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7cyl

Crystal structure of Karyopherin-beta2 in complex with FUS PY-NLS(P525L)

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Transportin-1

Homo sapiens

UniProt Q92973

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 RNA-binding protein FUS × 1 （P35637） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
2qmr 2qmr 2qmr 2qmr 2z5j 2z5m 2z5n 2z5o

8 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1qbk 1qbk 2h4m 2ot8 2ot8 2z5k 4fdd 4fq3 4jlq 4oo6 5j3v 5j3v

20 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name TNPO1_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 3–338； UniProt 9–344 Author chain A； PDBConstruct 346–868； UniProt 376–898

RNA-binding protein FUS

Homo sapiens

UniProt P35637

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 Transportin-1 × 1 （Q92973） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
2la6 2lcw 5xrr 5xsg 6kj1 6kj2 6kj3 6kj4

8 assemblies

Homodimer
5xrr

1 assemblies

Homotetramer

None

Other homooligomers
5w3n 6bzp 6xfm 7vqq

4 assemblies

Heteromeric or nucleic-acid complex
4fdd 5yvg 5yvg 5yvh 5yvi 6g99 6gbm 6snj 7cyl

9 assemblies

View Construct and Data Evidence
UniProt name FUS_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 4–54； UniProt 476–526

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id7cyl
Deposition date deposition_date2020-09-03
Structure title titleCrystal structure of Karyopherin-beta2 in complex with FUS PY-NLS(P525L)
Keywords keywordsNuclear import, Karyopherin, TRANSPORT PROTEIN, TRANSPORT PROTEIN-RNA BINDING PROTEIN complex; TRANSPORT PROTEIN/RNA BINDING PROTEIN
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

7cyl__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

7cyl__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

7cyl__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）34.98 Å
Rg (electron density)34.42 Å
Total Rg34.79 Å
Atom count6827
Residues856
Excluded volume122780 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 7cyl__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (2)

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6. Fold Classification (SCOP + CATH) 1 domains

SCOP 2.08 (1 domains)

Domain ID domain_idd7cyla_
Class classa — All alpha proteins
Fold Fold folda.118 — alpha-alpha superhelix
Superfamily Superfamily superfamilya.118.1 — ARM repeat
Family Family familya.118.1.1 — Armadillo repeat
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7. Citations (1)