Å
总原子数 total_atoms	1106
残基数 n_residues	137
球谐函数阶数 n_harmonics	20
q 范围 q_range	— – 0.5000 Å⁻¹
数据点数 n_points	101
壳层类型 shell_type	directional
溶剂电子密度 solvent_density	0.3340 e/Å³
壳层衬度 contrast_shell	0.0300 e/Å³
CRYSOL 版本 crysol_version	4.1.3

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4. P(r) 距离分布 (GNOM 反演) 4. P(r) Analysis (GNOM)

最大尺寸 Dmax dmax	50.0 Å
Rg (实空间) rg_real	15.53 Å
Rg 误差 (实空间) rg_real_error	0.25 Å
I(0) (实空间) i0_real	4.5800e+06
I(0) 误差 (实空间) i0_real_error	4.9650e+04
Rg (倒空间) rg_reciprocal	15.54 Å
I(0) (倒空间) i0_reciprocal	4580000.0000
解质量估计 total_estimate	0.8892
解质量评级 solution_quality	GOOD a GOOD solution
P(r) 峰数 n_peaks	2
主峰位置 r_peak_primary	20.2 Å
偏度 Skewness skewness	0.086
峰度 Kurtosis kurtosis	-0.405
角度范围 angular_range	— – 0.5000 Å⁻¹
当前正则化参数 α current_alpha	0.0000
最高正则化参数 α highest_alpha	817900.0000
实空间数据点数 n_real_points	80
GNOM 版本 gnom_version	4.1.3
质量判据 quality_criteria	AN1: 0.000; Oscil: 0.855; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.994; Smooth: 0.995

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5. 晶体学与实验 5. Crystallography & Experiment

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6. 实体与聚合物信息 Entities & Polymers (3)

实体 1 Entity 1 polymer

描述 description	Cellular retinoic acid-binding protein 2
分子量 formula_weight	15559.7 kDa
突变 mutation	R111K, Y134F, T54V, R132Q, P39Q, R59Y, L121E
来源方法 src_method	man
拷贝数 entity_count	1

聚合物 Polymer

聚合物类型 type	polypeptide(L)
链编号 strand_id	A
原子数 atom_count	1157

PNFSGNWKIIRSENFEELLKVLGVNVMLRKIAVAAASKQAVEIKQEGDTFYIKVSTTVYTTEINFKVGEEFEEQTVDGRPCKSLVKWESENKMVCEQKLLKGEGPKTSWTKELTNDGELIETMTADDVVCTQVFVRE

来源 Source

来源生物 organism	Homo sapiens
通用名 common_name	Human
NCBI 分类编号 ncbi_taxonomy_id	9606
宿主生物 host_organism	Escherichia coli BL21(DE3)

实体 2 Entity 2 non-polymer

描述 description	RETINAL
分子量 formula_weight	284.4 kDa
来源方法 src_method	syn
拷贝数 entity_count	1

实体 3 Entity 3 water

描述 description	water
分子量 formula_weight	18.0 kDa
来源方法 src_method	nat
拷贝数 entity_count	25

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7. 折叠分类 (SCOP + CATH) 2 domains

SCOP 2.08 (1 domains)

结构域编号 domain_id	d6moxa_
类 Class class	b — All beta proteins
折叠类型 Fold fold	b.60 — Lipocalins
超家族 Superfamily superfamily	b.60.1 — Lipocalins
家族 Family family	b.60.1.2 — Fatty acid binding protein-like

CATH v4.4 (1 domains)

结构域编号 domain_id	6moxA00
类 Class class	2 — Mainly Beta
架构 Architecture architecture	40 — Beta Barrel
拓扑 Topology topology	128 — Lipocalin
同源超家族 H-superfamily homologous superfamily	20 — Calycin beta-barrel core domain

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8. 引用文献 (1)

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晶胞边长 a length_a	58.546 Å
晶胞边长 b length_b	58.546 Å
晶胞边长 c length_c	99.525 Å
晶胞夹角 α angle_alpha	90.00 °
晶胞夹角 β angle_beta	90.00 °
晶胞夹角 γ angle_gamma	120.00 °
晶胞分子数 Z z_pdb	6

空间群 space_group	P 31 2 1
空间群编号 int_tables_number	152
晶系 crystal_system	—

分辨率 resolution	2.180 Å
最低分辨率 resolution_low	45.178 Å
R 因子 r_factor	0.2083
R_work r_work	0.2034
R_free r_free	0.2501

fit	/app/data/saxs_computation/mo/6mox/6mox.fit
pddf	/app/data/pr_computation/mo/6mox/6mox.pr.out
profile	/app/data/saxs_computation/mo/6mox/6mox.dat