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6uh7

EV-A71 strain 11316 complexed with MADAL compound 30

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

VP1

OrganismNot specified

UniProt D4QGA8

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 240 VP2 × 60 （I6W7A3） VP3 × 60 （A0A0E3SXU7） VP4 × 60 （E9RGA0） SPHINGOSINE × 60 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 4 VP2 × 1 （I6W7A3） VP3 × 1 （A0A0E3SXU7） VP4 × 1 （E9RGA0） SPHINGOSINE × 1 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 20 VP2 × 5 （I6W7A3） VP3 × 5 （A0A0E3SXU7） VP4 × 5 （E9RGA0） SPHINGOSINE × 5 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 24 VP2 × 6 （I6W7A3） VP3 × 6 （A0A0E3SXU7） VP4 × 6 （E9RGA0） SPHINGOSINE × 6 Consistent with protein count
5 Protein heterocomplex Heteromer Protein 4 VP2 × 1 （I6W7A3） VP3 × 1 （A0A0E3SXU7） VP4 × 1 （E9RGA0） SPHINGOSINE × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
6diz 6diz 6diz 6diz 6diz 6uh1 6uh1 6uh1 6uh1 6uh1 6uh6 6uh6

20 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name D4QGA8_9ENTO
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–297； UniProt 566–862

VP2

OrganismNot specified

UniProt I6W7A3

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 240 VP1 × 60 （D4QGA8） VP3 × 60 （A0A0E3SXU7） VP4 × 60 （E9RGA0） SPHINGOSINE × 60 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 4 VP1 × 1 （D4QGA8） VP3 × 1 （A0A0E3SXU7） VP4 × 1 （E9RGA0） SPHINGOSINE × 1 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 20 VP1 × 5 （D4QGA8） VP3 × 5 （A0A0E3SXU7） VP4 × 5 （E9RGA0） SPHINGOSINE × 5 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 24 VP1 × 6 （D4QGA8） VP3 × 6 （A0A0E3SXU7） VP4 × 6 （E9RGA0） SPHINGOSINE × 6 Consistent with protein count
5 Protein heterocomplex Heteromer Protein 4 VP1 × 1 （D4QGA8） VP3 × 1 （A0A0E3SXU7） VP4 × 1 （E9RGA0） SPHINGOSINE × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
6diz 6diz 6diz 6diz 6diz 6uh1 6uh1 6uh1 6uh1 6uh1 6uh6 6uh6

20 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name I6W7A3_9ENTO
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 1–254； UniProt 70–323

VP3

OrganismNot specified

UniProt A0A0E3SXU7

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 240 VP1 × 60 （D4QGA8） VP2 × 60 （I6W7A3） VP4 × 60 （E9RGA0） SPHINGOSINE × 60 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 4 VP1 × 1 （D4QGA8） VP2 × 1 （I6W7A3） VP4 × 1 （E9RGA0） SPHINGOSINE × 1 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 20 VP1 × 5 （D4QGA8） VP2 × 5 （I6W7A3） VP4 × 5 （E9RGA0） SPHINGOSINE × 5 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 24 VP1 × 6 （D4QGA8） VP2 × 6 （I6W7A3） VP4 × 6 （E9RGA0） SPHINGOSINE × 6 Consistent with protein count
5 Protein heterocomplex Heteromer Protein 4 VP1 × 1 （D4QGA8） VP2 × 1 （I6W7A3） VP4 × 1 （E9RGA0） SPHINGOSINE × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
6diz 6diz 6diz 6diz 6diz 6uh1 6uh1 6uh1 6uh1 6uh1 6uh6 6uh6

23 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name A0A0E3SXU7_9ENTO
Isoform —
PDB entities 3
Chains and sequence ranges Author chain C； PDBConstruct 1–242； UniProt 324–565

VP4

OrganismNot specified

UniProt E9RGA0

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 240 VP1 × 60 （D4QGA8） VP2 × 60 （I6W7A3） VP3 × 60 （A0A0E3SXU7） SPHINGOSINE × 60 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 4 VP1 × 1 （D4QGA8） VP2 × 1 （I6W7A3） VP3 × 1 （A0A0E3SXU7） SPHINGOSINE × 1 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 20 VP1 × 5 （D4QGA8） VP2 × 5 （I6W7A3） VP3 × 5 （A0A0E3SXU7） SPHINGOSINE × 5 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 24 VP1 × 6 （D4QGA8） VP2 × 6 （I6W7A3） VP3 × 6 （A0A0E3SXU7） SPHINGOSINE × 6 Consistent with protein count
5 Protein heterocomplex Heteromer Protein 4 VP1 × 1 （D4QGA8） VP2 × 1 （I6W7A3） VP3 × 1 （A0A0E3SXU7） SPHINGOSINE × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
6uh1 6uh1 6uh1 6uh1 6uh1 6uh6 6uh6 6uh6 6uh6 6uh6 6uh7 6uh7

15 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name E9RGA0_9ENTO
Isoform —
PDB entities 4
Chains and sequence ranges Author chain D； PDBConstruct 1–69； UniProt 1–69

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id6uh7
Deposition date deposition_date2019-09-26
Structure title titleEV-A71 strain 11316 complexed with MADAL compound 30
Keywords keywordsEnterovirus, VIRUS, inhibitor; VIRUS
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6uh7__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6uh7__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 1010 1011 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

6uh7__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）0.00 Å
Rg (electron density)131.30 Å
Total Rg131.30 Å
Atom count392160
Residues50520
Excluded volume6965300 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 6uh7__assembly_1__model_1 240-meric （240） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 6uh7__assembly_2__model_1 tetrameric （4） Excluded — —
Exclusion reason： Auxiliary symmetry representation; not a complete or representative biological assembly.
3 1 6uh7__assembly_3__model_1 eicosameric （20） Excluded — —
Exclusion reason： Auxiliary symmetry representation; not a complete or representative biological assembly.
4 1 6uh7__assembly_4__model_1 24-meric （24） Excluded — —
Exclusion reason： Auxiliary symmetry representation; not a complete or representative biological assembly.
5 1 6uh7__assembly_5__model_1 tetrameric （4） Excluded — —
Exclusion reason： Auxiliary symmetry representation; not a complete or representative biological assembly.
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (5)

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6. Fold Classification (SCOP + CATH) 6 domains

SCOP 2.08 (3 domains)

Domain ID domain_idd6uh7a_
Class classb — All beta proteins
Fold Fold foldb.121 — Nucleoplasmin-like/VP (viral coat and capsid proteins)
Superfamily Superfamily superfamilyb.121.4 — Positive stranded ssRNA viruses
Family Family familyb.121.4.0 — automated matches
Domain ID domain_idd6uh7b_
Class classb — All beta proteins
Fold Fold foldb.121 — Nucleoplasmin-like/VP (viral coat and capsid proteins)
Superfamily Superfamily superfamilyb.121.4 — Positive stranded ssRNA viruses
Family Family familyb.121.4.0 — automated matches
Domain ID domain_idd6uh7c_
Class classb — All beta proteins
Fold Fold foldb.121 — Nucleoplasmin-like/VP (viral coat and capsid proteins)
Superfamily Superfamily superfamilyb.121.4 — Positive stranded ssRNA viruses
Family Family familyb.121.4.1 — Picornaviridae-like VP (VP1, VP2, VP3 and VP4)

CATH v4.4 (3 domains)

Domain ID domain_id6uh7A00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology120 — Jelly Rolls
Homologous superfamily homologous superfamily20 —
Domain ID domain_id6uh7B00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology120 — Jelly Rolls
Homologous superfamily homologous superfamily20 —
Domain ID domain_id6uh7C00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology120 — Jelly Rolls
Homologous superfamily homologous superfamily20 —
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7. Citations (1)