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6uya

Crystal structure of Compound 19 bound to IRAK4

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Interleukin-1 receptor-associated kinase 4

Homo sapiens

UniProt Q9NWZ3

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 4 ;N-{2-[(2R)-2-fluoro-3-hydroxy-3-methylbutyl]-6-(morpholin-4-yl)-1-oxo-2,3-dihydro-1H-isoindol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide ; × 4 SULFATE ION × 1 water × 4 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
2nru 2nru 2nru 2nru 2nry 2nry 2nry 2nry 2o8y 2o8y 2oib 2oib

264 assemblies; showing the first 12

Homodimer
4u97 4u9a 6eg9 6ega 6egd 6ege

6 assemblies

Homotetramer
6eg9 6ega 6uya 6vql 7c2v 7c2w

6 assemblies

Other homooligomers

None

Heteromeric or nucleic-acid complex
3mop

1 assemblies

View Construct and Data Evidence
UniProt name IRAK4_HUMAN
Isoform Q9NWZ3-2
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 17–317； UniProt 36–336 Author chain B； PDBConstruct 17–317； UniProt 36–336 Author chain C； PDBConstruct 17–317； UniProt 36–336 Author chain D； PDBConstruct 17–317； UniProt 36–336

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id6uya
Deposition date deposition_date2019-11-12
Structure title titleCrystal structure of Compound 19 bound to IRAK4
Keywords keywordskinase, inflammation, lupus, immunology, inhibitor, cancer, SIGNALING PROTEIN, SIGNALING PROTEIN-INHIBITOR complex; SIGNALING PROTEIN/INHIBITOR
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6uya__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6uya__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

6uya__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）33.69 Å
Rg (electron density)32.72 Å
Total Rg33.41 Å
Atom count9180
Residues1135
Excluded volume163010 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 6uya__assembly_1__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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6. Fold Classification (SCOP + CATH) 4 domains

SCOP 2.08 (4 domains)

Domain ID domain_idd6uyaa_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.144 — Protein kinase-like (PK-like)
Superfamily Superfamily superfamilyd.144.1 — Protein kinase-like (PK-like)
Family Family familyd.144.1.0 — automated matches
Domain ID domain_idd6uyab_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.144 — Protein kinase-like (PK-like)
Superfamily Superfamily superfamilyd.144.1 — Protein kinase-like (PK-like)
Family Family familyd.144.1.0 — automated matches
Domain ID domain_idd6uyac_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.144 — Protein kinase-like (PK-like)
Superfamily Superfamily superfamilyd.144.1 — Protein kinase-like (PK-like)
Family Family familyd.144.1.0 — automated matches
Domain ID domain_idd6uyad_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.144 — Protein kinase-like (PK-like)
Superfamily Superfamily superfamilyd.144.1 — Protein kinase-like (PK-like)
Family Family familyd.144.1.0 — automated matches
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7. Citations (1)