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6tca

Phosphorylated p38 and MAPKAPK2 complex with inhibitor

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

MAP kinase-activated protein kinase 2

Homo sapiens

UniProt P49137

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 Mitogen-activated protein kinase 14 × 1 （Q16539） N-[5-(dimethylsulfamoyl)-2-methylphenyl]-1-phenyl-5-propyl-1H-pyrazole-4-carboxamide × 1 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 Mitogen-activated protein kinase 14 × 1 （Q16539） N-[5-(dimethylsulfamoyl)-2-methylphenyl]-1-phenyl-5-propyl-1H-pyrazole-4-carboxamide × 1 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 2 Mitogen-activated protein kinase 14 × 1 （Q16539） N-[5-(dimethylsulfamoyl)-2-methylphenyl]-1-phenyl-5-propyl-1H-pyrazole-4-carboxamide × 1 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 2 Mitogen-activated protein kinase 14 × 1 （Q16539） N-[5-(dimethylsulfamoyl)-2-methylphenyl]-1-phenyl-5-propyl-1H-pyrazole-4-carboxamide × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1kwp 1kwp 1nxk 1nxk 1nxk 1nxk 1ny3 2jbo 2jbp 2jbp 2jbp 2jbp

72 assemblies; showing the first 12

Homodimer

None

Homotetramer

None

Other homooligomers
1kwp 1nxk 1ny3 2pzy 3a2c 3fpm 3fyj 3fyk 3gok 3gok 3gok 3gok

23 assemblies; showing the first 12

Heteromeric or nucleic-acid complex
2okr 2okr 2onl 2onl 2oza 4tyh 6tca 6tca 6tca 6tca

10 assemblies

View Construct and Data Evidence
UniProt name MAPK2_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 3–362； UniProt 41–400 Author chain C； PDBConstruct 3–362； UniProt 41–400 Author chain E； PDBConstruct 3–362； UniProt 41–400 Author chain G； PDBConstruct 3–362； UniProt 41–400

Mitogen-activated protein kinase 14

Homo sapiens

UniProt Q16539

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 MAP kinase-activated protein kinase 2 × 1 （P49137） N-[5-(dimethylsulfamoyl)-2-methylphenyl]-1-phenyl-5-propyl-1H-pyrazole-4-carboxamide × 1 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 MAP kinase-activated protein kinase 2 × 1 （P49137） N-[5-(dimethylsulfamoyl)-2-methylphenyl]-1-phenyl-5-propyl-1H-pyrazole-4-carboxamide × 1 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 2 MAP kinase-activated protein kinase 2 × 1 （P49137） N-[5-(dimethylsulfamoyl)-2-methylphenyl]-1-phenyl-5-propyl-1H-pyrazole-4-carboxamide × 1 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 2 MAP kinase-activated protein kinase 2 × 1 （P49137） N-[5-(dimethylsulfamoyl)-2-methylphenyl]-1-phenyl-5-propyl-1H-pyrazole-4-carboxamide × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
11oy 1a9u 1bl6 1bl7 1bmk 1di9 1ian 1kv1 1kv2 1m7q 1ouk 1ouy

270 assemblies; showing the first 12

Homodimer
3c5u 3gcu 3gcu

3 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2okr 2okr 2onl 2onl 2y8o 5eta 5eta 5etf 6qyx 6rfo 6tca 6tca

16 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name MK14_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 5–364； UniProt 1–360 Author chain D； PDBConstruct 5–364； UniProt 1–360 Author chain F； PDBConstruct 5–364； UniProt 1–360 Author chain H； PDBConstruct 5–364； UniProt 1–360

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id6tca
Deposition date deposition_date2019-11-05
Structure title titlePhosphorylated p38 and MAPKAPK2 complex with inhibitor
Keywords keywordsMAPK, MAPKAPK, phosphorylated, p38, MK2, SIGNALING PROTEIN; SIGNALING PROTEIN
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6tca__assembly_2__model_1

Assembly 2 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6tca__assembly_2__model_1 | I(q)

10-2 10-1 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

6tca__assembly_2__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）27.79 Å
Rg (electron density)26.65 Å
Total Rg27.54 Å
Atom count5413
Residues670
Excluded volume97029 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 6tca__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 6tca__assembly_2__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 6tca__assembly_3__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
4 1 6tca__assembly_4__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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7. Citations (1)