7cft

Cryo-EM strucutre of human acid-sensing ion channel 1a in complex with snake toxin Mambalgin1 at pH 8.0

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Acid-sensing ion channel 1

Homo sapiens

UniProt P78348

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 6 Mambalgin-1 × 3 (P0DKR6) 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name ASIC1_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A; PDBConstruct 10–477; UniProt 1–468 Author chain B; PDBConstruct 10–477; UniProt 1–468 Author chain C; PDBConstruct 10–477; UniProt 1–468

Mambalgin-1

OrganismNot specified

UniProt P0DKR6

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 6 Acid-sensing ion channel 1 × 3 (P78348) 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name 3SX1_DENPO
Isoform —
PDB entities 2
Chains and sequence ranges Author chain D; PDBConstruct 1–57; UniProt 22–78 Author chain E; PDBConstruct 1–57; UniProt 22–78 Author chain F; PDBConstruct 1–57; UniProt 22–78

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id7cft
Deposition date deposition_date2020-06-28
Structure title titleCryo-EM strucutre of human acid-sensing ion channel 1a in complex with snake toxin Mambalgin1 at pH 8.0
Keywords keywordsASIC, human, Mambalgin1 toxin, cryo-EM structure, MEMBRANE PROTEIN; MEMBRANE PROTEIN
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

7cft__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

7cft__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

7cft__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg(Guinier)37.30 Å
Rg (electron density)37.04 Å
Total Rg37.45 Å
Atom count11283
Residues1425
Excluded volume200480 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 7cft__assembly_1__model_1 hexameric (6) Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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7. Citations (1)