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6wj5

Structure of human TRPA1 in complex with inhibitor GDC-0334

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Transient receptor potential cation channel subfamily A member 1

Homo sapiens

UniProt O75762

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 4 ;(4R,5S)-4-fluoro-1-[(4-fluorophenyl)sulfonyl]-5-methyl-N-({5-(trifluoromethyl)-2-[2-(trifluoromethyl)pyrimidin-5-yl]pyridin-4-yl}methyl)-L-prolinamide ; × 4 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer
6pqq 6v9v 6v9w 6v9x 6v9y 6wj5 6x2j 7jup 9m8n 9m8s 9moe

11 assemblies

Other homooligomers

None

Heteromeric or nucleic-acid complex
3j9p 6hc8 6pqo 6pqp 7or0 7or1

6 assemblies

View Construct and Data Evidence
UniProt name TRPA1_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–631； UniProt 448–1078 Author chain B； PDBConstruct 1–631； UniProt 448–1078 Author chain C； PDBConstruct 1–631； UniProt 448–1078 Author chain D； PDBConstruct 1–631； UniProt 448–1078

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id6wj5
Deposition date deposition_date2020-04-11
Structure title titleStructure of human TRPA1 in complex with inhibitor GDC-0334
Keywords keywordsTRPA1, channel, inhibitor, antagonist, MEMBRANE PROTEIN, MEMBRANE PROTEIN-Inhibitor complex; MEMBRANE PROTEIN/Inhibitor
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6wj5__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6wj5__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

6wj5__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）45.72 Å
Rg (electron density)45.24 Å
Total Rg45.44 Å
Atom count36396
Residues2248
Excluded volume328690 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 6wj5__assembly_1__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (2)

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7. Citations (1)