6zol

SARS-CoV-2-Nsp1-40S complex, focused on head

Method: ELECTRON MICROSCOPY

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1. Protein Identity and Related Structures Protein Identity & Related Structures

40S ribosomal protein S3

OrganismNot specified

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 15 RNA 1	18S ribosomal RNA × 1 40S ribosomal protein S5 × 1 （P46782） 40S ribosomal protein S10 × 1 （P46783） 40S ribosomal protein S12 × 1 （P25398） 40S ribosomal protein S15 × 1 （P62841） 40S ribosomal protein S16 × 1 （P62249） 40S ribosomal protein S17 × 1 （P08708） 40S ribosomal protein S18 × 1 （P62269） 40S ribosomal protein S19 × 1 （P39019） 40S ribosomal protein S20 × 1 （P60866） 40S ribosomal protein S25 × 1 （P62851） 40S ribosomal protein S28 × 1 （P62857） 40S ribosomal protein S29 × 1 （P62273） Ribosomal protein S27a × 1 （Q5RKT7） Receptor of activated protein C kinase 1 × 1 （P63244） MAGNESIUM ION × 57 ZINC ION × 2	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RS3_HUMAN
Isoform	—
PDB entities	2
Chains and sequence ranges	Author chain D； PDBConstruct 1–243； UniProt 1–243

40S ribosomal protein S5

OrganismNot specified

UniProt P46782

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 15 RNA 1	18S ribosomal RNA × 1 40S ribosomal protein S3 × 1 （P23396） 40S ribosomal protein S10 × 1 （P46783） 40S ribosomal protein S12 × 1 （P25398） 40S ribosomal protein S15 × 1 （P62841） 40S ribosomal protein S16 × 1 （P62249） 40S ribosomal protein S17 × 1 （P08708） 40S ribosomal protein S18 × 1 （P62269） 40S ribosomal protein S19 × 1 （P39019） 40S ribosomal protein S20 × 1 （P60866） 40S ribosomal protein S25 × 1 （P62851） 40S ribosomal protein S28 × 1 （P62857） 40S ribosomal protein S29 × 1 （P62273） Ribosomal protein S27a × 1 （Q5RKT7） Receptor of activated protein C kinase 1 × 1 （P63244） MAGNESIUM ION × 57 ZINC ION × 2	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RS5_HUMAN
Isoform	—
PDB entities	3
Chains and sequence ranges	Author chain F； PDBConstruct 1–204； UniProt 1–204

40S ribosomal protein S10

OrganismNot specified

UniProt P46783

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 15 RNA 1	18S ribosomal RNA × 1 40S ribosomal protein S3 × 1 （P23396） 40S ribosomal protein S5 × 1 （P46782） 40S ribosomal protein S12 × 1 （P25398） 40S ribosomal protein S15 × 1 （P62841） 40S ribosomal protein S16 × 1 （P62249） 40S ribosomal protein S17 × 1 （P08708） 40S ribosomal protein S18 × 1 （P62269） 40S ribosomal protein S19 × 1 （P39019） 40S ribosomal protein S20 × 1 （P60866） 40S ribosomal protein S25 × 1 （P62851） 40S ribosomal protein S28 × 1 （P62857） 40S ribosomal protein S29 × 1 （P62273） Ribosomal protein S27a × 1 （Q5RKT7） Receptor of activated protein C kinase 1 × 1 （P63244） MAGNESIUM ION × 57 ZINC ION × 2	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RS10_HUMAN
Isoform	—
PDB entities	4
Chains and sequence ranges	Author chain K； PDBConstruct 1–165； UniProt 1–165

40S ribosomal protein S12

OrganismNot specified

UniProt P25398

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 15 RNA 1	18S ribosomal RNA × 1 40S ribosomal protein S3 × 1 （P23396） 40S ribosomal protein S5 × 1 （P46782） 40S ribosomal protein S10 × 1 （P46783） 40S ribosomal protein S15 × 1 （P62841） 40S ribosomal protein S16 × 1 （P62249） 40S ribosomal protein S17 × 1 （P08708） 40S ribosomal protein S18 × 1 （P62269） 40S ribosomal protein S19 × 1 （P39019） 40S ribosomal protein S20 × 1 （P60866） 40S ribosomal protein S25 × 1 （P62851） 40S ribosomal protein S28 × 1 （P62857） 40S ribosomal protein S29 × 1 （P62273） Ribosomal protein S27a × 1 （Q5RKT7） Receptor of activated protein C kinase 1 × 1 （P63244） MAGNESIUM ION × 57 ZINC ION × 2	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RS12_HUMAN
Isoform	—
PDB entities	5
Chains and sequence ranges	Author chain M； PDBConstruct 1–132； UniProt 1–132

40S ribosomal protein S15

OrganismNot specified

UniProt P62841

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 15 RNA 1	18S ribosomal RNA × 1 40S ribosomal protein S3 × 1 （P23396） 40S ribosomal protein S5 × 1 （P46782） 40S ribosomal protein S10 × 1 （P46783） 40S ribosomal protein S12 × 1 （P25398） 40S ribosomal protein S16 × 1 （P62249） 40S ribosomal protein S17 × 1 （P08708） 40S ribosomal protein S18 × 1 （P62269） 40S ribosomal protein S19 × 1 （P39019） 40S ribosomal protein S20 × 1 （P60866） 40S ribosomal protein S25 × 1 （P62851） 40S ribosomal protein S28 × 1 （P62857） 40S ribosomal protein S29 × 1 （P62273） Ribosomal protein S27a × 1 （Q5RKT7） Receptor of activated protein C kinase 1 × 1 （P63244） MAGNESIUM ION × 57 ZINC ION × 2	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RS15_HUMAN
Isoform	—
PDB entities	6
Chains and sequence ranges	Author chain P； PDBConstruct 1–145； UniProt 1–145

40S ribosomal protein S16

OrganismNot specified

UniProt P62249

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 15 RNA 1	18S ribosomal RNA × 1 40S ribosomal protein S3 × 1 （P23396） 40S ribosomal protein S5 × 1 （P46782） 40S ribosomal protein S10 × 1 （P46783） 40S ribosomal protein S12 × 1 （P25398） 40S ribosomal protein S15 × 1 （P62841） 40S ribosomal protein S17 × 1 （P08708） 40S ribosomal protein S18 × 1 （P62269） 40S ribosomal protein S19 × 1 （P39019） 40S ribosomal protein S20 × 1 （P60866） 40S ribosomal protein S25 × 1 （P62851） 40S ribosomal protein S28 × 1 （P62857） 40S ribosomal protein S29 × 1 （P62273） Ribosomal protein S27a × 1 （Q5RKT7） Receptor of activated protein C kinase 1 × 1 （P63244） MAGNESIUM ION × 57 ZINC ION × 2	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RS16_HUMAN
Isoform	—
PDB entities	7
Chains and sequence ranges	Author chain Q； PDBConstruct 1–146； UniProt 1–146

40S ribosomal protein S17

OrganismNot specified

UniProt P08708

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 15 RNA 1	18S ribosomal RNA × 1 40S ribosomal protein S3 × 1 （P23396） 40S ribosomal protein S5 × 1 （P46782） 40S ribosomal protein S10 × 1 （P46783） 40S ribosomal protein S12 × 1 （P25398） 40S ribosomal protein S15 × 1 （P62841） 40S ribosomal protein S16 × 1 （P62249） 40S ribosomal protein S18 × 1 （P62269） 40S ribosomal protein S19 × 1 （P39019） 40S ribosomal protein S20 × 1 （P60866） 40S ribosomal protein S25 × 1 （P62851） 40S ribosomal protein S28 × 1 （P62857） 40S ribosomal protein S29 × 1 （P62273） Ribosomal protein S27a × 1 （Q5RKT7） Receptor of activated protein C kinase 1 × 1 （P63244） MAGNESIUM ION × 57 ZINC ION × 2	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RS17_HUMAN
Isoform	—
PDB entities	8
Chains and sequence ranges	Author chain R； PDBConstruct 1–135； UniProt 1–135

40S ribosomal protein S18

OrganismNot specified

UniProt P62269

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 15 RNA 1	18S ribosomal RNA × 1 40S ribosomal protein S3 × 1 （P23396） 40S ribosomal protein S5 × 1 （P46782） 40S ribosomal protein S10 × 1 （P46783） 40S ribosomal protein S12 × 1 （P25398） 40S ribosomal protein S15 × 1 （P62841） 40S ribosomal protein S16 × 1 （P62249） 40S ribosomal protein S17 × 1 （P08708） 40S ribosomal protein S19 × 1 （P39019） 40S ribosomal protein S20 × 1 （P60866） 40S ribosomal protein S25 × 1 （P62851） 40S ribosomal protein S28 × 1 （P62857） 40S ribosomal protein S29 × 1 （P62273） Ribosomal protein S27a × 1 （Q5RKT7） Receptor of activated protein C kinase 1 × 1 （P63244） MAGNESIUM ION × 57 ZINC ION × 2	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RS18_HUMAN
Isoform	—
PDB entities	9
Chains and sequence ranges	Author chain S； PDBConstruct 1–152； UniProt 1–152

40S ribosomal protein S19

OrganismNot specified

UniProt P39019

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 15 RNA 1	18S ribosomal RNA × 1 40S ribosomal protein S3 × 1 （P23396） 40S ribosomal protein S5 × 1 （P46782） 40S ribosomal protein S10 × 1 （P46783） 40S ribosomal protein S12 × 1 （P25398） 40S ribosomal protein S15 × 1 （P62841） 40S ribosomal protein S16 × 1 （P62249） 40S ribosomal protein S17 × 1 （P08708） 40S ribosomal protein S18 × 1 （P62269） 40S ribosomal protein S20 × 1 （P60866） 40S ribosomal protein S25 × 1 （P62851） 40S ribosomal protein S28 × 1 （P62857） 40S ribosomal protein S29 × 1 （P62273） Ribosomal protein S27a × 1 （Q5RKT7） Receptor of activated protein C kinase 1 × 1 （P63244） MAGNESIUM ION × 57 ZINC ION × 2	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RS19_HUMAN
Isoform	—
PDB entities	10
Chains and sequence ranges	Author chain T； PDBConstruct 1–145； UniProt 1–145

40S ribosomal protein S20

OrganismNot specified

UniProt P60866

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 15 RNA 1	18S ribosomal RNA × 1 40S ribosomal protein S3 × 1 （P23396） 40S ribosomal protein S5 × 1 （P46782） 40S ribosomal protein S10 × 1 （P46783） 40S ribosomal protein S12 × 1 （P25398） 40S ribosomal protein S15 × 1 （P62841） 40S ribosomal protein S16 × 1 （P62249） 40S ribosomal protein S17 × 1 （P08708） 40S ribosomal protein S18 × 1 （P62269） 40S ribosomal protein S19 × 1 （P39019） 40S ribosomal protein S25 × 1 （P62851） 40S ribosomal protein S28 × 1 （P62857） 40S ribosomal protein S29 × 1 （P62273） Ribosomal protein S27a × 1 （Q5RKT7） Receptor of activated protein C kinase 1 × 1 （P63244） MAGNESIUM ION × 57 ZINC ION × 2	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RS20_HUMAN
Isoform	—
PDB entities	11
Chains and sequence ranges	Author chain U； PDBConstruct 1–119； UniProt 1–119

40S ribosomal protein S25

OrganismNot specified

UniProt P62851

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 15 RNA 1	18S ribosomal RNA × 1 40S ribosomal protein S3 × 1 （P23396） 40S ribosomal protein S5 × 1 （P46782） 40S ribosomal protein S10 × 1 （P46783） 40S ribosomal protein S12 × 1 （P25398） 40S ribosomal protein S15 × 1 （P62841） 40S ribosomal protein S16 × 1 （P62249） 40S ribosomal protein S17 × 1 （P08708） 40S ribosomal protein S18 × 1 （P62269） 40S ribosomal protein S19 × 1 （P39019） 40S ribosomal protein S20 × 1 （P60866） 40S ribosomal protein S28 × 1 （P62857） 40S ribosomal protein S29 × 1 （P62273） Ribosomal protein S27a × 1 （Q5RKT7） Receptor of activated protein C kinase 1 × 1 （P63244） MAGNESIUM ION × 57 ZINC ION × 2	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RS25_HUMAN
Isoform	—
PDB entities	12
Chains and sequence ranges	Author chain Z； PDBConstruct 1–125； UniProt 1–125

40S ribosomal protein S28

OrganismNot specified

UniProt P62857

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 15 RNA 1	18S ribosomal RNA × 1 40S ribosomal protein S3 × 1 （P23396） 40S ribosomal protein S5 × 1 （P46782） 40S ribosomal protein S10 × 1 （P46783） 40S ribosomal protein S12 × 1 （P25398） 40S ribosomal protein S15 × 1 （P62841） 40S ribosomal protein S16 × 1 （P62249） 40S ribosomal protein S17 × 1 （P08708） 40S ribosomal protein S18 × 1 （P62269） 40S ribosomal protein S19 × 1 （P39019） 40S ribosomal protein S20 × 1 （P60866） 40S ribosomal protein S25 × 1 （P62851） 40S ribosomal protein S29 × 1 （P62273） Ribosomal protein S27a × 1 （Q5RKT7） Receptor of activated protein C kinase 1 × 1 （P63244） MAGNESIUM ION × 57 ZINC ION × 2	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RS28_HUMAN
Isoform	—
PDB entities	13
Chains and sequence ranges	Author chain c； PDBConstruct 1–61； UniProt 8–68

40S ribosomal protein S29

OrganismNot specified

UniProt P62273

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 15 RNA 1	18S ribosomal RNA × 1 40S ribosomal protein S3 × 1 （P23396） 40S ribosomal protein S5 × 1 （P46782） 40S ribosomal protein S10 × 1 （P46783） 40S ribosomal protein S12 × 1 （P25398） 40S ribosomal protein S15 × 1 （P62841） 40S ribosomal protein S16 × 1 （P62249） 40S ribosomal protein S17 × 1 （P08708） 40S ribosomal protein S18 × 1 （P62269） 40S ribosomal protein S19 × 1 （P39019） 40S ribosomal protein S20 × 1 （P60866） 40S ribosomal protein S25 × 1 （P62851） 40S ribosomal protein S28 × 1 （P62857） Ribosomal protein S27a × 1 （Q5RKT7） Receptor of activated protein C kinase 1 × 1 （P63244） MAGNESIUM ION × 57 ZINC ION × 2	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RS29_HUMAN
Isoform	—
PDB entities	14
Chains and sequence ranges	Author chain d； PDBConstruct 1–55； UniProt 2–56

Ribosomal protein S27a

OrganismNot specified

UniProt Q5RKT7

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 15 RNA 1	18S ribosomal RNA × 1 40S ribosomal protein S3 × 1 （P23396） 40S ribosomal protein S5 × 1 （P46782） 40S ribosomal protein S10 × 1 （P46783） 40S ribosomal protein S12 × 1 （P25398） 40S ribosomal protein S15 × 1 （P62841） 40S ribosomal protein S16 × 1 （P62249） 40S ribosomal protein S17 × 1 （P08708） 40S ribosomal protein S18 × 1 （P62269） 40S ribosomal protein S19 × 1 （P39019） 40S ribosomal protein S20 × 1 （P60866） 40S ribosomal protein S25 × 1 （P62851） 40S ribosomal protein S28 × 1 （P62857） 40S ribosomal protein S29 × 1 （P62273） Receptor of activated protein C kinase 1 × 1 （P63244） MAGNESIUM ION × 57 ZINC ION × 2	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	Q5RKT7_HUMAN
Isoform	—
PDB entities	15
Chains and sequence ranges	Author chain f； PDBConstruct 1–72； UniProt 78–149

Receptor of activated protein C kinase 1

OrganismNot specified

UniProt P63244

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 15 RNA 1	18S ribosomal RNA × 1 40S ribosomal protein S3 × 1 （P23396） 40S ribosomal protein S5 × 1 （P46782） 40S ribosomal protein S10 × 1 （P46783） 40S ribosomal protein S12 × 1 （P25398） 40S ribosomal protein S15 × 1 （P62841） 40S ribosomal protein S16 × 1 （P62249） 40S ribosomal protein S17 × 1 （P08708） 40S ribosomal protein S18 × 1 （P62269） 40S ribosomal protein S19 × 1 （P39019） 40S ribosomal protein S20 × 1 （P60866） 40S ribosomal protein S25 × 1 （P62851） 40S ribosomal protein S28 × 1 （P62857） 40S ribosomal protein S29 × 1 （P62273） Ribosomal protein S27a × 1 （Q5RKT7） MAGNESIUM ION × 57 ZINC ION × 2	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RACK1_HUMAN
Isoform	—
PDB entities	16
Chains and sequence ranges	Author chain g； PDBConstruct 1–315； UniProt 1–315

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	6zol
Deposition date deposition_date	2020-07-07
Structure title title	SARS-CoV-2-Nsp1-40S complex, focused on head
Keywords keywords	inhibitor, mRNA channel, 40S ribosomal subunit, TRANSLATION; TRANSLATION
Experimental Method method	ELECTRON MICROSCOPY

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6zol__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6zol__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

6zol__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	46.17 Å
Rg (electron density)	47.82 Å
Total Rg	47.80 Å
Atom count	25591
Residues	2416
Excluded volume	421070 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`6zol__assembly_1__model_1`	hexadecameric （16）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (18)

Entity 1 Entity 1 polymer

Description description	18S ribosomal RNA
Molecular weight formula_weight	602777.9 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polyribonucleotide
Chain IDs strand_id	2
Atom count atom_count	25591

UACCUGGUUGAUCCUGCCAGUAGCAUAUGCUUGUCUCAAAGAUUAAGCCAUGCAUGUCUAAGUACGCACGGCCGGUACAGUGAAACUGCGAAUGGCUCAUUAAAUCAGUUAUGGUUCCUUUGGUCGCUCGCUCCUCUCCUACUUGGAUAACUGUGGUAAUUCUAGAGCUAAUACAUGCCGACGGGCGCUGACCCCCUUCGCGGGGGGGAUGCGUGCAUUUAUCAGAUCAAAACCAACCCGGUCAGCCCCUCUCCGGCCCCGGCCGGGGGGCGGGCGCCGGCGGCUUUGGUGACUCUAGAUAACCUCGGGCCGAUCGCACGCCCCCCGUGGCGGCGACGACCCAUUCGAACGUCUGCCCUAUCAACUUUCGAUGGUAGUCGCCGUGCCUACCAUGGUGACCACGGGUGACGGGGAAUCAGGGUUCGAUUCCGGAGAGGGAGCCUGAGAAACGGCUACCACAUCCAAGGAAGGCAGCAGGCGCGCAAAUUACCCACUCCCGACCCGGGGAGGUAGUGACGAAAAAUAACAAUACAGGACUCUUUCGAGGCCCUGUAAUUGGAAUGAGUCCACUUUAAAUCCUUUAACGAGGAUCCAUUGGAGGGCAAGUCUGGUGCCAGCAGCCGCGGUAAUUCCAGCUCCAAUAGCGUAUAUUAAAGUUGCUGCAGUUAAAAAGCUCGUAGUUGGAUCUUGGGAGCGGGCGGGCGGUCCGCCGCGAGGCGAGCCACCGCCCGUCCCCGCCCCUUGCCUCUCGGCGCCCCCUCGAUGCUCUUAGCUGAGUGUCCCGCGGGGCCCGAAGCGUUUACUUUGAAAAAAUUAGAGUGUUCAAAGCAGGCCCGAGCCGCCUGGAUACCGCAGCUAGGAAUAAUGGAAUAGGACCGCGGUUCUAUUUUGUUGGUUUUCGGAACUGAGGCCAUGAUUAAGAGGGACGGCCGGGGGCAUUCGUAUUGCGCCGCUAGAGGUGAAAUUCUUGGACCGGCGCAAGACGGACCAGAGCGAAAGCAUUUGCCAAGAAUGUUUUCAUUAAUCAAGAACGAAAGUCGGAGGUUCGAAGACGAUCAGAUACCGUCGUAGUUCCGACCAUAAACGAUGCCGACCGGCGAUGCGGCGGCGUUAUUCCCAUGACCCGCCGGGCAGCUUCCGGGAAACCAAAGUCUUUGGGUUCCGGGGGGAGUAUGGUUGCAAAGCUGAAACUUAAAGGAAUUGACGGAAGGGCACCACCAGGAGUGGAGCCUGCGGCUUAAUUUGACUCAACACGGGAAACCUCACCCGGCCCGGACACGGACAGGAUUGACAGAUUGAUAGCUCUUUCUCGAUUCCGUGGGUGGUGGUGCAUGGCCGUUCUUAGUUGGUGGAGCGAUUUGUCUGGUUAAUUCCGAUAACGAACGAGACUCUGGCAUGCUAACUAGUUACGCGACCCCCGAGCGGUCGGCGUCCCCCAACUUCUUAGAGGGACAAGUGGCGUUCAGCCACCCGAGAUUGAGCAAUAACAGGUCUGUGAUGCCCUUAGAUGUCCGGGGCUGCACGCGCGCUACACUGACUGGCUCAGCGUGUGCCUACCCUACGCCGGCAGGCGCGGGUAACCCGUUGAACCCCAUUCGUGAUGGGGAUCGGGGAUUGCAAUUAUUCCCCAUGAACGAGGAAUUCCCAGUAAGUGCGGGUCAUAAGCUUGCGUUGAUUAAGUCCCUGCCCUUUGUACACACCGCCCGUCGCUACUACCGAUUGGAUGGUUUAGUGAGGCCCUCGGAUCGGCCCCGCCGGGGUCGGCCCACGGCCCUGGCGGAGCGCUGAGAAGACGGUCGAACUUGACUAUCUAGAGGAAGUAAAAGUCGUAACAAGGUUUCCGUAGGUGAACCUGCGGAAGGAUCAUUA

Entity 2 Entity 2 polymer

Description description	40S ribosomal protein S3
Molecular weight formula_weight	26729.4 kDa
EC 编号 ec_number	4.2.99.18
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	D

MAVQISKKRKFVADGIFKAELNEFLTRELAEDGYSGVEVRVTPTRTEIIILATRTQNVLGEKGRRIRELTAVVQKRFGFPEGSVELYAEKVATRGLCAIAQAESLRYKLLGGLAVRRACYGVLRFIMESGAKGCEVVVSGKLRGQRAKSMKFVDGLMIHSGDPVNYYVDTAVRHVLLRQGVLGIKVKIMLPWDPTGKIGPKKPLPDHVSIVEPKDEILPTTPISEQKGGKPEPPAMPQPVPTA

Entity 3 Entity 3 polymer

Description description	40S ribosomal protein S5
Molecular weight formula_weight	22913.5 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	F

MTEWETAAPAVAETPDIKLFGKWSTDDVQINDISLQDYIAVKEKYAKYLPHSAGRYAAKRFRKAQCPIVERLTNSMMMHGRNNGKKLMTVRIVKHAFEIIHLLTGENPLQVLVNAIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGAREAAFRNIKTIAECLADELINAAKGSSNSYAIKKKDELERVAKSNR

Entity 4 Entity 4 polymer

Description description	40S ribosomal protein S10
Molecular weight formula_weight	18933.8 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	K

MLMPKKNRIAIYELLFKEGVMVAKKDVHMPKHPELADKNVPNLHVMKAMQSLKSRGYVKEQFAWRHFYWYLTNEGIQYLRDYLHLPPEIVPATLRRSRPETGRPRPKGLEGERPARLTRGEADRDTYRRSAVPPGADKKAEAGAGSATEFQFRGGFGRGRGQPPQ

Entity 5 Entity 5 polymer

Description description	40S ribosomal protein S12
Molecular weight formula_weight	14539.0 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	M

MAEEGIAAGGVMDVNTALQEVLKTALIHDGLARGIREAAKALDKRQAHLCVLASNCDEPMYVKLVEALCAEHQINLIKVDDNKKLGEWVGLCKIDREGKPRKVVGCSCVVVKDYGKESQAKDVIEEYFKCKK

Entity 6 Entity 6 polymer

Description description	40S ribosomal protein S15
Molecular weight formula_weight	17076.2 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	P

MAEVEQKKKRTFRKFTYRGVDLDQLLDMSYEQLMQLYSARQRRRLNRGLRRKQHSLLKRLRKAKKEAPPMEKPEVVKTHLRDMIILPEMVGSMVGVYNGKTFNQVEIKPEMIGHYLGEFSITYKPVKHGRPGIGATHSSRFIPLK

Entity 7 Entity 7 polymer

Description description	40S ribosomal protein S16
Molecular weight formula_weight	16477.4 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	Q

MPSKGPLQSVQVFGRKKTATAVAHCKRGNGLIKVNGRPLEMIEPRTLQYKLLEPVLLLGKERFAGVDIRVRVKGGGHVAQIYAIRQSISKALVAYYQKYVDEASKKEIKDILIQYDRTLLVADPRRCESKKFGGPGARARYQKSYR

Entity 8 Entity 8 polymer

Description description	40S ribosomal protein S17
Molecular weight formula_weight	15578.2 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	R

MGRVRTKTVKKAARVIIEKYYTRLGNDFHTNKRVCEEIAIIPSKKLRNKIAGYVTHLMKRIQRGPVRGISIKLQEEERERRDNYVPEVSALDQEIIEVDPDTKEMLKLLDFGSLSNLQVTQPTVGMNFKTPRGPV

Entity 9 Entity 9 polymer

Description description	40S ribosomal protein S18
Molecular weight formula_weight	17759.8 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	S

MSLVIPEKFQHILRVLNTNIDGRRKIAFAITAIKGVGRRYAHVVLRKADIDLTKRAGELTEDEVERVITIMQNPRQYKIPDWFLNRQKDVKDGKYSQVLANGLDNKLREDLERLKKIRAHRGLRHFWGLRVRGQHTKTTGRRGRTVGVSKKK

Entity 10 Entity 10 polymer

Description description	40S ribosomal protein S19
Molecular weight formula_weight	16091.6 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	T

MPGVTVKDVNQQEFVRALAAFLKKSGKLKVPEWVDTVKLAKHKELAPYDENWFYTRAASTARHLYLRGGAGVGSMTKIYGGRQRNGVMPSHFSRGSKSVARRVLQALEGLKMVEKDQDGGRKLTPQGQRDLDRIAGQVAAANKKH

Entity 11 Entity 11 polymer

Description description	40S ribosomal protein S20
Molecular weight formula_weight	13398.8 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	U

MAFKDTGKTPVEPEVAIHRIRITLTSRNVKSLEKVCADLIRGAKEKNLKVKGPVRMPTKTLRITTRKTPCGEGSKTWDRFQMRIHKRLIDLHSPSEIVKQITSISIEPGVEVEVTIADA

Entity 12 Entity 12 polymer

Description description	40S ribosomal protein S25
Molecular weight formula_weight	13776.2 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	Z

MPPKDDKKKKDAGKSAKKDKDPVNKSGGKAKKKKWSKGKVRDKLNNLVLFDKATYDKLCKEVPNYKLITPAVVSERLKIRGSLARAALQELLSKGLIKLVSKHRAQVIYTRNTKGGDAPAAGEDA

Entity 13 Entity 13 polymer

Description description	40S ribosomal protein S28
Molecular weight formula_weight	6878.9 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	c

PIKLARVTKVLGRTGSQGQCTQVRVEFMDDTSRSIIRNVKGPVREGDVLTLLESEREARRL

Entity 14 Entity 14 polymer

Description description	40S ribosomal protein S29
Molecular weight formula_weight	6559.6 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	d

GHQQLYWSHPRKFGQGSRSCRVCSNRHGLIRKYGLNMCRQCFRQYAKDIGFIKLD

Entity 15 Entity 15 polymer

Description description	Ribosomal protein S27a
Molecular weight formula_weight	8453.1 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	f

KKRKKKSCTTPKKNKHKRKKVKLAVLKYYKVDENGKISRLRRECPSDECGAGVFMASHFDRHYCGKCCLTYC

Entity 16 Entity 16 polymer

Description description	Receptor of activated protein C kinase 1
Molecular weight formula_weight	34857.4 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	g

MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIG

Entity 17 Entity 17 non-polymer

Description description	MAGNESIUM ION
Molecular weight formula_weight	24.3 kDa
Source method src_method	syn
Copy count entity_count	57

Entity 18 Entity 18 non-polymer

Description description	ZINC ION
Molecular weight formula_weight	65.4 kDa
Source method src_method	syn
Copy count entity_count	2

▼

6. Fold Classification (SCOP + CATH) 2 domains

SCOP 2.08 (1 domains)

Domain ID domain_id	d6zolg_
Class class	b — All beta proteins
Fold Fold fold	b.69 — 7-bladed beta-propeller
Superfamily Superfamily superfamily	b.69.4 — WD40 repeat-like
Family Family family	b.69.4.1 — WD40-repeat

CATH v4.4 (1 domains)

Domain ID domain_id	6zolD01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	300 — GMP Synthetase; Chain A, domain 3
Homologous superfamily homologous superfamily	20 — K homology (KH) domain

▶

Unit-cell length a length_a	1.000 Å
Unit-cell length b length_b	1.000 Å
Unit-cell length c length_c	1.000 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	90.00 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	—

Space group space_group	P 1
Space-group number int_tables_number	1
Crystal system crystal_system	—

Resolution resolution	2.80 Å
Resolution测定Method resolution_method	—
颗粒数 num_particles	118765

SARS-CoV-2-Nsp1-40S complex, focused on head

1. Protein Identity and Related Structures Protein Identity & Related Structures

40S ribosomal protein S3

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

40S ribosomal protein S5

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

40S ribosomal protein S10

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

40S ribosomal protein S12

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

40S ribosomal protein S15

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

40S ribosomal protein S16

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

40S ribosomal protein S17

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

40S ribosomal protein S18

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

40S ribosomal protein S19

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

40S ribosomal protein S20

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer