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6tjk

Crystal Structure of Recombinant GBA in Complex with Bis-Tris Propane.

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Lysosomal acid glucosylceramidase

Homo sapiens

UniProt P04062

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Other combination Monomer Protein 1 其他Polymer 1 ;alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 SULFATE ION × 5 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 1,2-ETHANEDIOL × 19 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 water × 1 Consistent with protein count
2 Other combination Monomer Protein 1 其他Polymer 1 ;alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 SULFATE ION × 5 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 1,2-ETHANEDIOL × 24 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 water × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1ogs 2nsx 2nsx 2nsx 2nsx 2nt0 2nt0 2nt0 2nt0 2nt1 2nt1 2nt1

16 assemblies; showing the first 12

Homodimer
2nsx 2nsx 2nsx 3gxi 3gxi 3gxm 3gxm 3rik 3rik 3ril 3ril

11 assemblies

Homotetramer
2nsx 2nsx 2nt1 3gxd 3gxf 3gxf 3gxi 3gxi 3gxm 3gxm

10 assemblies

Other homooligomers

None

Heteromeric or nucleic-acid complex
1ogs 1y7v 1y7v 1y7v 1y7v 1y7v 1y7v 2j25 2j25 2v3d 2v3d 2v3e

64 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name GLCM_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain AAA； PDBConstruct 1–497； UniProt 40–536 Author chain BBB； PDBConstruct 1–497； UniProt 40–536

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id6tjk
Deposition date deposition_date2019-11-26
Structure title titleCrystal Structure of Recombinant GBA in Complex with Bis-Tris Propane.
Keywords keywordsbeta-glucocerebrosidase, lysosomal glycoside hydrolase, GH30, HYDROLASE; HYDROLASE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6tjk__assembly_2__model_1

Assembly 2 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6tjk__assembly_2__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

6tjk__assembly_2__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）23.96 Å
Rg (electron density)22.86 Å
Total Rg23.81 Å
Atom count8204
Residues497
Excluded volume73554 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 6tjk__assembly_1__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 6tjk__assembly_2__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (7)

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7. Citations (1)