Room temperature X-ray crystallography reveals catalytic cysteine in the SARS-CoV-2 3CL Mpro is highly reactive: Insights for enzyme mechanism and drug design
Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures
The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links.
Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.
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2. Structure Basics 2. Structure Basics
Entry ID entry_id
6xb2
Deposition date deposition_date
2020-06-05
Structure title title
Room temperature X-ray crystallography reveals catalytic cysteine in the SARS-CoV-2 3CL Mpro is highly reactive: Insights for enzyme mechanism and drug design
b.47.1.4 — Viral cysteine protease of trypsin fold
CATH v4.4 (2 domains)
Domain ID domain_id
6xb2A01
Class class
2 — Mainly Beta
Architecture architecture
40 — Beta Barrel
Topology topology
10 — Thrombin, subunit H
Homologous superfamily homologous superfamily
10 — Trypsin-like serine proteases
Domain ID domain_id
6xb2A02
Class class
1 — Mainly Alpha
Architecture architecture
10 — Orthogonal Bundle
Topology topology
1840 — main proteinase (3clpro) structure, domain 3
Homologous superfamily homologous superfamily
10 — main proteinase (3clpro) structure, domain 3
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7. Citations (1)
;Room-temperature X-ray crystallography reveals the oxidation and reactivity of cysteine residues in SARS-CoV-2 3CL M pro : insights into enzyme mechanism and drug design.
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