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7cjt

Crystal Structure of SETDB1 Tudor domain in complexed with (R,R)-59

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Histone-lysine N-methyltransferase SETDB1

Homo sapiens

UniProt Q15047

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein monomer Monomer Protein 1 2-[[(3~{R},5~{R})-1-methyl-5-(4-phenylmethoxyphenyl)piperidin-3-yl]amino]-3-prop-2-enyl-5~{H}-pyrrolo[3,2-d]pyrimidin-4-one × 1 water × 1 Consistent with protein count
2 Protein monomer Monomer Protein 1 2-[[(3~{R},5~{R})-1-methyl-5-(4-phenylmethoxyphenyl)piperidin-3-yl]amino]-3-prop-2-enyl-5~{H}-pyrrolo[3,2-d]pyrimidin-4-one × 1 water × 1 Consistent with protein count
3 Protein monomer Monomer Protein 1 2-[[(3~{R},5~{R})-1-methyl-5-(4-phenylmethoxyphenyl)piperidin-3-yl]amino]-3-prop-2-enyl-5~{H}-pyrrolo[3,2-d]pyrimidin-4-one × 1 Consistent with protein count
4 Protein monomer Monomer Protein 1 2-[[(3~{R},5~{R})-1-methyl-5-(4-phenylmethoxyphenyl)piperidin-3-yl]amino]-3-prop-2-enyl-5~{H}-pyrrolo[3,2-d]pyrimidin-4-one × 1 water × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
3dlm 5kch 5kco 5ke2 5ke3 5kh6 5qt1 5qt2 6au2 6au3 7cjt 7cjt

19 assemblies; showing the first 12

Homodimer
7c9n 7caj 7cd9

3 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
6bhd 6bhe 6bhg 6bhh 6bhi 6bpi 8iya 8iya 8iya

9 assemblies

View Construct and Data Evidence
UniProt name SETB1_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 20–240； UniProt 190–410 Author chain B； PDBConstruct 20–240； UniProt 190–410 Author chain C； PDBConstruct 20–240； UniProt 190–410 Author chain D； PDBConstruct 20–240； UniProt 190–410

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id7cjt
Deposition date deposition_date2020-07-13
Structure title titleCrystal Structure of SETDB1 Tudor domain in complexed with (R,R)-59
Keywords keywordsSETDB1, Tudor domian, inhibitor, TRANSFERASE; TRANSFERASE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

7cjt__assembly_3__model_1

Assembly 3 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

7cjt__assembly_3__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

7cjt__assembly_3__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）19.77 Å
Rg (electron density)19.07 Å
Total Rg20.14 Å
Atom count3459
Residues215
Excluded volume31477 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 7cjt__assembly_1__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 7cjt__assembly_2__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 7cjt__assembly_3__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
4 1 7cjt__assembly_4__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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7. Citations (1)