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6r4r

Cryo-EM Structure of the PI3-Kinase SH3 Domain Amyloid Fibril

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Phosphatidylinositol 3-kinase regulatory subunit alpha

Bos taurus

UniProt P23727

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 7 No other associated polymer Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1bfi 1bfj 1oo3 1pnj 1qad 2pna 2pnb 2pni 6d81 6d81 6d82 6d82

16 assemblies; showing the first 12

Homodimer
6d81 6d82 6d85 6d86 6d87 6mrp

6 assemblies

Homotetramer

None

Other homooligomers
6r4r

1 assemblies

Heteromeric or nucleic-acid complex
1oo4 5dxh 5dxh 5dxu 5t8f 6g6w 6oco 6ocu 7jis 8bcy 8s3r 9gcf

14 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name P85A_BOVIN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 3–86； UniProt 1–84 Author chain B； PDBConstruct 3–86； UniProt 1–84 Author chain C； PDBConstruct 3–86； UniProt 1–84 Author chain D； PDBConstruct 3–86； UniProt 1–84 Author chain E； PDBConstruct 3–86； UniProt 1–84 Author chain F； PDBConstruct 3–86； UniProt 1–84 Author chain G； PDBConstruct 3–86； UniProt 1–84

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id6r4r
Deposition date deposition_date2019-03-23
Structure title titleCryo-EM Structure of the PI3-Kinase SH3 Domain Amyloid Fibril
Keywords keywordsamyloid fibril, sh3 domain, PROTEIN FIBRIL; PROTEIN FIBRIL
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6r4r__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6r4r__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

6r4r__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）31.60 Å
Rg (electron density)31.28 Å
Total Rg31.89 Å
Atom count4312
Residues539
Excluded volume75474 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 6r4r__assembly_1__model_1 heptameric （7） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (1)

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7. Citations (1)