SAXSdb — 6soy

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1. Protein Identity and Related Structures Protein Identity & Related Structures

ESAG6, subunit of heterodimeric transferrin receptor

Trypanosoma brucei

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 3	ESAG7, subunit of heterodimeric transferrin receptor × 1 （Q8WPU2） Serotransferrin × 1 （P02787） FE (III) ION × 1 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 water × 3	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	Q8WPU1_9TRYP
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 1–399； UniProt 1–399

ESAG7, subunit of heterodimeric transferrin receptor

Trypanosoma brucei

UniProt Q8WPU2

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 3	ESAG6, subunit of heterodimeric transferrin receptor × 1 （Q8WPU1） Serotransferrin × 1 （P02787） FE (III) ION × 1 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 water × 3	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	Q8WPU2_9TRYP
Isoform	—
PDB entities	2
Chains and sequence ranges	Author chain B； PDBConstruct 1–338； UniProt 1–338

Serotransferrin

Homo sapiens

UniProt P02787

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 3	ESAG6, subunit of heterodimeric transferrin receptor × 1 （Q8WPU1） ESAG7, subunit of heterodimeric transferrin receptor × 1 （Q8WPU2） FE (III) ION × 1 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 water × 3	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	TRFE_HUMAN
Isoform	—
PDB entities	3
Chains and sequence ranges	Author chain C； PDBConstruct 1–677； UniProt 22–698

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	6soy
Deposition date deposition_date	2019-08-30
Structure title title	Trypanosoma brucei transferrin receptor in complex with human transferrin
Keywords keywords	Trypanosoma brucei Trypanosome Transferrin receptor Transferrrin Cell surface, PROTEIN BINDING; PROTEIN BINDING
Experimental Method method	X-RAY DIFFRACTION

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6soy__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6soy__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

6soy__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	41.66 Å
Rg (electron density)	42.18 Å
Total Rg	42.33 Å
Atom count	10020
Residues	1288
Excluded volume	177530 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`6soy__assembly_1__model_1`	trimeric （3）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (6)

Entity 1 Entity 1 polymer

Description description	ESAG6, subunit of heterodimeric transferrin receptor
Molecular weight formula_weight	43898.5 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	A
Atom count atom_count	10058

MRFWFVLLALLGKEIYAYENERNALNATAANKVCGLSTYLKGIAHRVNSESAVVTEKLSDLKMRSIQLQLSVMRNRVPSGEQDCKDIRTLLKTVLRNEFTFQQELEEMRNASALAAAAAGLAAGRLEEWIFVFAQAAGRSSQFCISVGKTGPAEYNNLQECFDGTIGPETLYKIEDSRVKESAKTSLQLHEVLSSISFGSLGVKNIRGGNGKDGCNLVRTDTDGVLEGGSPTRHNLTWGGGVMNFGSYQNGSMYVEGGEYGDATEYGAVRWTEDPSKVSIFKDVIRLFARFQEAKNAVVKKIKTTVDELTKCIGQKEAELTNDQLYEEFIWETINRLELSKRVSEQSAFGEEEETIVKFNYTAEPVRGPFTVAGANAAAIHLSVSTAALCRSALLLGVL

Source Source

Source organism organism	Trypanosoma brucei
NCBI taxonomy ID ncbi_taxonomy_id	5691
Host organism host_organism	Cricetulus longicaudatus

Entity 2 Entity 2 polymer

Description description	ESAG7, subunit of heterodimeric transferrin receptor
Molecular weight formula_weight	37671.8 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	B

MRFWFVLLALLGKEIYAYENERNALNATAANKVCGLSTYLKGIAHRVNSESAVVTEKLSDLKMRSIQLQLSVMRNRVPSGEQDCKDIRTLLKTVLRNEFTFQQELEEMRNASALAAAAAGIAAGRLEEWIFVFAQAAGGSSQFCISVGTNIPAEYNNLQECFDGTIGPETLYKIEDSRVKESAQKSLQLHEVLSSISFSSLGAESIVEKGENRGCNLMRTADGGLLKDVCLNRNFTWGGGVLNFGYCVAGNLKIKGGEYGDVGSHDAVRWTEDPSKVSIFKDVIRLFARFQEVKNAVVKKIKTTVDELTKCIGQKEAELTNDQLYEEFEVIQKYLWFL

Source Source

Source organism organism	Trypanosoma brucei
NCBI taxonomy ID ncbi_taxonomy_id	5691
Host organism host_organism	Cricetulus longicaudatus

Entity 3 Entity 3 polymer

Description description	Serotransferrin
Molecular weight formula_weight	75088.2 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	C

DKTVRWCAVSEHEATKCQSFRDHMKSVIPSDGPSVACVKKASYLDCIRAIAANEADAVTLDAGLVYDAYLAPNNLKPVVAEFYGSKEDPQTFYYAVAVVKKDSGFQMNQLRGKKSCHTGLGRSAGWNIPIGLLYCDLPEPRKPLEKAVANFFSGSCAPCADGTDFPQLCQLCPGCGCSTLNQYFGYSGAFKCLKDGAGDVAFVKHSTIFENLANKADRDQYELLCLDNTRKPVDEYKDCHLAQVPSHTVVARSMGGKEDLIWELLNQAQEHFGKDKSKEFQLFSSPHGKDLLFKDSAHGFLKVPPRMDAKMYLGYEYVTAIRNLREGTCPEAPTDECKPVKWCALSHHERLKCDEWSVNSVGKIECVSAETTEDCIAKIMNGEADAMSLDGGFVYIAGKCGLVPVLAENYNKSDNCEDTPEAGYFAVAVVKKSASDLTWDNLKGKKSCHTAVGRTAGWNIPMGLLYNKINHCRFDEFFSEGCAPGSKKDSSLCKLCMGSGLNLCEPNNKEGYYGYTGAFRCLVEKGDVAFVKHQTVPQNTGGKNPDPWAKNLNEKDYELLCLDGTRKPVEEYANCHLARAPNHAVVTRKDKEACVHKILRQQQHLFGSNVTDCSGNFCLFRSETKDLLFRDDTVCLAKLHDRNTYEKYLGEEYVKAVGNLRKCSTSSLLEACTFRRP

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Homo sapiens

Entity 4 Entity 4 non-polymer

Description description	FE (III) ION
Molecular weight formula_weight	55.8 kDa
Source method src_method	syn
Copy count entity_count	1

Entity 5 Entity 5 non-polymer

Description description	2-acetamido-2-deoxy-beta-D-glucopyranose
Molecular weight formula_weight	221.2 kDa
Source method src_method	man
Copy count entity_count	1

Entity 6 Entity 6 water

Description description	water
Molecular weight formula_weight	18.0 kDa
Source method src_method	nat
Copy count entity_count	38

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6. Fold Classification (SCOP + CATH) 2 domains

CATH v4.4 (2 domains)

Domain ID domain_id	6soyC01
Class class	3 — Alpha Beta
Architecture architecture	40 — 3-Layer(aba) Sandwich
Topology topology	190 — D-Maltodextrin-Binding Protein; domain 2
Homologous superfamily homologous superfamily	10 — Periplasmic binding protein-like II

Domain ID domain_id	6soyC02
Class class	3 — Alpha Beta
Architecture architecture	40 — 3-Layer(aba) Sandwich
Topology topology	190 — D-Maltodextrin-Binding Protein; domain 2
Homologous superfamily homologous superfamily	10 — Periplasmic binding protein-like II

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Unit-cell length a length_a	163.490 Å
Unit-cell length b length_b	108.110 Å
Unit-cell length c length_c	115.000 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	128.74 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	4

Space group space_group	C 1 2 1
Space-group number int_tables_number	5
Crystal system crystal_system	—

Resolution resolution	2.750 Å
Low-resolution limit resolution_low	40.260 Å
R factor r_factor	0.1850
R_work r_work	0.1830
R_free r_free	0.2330

Trypanosoma brucei transferrin receptor in complex with human transferrin

1. Protein Identity and Related Structures Protein Identity & Related Structures

ESAG6, subunit of heterodimeric transferrin receptor

State in the Current Structure

Other States of the Same Protein in the Database

ESAG7, subunit of heterodimeric transferrin receptor

State in the Current Structure

Other States of the Same Protein in the Database

Serotransferrin

State in the Current Structure

Other States of the Same Protein in the Database

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

6soy__assembly_1__model_1

6soy__assembly_1__model_1 | I(q)

6soy__assembly_1__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

Refinement Refinement

Diffraction experiment Diffraction

5. Entities and Polymers Entities & Polymers (6)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

Entity 2 Entity 2 polymer

Polymer Polymer

Source Source

Entity 3 Entity 3 polymer

Polymer Polymer

Source Source

Entity 4 Entity 4 non-polymer

Entity 5 Entity 5 non-polymer

Entity 6 Entity 6 water

6. Fold Classification (SCOP + CATH) 2 domains

CATH v4.4 (2 domains)

7. Citations (1)

Trypanosoma brucei transferrin receptor in complex with human transferrin

1. Protein Identity and Related Structures Protein Identity & Related Structures

ESAG6, subunit of heterodimeric transferrin receptor

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

ESAG7, subunit of heterodimeric transferrin receptor

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Serotransferrin

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

6soy__assembly_1__model_1

6soy__assembly_1__model_1 | I(q)

6soy__assembly_1__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

Refinement Refinement

Diffraction experiment Diffraction

5. Entities and Polymers Entities & Polymers (6)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

Entity 2 Entity 2 polymer

Polymer Polymer

Source Source

Entity 3 Entity 3 polymer

Polymer Polymer

Source Source

Entity 4 Entity 4 non-polymer

Entity 5 Entity 5 non-polymer

Entity 6 Entity 6 water

6. Fold Classification (SCOP + CATH) 2 domains

CATH v4.4 (2 domains)

7. Citations (1)