SAXSdb — 7c5d

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1. Protein Identity and Related Structures Protein Identity & Related Structures

Telomeric repeat-binding factor 2

Homo sapiens

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 2	Microcephalin × 1 （Q8NEM0） water × 2	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 2	Microcephalin × 1 （Q8NEM0） GLYCEROL × 2 water × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	TERF2_HUMAN
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 1–204； UniProt 84–287 Author chain B； PDBConstruct 1–204； UniProt 84–287

Microcephalin

Homo sapiens

UniProt Q8NEM0

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 2	Telomeric repeat-binding factor 2 × 1 （Q15554） water × 2	Consistent with protein count
2	Protein heterocomplex	Heteromer	Protein 2	Telomeric repeat-binding factor 2 × 1 （Q15554） GLYCEROL × 2 water × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MCPH1_HUMAN
Isoform	—
PDB entities	2
Chains and sequence ranges	Author chain C； PDBConstruct 1–21； UniProt 322–342 Author chain D； PDBConstruct 1–21； UniProt 322–342

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	7c5d
Deposition date deposition_date	2020-05-19
Structure title title	Crystal structure of TRF2 TRFH domain in complex with a MCPH1 peptide
Keywords keywords	Telomere, shelterin complex, TRF2, MCPH1, DNA repair, PROTEIN BINDING; PROTEIN BINDING
Experimental Method method	X-RAY DIFFRACTION

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

7c5d__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

7c5d__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

7c5d__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	19.24 Å
Rg (electron density)	18.51 Å
Total Rg	19.46 Å
Atom count	1715
Residues	210
Excluded volume	30833 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`7c5d__assembly_1__model_1`	dimeric （2）	Success	4.1.3-1-20251215 (887e7ef)	View Download
2	1	`7c5d__assembly_2__model_1`	dimeric （2）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

Entity 1 Entity 1 polymer

Description description	Telomeric repeat-binding factor 2
Molecular weight formula_weight	23724.6 kDa
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	A,B
Atom count atom_count	3582

GAGEARLEEAVNRWVLKFYFHEALRAFRGSRYGDFRQIRDIMQALLVRPLGKEHTVSRLLRVMQCLSRIEEGENLDCSFDMEAELTPLESAINVLEMIKTEFTLTEAVVESSRKLVKEAAVIICIKNKEFEKASKILKKHMSKDPTTQKLRNDLLNIIREKNLAHPVIQNFSYETFQQKMLRFLESHLDDAEPYLLTMAKKALK

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Escherichia coli BL21(DE3)

Entity 2 Entity 2 polymer

Description description	Microcephalin
Molecular weight formula_weight	2429.6 kDa
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	C,D

SQETFEEKYRLSPTLSSTKGH

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Escherichia coli BL21(DE3)

Entity 3 Entity 3 non-polymer

Description description	GLYCEROL
Molecular weight formula_weight	92.1 kDa
Source method src_method	syn
Copy count entity_count	2

Entity 4 Entity 4 water

Description description	water
Molecular weight formula_weight	18.0 kDa
Source method src_method	nat
Copy count entity_count	140

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6. Fold Classification (SCOP + CATH) 2 domains

SCOP 2.08 (2 domains)

Domain ID domain_id	d7c5da_
Class class	a — All alpha proteins
Fold Fold fold	a.146 — Telomeric repeat binding factor (TRF) dimerisation domain
Superfamily Superfamily superfamily	a.146.1 — Telomeric repeat binding factor (TRF) dimerisation domain
Family Family family	a.146.1.1 — Telomeric repeat binding factor (TRF) dimerisation domain

Domain ID domain_id	d7c5db_
Class class	a — All alpha proteins
Fold Fold fold	a.146 — Telomeric repeat binding factor (TRF) dimerisation domain
Superfamily Superfamily superfamily	a.146.1 — Telomeric repeat binding factor (TRF) dimerisation domain
Family Family family	a.146.1.1 — Telomeric repeat binding factor (TRF) dimerisation domain

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Unit-cell length a length_a	60.737 Å
Unit-cell length b length_b	74.941 Å
Unit-cell length c length_c	98.418 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	90.00 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	8

Space group space_group	P 21 21 21
Space-group number int_tables_number	19
Crystal system crystal_system	—

Resolution resolution	2.151 Å
Low-resolution limit resolution_low	31.890 Å
R factor r_factor	0.1911
R_work r_work	0.1888
R_free r_free	0.2348

Crystal structure of TRF2 TRFH domain in complex with a MCPH1 peptide

1. Protein Identity and Related Structures Protein Identity & Related Structures

Telomeric repeat-binding factor 2

State in the Current Structure

Other States of the Same Protein in the Database

Microcephalin

State in the Current Structure

Other States of the Same Protein in the Database

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

7c5d__assembly_1__model_1

7c5d__assembly_1__model_1 | I(q)

7c5d__assembly_1__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

Refinement Refinement

Diffraction experiment Diffraction

5. Entities and Polymers Entities & Polymers (4)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

Entity 2 Entity 2 polymer

Polymer Polymer

Source Source

Entity 3 Entity 3 non-polymer

Entity 4 Entity 4 water

6. Fold Classification (SCOP + CATH) 2 domains

SCOP 2.08 (2 domains)

7. Citations (1)

Crystal structure of TRF2 TRFH domain in complex with a MCPH1 peptide

1. Protein Identity and Related Structures Protein Identity & Related Structures

Telomeric repeat-binding factor 2

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Microcephalin

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

7c5d__assembly_1__model_1

7c5d__assembly_1__model_1 | I(q)

7c5d__assembly_1__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

Refinement Refinement

Diffraction experiment Diffraction

5. Entities and Polymers Entities & Polymers (4)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

Entity 2 Entity 2 polymer

Polymer Polymer

Source Source

Entity 3 Entity 3 non-polymer

Entity 4 Entity 4 water

6. Fold Classification (SCOP + CATH) 2 domains

SCOP 2.08 (2 domains)

7. Citations (1)