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7k2l

Kelch domain of human KEAP1 bound to Nrf2 cyclic peptide, c[BAL-NPETGE]

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Kelch-like ECH-associated protein 1

Homo sapiens

UniProt Q14145

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein monomer Monomer Protein 1 water × 1 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 Nrf2 cyclic peptide,c[BAL-NPETGE] × 1 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1u6d 1zgk 3vng 3vnh 3zgc 4cxi 4ifj 4ifn 4in4 4in4 4in4 4iqk

105 assemblies; showing the first 12

Homodimer
3zgd 4cxj 4cxt 4l7b 5dad 5daf 6ffm 6rog 6w67 6w68 6w69 7exi

35 assemblies; showing the first 12

Homotetramer

None

Other homooligomers
4l7c 4l7d 4n1b

3 assemblies

Heteromeric or nucleic-acid complex
3zgc 4ifl 4ifl 5f72 5f72 5nlb 5wfv 5wg1 5x54 5x54 6fmp 6fmq

52 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name KEAP1_HUMAN
Isoform —
PDB entities 1, 2
Chains and sequence ranges Author chain B； PDBConstruct 1–289； UniProt 326–614 Author chain A； PDBConstruct 1–284； UniProt 326–609

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id7k2l
Deposition date deposition_date2020-09-08
Structure title titleKelch domain of human KEAP1 bound to Nrf2 cyclic peptide, c[BAL-NPETGE]
Keywords keywordsPeptide inhibitor, Inhibitor complex, Loop-mimic, PROTEIN BINDING, cyclic peptide; PROTEIN BINDING
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

7k2l__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

7k2l__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

7k2l__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）18.83 Å
Rg (electron density)17.59 Å
Total Rg18.51 Å
Atom count2216
Residues289
Excluded volume38729 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 7k2l__assembly_1__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 7k2l__assembly_2__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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7. Citations (1)